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Computational algorithms to simulate the steel continuous casting

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International Journal of Minerals,Metallurgy and Materials 2010年第5期17卷 596-607页

作者： A. Ramírez-lópez G. Soto-Cortés M. Palomar-Pardavé M.A. Romero-Romo R. Aguilar-lópez Institute Polytechnic National(Mexico) Department of Materials Metropolitan Autonomous University

Computational simulation is a very powerful tool to analyze industrial processes to reduce operating risks and improve profits from equipment. The present work describes the development of some computational algorithms based on the numerical method to create a simulator for the continuous casting process, which is the most popular method to produce steel products for metallurgical industries. The kinematics of industrial processing was computationally reproduced using subroutines logically programmed. The cast steel by each strand was calculated using an iterative method nested in the main loop. The process was repeated at each time step （？t） to calculate the casting time, simultaneously, the steel billets produced were counted and stored. The subroutines were used for creating a computational representation of a continuous casting plant （CCP） and displaying the simulation of the steel displacement through the CCP. These algorithms have been developed to create a simulator using the programming language C＋＋. Algorithms for computer animation of the continuous casting process were created using a graphical user interface （GUI）. Finally, the simulator functionality was shown and validated by comparing with the industrial information of the steel production of three casters.

关键词： continuous casting simulation numerical method computational algorithm

lymphocyte subsets predictive value and possible involvement of human papilloma virus infection on breast cancer molecular subtypes

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World Journal of Clinical Oncology 2018年第7期9卷 123-132页

作者： Andreína Fernandes adriana Pesci-Feltri Isabel García-Fleury Marco lópez Vincent Guida Marisol De Macedo María Correnti Oncology and Hematology Institute University Hospital of Caracas

AIM To detect human papilloma virus(HPV) presence and to characterize cellular immune response in breast cancer patients. METHODS A total of 74 women were included, of which 48 samples were from patients diagnosed with breast cancer and 26 patients with benign pathology of the breast. Molecular subtype classification was performed based on the immunohistochemical reports of the tumor piece. HPV genome detection and genotyping from fresh breast biopsies was performed using the INNO-lIPA HPV Genotyping Extra test(Innogenetics, Ghent, Belgium). CD3+, CD4+, CD8+ and natural killer(NK)+ cells levels from peripheral blood samples from patients with breast cancer and benign pathology were measured by flow cytometry. RESUlTS luminal A was the most frequent breast cancer molecular subtype(33.33%). HPV was detected in 25% of the breast cancer patients, and genotype 18 was the most frequent in the studied population. The mean of CD3+, CD4+ and CD8+ subpopulations were decreased in patients with breast cancer, in relation to those with benign pathology, with a statistically significant difference in CD8+ values(P = 0.048). The mean of NK+ cells was increased in the benign pathology group. The average level of CD3+, CD4+, CD8+ and NK+ cells decreased as the disease progressed. HER2+ and luminal B HER2+ tumors had the lowest counts of cell subsets. HPV breast cancer patients had elevated counts of cellular subsets. CONClUSION Determining level changes in cellular subsets in breast cancer patients is a useful tool to evaluate treatment response.

关键词： Breast cancer Human papilloma virus Molecular subtypes Immune response T lymphocytes NK cells

Behavior of diatomaceous soil in lacustrine deposits of Bogota, Colombia

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第2期10卷 367-379页

作者： Bernardo Caicedo Cristhian Mendoza Fernando lópez Arcesio lizcano Department of Civil and Environmental Engineering Universidad de Los AndesBogotáColombia Department of Civil Engineering Universidad Nacional de Colombia Sede ManizalesManizalesColombia Ecole Centrale Paris Laboratoire MSSMat-UMR CNRS 8579ParisFrance SRK Consulting VancouverCanada

This work presents a study on the behaviors of diatomaceous soils. Although studies are rarely reported on these soils, they have been identified in Mexico City, the Sea of Japan, the northeast coast of Australia,the equatorial Pacific, and the lacustrine deposit of Bogota(Colombia), among other locations. Features of this kind of soil include high friction angle, high initial void ratio, high compressibility index, high liquid limit, and low density. Some of these features are counterintuitive from a classical soil mechanics viewpoint. To understand the geotechnical properties of the diatomaceous soil, a comprehensive experimental plan consisting of more than 2400 tests was performed, including physical tests such as grain size distribution, Atterberg limits, density of solid particles, and organic matter content; and mechanical tests such as oedometric compression tests, unconfined compression tests, and triaxial *** tests were complemented with scanning electron microscope(SEM) observations to evaluate the microstructure of the soil. The test results show that there is an increase in liquid limit with increasing diatomaceous content, and the friction angle also increases with increasing diatomaceous content. In addition, several practical correlations were proposed for this soil type for shear strength mobilization and intrinsic compression line. Finally, useful correlations were presented, such as the relationship between the state consistency and the undrained shear strength, the friction angle and the liquid limit, the void ratio at 100 kPa and the liquid limit, the plasticity index and the diatomaceous content, among others.

