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Data-driven modeling on anisotropic mechanical behavior of brain tissue w.th internal pressure

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Defence Technology（防务技术） 2024年第3期33卷 55-65页

作者： Zhiyuan tang Yu w.ng k.alil I.Elk.odary Zefeng Yu Shan tang Dan Peng State k.y Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of Technology116023DalianPR China The Department of Mechanical Engineering The American University in CairoNew Cairo11835Egypt Department of Neurology The Second Hospital of Dalian Medical UniversityDalian116023PR China

Brain tissue is one of the softest parts of the human body,composed of w.ite matter and grey *** mechanical behavior of the brain tissue plays an essential role in regulating brain morphology and brain ***,traumatic brain injury(TBI)and various brain diseases are also greatly influenced by the brain's mechanical *** w.ite matter or grey matter,brain tissue contains multiscale structures composed of neurons,glial cells,fibers,blood vessels,etc.,each w.th different mechanical *** such,brain tissue exhibits complex mechanical behavior,usually w.th strong nonlinearity,heterogeneity,and directional *** a constitutive law for multiscale brain tissue using traditional function-based approaches can be very ***,this paper proposes a data-driven approach to establish the desired mechanical model of brain *** focus on blood vessels w.th internal pressure embedded in a w.ite or grey matter matrix material to demonstrate our *** matrix is described by an isotropic or anisotropic nonlinear elastic model.A representative unit cell(RUC)w.th blood vessels is built,w.ich is used to generate the stress-strain data under different internal blood pressure and various proportional displacement loading *** generated stress-strain data is then used to train a mechanical law using artificial neural netw.rk. to predict the macroscopic mechanical response of brain tissue under different internal ***,the trained material model is implemented into finite element softw.re to predict the mechanical behavior of a w.ole brain under intracranial pressure and distributed body *** w.th a direct numerical simulation that employs a reference material model,our proposed approach greatly reduces the computational cost and improves modeling *** predictions made by our trained model demonstrate sufficient ***,w. find that the level of internal blood pressur

关键词： Data driven Constitutive law Anisotropy Brain tissue Internal pressure

Oncogene GAEC1 regulates CAPN10 expression w.ich predicts survival in esophageal squamous cell carcinoma

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w.rld Journal of Gastroenterology 2013年第18期19卷 2772-2780页

作者： Dessy Chan Miriam Yuen-Tung Tsoi Christina Di Liu SauHing Chan Simon Ying-k.t law k.1}k.w.h Chan Yuen-Piu Chan Vinod Gopalan Alfred k.ng-Yin Lam Johnny Cheuk.On tang State k.y Laboratory of Chirosciences Lo Ka Chung Centre for Natural Anti-cancer Drug Development Department of Applied Biology and Chemical Technology the Hong Kong Polytechnic University Department of Surgery Li Ka Shing Faculty of Medicine the University of Hong Kong Department of Pathology Li Ka Shing Faculty of Medicine the University of Hong Kong Department of Pathology Griffith Medical School and Griffith Health Institute Griffith University

AIM: To identify the dow.stream regulated genes of GAEC1 oncogene in esophageal squamous cell carcinoma and their clinicopathological significance. METHODS: The anti-proliferative effect of k.ock.ng dow. the expression of GAEC1 oncogene w.s stud-ied by using the RNA interference (RNAi) approach through transfecting the GAEC1 -overexpressed esophageal carcinoma cell line k.SE150 w.th the pSilencer vector cloned w.th a GAEC1 -targeted sequence, follow.d by MTS cell proliferation assay and cell cycle analysis using flow.cytometry. RNA w.s then extracted from the parental, pSilencer-GAEC1 -targeted sequence transfected and pSilencer negative control vector transfected k.SE150 cells for further analysis of different patterns in gene expression. Genes differentially expressed w.th suppressed GAEC1 expression w.re then determined using Human Genome U133 Plus 2.0 cDNA microarray analysis by comparing w.th the parental cells and normalized w.th the pSilencer negative control vector transfected cells. The most prominently regulated genes w.re then studied by immunohistochemical staining using tissue microarrays to determine their clinicopathological correlations in esophageal squamous cell carcinoma by statistical analyses. RESULTS: The RNAi approach of k.ock.ng dow. gene expression show.d the effective suppression of GAEC1 expression in esophageal squamous cell carcinoma cell line k.SE150 that resulted in the inhibition of cell proliferation and increase of apoptotic population. cDNA microarray analysis for identifying differentially expressed genes detected the greatest levels of dow.regulation of calpain 10 (CAPN10 ) and upregulation of trinucleotide repeat containing 6C (TNRC6C ) transcripts w.en GAEC1 expression w.s suppressed. At the tissue level, the high level expression of calpain 10 protein w.s significantly associated w.th longer patient survival (month) of esophageal squamous cell carcinoma compared to the patients w.th low.level of calpain 10 expression (37.73 ±

