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Functional recovery after peripheral nerve injury via sustained growth factor delivery from mineral-coated microparticles

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Neural Regeneration Research 2021年第5期16卷 871-877页

作者： Daniel J.Hellenbrand Clayton L.Haldeman Jae-Sung Lee Angela G.Gableman Elena K.Dai Stephen D.Ortmann Jerrod CGotchy Kierra K.miller adrianna m.doucas Nicole C.Nowak William L.murphy Amgad S.Hanna Department of Neurological Surgery University of WisconsinMadisonWIUSA Department of Biomedical Engineering University of WisconsinMadisonWIUSA Department of Orthopedics and Rehabilitation University of Wisconsin madison WIUSA

The gold standard for treating peripheral nerve injuries that have large nerve gaps where the nerves cannot be directly sutured back together because it creates tension on the nerve,is to incorporate an autologous nerve ***,even with the incorporation of a nerve graft,generally patients only regain a small portion of function in limbs affected by the ***,there has been some promising results using growth factors to induce more axon growth through the nerve graft,many of these previous therapies are limited in their ability to release growth factors in a sustained manner and tailor them to a desired time *** ideal drug delivery platform would deliver growth factors at therapeutic levels for enough time to grow axons the entire length of the nerve *** hypothesized that mineral coated microparticles(mCms)would bind,stabilize and release biologically active glial cell-derived neurotrophic factor(GDNF)and nerve growth factor(NGF)in a sustained ***,the objective of this study was to test the ability of mCms releasing growth factors at the distal end of a 10 mm sciatic nerve graft,to induce axon growth through the nerve graft and restore hind limb *** sciatic nerve grafting in Lewis rats,the hind limb function was tested weekly by measuring the angle of the ankle at toe lift-off while walking down a *** weeks after grafting,the grafts were harvested and myelinated axons were analyzed proximal to the graft,in the center of the graft,and distal to the *** physiological conditions in vitro,the mCms delivered a burst release of NGF and GDNF for 3 days followed by a sustained release for at least 22 *** vivo,mCms releasing NGF and GDNF at the distal end of sciatic nerve grafts resulted in significantly more myelinated axons extending distal to the graft when compared to rats that received nerve grafts without growth factor *** rats with nerve grafts incorporated with mCms releasing NGF and G

关键词： autografts axon growth drug delivery glial cell-derived neurotrophic factor growth factors mineral coatings nerve grafting nerve growth factor

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A direct solver with O（N） complexity for integral equations on one-dimensional domains

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Frontiers of mathematics in China 2012年第2期7卷 217-247页

作者： adrianna GILLmAN Patrick m. YOUNG Per-Gunnar mARTINSSON Department of Applied mathematics University of Colorado at Boulder BoulderCO 80309-0526 USA

An algorithm for the direct inversion of the linear systems arising from NystrSm discretization of integral equations on one-dimensional domains is described. The method typically has O（N） complexity when applied to boundary integral equations （BIEs） in the plane with non-oscillatory kernels such as those associated with the Laplace and Stokes＇ equations. The scaling coefficient suppressed by the ＂big-O＂ notation depends logarithraically on the requested accuracy. The method can also be applied to BIEs with oscillatory kernels such as those associated with the Helmholtz and time-harmonic maxwell equations; it is efficient at long and intermediate wave-lengths, but will eventually become prohibitively slow as the wave-length decreases. To achieve linear complexity, rank： deficiencies in the off-diagonal blocks of the coefficient matrix are exploited. The technique is conceptually related to the H- and H2-matrix arithmetic of Hackbusch and coworkers, and is closely related to previous work on Hierarchically Semi-Separable matrices.

