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Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells

World Journal of Gastroenterology 2016年第26期22卷 6016-6026页

作者： Giulia Vecchione Elena Grasselli adriana voci Francesca Baldini Ignazio Grattagliano David QH Wang Piero Portincasa Laura Vergani DISTAV Department of Earth Environment and Life Sciences University of Genova Department of Biomedical Sciences and Human Oncology University School of Medicine Department of Internal Medicine Division of Gastroenterology and Hepatology Saint Louis University School of Medicine

AIM: To investigate in vitro the therapeutic effect and mechanisms of silybin in a cellular model of hepatic ***: Rat hepatoma FaO cells were loaded with lipids by exposure to 0.75 mmol/L oleate/palmitate for 3 h to mimic liver steatosis. Then, the steatotic cells were incubated for 24 h with different concentrations (25 to 100 μmol/L) of silybin as phytosome complex with vitamin E. The effects of silybin on lipid accumulation and metabolism, and on indices of oxidative stress were evaluated by absorption and fluorescence microscopy, quantitative real-time PCR, Western blot, spectrophotometric and fluorimetric ***: Lipid-loading resulted in intracellular triglyceride (TG) accumulation inside lipid droplets, whose number and size increased. TG accumulation was mediated by increased levels of peroxisome proliferator-activated receptors (PPARs) and sterol regulatory element-binding protein-1c (SREBP-1c). The lipid imbalance was associated with higher production of reactive oxygen species (ROS) resulting in increased lipid peroxidation, stimulation of catalase activity and activation of nuclear factor kappa-B (NF-κB). Incubation of steatotic cells with silybin 50 μmol/L significantly reduced TG accumulation likely by promoting lipid catabolism and by inhibiting lipogenic pathways, as suggested by the changes in carnitine palmitoyltransferase 1 (CPT-1), PPAR and SREBP-1c levels. The reduction in fat accumulation exerted by silybin in the steatotic cells was associated with the improvement of the oxidative imbalance caused by lipid excess as demonstrated by the reduction in ROS content, lipid peroxidation, catalase activity and NF-κB ***: We demonstrated the direct anti-steatotic and anti-oxidant effects of silybin in steatotic cells, thus elucidating at a cellular level the encouraging results demonstrated in clinical and animal studies.

关键词： Non-alcoholic fatty liver disease Steatotic hepatocytes Silybin Lipid metabolism Oxidative stress Lipid droplets Mitochondrial β -oxidation

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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis： perspectives for remyelination therapeutic strategies

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Neural Regeneration Research 2017年第12期12卷 1939-1944页

作者： adriana Octaviana Dulamea Department of Neurology Fundeni Clinical Institute University of Medicine and Pharmacy "Carol Davila" Bucharest Romania

Oligodencrocytes（OLs） are the main glial cells of the central nervous system involved in myelination of axons. In multiple sclerosis（MS）, there is an imbalance between demyelination and remyelination processes, the last one performed by oligodendrocyte progenitor cells（OPCs） and OLs, resulting into a permanent demyelination, axonal damage and neuronal loss. In MS lesions, astrocytes and microglias play an important part in permeabilization of blood-brain barrier and initiation of OPCs proliferation. Migration and differentiation of OPCs are influenced by various factors and the process is finalized by insufficient acummulation of OLs into the MS lesion. In relation to all these processes, the author will discuss the potential targets for remyelination strategies.

