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Heart regeneration:Past,present and future

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World Journal of Cardiology 2010年第5期2卷 107-111页

作者： adriana bastos carvalho Antonio Carlos Campos de carvalho National Institute of Cardiology Rio de Janeiro Carlos Chagas Filho Institute of Biophysics and Institute for Science and Technology in Structural Biology and Bioimaging

The heart has been considered a post-mitotic organ without regenerative capacity for most of the last *** review the evidence that led to this hypothesis in the early 1900s and how it was progressively modified,culminating with the report that we renew 50% of our cardiomyocytes during our *** future of cardiac regenerative therapies is discussed,presenting the difficulties to overcome before repair of the diseased heart can come into clinical practice.

关键词： Cardiomyocyte proliferation Cardiac stem cells Self-renewal Stem cell-based therapies

Turning scar into muscle

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World Journal of Cardiology 2012年第9期4卷 267-270页

作者： Antonio Carlos Campos de carvalho adriana bastos carvalho National Institute of Cardiology Rio de JaneiroRJ 22240-006Brazil Carlos Chagas Filho Institute of Biophysics Federal University of Rio de JaneiroRio de JaneiroRJ 21941-902Brazil

After the demonstration that somatic cells could be reprogrammed to a pluripotent state,exciting new prospects were opened for the cardiac regeneration *** did not take long for the development of strategies to convert somatic cells directly into *** the intrinsic difficulties of cell reprogramming,such as low efficiency,the therapeutic possibilities created by the ability to turn scar into muscle are ***,we discuss some of the major advances and strategies used in direct cardiac reprogramming and examine discrepancies and concerns that still need to be resolved in the field.

关键词： Direct reprogramming Cardiomyocytes Induced pluripotent stem cells Cardiac regeneration microRNAs

Association of Helicobacter pylori infection and giardiasis: Results from a study of surrogate markers for fecal exposure among children

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World Journal of Gastroenterology 2005年第18期11卷 2759-2763页

作者： Edson Duarte Moreira Jr Victor bastos Nassri Rafaela Sousa Santos Junísia Ferraz Matos Wilson Andrade de carvalho Célia Stolve Silvani Círia Santana e Sant'Ana Núcleo de Apoio à Pesquisa Fundac■o Irm■ Dulce Salvador Bahia Brazil Centro de Pesquisas Goncalo Moniz Fundac■o Oswaldo Cruz Salvador Bahia Brazil Diretoria Científica e Laboratório do Hospital S■o Rafael Salvador Bahia Brazil Núcleo de Apoio à Pesquisa Fundac■o Irm■Dulce Salvador Bahia Brazil Centro de Pesquisas Goncalo Moniz Fundac■o Oswaldo Cruz Salvador Bahia Brazil Diretoria Científica e Laboratório do Hospital S■o Rafael Salvador Bahia Brazil Diretoria Científica e Laboratório do Hospital S■o Rafael Salvador Bahia Brazil Diretoria Científica e Laboratório do Hospital S(?)o Rafael Salvador Bahia Brazil Núcleo de Apoio à Pesquisa Fundac(?)o Irm(?) Dulce Salvador Bahia Brazil

AIM: To investigate whether Helicobacter pylori (H pylori) infection is associated with hepatitis A virus (HAV) infection, presence of enteroparasites, and other surrogates of fecal exposure. METHODS: We conducted a cross-sectional study in 121 children consecutively admitted at a pediatric hospital in Salvador, Brazil. H pyloriand HAV infection were identified by the presence of serum antibodies. Stool specimens were examined for the presence of ova and parasites. A structured questionnaire inquiring about sanitary conditions and life style was applied to each subject. RESULTS: Fifty-one of the 121 children (42.1%) were found to be seropositive for H pylori, and 45 (37.2%) for HAV. The seroprevalence of Hpyloriand HAV both increased significantly with age. Cross-tabulation of data showed that 26 (21.5%) were seropositive and 51 (42.1%) were negative for both H py/lriand HAV antibodies (x^2=7.18, OR=2.8, CI 1.30-5.97). The age adjusted OR for an HAV-infected child being H pylori positive was 2.3 (CI 1.02-5.03). The agreement between H pylori and HAV seropositivity was fair (k=0.24). After controlling for possible confounding, the variables remaining independently associated with seropositivity to H pylori were age, presence of Giardia lamblia in feces (OR=3.2, 95%CI, 1.1-9.5) and poor garbage disposal quality (OR=2.4, 95%CI, 1.1-5.1). CONCLUSION: Our data suggest that H pylori infection is associated with surrogate markers of fecal exposure. Thus, we conclude that the fecal-oral route is relevant in the transmission of HP among children in an urban setting of a developing country. The association observed between G. lamblia and H pylori infection may have several explanations. Further studies to investigate this relationship are warranted.