关键词： Diatomaceous soil Soft soils Compressibility Friction angle Natural soil

Comorbidity in inflammatory bowel disease

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World Journal of Gastroenterology 2011年第22期17卷 2723-2733页

作者： Antonio lópez San Román Fernando Muoz Gastroenterology Ramón y Cajal Hospital E28034 Madrid Spain Digestive Diseases Complejo Hospitalario Hospital Altos de Nava 24080 León Spain

Patients with inflammatory bowel disease (IBD) can be affected by other unrelated diseases. These are called comorbid conditions, and can include any secondary health problem that affects a person suffering from a primary or main disease, and which is neither linked physiopathologically to the primary condition, nor is it due to the treatments used for the primary condition or to its long-term anatomical or physiological consequences. Different comorbid conditions, as well as their influence on IBD, are discussed.

关键词： Comorbidity Comorbid conditions Crohn’ disease Inflammatory bowel disease Ulcerative colitis

Effects of thermophoresis particle deposition and of the thermal conductivity in a porous plate with dissipative heat and mass transfer

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Acta Mechanica Sinica 2011年第3期27卷 389-398页

作者： Joaquín Zueco O.Anwar Bég l.M.lpez-Ochoa Thermal Engineering and Fluids Department Technical University of CartagenaETSII Campus Muralla del Mar Aerospace Engineering Department of Engineering and MathematicsSheaf BuildingSheffield Hallam University Mechanical Engineering Departament University of RiojaC/Luís de UlloaLogrono (La Rioja)20E-26004Spain

Network simulation method（NSM） is used to solve the laminar heat and mass transfer of an electricallyconducting,heat generating/absorbing fluid past a perforated horizontal surface in the presence of viscous and Joule heating problem. The governing partial differential equations are non-dimensionalized and transformed into a system of nonlinear ordinary differential similarity equations,in a single independent variable,畏. The resulting coupled,nonlinear equations are solved under appropriate transformed boundary conditions. Computations are performed for a wide range of the governing flow parameters,viz Prandtl number,thermophoretic coeffcient（a function of Knudsen number）,thermal conductivity parameter,wall transpiration parameter and Schmidt number. The numerical details are discussed with relevant applications. The present problem finds applications in optical fiber fabrication,aerosol filter precipitators,particle deposition on hydronautical blades,semiconductor wafer design,thermo-electronics and problems including nuclear reactor safety.

关键词： Thermophoresis . MHD . Network simulation model . Heat and mass transfer- Hartmann number

Oligodendroctyes:the forgotten players of diabetes pathophysiology

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Neural Regeneration Research 2024年第11期19卷 2349-2350页

作者： Juan Antonio lópez-Villodres Beatriz García-Díaz Departamento Fisiología Humana Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neurociencia.Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma Bionand) MálagaSpain

Oligodendrocytes(Ols),glial cells that provide myelin sheaths to axons in the central nervous system(CNS),have a dual ***,this myelin fatty cover around the axons protects the nerves and is crucial for the saltatory propagation of action *** and not less important,Ols provide trophic support to neurons and ***,Ol metabolism is important for Ol well-being and the proper accomplishment of their functions,and Ol metabolism energetics directly affect the energy metabolism of neighboring neurons.

关键词： metabolism nerves myelin

Discriminatory capacity of serum interleukin-6 between complicated and uncomplicated acute appendicitis in children:a prospective validation study

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World Journal of Pediatrics 2022年第12期18卷 810-817页

作者： Javier Arredondo Montero Giuseppa Antona adriana Rivero Marcotegui Carlos BardajíPascual Mónica Bronte Anaut Raquel Ros Briones Amaya Fernández-Celis Natalia lópez-Andrés Nerea Martín-Calvo Pediatric Surgery Department Hospital Universitario de NavarraIrunlarrea 331008PamplonaSpain Clinical Analysis Department Hospital Universitario de NavarraPamplonaSpain Pathology Department Hospital Universitario de NavarraPamplonaSpain Cardiovascular Translational Research NavarraBiomed(Miguel Servet Foundation)Hospital Universitario de NavarraUniversidad Pública de Navarra(UPNA)IdiSNAPamplonaSpain School of Medicine Department of Preventive Medicine and Public HealthUniversity of NavarraPamplonaSpain CIBER Fisiopatología de la Obesidad y Nutrición(CIBERobn) Health Institute Carlos IIIMadridSpain Instituto de Investigación Sanitaria de Navarra IdiSNAPamplonaNavarraSpain