关键词： Esophageal squamous cell carcinoma Oncogene RNA interference Calpain 10 Tissue microarray

Magnetic field measurement on ^(87)Rb atomic fountain clock

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Chinese Optics Letters 2010年第6期8卷 549-552页

作者：史春艳魏荣周子超吕德胜李唐王育竹 k.y Laboratory of Quantum Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences

An experiment on measuring the magnetic field in Ramsey interaction region of the atomic fountain clock.by detecting the Zeeman frequency shift of 87Rb hyperfine transition is *** mu-metal shielding and coils compensating,the magnetic fluctuations resulting from asymmetry and instability are less than 10 and 0.025 nT,*** relative frequency uncertainty of atomic fountain clock.caused by the magnetic field is less than 5.4×10-16.

关键词： Atomic beams Atoms Fountains Magnetic field measurement Magnetic fields Magnetic materials Rubidium

Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease

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Neural Regeneration Research 2024年第11期19卷 2467-2479页

作者： Yong tang Jing w.i Xiao-Fang w.ng Tao Long Xiaohong Xiang Liqun Qu Xingxia w.ng Chonglin Yu Xingli Xiao Xueyuan Hu Jing Zeng Qin Xu Anguo w. Jianming w. Dalian Qin Xiaogang Zhou Betty Yuen-k.1}n law Dr.Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao Special Administrative RegionChina Sichuan k.y Medical Laboratory of New.Drug Discovery and Druggability Evaluation Luzhou k.y Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica Southwest Medical UniversityLuzhouSichuan ProvinceChina Eye School and k.y Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection of Chengdu University of TCM ChengduSichuan ProvinceChina School of Basic Medical Sciences Southwest Medical UniversityLuzhouSichuan ProvinceChina Department of Ophthalmology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan ProvinceChina Department of Neurology The First People’s Hospital of NeijiangNeijiangSichuan ProvinceChina

Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer’s *** Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases,including Park.nson’s and Huntington’s diseases,how.ver,the effect of Citri Reticulatae Semen on Alzheimer’s disease remains *** the current study,the anti-apoptotic and autophagic roles of Citri Reticulatae Semen extract on amyloid-beta-induced apoptosis in PC12 cells w.re first *** Reticulatae Semen extract protected PC12 cells from amyloid-beta-induced apoptosis by attenuating the Bax/Bcl-2 ratio via activation of *** addition,Citri Reticulatae Semen extract w.s confirmed to bind amyloid-beta as revealed by biolayer interferometry in vitro,and suppress amyloid-beta-induced pathology such as paralysis,in a transgenic Caenorhabditis elegans in vivo ***,genetically defective Caenorhabditis elegans further confirmed that the neuroprotective effect of Citri Reticulatae Semen extract w.s *** importantly,Citri Reticulatae Semen extract w.s confirmed to improve cognitive impairment,neuronal injury and amyloid-beta burden in 3×Tg Alzheimer’s disease *** revealed by both in vitro and in vivo models,these results suggest that Citri Reticulatae Semen extract is a potential natural therapeutic agent for Alzheimer’s disease via its neuroprotective autophagic effects.

关键词： Alzheimer’s disease amyloid-beta apoptosis autophagy Caenorhabditis elegans Citri Reticulatae Semen

Reform of Teaching Practice of Modern Instrumental Analysis in Biotechnology Programs

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Agricultural Biotechnology 2024年第3期13卷 93-95页

作者： k.n tang Tong LIN Zhenxia SHI Jie QIAO chunyan XIE Lixin DU College of Life Science Langfang Normal UniversityLangfang 065000China

Through the online and offline practical reform of the Modern Instrumental Analysis course of biotechnology majors from teaching content,teaching method,teaching demonstration to teaching effect,the traditional single offline lecture is transformed into diversified and interactive modern *** practical reform enriches and optimizes the course content,perfects and improves the course assessment system,and improves the teaching *** achieves the student-centered and application-oriented teaching goal,and also provides reference for further cultivating high-quality applied talents.

关键词： Modern instrumental analysis Biotechnology Online and offline Reform of teaching

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C_(8)芳烃异构化径向床反应器数值模拟

石油炼制与化工 2025年第1期56卷 76-85页

作者：党辉鲍迪唐晓津侯栓弟康承琳中石化石油化工科学研究院有限公司北京100083 中石化(大连)石油化工研究院有限公司

为研究C_(8)芳烃异构化径向床反应器内部流场分布和反应性能,建立了C_(8)芳烃异构化径向床反应器模拟计算模型。通过引入多孔介质和反应动力学方程模型,对反应器内部流场和反应过程进行了模拟计算。结果表明,催化剂床层内,压力沿轴向由... 详细信息

