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Bismuth-based halide double perovskite Cs_(2)KBiCl_(6): Disorder and luminescence

Chinese Chemical Letters 2024年第5期35卷 504-508页

作者： Pan Liu Yanming Sun Alberto J.Fernández-Carrión Bowen Zhang Hui Fu Lunhua He Xing Ming Congling Yin Xiaojun Kuang MOE Key Laboratory of New Processing Technology for Nonferrous Metal and Materials Guangxi Key Laboratory of Optic and Electronic Materials and DevicesCollege of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004China Analytical Instrumentation Center College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Spallation Neutron Source Science Center Dongguan 523803China Chinese Academic of Science Institute of PhysicsBeijing National Laboratory for Condensed Matter PhysicsBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China College of Science Guilin University of TechnologyGuilin 541004China College of Chemistry and Bioengineering Guilin University of TechnologyGuilin 541004China

A new bismuth-based halide double perovskite Cs_(2)KBiCl_(6) was isolated successfully through solid-state reactions and investigated using X-ray and neutron *** than an ordered structure,the crystal structure consists of shifted Cs,K,Bi,and Cl sites from the ideal positions with fractional occupancy in compensation,leading to variable local coordination of Cs^(+)ions,as revealed by^(133)Cs solid-state nuclear magnetic resonance ***_(2)KBiCl_(6) displays volume hysteresis at 5-298 K range upon heating and *** Cs_(2)KBiCl_(6) has a direct bandgap of 3.35(2)eV and red-shift luminescence of around 600 nm upon Mn doping compared with the Na *** stabilization of disordered structure in Cs_(2)KBiCl_(6) is related to two factors including the large-sized K^(+)cation which prefers to coordinate with more than six Cl^(-),and the Bi^(3+)with 6s^(2) lone pair which has a preference for a local asymmetric *** findings could have general application and help to understand the structure and property of halide perovskites.

关键词： Halide perovskite Double perovskite Luminescence Disordered structure Direct bandgap

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Unusual presentation of multiorgan extrapulmonary sarcoidosis

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Rheumatology & Autoimmunity 2024年第1期4卷 62-64页

作者： Ana Lilia Peralta Amaro Tania Stefanía Cabrera Castillo María de losÁngeles Macias Clavijo Fernando Méndez Gallegos Abihai Lucas hernández Internal Medicine Department Hospital de Especialidades“Dr.Antonio Fraga Mouret”Centro Médico Nacional La RazaInstituto Mexicano del Seguro SocialCiudad de MéxicoMéxico Departamento de Estudios de Posgrado Universidad Nacional Autónoma de México(UNAM)Ciudad de MéxicoMéxico Pathological Anatomy Department Hospital de Especialidades“Dr.Antonio Fraga Mouret”Centro Médico Nacional La RazaInstituto Mexicano del Seguro SocialCiudad de MéxicoMéxico

To the Editor,Sarcoidosis is a disease known for over a century and remains enigmatic in etiology and pathophysiology.1 While the pulmonary manifestation prevails in more than 90%of cases,sarcoidosis can affect any ***,it targets the eyes,skin,lymph nodes,and,in rare instances,the liver and spleen.2 The development of the disease is significantly influenced by genetic and environmental factors,as well as gene variations on chromosome ***,first-degree relatives of patients have a heightened risk factor of *** adverse prognostic factors involve being of Black race,female gender,and having a lower *** increased incidence of sarcoidosis among firefighters who responded to the 9/11 disaster highlighted environmental triggers,including agricultural employment,metalworking,firefighting,exposure to inorganic and silica dust,and handling building supplies.1 Clinical symptoms can vary widely depending on the affected *** often relies on characteristic chest radiography findings,but approximately 10%of patients show noncaseating granulomas on biopsy without pulmonary abnormalities.2 Herein,we present a unique case of multiorgan sarcoidosis,where the sole manifestations were severe thrombocytopenia,weight loss,and a history of cerebral vascular events.