关键词： H pylori Hepatitis A virus Epidemiology Transmission Enteroparasites Brazil

Marigold(Tagetes erecta): The Potential Value in the Phytoremediation of Chromium

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Pedosphere 2017年第3期27卷 559-568页

作者： Lívia C.COELHO Ana Rosa R.bastos Paulo J.PINHO Guilherme A.SOUZA Janice G.carvalho Viviane A.T.COELHO Luiz Carlos A.OLIVEIRA Rimena R.DOMINGUES Valdemar FAQUIN Soil Science Department Federal University of Lavras Chemistry Department Federal University of Minas Gerais

Environmental pollution with chromium （Cr） is harmful to humans, animals and plants, while in plants it causes diminished growth, anatomical alterations and death. In the present study, the potential value of marigold （Tagetes erecta） in the phytoremediation of Cr has been investigated. The randomized experimental design involved the exposure of plants to nutrient solutions containing 0.00, 0.04, 0.08, 0.12, 0.16 or 0.24 mmol L-1 Cr（III）. Chromium toxicity was observed at Cr（III） concentrations ≥ 0.12 mmol L-1 as demonstrated by diminished growth of the aerial parts and reduced density of the root system. Increasing Cr（III） concentrations in the nutrient solution resulted in a higher bioaccumulation of total Cr in the tissues, although translocation from roots to aerial parts was not efficient （maximum value of 25% at 0.12 mmol L-1 Cr（III））. The Cr bioaccumulation was up to 11-fold greater in roots than in the aerial parts. Tagetes erecta exhibited leaf plasticity when exposed to Cr, indicating the existence of a tolerance mechanism to Cr in this species. Chromium caused a reduction in xilem vases, resulting in a plastic effect in T. erecta leaves that increased the metal tolerance in culture solution. Tagetes spp. are potential Cr hyperaccumulators; at Cr（III） concentrations up to 0.12 mmol L-1, the plants accumulated levels above that proposed for hyperaccumulators and still maintained a considerable growth and even flourished. However, this study was conducted in nutrient solution, and studies on species confirmation as Cr hyperaccumulator should be conducted in soils for further clarification.

关键词： anatomical alterations heavy metal hyperaccumulor leaf anatomy toxicity

Cross-sectional study to determine viral hepatitis knowledge in different urban populations in Brazil

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World Journal of Hepatology 2018年第11期10卷 867-876页

作者： Helena Medina Cruz Jakeline Ribeiro Barbosa Jeová Keny Baima Colares Antonio Henrique Almeida de Moraes Neto Maria de Fátima Leal Alencar Francisco Inácio bastos Jurema Corrêa da Mota Filipe Aníbal carvalho-Costa Claudia Alexandra Pontes Ivantes Lia Laura Lewis-Ximenez Livia Melo Villar Laboratory of Viral HepatitisOswaldo Cruz Institute Fiocruz Rio de Janeiro 21040360 Brazi Postgraduate Program in Pathology Federal University of Ceará Fortaleza Ceará 60020181 Brazil Postgraduate Program in Medical Sciences University of Fortaleza Ceará 60430160 Brazil Laboratory of Innovations in Therapies Teaching and Bioproducts Oswaldo Cruz Institute Fiocruz Rio de Janeiro 21040360 Brazil Institute of Communication and Scientifc Information and Technology for Health Oswaldo Cruz Foundation Rio de Janeiro 21040900 Brazil Laboratory of Epidemiology and Molecular Systematics Oswaldo Cruz Institute Fiocruz Rio de Janeiro 21040900 Brazil Orientation and Counselling Centre Curitiba Paraná 80810070 Brazil

