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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Gastrointestinal stromal tumour of the rectum: Report of a case and review of literature

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World Journal of Gastroenterology 2008年第8期14卷 1302-1304页

作者： Nello Grassi Calogero Cipolla adriana Torcivia Stefano Mandalà Giuseppa Graceffa Alessandro bottino Federica Latteri Department of Oncology Division of General and Oncological Surgery University of Palermo Via del Vespro 129 Palermo 90127 Italy

Gastrointestinal stromal tumour （GIST） is a rare tumour of the gastrointestinal tract which does not generally originate in the rectum. The authors describe a case of a 70-year-old man who underwent an anterior resection of the rectum for a low-risk GIST. The patient was not given adjuvant chemotherapy with imatinib and is still disease-free 30 mo after surgery. The authors conclude that although rectal GIST is extremely uncommon, it should be included in differential diagnosis when a tumour in the rectum is detected. Biopsy of the tumour is essential, since this makes it possible to reach a sure preoperative diagnosis based on the immunohistological features of the CDl17 and CD34. Although complete surgical resection with negative tumour margins is the principal curative procedure for primary and nonmetastatic tumours, further studies are still needed for the determination of the most effective treatment strategy for patients with rectal GIST.

关键词： Rectal Gastrointestinal stromal tumour Diagnosis Treatment Surgery

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis： perspectives for remyelination therapeutic strategies

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Neural Regeneration Research 2017年第12期12卷 1939-1944页

作者： adriana Octaviana Dulamea Department of Neurology Fundeni Clinical Institute University of Medicine and Pharmacy "Carol Davila" Bucharest Romania

Oligodencrocytes（OLs） are the main glial cells of the central nervous system involved in myelination of axons. In multiple sclerosis（MS）, there is an imbalance between demyelination and remyelination processes, the last one performed by oligodendrocyte progenitor cells（OPCs） and OLs, resulting into a permanent demyelination, axonal damage and neuronal loss. In MS lesions, astrocytes and microglias play an important part in permeabilization of blood-brain barrier and initiation of OPCs proliferation. Migration and differentiation of OPCs are influenced by various factors and the process is finalized by insufficient acummulation of OLs into the MS lesion. In relation to all these processes, the author will discuss the potential targets for remyelination strategies.

关键词： multiple sclerosis oligodencrocytes oligodendrocyte progenitor cells demyelination remyelination semaphorin basic helix-loop-helix transcription factor oligodendrocyte transcription factor 2 leucin-rich repeatand immunoglobulin-like-domain-containing nogo receptor-interacting protein I canonical Notch signaling endocrine receptors

INFLUENCE OF RARE EARTH DOPING ON MECHANICAL PROPERTY AND MICRO-STRUCTURE OF CHROMIA OXIDE FILM

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Chinese Journal of Mechanical Engineering 2008年第3期21卷 16-19页

作者： JIN Huiming FELIX adriana College of Mechanical Engineering Yangzhou University Yangzhou 225005 China College of Materials Engineenng National University of Antiuquia Medellin 23715 Colombia

The isothermal oxidizing kinetics of Co-40Cr alloy and its yttrium ion-implanted samples are studied at 1 000 ℃ in air by thermal-gravity analysis （TGA）. Scanning electronic microscopy （SEM） is used to examine the Cr2O3 oxide film＇s morphology after oxidation. Acoustic emission （AE） method is used in situ for monitoring the cracking and spalling of oxide films formed on both samples during oxidizing and subsequent air-cooling stages. Theoretical model is proposed relating to the film fracture process and is used for analyzing the acoustic emission spectrum both on time domain and on AE-event number domain. It is found that yttrium implantation remarkably reduces the isothermal oxidizing rate of Co-40Cr and improves the anti-cracking and anti-spalling properties of Cr2O3 oxide film. The reasons for the improvement are mainly that the implanted yttrium reduced the grain size of Cr2O3 oxide, increased the high temperature plasticity of oxide film, and remarkably reduced the number and size of Cr2O3/Co-40Cr inteffacial defects.