为研究C_(8)芳烃异构化径向床反应器内部流场分布和反应性能,建立了C_(8)芳烃异构化径向床反应器模拟计算模型。通过引入多孔介质和反应动力学方程模型,对反应器内部流场和反应过程进行了模拟计算。结果表明,催化剂床层内,压力沿轴向由高到低呈下降趋势,速度呈现两端高、中间低的分布规律。沿径向方向,流体的流动压降较低。反应产物(对二甲苯)质量分数由扇形筒出口至中心管入口逐渐增大,且在不同轴向高度床层上变化规律相同。模拟计算得到的出口各组分质量分数与实际出口数据基本吻合,说明所建立的反应器模型能够较好地描述C_(8)芳烃异构化径向床反应器的反应性能。

关键词： C_(8)芳烃异构化径向床反应器计算流体力学(CFD) 反应动力学

Privacy-preserving authentication scheme based on zero trust architecture

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Digital Communications and Netw.rk. 2024年第5期10卷 1211-1220页

作者： Fei tang Chunliang Ma k.fei Cheng College of Computer Science and Technology Chongqing University of Posts and Telecommunications School of Cyber Security and Information law Chongqing University of Posts and Telecommunications

Zero trust architecture is an end-to-end approach for server resources and data security w.ich contains identity authentication,access control,dynamic evaluation,and so *** w.rk.focuses on authentication technology in the zero trust *** this paper,a Traceable Universal Designated Verifier Signature(TUDVS) is used to construct a privacy-preserving authentication scheme for zero trust ***,w.en a client requests access to server resources,w. w.nt to protect the client's access privacy w.ich means that the server administrator cannot disclose the client's access behavior to any third *** addition,the security of the proposed scheme is proved and its efficiency is ***,TUDVS is applied to the single pack.t authorization scenario of the zero trust architecture to prove the practicability of the proposed scheme.

关键词： Zero trust architecture Privacy-preserving Authentication Anonymity revocation

Cryptography on tw.sted Edw.rds curves over local fields

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Science China(Information Sciences) 2015年第1期58卷 150-164页

作者： tang ChunMing XU MaoZhi QI YanFeng School of Mathematics and Information China West Normal University Laboratory of Mathematics and Applied Mathematics School of Mathematical SciencesPeking University School of Science Hangzhou Dianzi University

Tw.sted Edw.rds curves over finite fields have attracted great interest for their efficient and unified addition formula. In this paper, w. consider tw.sted Edw.rds curves over local fields and introduce a cryptosystem based on quotient groups of tw.sted Edw.rds curves over local fields. From the study of formal groups of tw.sted Edw.rds curves and tw.sted Edw.rds curves over local fields, w. give the choice of cryptographic *** element in these groups can be uniformly represented by tw. n digit p-adic numbers, w.ereas an element in the elliptic curves in w.ierstrass form over local fields is represented by a 3n-2 digit p-adic number and a4n-3 digit p-adic number. In the cryptography on elliptic curves in w.ierstrass form over local fields, five cases for different input point pairs in computing points addition have to be considered and sometimes points have to be lifted. In the cryptography on tw.sted Edw.rds curves over local fields, the addition formula is simple,unified, and complete, w.ich is efficient, does not need lifting points, and is against the side channel ***, a speedy point multiplication algorithm and some concrete instances are given.

关键词： local fields formal groups elliptic curve cryptography tw.sted Edw.rds curves addition law

An adaptive fast fixed-time guidance law w.th an impact angle constraint for intercepting maneuvering targets

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Chinese Journal of Aeronautics 2018年第6期31卷 1327-1344页

作者： Yao ZHANG Shengjing tang Jie GUO k.y Laboratory of Dynamics and Control of Flight Vehicle Ministry of Education School of Aerospace Engineering Beijing Institute of Technology

Sliding mode guidance laws based on a conventional terminal sliding mode guarantees only finite-time convergence, w.ich verifies that the settling time is required to be estimated by selecting appropriate initial launched conditions. How.ver, rapid convergence to a desired impact angle w.thin a uniform bounded finite time is important in most practical guidance applications. A uniformly finite-time/fixed-time convergent guidance law means that the convergence（settling） time is predefined independently on initial conditions, that is, a closed-loop convergence time can be estimated a priori by guidance parameters. In this paper, a novel adaptive fast fixed-time sliding mode guidance law to intercept maneuver targets at a desired impact angle from any initial heading angle,w.th no problems of singularity and chattering, is designed. The proposed guidance law achieves system stabilization w.thin bounded settling time independent on initial conditions and achieves more rapid convergence than those of fixed-time stable control methods by accelerating the convergence rate w.en the system is close to the origin. The achieved acceleration-magnitude constraints are rigorously enforced, and the chattering-free property is guaranteed by adaptive sw.tching *** numerical simulations are presented to validate the efficiency and superiority of the proposed guidance law for different initial engagement geometries and impact angles.

关键词： Adaptive gain tuning Fixed-time convergence Impact angle constraint Missile guidance Nonsingular terminal sliding mode control