AIM To evaluate viral hepatitis knowledge among individuals from different resource areas and health conditions to identify possible *** A cross-sectional, descriptive study was carried out among 447 individuals from five distinct populations in Brazil: Southeast Viral Hepatitis Ambulatory(n = 100), South(n = 89) and Northeast(n = 114) Health Center, Southeast(n = 77) and Northeast(n = 67) low resource areas. All individuals answered a questionnaire assessing sociodemographic characteristics and viral hepatitis awareness. The perception was scored based on the average number of correct answers of all participants and categorized as "low"(0-28 correct answers) or "desirable"(29-46 correct answers). Associations between sociodemographic characteristics and perception were also *** A low level of knowledge was observed in individuals from Northeast Health Center, Northeast and Southeast low resource areas while desirable knowledge was observed in individuals from Viral Hepatitis Ambulatory and South Health Center. According to sociodemographic characteristics, desirable scores were more common among those with secondary education(47.1%), those who declared themselves as white(46.3%), and those who lived in houses with three individuals(25.5%). Multivariate analysis showed an association between viral hepatitis perception and type of population. CONCLUSION The results demonstrated high level of knowledge among study participants from health clinics from the Southeast region of Brazil and the importance of education programs in increasing the level of knowledge in low resource areas.

关键词： Viral hepatitis Knowledge Perception Urban population Brazil

Intravenous immune globulin suppresses angiogenesis in mice and humans

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Signal Transduction and Targeted Therapy 2016年第1期1卷 141-148页

作者： Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana bastos-carvalho Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Physiology University of KentuckyLexingtonKYUSA Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.ar.l.NaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Rheumatology Unit Department of MedicineKarolinska InstitutetKarolinska University HospitalStockholmSweden Department of Nephrology Institute for Clinical and Experimental MedicinePrague 4Czech Republic Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMedica MilanoItaly

Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of *** biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc ***,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for *** we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic *** was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human Fcγ***,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel *** data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical *** addition,they raise the possibility of an unintended effect of IVIg on blood vessels.

关键词： doses inhibited degeneration

Necrotizing Pneumonia and Conservative Treatment: A Case Report and Review of the Literature

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Open Journal of Respiratory Diseases 2024年第3期14卷 69-76页

作者： Pedro Rogerio Magalhães Braga Eduarda Kipper Beck Carolina de Mello Viera Cecília Gatti Wolff Laura Gazal Passos Guilherme bastos de Mello Luis Felipe Pilar Gomes Giacomo Farias Tramontin Taíse Rosa de carvalho Department of Internal Medicine Hospital So Lucas da PUCRS Porto Alegre Brazil School of Medicine Pontifcia Universidade Catlica do Rio Grande do Sul Porto Alegre Brazil Department of Radiology Hospital So Lucas da PUCRS Porto Alegre Brazil

We present a case of necrotizing pneumonia in an 87-year-old man without severe respiratory instability. Clinical suspicion arose due to the need for supplementary oxygen and persistent fever during treatment for community-acquired pneumonia. The diagnosis was confirmed by chest computed tomography. Although necrotizing pneumonia typically requires major surgical intervention upon diagnosis, we chose conservative management with antimicrobials and chest drainage alone. The patient experienced significant improvement and resolution of pneumonia with conservative management.