Background Serum interleukin-6(Il-6)has a moderate diagnostic performance in pediatric acute appendicitis(PAA).The evidence regarding its capacity to discern between complicated and uncomplicated PAA is *** We designed a prospective observational study to validate serum Il-6 as a marker for diagnostic classification between complicated and uncomplicated *** study included 205 patients divided into three groups:(1)patients who underwent major outpatient surgery(n=57);(2)patients with non-surgical abdominal pain(NSAP)in whom the diagnosis of PAA was excluded(n=53),and(3)patients with a confirmed diagnosis of PAA(n=95).The PAA patients were further classified as uncomplicated or complicated ***-6 concentration was determined in all patients at *** statistical analysis was performed using the Mann-Whitney U test,the Fisher exact test and the Kruskall Wallis *** area under the receiver operating characteristic curves(AUC)were *** Median(interquartile range,IQR)serum Il-6 values were 2 pg/ml(2.0–3.4)in group 1,3.9 pg/ml(2.4–11.9)in group 2,and 23.9 pg/ml(11.1–61.0)in group 3(Plicated PAA had median(IQR)serum Il-6 values of 17.2 pg/ml(8.5–36.8),and those with complicated PAA had 60.25 pg/ml(27.1–169)serum Il-6(Pl,the AUC for the discrimination between patients in group 2 vs.3 was 0.83[95%confidence interval(CI)0.76–0.90],with a sensitivity of 61.3%and a specificity of *** AUC for the discrimination between patients with uncomplicated and complicated PAA was 0.77(95%CI 0.68–0.86)and the cut-off point was 25.90 pg/ml,with a sensitivity and specificity of 84.6%and 65.6%,*** Serum Il-6 has a good performance in discerning between complicated and uncomplicated PAA.A score including clinical and radiological variables may increase the diagnostic performance of this molecule.

关键词： Acute Appendicitis Complicated Diagnostic Interleukin-6 Pediatric Uncomplicated

Novel kinetic model for the simulation analysis of the butanol productivity of Clostridium acetobutylicum ATCC 824 under different reactor configurations

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Chinese Journal of Chemical Engineering 2018年第4期26卷 812-821页

作者： Hugo I.Velázquez-Sánchez Ricardo Aguilar-lópez Center of Research and Advances Studies of the National Polytechnic Institute (CINVESTAV) Biotechnology and Bioengineering DepartmentAv. National Polytechnic Institute 2508 Col. San Pedro Zacatenco

Acetone–butanol–ethanol(ABE)fermentation process can be exploited for the generation of butanol as biofuel,however it does need to overcome its low volumetric solvent productivity before it can commercially compete with fossil fuel *** this regard,mathematical modelling and simulation analysis are tools that can serve as the base for process engineering development of biological *** this work,a novel phenomenological kinetic model of Clostridium acetobutylicum ATCC 824 was considered as a benchmark system to evaluate the behaviour of an ABE fermentation under different process configurations using both free and immobilized cells:single stage batch operation,fed-batch,single stage Continuous Stirred Tank Reactor(CSTR)and multistage CSTRs with and without biomass *** proposed model achieved a linear correlation index r^2=0.9952 and r^2=0.9710 over experimental data for free and immobilized cells *** predicted maximum butanol concentration and productivity obtained were 13.08 g·l^(-1)and 1.9620 g·l^(-1)·h^(-1)respectively,which represents an increase of 1.01%and 990%versus the currently developed industrial scale process reported currently into the *** results provide a reliable platform for the design and optimization of the ABE fermentation system and showcase the adequate predictive nature of the proposed model.

关键词： Biofuels Butanol Clostridium acetobutylicum Mathematical modelling Process configurations

Metal-modulated epitaxy of Mg-doped Al_(0.80)In_(0.20)N-based layer for application as the electron blocking layer in deep ultraviolet light-emitting diodes

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Journal of Semiconductors 2024年第5期45卷 80-89页

作者： Horacio Irán Solís-Cisneros Carlos Alberto Hernández-Gutiérrez Enrique Campos-González Máximo lópez-lópez Optomechatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInN layers doped with Mg by plasma-assisted molecular beam epitaxy(PAMBE).AlInN was grown with an Al molar fraction of 0.80 by metal-modulated epitaxy(MME)with a thickness of 180 nm on Si(111)substrates using AlN as buffer *** substrate temperatures were used to enhance the incorporation of indium atoms into the alloy without clustering,as confirmed by X-ray diffraction(XRD).Cathodoluminescence measurements revealed ultraviolet(UV)range ***,Hall effect measurements indicated a maximum hole mobility of 146 cm^(2)/(V∙s),corresponding to a free hole concentration of 1.23×10^(19)cm^(−3).The samples were analyzed by X-ray photoelectron spectroscopy(XPS)estimating the alloy composition and extracting the Fermi level by valence band ***-doped AlInN layers were studied for use as the electron-blocking layer(EBl)in lED *** varied the Al composition in the EBl from 0.84 to 0.96 molar fraction to assess its theoretical effects on electroluminescence,carrier concentration,and electric field,using SIlVACO *** results from this study highlight the importance and capability of producing high-quality Mg-doped p-AlInN layers through *** simulations suggest that an Al content of 0.86 is optimal for achieving desired outcomes in electroluminescence,carrier concentration,and electric field.

关键词： metal-modulated epitaxy AlInN DUV-lED EBl simulation