关键词： Stress Acoustic emission Interface Yttrium Oxidation

The role of structural inheritance in continental break-up and exhumation of Alpine Tethyan mantle(Canavese Zone,Western Alps)

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Geoscience Frontiers 2020年第1期11卷 167-188页

作者： Andrea Festa Gianni Balestro Alessandro Borghi Sara De caroli Andrea Succo Dipartimento di Scienze della Terra Universitàdi TorinoTorinoItaly Dipartimento di Scienze Chimiche della Vita e della SostenibilitàAmbientaleUniversitàdi ParmaParmaItaly

The Canavese Zone(CZ)in the Western Alps represents the remnant of the distal passive margin of the Adria microplate,which was stretched and thinned during the Jurassic opening of the Alpine *** detailed geological mapping,stratigraphic and structural analyses,we document that the continental break-up of Pangea and tectonic dismemberment of the Adria distal margin,up to mantle rocks exhumation and oceanization,did not simply result from the syn-rift Jurassic extension but was strongly favored by older structu ral inheritances(the Proto-Canavese Shear Zone),which controlled earlier lithospheric *** findings allowed to redefine in detail(i)the tectono-stratigraphic setting of the Variscan metamorphic basement and the Late Carbonife rous to Early Cretaceous CZ succession,(ii)the role played by inherited Late Carboniferous to Early Triassic structures and(iii)the significance of the CZ in the geodynamic evolution of the Alpine *** large amount of extensional displacement and crustal thinning occurred during different pulses of Late Carbonife rous-Early Triassic strike-slip tectonics is wellconsistent with the role played by long-lived regional-scale wrench faults(e.g.,the East-Variscan Shear Zone),suggesting a re-discussion of models of mantle exhumation driven by low-angle detachment faults as unique efficient mechanism in stretching and thinning continental crust.

关键词： Alpine Tethys Western Alps Jurassic ophiolite Structural inheritance Continental break-up Mantle exhumation

Laparoscopic resection vs laparoscopic radiofrequency ablation for the treatment of small hepatocellular carcinomas: A single-center analysis

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World Journal of Gastroenterology 2017年第4期23卷 653-660页

作者： Marco Casaccia Gregorio Santori Giuliano bottino Pietro Diviacco Enzo Andorno Department of Surgery IRCCSSan Martino University Hospital-ISTUniversity of Genoa Department of Surgical Sciences and Integrated Diagnostics School of MedicineUniversity of Genoa

AIMTo compare survival and recurrence after laparoscopic liver resection (LLR) and laparoscopic radiofrequency ablation (LRFA) for the treatment of small hepatocellular carcinoma (HCC).METHODSBetween June 1, 2005 and November 30, 2010, 46 patients (62.26 ± 8.55 years old; female/male: 12/34) treated for small HCC were enrolled following strict criteria. Patients with better liver function and larger tumors were referred for LLR (n = 24), while those with poorer liver function and multiple tumors were referred for LRFA (n = 22), and they were then followed for similar durations (44.74 ± 21.3 mo for LLR vs 40.27 ± 30.8 mo for LRFA).RESULTSThe LLR and LRFA groups were homogeneous with regard to age, sex, etiology of liver cirrhosis, and AFP levels. The overall survival (OS) and disease-free survival (DFS) probability was 0.354 and 0.260, respectively. A significantly higher OS was observed in the LLR group (LLR: 0.442; LRFA: 0.261; P = 0.048), whereas no statistical difference was found for DFS (LLR: 0.206; LRFA: 0.286; P = 0.205). In the LRFA group was treated a greater number of nodules (LLR: 1.41 ± 0.77; LRFA: 2.72 ± 1.54; P *** preliminary results confirm the superiority of hepatic resection on thermoablation in the treatment of small HCC in selected patients, when both approaches are made laparoscopically. LLR showed better results compared to LRFA in terms of OS. These data need to be confirmed by further studies on a larger number of patients.