关键词： sarcoidosis spleen disaster

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Physical activity and amyloid beta in middle-aged and older adults:A systematic review and meta-analysis

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Journal of Sport and Health Science 2024年第2期13卷 133-144页

作者： María Rodriguez-Ayllon Patricio Solis-Urra Cristina Arroyo-ávila Miriam álvarez-ortega Pablo Molina-García Cristina Molina-Hidalgo Manuel Gómez-Río Belinda Brown Kirk I.Erickson Irene Esteban-Cornejo Department of Epidemiology Erasmus University Medical Center RotterdamRotterdamGD 3015the Netherlands Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18071Spain Faculty of Education and Social Sciences Universidad Andres BelloVina del Mar 2531015Chile Department of Nuclear Medicine Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Physical Medicine and Rehabilitation Service Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Department of Psychology University of PittsburghPittsburghPA 15260USA Centre for Healthy Ageing Health Futures InstituteMurdoch UniversityMurdochWA 6150Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia Advent Health Research Institute Neuroscience Institute OrlandoOrlandoFL 32803USA Physiopathology of Obesity and Nutrition Research Center(CIBERobn) Institute of Health Carlos Ⅲ(ISCⅢ)Madrid 28029Spain

Background:One of the pathological hallmarks distinguishing Alzheimer’s disease from other dementias is the accumulation of amyloid beta(Aβ).Higher physical activity is associated with decreased dementia risk,and one potential path could be through Aβlevels *** aimed to explore the relationship between physical activity and Aβin middle-aged and older ***:A systematic search of PubMed,Web of Science,PsycINFO,Cochrane Central Register of Controlled Trials,and SPORTDiscus was performed from inception to April 28,*** were eligible if they included physical activity and Aβdata in adults aged 45 years or ***-level metaanalyses of intervention and observational studies were performed to examine the role of physical activity in modulating Aβ***:In total,37 articles were included(8 randomized controlled trials,3 non-randomized controlled trials,4 prospective longitudinal studies,and 22 cross-sectional studies).The overall effect size of physical activity interventions on changes in blood Aβwas medium(pooled standardized mean difference=-0.69,95%confidence interval(95%CI):-1.41 to 0.03;I^(2)=74.6%).However,these results were not statistically significant,and there were not enough studies to explore the effects of physical activity on cerebrospinal fluid(CSF)and brain Aβ.Data from observational studies were examined based on measurements of Aβin the brain using positron emission tomography scans,CSF,and *** physical activity was positively associated with Aβonly in the CSF(Estimate r=0.12;95%CI:0.05-0.18;I^(2)=38.00%).Conclusion:Physical activity might moderately reduce blood Aβin middle-aged and older ***,results were only near statistical significance and might be interpreted with caution given the methodological limitations observed in some of the included *** observational studies,higher levels of physical activity were positively associated with Aβonly in ***,further research is needed t

关键词： Aging Cognitive impairment Dementia Exercise PET

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阿尔茨海默病小胶质细胞CX3CR1产物增加并受去甲肾上腺素的调节

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神经损伤与功能重建 2020年第7期15卷 F0003-F0003页

作者： Marta González-Prieto Irene LGutiérrez Borja García-Bueno Javier RCaso Juan CLeza adriana ortega-hernández Dulcenombre Gómez-Garre JoséLMMadrigal 杜一星(编译) Department of Pharmacology and Toxicology School of MedicineUniversidad Complutense de Madrid(UCM)MadridSpain Centro de Investigación Biomédica en Red de Salud Mental(CIBERSAM) Instituto de Investigación Neuroquímica(IUINQ-UCM)Instituto de Investigación Sanitaria HospitalMadridSpain Vascular Biology Laboratory and Flow Cytometric Unit Hospital Clínico San Carlos-Instituto de Investigación Sanitaria San Carlos(IdISSC)MadridSpain Biomedical Research Networking Center in Cardiovascular Diseases(CIBERCV) MadridSpain 不详

去甲肾上腺素能神经元的丧失及其引起的脑去甲肾上腺素(NA)水平的降低与阿尔茨海默病(AD)的进展有关。这似乎主要是由于NA减少小胶质细胞活化的能力。我们以前观察到NA诱导神经元产生趋化因子Fractalkine/CX3CL1。小胶质细胞CX3CR1(CX3... 详细信息