关键词： Respiratory Tract Infections Lung Disease Bacterial Pneumonia

Molecular Docking and Evaluation of Antileishmania Activity of a Ruthenium Complex with Epiisopiloturine and Nitric Oxide

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Journal of Biosciences and Medicines 2020年第5期8卷 42-53页

作者： Joabe Lima Araújo Ruan Sousa bastos Gardênia Taveira Santos Michel Muálem de Moraes Alves Kayo Alves Figueiredo Lucas Aires de Sousa Ionara Nayana Gomes Passos Fernando Aécio de Amorim carvalho Francisco das Chagas Alves Lima Jefferson Almeida Rocha Postgraduate Program in Nanoscience and Nanobiotechnology Department of Genetics and Morphology University of Brasília Brasília DF Brazil Research Group in Natural Sciences and Biotechnology Department of Natural Sciences/Chemistry Federal University of Maranhao Grajaú MA Brazil Research Group in Medicinal Chemistry and Biotechnology QUIMEBIO Federal University of Maranhao Sao Bernardo MA Brazil Postgraduate Program in Medicinal Chemistry and Molecular Modeling Federal University of Pará Belém PA Brazil Department of Nursing State University of Maranhao Colinas MA Brazil Department of Veterinary Morphophysiology Federal University of Piauí Teresina PI Brazil Department of Health Federal Institute of Education Science and Technology of Piauí Teresina PI Brazil Postgraduate Program in Materials Science Center for Social Sciences Health and Technology Federal University of Maranhao Imperatriz MA Brazil Department of Biochemistry and Pharmacology Federal University of Piauí Teresina PI Brazil Department of Chemistry Quantum Computational Chemistry Laboratory Federal University of Piauí Teresina PI Brazil

Leishmaniasis is an infectious disease that affects both animals and humans, caused by flagellated parasites belonging to the genus Leishmania. The disease is estimated to reach about 700,000 to 1 million people, causing the deaths of 20 to 30,000 individuals annually. Thus, the present study aims to perform molecular docking tests and evaluation of antileishmania activity in vitro of a ruthenium complex with epiisopiloturine and nitric oxide. AutoDockTools-1.5.6 software was used to perform molecular docking tests. Molecular targets were considered rigid, and Epiruno2 considered flexible. The genetic algorithm Lamarckian (AGL) with global search and pseudo-Solis and Wets with local search were the methods adopted in the docking. The most promising results of molecular interaction were achieved in the targets Pteridine reductase and UDP-glucose Pyrophosphorylase with rates of -10.68 Kcal·mol-1 and -10.51 Kcal·mol-1, respectively. This demonstrates that Epiruno2 has molecular affinity with the targets of L. major. In vitro assays prove the antileishmania activity of the complex in the face of promastigote forms with inhibition of growth, concluding through this study that the Epiruno2 complex has antileishmania activity.

关键词： Molecular Docking Simulation Neglected Diseases Leishmania major

Liver transplantation in patients with SARS-CoV-2:Two case reports

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World Journal of Clinical Infectious Diseases 2021年第1期11卷 27-34页

作者： Camilla Bezerra bastos Limeira Camila Monteiro Veras JoséHicaro Hellano Gonçalves Lima Paiva Marina Seixas Studart e Neves Themístocles Mesquita Teles de carvalho Natália Stefani de Assunção Ferreira Alessandra Maria Mont`Alverne Pierre Ivelise Regina Canito Brasil Transplantation Division Hospital Geral de FortalezaFORTALEZA 60175742CEBrazil UECE UeceFORTALEZA 60175742CearaBrazil

BACKGROUND Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19).This disease was declared a worldwide health problem with the characteristics of a *** patients have mild symptoms and a good *** on the evolution and prognosis of COVID-19 in solid organ recipients is *** SUMMARY We describe two patients who underwent liver transplantation with a positive test result for detection of the viral sequence for COVID-19,using reversetranscription polymerase chain reaction(RT-PCR),immediately before *** patients showed good evolution in the postoperative period,without signs of graft *** immunosuppressive therapy was not *** patients were discharged for subsequent outpatient *** In conclusion,it is expected that the experience at this center can be used as an example,aimed at the continuation of transplantations by other services and,thus,the morbidity and mortality of patients with liver disease on the transplantation waiting list can be *** centers must be able to readjust daily to the evolution of the COVID-19 pandemic.

关键词： COVID-19 Liver transplantation Coronavirus Pneumonia Immunosuppressed patients Case report Infection diseases