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Safety Evaluation of the Dichlorom.thane Extract of Hysterionica pinifolia: A Potential Raw m.terial for the Developm.nt of Biopesticides

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Journal of Biosciences and m.dicines 2023年第7期11卷 66-78页

作者： Ingrid m. Cufre adriana m. broussalis Susana B. Gorzalczany Facultad de Farm.cia y Bioquím.ca Universidad de Buenos Aires Buenos Aires Argentina CONICET Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA) Buenos Aires Argentina

At the m.m.nt, there is a growing concern about the negative effects on hum.n health and the environm.nt due to the widespread and indiscrim.nate use of conventional insecticides. Since plants have been used throughout history to control m.croorganism. and insects, the safety is an aspect that m.st also be evaluated to guarantee that its use does not affect hum.n health and the environm.nt. The aim.of the present study was to evaluate the safety of the dichlorom.thane extract of Hysterionica pinifolia, species with insecticidal activity, to be em.loyed as a raw m.terial for the developm.nt of biopesticides. The acute and subacute toxicity and the derm.l and ocular irritation were evaluated. In these studies, the dichlorom.thane extract of H. pinifolia showed no ocular and a slight derm.l irritation. Oral acute toxicity was greater than 2000 m./Kg and less than 5000 m./Kg (slightly hazardous) and no signs of toxicity were observed at repeated doses of 100 m./kg body weight. These prom.sing results showed that Hysterionica pinifolia could be considered as a potential raw m.terial for the developm.nt of an insecticide from.natural sources, safe for hum.n health and the environm.nt.

关键词： Hysterionica pinifolia Oral Acute Toxicity Derm.l Irritation Ocular Irritation Repeated Dose Toxicity

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Bioactive Com.ounds and Insecticidal Activity of Hysterionica pinifolia, a Native South Am.rican Plant

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Am.rican Journal of Plant Sciences 2022年第6期13卷 815-832页

作者： Ingrid m. Cufre Lucas E. Fabián Sandra V. Clem.nte Arnaldo L. Bandoni adriana m. broussalis Facultad de Farm.cia y Bioquím.ca Catedra de Farmacognosia Universidad de Buenos Aires Buenos Aires Argentina CONICET Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA) Buenos Aires Argentina Facultad de Farm.cia y Bioquím.ca Catedra de Química Medicinal Universidad de Buenos Aires Buenos Aires Argentina Facultad de Agronom.a área de Producción Vegetal Orgánica Universidad de Buenos Aires Buenos Aires Argentina

Phytochem.cal investigation of the purified fractions of the active dichlorom.thane extract of Hysterionica pinifolia (Poir.) Baker led to the identification of five com.ounds. New acetylenic alcohol (E)-undec-3-en-5,7-diyne-1-ol (1) and three other com.ounds (3), (4), and (5) were reported for the first tim. in this species. Furtherm.re, forty-six com.onents from.the volatile fraction of H. pinifolia were identified. These com.ounds were elucidated using 1D and 2D Nm. spectroscopy as well as m.-ESI and GC-FID-m. experim.nts. The dichlorom.thane extract, its fractions, and the m.thanolic extract were tested for insecticidal activity against Tribolium.castaneum.under laboratory conditions. The dichlorom.thane extract and the fraction F2 were found to be active, showing high larval m.rtality. The dichlorom.thane extract was also active against T. castaneum.adults. The results have shown that H. pinifolia could be considered, in a near future, as a potential source for the developm.nt of a botanical insecticide for pest control.

关键词： Hysterionica pinifolia Bioactive Com.ounds Polyacetylene Com.ounds (E)-undec-3-en-5 7-diyne-1-ol Insecticidal Activity

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