去甲肾上腺素能神经元的丧失及其引起的脑去甲肾上腺素(NA)水平的降低与阿尔茨海默病(AD)的进展有关。这似乎主要是由于NA减少小胶质细胞活化的能力。我们以前观察到NA诱导神经元产生趋化因子Fractalkine/CX3CL1。小胶质细胞CX3CR1(CX3CL1的唯一受体)的激活会减少小胶质细胞的活化,已知这在很大程度上引起AD特征性的神经元损伤。因此,操控小胶质细胞中CX3CR1的产物可能转化为对CX3CL1抗炎作用的增强或抑制。为了确定小胶质细胞CX3CR1产物在AD中是否发生改变,以及NA是否可以控制这种改变,我们在5xFAD小鼠和人类AD脑样本中分析了CX3CR1的表达和合成。此外,我们分别在小胶质细胞培养物和小鼠中分析了NA及NA再摄取抑制剂瑞波西汀的作用。我们的结果表明,CX3CR1在AD大脑皮质中的产量增加,而给予瑞波西汀进一步增加了它的含量,并增强了小胶质对淀粉样β斑的反应性。然而,直接向原代大鼠小胶质细胞或人类HMC3细胞给予NA会抑制CX3CR1的产生,这表明小胶质细胞对NA的反应可能会在不存在产生CX3CL1的神经元或其他非小胶质外在因素的作用下发生改变。

关键词： (5-7)CX3C趋化因子受体1 表达5种人类AβPP和PS1突变的小鼠阿尔茨海默病 C-X3-C基序趋化因子配体1 不规则趋化因子去甲肾上腺素瑞波西汀

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Model of Mediating Determinants of Time Differences in INDYCAR

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Journalism and Mass Communication 2024年第4期14卷 232-240页

作者： Wilfrido Isidro Aldana Balderas Héctor Daniel Molina Ruiz Enrique Martínez Muñoz Eleazar Villegas González Tirso Javier hernández Gracia Arturo Sánchez Sánchez Cruz García Lirios Alfredo Barrera Escobar University of México HuehuetocaMèxico University of Hidalgo PachucaMèxico University of Tlaxcala Mèxico University of CDMX Mexico University of FV Mexico

The IndyCar series distinguishes itself by providing the same design and operation of the single-seater to its *** difference in times is then attributable to the skills of the drivers,but considering the data from the races could test this *** objective of this work was to establish a trajectory model to predict race times.A cross-sectional,correlational,and explanatory work was carried out with a sample of 18,474 records in the period from 2020 to 2023 of the IndyCar *** results show that the time span predicts the time *** relation to the studies of acceptance of the technology,the adjustment of this to human capacities to explain the time differences in the series of racing cars is discussed.

关键词： time differences ranking differences ranking race time laps completed

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A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity

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Acta Pharmaceutica Sinica B 2018年第2期8卷 188-199页

作者： Eneida Turiján-Espinoza Rául Alejandro Salazar-González Edith Elena Uresti-Rivera Gloria Estela hernández-hernández Montserrat ortega-Juárez Rosa Milán Diana Portales-Pérez Laboratory of Immunology and Cellular and Molecular Biology Faculty of Chemical Science UASLP Laboratory of Biopharmacy and Pharmacokinetics Faculty of Chemical Science UASLP

Arylamine N-acetyltransferase(NAT; E.C. 2.***.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of degradation. Sirtuins are protein deacetylases, dependent on nicotine adenine dinucleotide,which perform post-translational modifications on cytosolic proteins. To explore possible sirtuin participation in the enzymatic activity of arylamine NATs, the expression levels of NAT1, NAT2,SIRT1 and SIRT6 in peripheral blood mononuclear cells(PBMC) from healthy subjects were examined by flow cytometry and Western blot. The in situ activity of the sirtuins on NAT enzymatic activity was analyzed by HPLC, in the presence or absence of an agonist(resveratrol) and inhibitor(nicotinamide) of sirtuins. We detected a higher percentage of positive cells for NAT2 in comparison with NAT1, and higher numbers of SIRT1t cells compared to SIRT6 in lymphocytes. In situ NAT2 activity in the presence of NAM inhibitors was higher than in the presence of its substrate, but not in the presence ofresveratrol. In contrast, the activity of NAT1 was not affected by sirtuins. These results showed that NAT2 activity might be modified by sirtuins.