关键词： multiple sclerosis oligodencrocytes oligodendrocyte progenitor cells demyelination remyelination semaphorin basic helix-loop-helix transcription factor oligodendrocyte transcription factor 2 leucin-rich repeatand immunoglobulin-like-domain-containing nogo receptor-interacting protein I canonical Notch signaling endocrine receptors

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INFLUENCE OF RARE EARTH DOPING ON MECHANICAL PROPERTY AND MICRO-STRUCTURE OF CHROMIA OXIDE FILM

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Chinese Journal of Mechanical Engineering 2008年第3期21卷 16-19页

作者： JIN Huiming FELIX adriana College of Mechanical Engineering Yangzhou University Yangzhou 225005 China College of Materials Engineenng National University of Antiuquia Medellin 23715 Colombia

The isothermal oxidizing kinetics of Co-40Cr alloy and its yttrium ion-implanted samples are studied at 1 000 ℃ in air by thermal-gravity analysis （TGA）. Scanning electronic microscopy （SEM） is used to examine the Cr2O3 oxide film＇s morphology after oxidation. Acoustic emission （AE） method is used in situ for monitoring the cracking and spalling of oxide films formed on both samples during oxidizing and subsequent air-cooling stages. Theoretical model is proposed relating to the film fracture process and is used for analyzing the acoustic emission spectrum both on time domain and on AE-event number domain. It is found that yttrium implantation remarkably reduces the isothermal oxidizing rate of Co-40Cr and improves the anti-cracking and anti-spalling properties of Cr2O3 oxide film. The reasons for the improvement are mainly that the implanted yttrium reduced the grain size of Cr2O3 oxide, increased the high temperature plasticity of oxide film, and remarkably reduced the number and size of Cr2O3/Co-40Cr inteffacial defects.

关键词： Stress Acoustic emission Interface Yttrium Oxidation

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Blood group type antigens in pancreatic intraductal papillary mucinous neoplasms

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 74-80页

作者： adriana Handra-Luca Departments of Pathology Sydney Kimmel Comprehensive Cancer Center Johns Hopkins Medical Institutions APHP Universite Paris Nord Sorbonne Cite-Sce Anatomie Pathologique GHU Avicenne 125 rue Stalingrad Bobigny 93000 France

BACKGROUND: There are few data on blood group(BG) types and types of pancreatic cancers. The aims of this study were to study BG types and BG-antigens in pancreatic intraductal papillary mucinous neoplasms(IPMNs). METHODS: BG type and tumor BG-antigen(glycoprotein) expression(studied by immunohistochemistry on tissue microarrays) were analyzed with regard to characteristics of 101 surgically resected pancreatic IPMNs. RESULTS: Non-O BG type predicted invasive carcinoma independently from high serum CA19-9 and male gender. BG type A was observed more frequently in women than in men. Chronic pancreatitis was more frequently seen in patients with BG type B or AB. Aberrant tumor expression(with regard to BG type) of loss of A antigen expression type occurred in 15.0% of IPMNs and of loss of B antigen expression type in 62.5% of IPMNs. Intraneoplasm BG-antigen expression was not related to dysplasia grade or invasion. CONCLUSION: The results of the study suggest that in pancreatic IPMN, non-O BG type predicted invasive carcinoma, whereas for intratumor BG-antigen expression no specific patterns were detected with regard to the progression of glandular epithelial dysplasia or invasion.

关键词： blood group type blood group antigen immunohistochemistry CA19-9 prognosis invasive carcinoma pancreas intraductal papillary mucinous neoplasm

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Biomimetic Control of Mechanical Systems Equipped with Musculotendon Actuators

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Journal of Bionic Engineering 2011年第1期8卷 56-68页

作者： Javicr Moreno-Valenzuel adriana Salinas-Avila Instituto Politecnico Naoional-CITEDl Av. del Parque 1310 Mesa de Otay Tianjuana B.C. 22510 Mexico

This paper addresses the problem of modelling, control, and simulation of a mechanical system actuated by an agonist-antagonist musculotendon subsystem. Contraction dynamics is given by case 1 of Zajac＇s model. Saturated semi positive proportional-derivative-type controllers with switching as neural excitation inputs are proposed. Stability theory of switched system and SOSTOOLS, which is a sum of squares optimization toolbox of Matlab, are used to determine the stability of the obtained closed-loop system. To corroborate the obtained theoretical results numerical simulations are carried out. As additional contribution, the discussed ideas are applied to the biomimetic control of a DC motor, i.e., the position control is addressed assuming the presence of musculotendon actuators. Real-experiments corroborate the expected results.