关键词： Direct solver integral equation fast direct solver boundary value problem boundary integral equation hierarchically semi-separable matrix mSC 65R20,65F05

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Validation of an mRI-based prostate cancer prebiopsy Gleason score predictive nomogram

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Current Urology 2022年第1期16卷 38-43页

作者： adrianna Jiaying Lee Amelia Wnorowski Nancy Ye Linhan Xu michael Naslund Bradford J.Wood maria J.merino Baris Turkbey Peter L.Choyke Peter A.Pinto m.minhaj Siddiqui University of maryland BaltimoreMDUSA Baltimore VA medical Center BaltimoreMDUSA molecular Imaging Program National Cancer InstituteNational Institutes of HealthBethesdaMDUSA Center for Interventional Oncology National Cancer Institute&Clinical CenterNational Institutes of HealthBethesdaMDUSA Urologic Oncology Branch National Cancer InstituteNational Institutes of HealthBethesdaMDUSA

Background:Gleason score grading is a cornerstone of risk stratification and management of patients with prostate cancer(PCa).In this work,we derive and validate a nomogram that uses prostate multiparametric magnetic resonance imaging(mP-mRI)and clinical patient characteristics to predict biopsy Gleason scores(bGS).materials and methods:A predictive nomogram was derived from 143 men who underwent mP-mRI prior to any prostate biopsy and then validated on an independent cohort of 235 men from a different institution who underwent mP-mRI for PCa *** positive lesions were defined as lesions positive on T2W and DWI sequences on *** specific antigen(PSA)density,number of screen positive lesions,and mRI suspicion were associated with PCa Gleason score on biopsy and were used to generate a predictive *** independent cohort was tested on the nomogram and the most likely bGS was ***:The mean PSA in the validation cohort was 9.25ng/mL versus 6.8ng/mL in the original cohort(p=0.001).The distribution of Gleason scores between the 2 cohorts were not significantly different(p=0.7).In the original cohort of men,the most probable nomogram generated Gleason score agreed with actual pathologic bGS findings in 61%of the *** the validation cohort,the most likely nomogram predicted bGS agreed with actual pathologic bGS 51%of the *** nomogram correctly identified any PCa versus non-PCa 63%of the time and clinically significant(Gleason score≥7)PCa 69%of the *** negative predictive value for clinically significant PCa using this prebiopsy nomogram was 74%in the validation ***:A preintervention nomogram based on PSA and mRI findings can help narrow down the likely pathologic finding on *** of the nomogram demonstrated a significant ability to correctly identify the most likely *** feasibility study demonstrates the potential of a prebiopsy prediction of bGS and based on the high negative predictive value,i

关键词： multiparametric magnetic resonance imaging Nomogram Prostate cancer

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减少制浆造纸工业污水的若干措施

减少制浆造纸工业污水的若干措施

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2002中国造纸学会学术报告会

作者： Subhash Chandra Hasan Jameel Hou-min Chang adrianna Kirkman 马忻 BE＆K Engineering of North Carolina morrisville NC 27560 Department of Wood and Paper Science North Carolina State University RaleighNC 27695 Department of Wood and Paper Science North Carolina State University RaleighNC 27695 Department of Wood and Paper Science North Carolina State University RaleighNC 27695

环境法规和经济上对减少北美造纸厂用水量和污水排放量越来越加以重视。1999年,美国的制浆造纸厂废水排放量为53m2／t（风干）。与1975年相比,这意味着污水的排放减少了44％。从 1975年到1999年,除了减少工艺废水的排放以外,BOD、TSS和... 详细信息

环境法规和经济上对减少北美造纸厂用水量和污水排放量越来越加以重视。1999年,美国的制浆造纸厂废水排放量为53m2／t（风干）。与1975年相比,这意味着污水的排放减少了44％。从 1975年到1999年,除了减少工艺废水的排放以外,BOD、TSS和AOX的量也明显地减少。同期 BOD和TSS分别减少了84％和68％。由于改进工艺减少有机氯化合物的排放使得AOX减少到低于0．4kg／t（风干）——自1975年以来减少了90％。本文讨论了目前现有的造纸厂能够实施的有关减少污水的对策。这些对策中包括了关于对典型造纸厂的供水系统、防止滴漏、密封水收集和再利用、筛选段封闭、蒸发器冷凝水再利用、冷凝水分离、漂白滤液循环和再利用、白水循环和再利用、真空泵密封水系统的用水管理。从这里提到的项目中总节水量可达12～56m3／t（风干）。

关键词：造纸工业制浆污水污水处理

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