关键词： Arylamine N-acetyltransferase NAT Sirtuins Peripheral blood mononuclear cells Nicotinamide Resveratrol

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Driving factors behind multiple populations

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 172-181页

作者： Ruoyun Huang Baitian Tang Chengyuan Li Doug Geisler Mario Mateo Ying-Yi Song Holger Baumgardt Julio A.Carballo-Bello Yue Wang Jundan Nie Bruno Dias JoséG.Fernández-Trincado School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area Zhuhai 519082China Departamento de Astronomía Universidad de ConcepcionConcepcionChile Instituto de Investigación Multidisciplinario en Ciencia y Tecnología Universidad de La SerenaLa SerenaChile Departamento de Astronomía Facultad de CienciasUniversidad de La SerenaChile Department of Astronomy University of MichiganAnn Arbor 48109USA David A.Dunlap Department of Astronomy&Astrophysics University of TorontoToronto ON M5S 3H4Canada Dunlap Institute for Astronomy&Astrophysics University of TorontoToronto ON M5S 3H4Canada School of Mathematics and Physics The University of QueenslandSt.Lucia QLD 4072Australia Instituto de Alta Investigación Universidad de TarapacáAricaChile CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Instituto de Astrofísica Departamento de Ciencias FísicasFacultad de Ciencias ExactasUniversidad Andres BelloSantiagoChile Instituto de Astronomía Universidad Católica del NorteAntofagastaChile

Star clusters were historically considered simple stellar populations,with all stars sharing the same age and initial chemical ***,the presence of chemical anomalies in globular clusters(GCs),called multiple stellar populations(MPs),has challenged star formation theories in dense *** studies show that mass,metallicity,and age are likely controlling parameters for the manifestation of *** the limit between clusters with/without MPs in physical parameter space is crucial to reveal the driving mechanism behind their *** this study,we look for MP signals in Whiting 1,which is traditionally considered a young *** the Magellan telescope,we obtained low-resolution spectra withinλλ=3850-5500?for eight giants of Whiting *** measured the C and N abundances from the CN and CH spectral indices.C and N abundances have variations comparable with their measurement errors(~0.1 dex),suggesting that MPs are absent from Whiting *** these findings with literature studies,we propose a limit in the metallicity *** compactness index parameter space,which relatively clearly separates star clusters with/without MPs(GCs/open clusters).This limit is physically *** a larger scale,the galactic environment determines cluster compactness and metallicity,leading to metal-rich,diffuse,old clusters formed ex *** proposed limit also impacts our understanding of the formation of the Sagittarius dwarf galaxy:star clusters formed after the first starburst(age≤8-10 Gyr).These clusters are simple stellar populations because the enriched galactic environment is no longer suitable for MP formation.

关键词： stellar galactic galaxy

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Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors

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Acta Pharmaceutica Sinica B 2024年第1期14卷 87-109页

作者： Letian Song Shenghua Gao Bing Ye Mianling Yang Yusen Cheng Dongwei Kang Fan Yi Jin-Peng Sun Luis Menéndez-Arias Johan Neyts Xinyong Liu Peng Zhan Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Shenzhen Research Institute of Shandong University Shenzhen 518057China The Key Laboratory of Infection and Immunity of Shandong Province Department of PharmacologySchool of Basic Medical SciencesShandong UniversityJinan 250012China Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Centro de Biologı´a Molecular“Severo Ochoa”(Consejo Superior de Investigaciones Cientı´ficas&Autonomous University of Madrid) Madrid 28049Spain KU Leuven Department of Microbiology and ImmunologyRega Institute for Medical ResearchLaboratory of Virology and ChemotherapyLeuven 3000Belgium