关键词： biomimetie control musculotendon dynamics neural excitation saturation switched systems

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Dendrite pathology and neurodegeneration:focus on m TOR

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Neural Regeneration Research 2015年第4期10卷 559-561页

作者： adriana Di Polo Department of Neuroscience and Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM) University of Montreal

Dendrites are exquisitely specialized cellular compart- ments that critically influence how neurons receive and process information. Most synaptic inputs are received onto dendritic shafts, or small protuberances known as dendritic spines, and are then integrated and transmitted to the cell soma. During nervous system development, dendrites are dynamic, expanding and retracting rapidly, in response to intrinsic and environmental cues. Selective elimination of dendritic processes, also known as developmental pruning, ensures precise connectivity and refines neuronal networks.

关键词： Dendrite pathology and neurodegeneration RGCs REDD TSC

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Renal elimination of organic anions in cholestasis

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World Journal of Gastroenterology 2008年第43期14卷 6616-6621页

作者： adriana Mónica Torres Facultad de Ciencias Bioquimicas y Farmacéuticas Universidad Nacional de RosarioCONICETSuipacha 5312000RosarioArgentina

The disposition of most drugs is highly dependent on specialized transporters. OAT1 and OAT3 are two organic anion transporters expressed in the basolateral membrane of renal proximal tubule cells, identified as contributors to xenobiotic and endogenous organic anion secretion. It is well known that cholestasis may cause renal damage. Impairment of kidney function produces modifications in the renal elimination of drugs. Recent studies have demonstrated that the renal abundance of OAT1 and OAT3 plays an important role in the renal elimination of organic anions in the presence of extrahepatic cholestasis. Time elapsed after obstructive cholestasis has an important impact on the regulation of both types of organic anion transporters. The renal expression of OAT1 and OAT3 should be taken into account in order to improve pharmacotherapeutic efficacy and to prevent drug toxicity during the onset of this hepatic disease.

关键词： Organic anions P-aminohippurate Furosemide OAT1 OAT3 Extrahepatic cholestasis

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No trade-off between trichome production and tolerance to leaf and inflorescence damage in a natural population of Arabidopsis lyrata

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Journal of Plant Ecology 2014年第4期7卷 373-383页

作者： adriana Puentes JonÅgren Department of Plant Ecology and Evolution Evolutionary Biology Centre(EBC)Uppsala UniversityNorbyvägen 18DSE-75236 UppsalaSweden

Aims Early models of plant defense conceived resistance and tolerance to herbivore damage as mutually exclusive *** for this idea has been equivocal and studies on these two strategies are still needed to understand the evolution of defenses in natural *** Arabidopsis lyrata,the production of trichomes,a documented resistance trait,has been associated with a fitness cost in the absence of *** examined whether trichome production is also associated with reduced tolerance to simulated herbivore *** We conducted a field experiment in a natural swedish population of *** where we inflicted leaf(0 vs.50%of the area of each leaf removed)and inflorescence damage(0 vs.50%of inflores-cences removed)to trichome-producing and glabrous plants in a factorial *** examined the response(survival,growth and reproduction)of the plants to the imposed damage over 2 *** Findingstrichome-producing plants were not less tolerant than glabrous plants to simulated herbivore damage(no significant morph×leaf damage or morph×inflorescence damage interactions).Inflorescence and leaf damage had independent negative effects on the performance of damaged *** damage reduced rosette size the year of damage,but effects on reproductive output in the year of damage,and on survival and reproductive performance the following year were weak and not statistically *** damage significantly reduced the number of flowers,fruits and seeds the year of damage,but not in the following *** of morph,the study population was more tolerant to leaf than to inflorescence *** results indicated no trade-off between trichome production and tolerance,suggesting that these two defense mechanisms have the potential to evolve indepen-dently in this *** population.

关键词： plant defense fitness costs resistance traits defoliation florivory

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