关键词： Hepatocellular carcinoma Laparoscopic liver resection Laparoscopic radiofrequency ablation Survival Disease-free survival

Multistage tectono-stratigraphic evolution of the Canavese Intracontinental Suture Zone:New constraints on the tectonics of the Inner Western Alps

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Geoscience Frontiers 2022年第6期13卷 91-110页

作者： Gianni Balestro Andrea Festa Sara De caroli Edoardo Barbero Alessandro Borghi Franco Gianotti Department of Earth Sciences University of TorinoTorinoItaly National Research Council of Italy Institute of Geosciences and Earth ResourcesTorinoItaly School of Earth and Environmental Sciences Cardiff UniversityCardiffWalesUK

The Canavese Intracontinental Suture Zone(CISZ) within the Inner Western Alps represents the remnant of a long-lived minor subduction zone involving a narrow, thinned continental crust/oceanic lithosphere seaway between two continental domains of the Adria microplate(i.e., the Sesia Zone and the IvreaVerbano Zone). As opposed to many suture zones, the CISZ mostly escaped pervasive tectonic deformation and metamorphism, thus preserving the original stratigraphy and allowing the relationships between tectonics and sedimentation to be defined. Through detailed geological mapping(1:5000 scale),structural analysis, stratigraphic and petrographic observations, we document evidences for the late Paleozoic to late Cenozoic tectonic evolution of the CISZ, showing that it played a significant role in the context of the tectonic evolution of the Inner Western Alps region from the early to late Permian Pangea segmentation, to the Jurassic Tethyan rifting, and up to the subduction and collisional stages,forming the Western Alps. The site of localization/formation of the CISZ was not accidental but associated with the re-use of structures inherited from regional-scale wrench tectonics related to the segmentation of Pangea, and from the subsequent extensional tectonics related to the Mesozoic rifting, as documented by crosscutting relationships between stratigraphic unconformities and tectonic features. Our findings document that evidences derived from stratigraphy, facies indicators, and relationships between tectonics and sedimentation in the shallow crustal portions of suture zones, such in the CISZ, are important to better constrain the tectonic history of those metamorphic orogenic belts around the world in which evolutionary details are commonly complicated by high-strain deformation and metamorphic transformations.

关键词： Suture zone Western Alps Structural inheritance Tectonics and sedimentation Multistage tectonic evolution

Blood group type antigens in pancreatic intraductal papillary mucinous neoplasms

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 74-80页

作者： adriana Handra-Luca Departments of Pathology Sydney Kimmel Comprehensive Cancer Center Johns Hopkins Medical Institutions APHP Universite Paris Nord Sorbonne Cite-Sce Anatomie Pathologique GHU Avicenne 125 rue Stalingrad Bobigny 93000 France

BACKGROUND: There are few data on blood group(BG) types and types of pancreatic cancers. The aims of this study were to study BG types and BG-antigens in pancreatic intraductal papillary mucinous neoplasms(IPMNs). METHODS: BG type and tumor BG-antigen(glycoprotein) expression(studied by immunohistochemistry on tissue microarrays) were analyzed with regard to characteristics of 101 surgically resected pancreatic IPMNs. RESULTS: Non-O BG type predicted invasive carcinoma independently from high serum CA19-9 and male gender. BG type A was observed more frequently in women than in men. Chronic pancreatitis was more frequently seen in patients with BG type B or AB. Aberrant tumor expression(with regard to BG type) of loss of A antigen expression type occurred in 15.0% of IPMNs and of loss of B antigen expression type in 62.5% of IPMNs. Intraneoplasm BG-antigen expression was not related to dysplasia grade or invasion. CONCLUSION: The results of the study suggest that in pancreatic IPMN, non-O BG type predicted invasive carcinoma, whereas for intratumor BG-antigen expression no specific patterns were detected with regard to the progression of glandular epithelial dysplasia or invasion.

关键词： blood group type blood group antigen immunohistochemistry CA19-9 prognosis invasive carcinoma pancreas intraductal papillary mucinous neoplasm