The main protease(M^(pro))of SARS-CoV-2 is an attractive target in anti-COVID-19 therapy for its high conservation and major role in the virus life *** covalent M^(pro)inhibitor nirmatrelvir(in combination with ritonavir,a pharmacokinetic enhancer)and the non-covalent inhibitor ensitrelvir have shown efficacy in clinical trials and have been approved for therapeutic *** antiviral drugs are needed to fight the pandemic,while non-covalent M^(pro)inhibitors could be promising alternatives due to their high selectivity and favorable *** non-covalent M^(pro)inhibitors with desirable properties have been developed based on available crystal structures of M^(pro).In this article,we describe medicinal chemistry strategies applied for the discovery and optimization of non-covalent M^(pro)inhibitors,followed by a general overview and critical analysis of the available *** viewpoints and insights into current strategies for the development of non-covalent M^(pro)inhibitors are also discussed.

关键词： COVID-19 SARS-CoV-2 Main protease Non-covalent inhibitors Medicinal chemistry strategies

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Short-and long-term effects of an extreme case of autotomy:does“tail”loss and subsequent constipation decrease the locomotor performance of male and female scorpions?

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Integrative Zoology 2022年第5期17卷 672-688页

作者： Solimary GARCÍA-hernÁndez Glauco MACHADO Programa de Pós-graduação em Ecologia Instituto de BiociênciasUniversidade de São PauloSão PauloBrazil LAGE do Departamento de Ecologia Instituto de BiociênciasUniversidade de São PauloSão PauloBrazil

In many taxa,individuals voluntarily detach a body part as a form to increase their chances of escaping *** defense mechanism,known as autotomy,has several consequences,such as changes in locomotor performance that may affectﬁ*** of the genus Ananteris autotomize the“tail”,which in fact corresponds to the last abdominal *** autotomy,individuals lose nearly 25%of their body mass and the last portion of the digestive tract,including the anus,which prevents defecation and leads to constipation,because regeneration does not ***,we experimentally investigated the short-and long-term effects of tail loss on the locomotor performance of Ananteris *** a short-term experiment,the maximum running speed(MRS)of males and females did not change after ***,the relative mass of the lost tail did not affect the change in MRS after *** a long-term experiment,autotomy had a negative effect on the MRS of males,but not of *** over-fed individuals suffered from severe constipation but were not slower than autotomized normally fed *** conclusion,tail loss has no immediate effect on the locomotor performance of *** long-term decrease in the locomotor performance of autotomized males may impair mate ***,because death by constipation takes several months,males have a long time toﬁnd mates and ***,the prolonged period between autotomy and death by constipation is crucial for understanding the evolution of one of the most extreme cases of autotomy in nature.

关键词： ﬁtness costs maximum running speed sex differences tail loss weight loss

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Clinical characteristics of a group of adults with nodular lymphoid hyperplasia:A single center experience

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World Journal of Gastroenterology 2006年第12期12卷 1945-1948页

作者： Alberto Rubio-Tapia Jorge hernández-Calleros Luis Uscanga Sagrario Trinidad-hernández Department of Gastroenterology Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran(INNSZ)Mexico CityMexico Department of Pathology Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran(INNSZ)Mexico CityMexico

AIM： To describe the clinical and histological characteristics of a group of adults with small-bowel nodular lymphoid hyperplasia （NLH）. METHODS： Patients were searched for five years in pathology records of our institution. The biopsy material was reassessed using strict histopathological criteria. Clinical data were obtained from medical records. RESULTS： Small-bowel NLH was diagnosed in 18 cases. The female： male ratio was 2 ： 1. The most frequent symptoms were diarrhea （72%）, involuntary weight loss （72%） and abdominal pain （61%）. Nine patients （50%） had immunodeficiency. Small-bowel bacterial overgrowth was found in three （17%） cases. At small-bowel NLH diagnosis, three （17%） had associated lymphoma： two intestinal and one extra-intestinal lymphomas. In two patients with villous atrophy and anti-endomysial antibodies the diagnosis of celiac disease was established. Giardia larnblia infection was found in only one patient with hypogammaglobulinemia （Herman＇s syndrome）. CONCLUSIONS： NLH is uncommon in adult patients. Associated diseases are immunodeficiency and lymphoid tissue malignancies.

关键词： Nodular lymphoid hyperplasia Hypogammaglobulinemia Lymphoma

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