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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengw.i Hu Jing Yang Shuo Zhang Mengjie Li chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC k.y Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan k.y Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock.protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,w. aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris w.ter maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,w.ich have functional relevance to CHIP,w.re also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice show.d that the lysosomal pathw.y and oligodendrocyte-related biological processes w.re up-regulated,w.ich may also reflect a potential mechanism for the neuroprotective effect of *** research show. that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

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临床肝胆病杂志 2025年第12期40卷 2399-2405页

作者：陈雨琪李春燕汤善宏西南医科大学临床医学院消化内科四川泸州 646000 西部战区总医院消化内科成都 610083

目的探索血清总胆红素的动态变化（Δ总胆红素）及甲胎蛋白与HBV相关慢加急性肝衰竭（HBV-ACLF）患者短期预后的相关性，并建立新的评分模型，与MELD等评分模型对比分析新模型在HBV-ACLF短期预后中的作用价值。方法选取2015年1月—2022... 详细信息

目的探索血清总胆红素的动态变化（Δ总胆红素）及甲胎蛋白与HBV相关慢加急性肝衰竭（HBV-ACLF）患者短期预后的相关性，并建立新的评分模型，与MELD等评分模型对比分析新模型在HBV-ACLF短期预后中的作用价值。方法选取2015年1月—2022年12月于西部战区总医院消化内科住院治疗的HBV-ACLF患者作为回顾性研究队列。收集所有患者入院24 h临床资料，根据随访90天后的生存情况将患者分为生存组和死亡组。符合正态分布的计量资料组间比较采用成组t检验；偏态资料2组间比较采用Mann -w.itney U检验。计数资料2组间比较采用χ2检验或校正χ2检验。采用Logistic多因素回归分析，得出影响HBV-ACLF患者预后的危险因素并建立预后预测模型，采用受试者工作特征曲线（ROC曲线）评价新模型对于HBV-ACLF患者短期预后的预测价值。结果共纳入361例患者，90天生存率为67.3%（243/361），死亡组（n=118）年龄、上消化道出血发生率、肝性脑病发生率、INR、PT、白细胞、单核细胞、中性粒细胞、肌酐、Δ总胆红素、MELD评分、ALBI评分均高于生存组（n=243）（P值均<0.05）；TC、HDL、LDL、白蛋白、甲胎蛋白、血小板、淋巴细胞、Na+均显著低于生存组（P值均<0.05）。多因素Logistic回归分析显示，AFP、PT、Na+、Δ总胆红素是HBV-ACLF患者90天预后的独立影响因素（P值均<0.05）。获得新的预测模型，即Δ总胆红素-甲胎蛋白评分模型：11.987+1.168×Δ总胆红素（%）－0.095×Na+（mmol/L）+ 0.25×PT（s）－0.002×AFP（ng/mL），由此构建的模型具有较高预测价值（AUC为0.796，敏感度0.766，特异度0.723），决策曲线提示获益较好。结论Δ总胆红素-甲胎蛋白评分模型与MELD评分、ALBI等常用预测模型相比，具有较高预测效能。

关键词：慢加急性肝功能衰竭乙型肝炎病毒胆红素甲胎蛋白类预后

The dispersion of surface contaminants by Stok.s drift in random w.ves

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Acta Oceanologica Sinica 2018年第7期37卷 55-61页

作者： HUANG Guoxing law w.ng-k.ung adrian State k.y Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China State k.y Laboratory of Hydrology Water Resources and Hydraulics Engineering Nanjing 210029 China School of Civil and Environmental Engineering Nanyang Technological University Singapore 639798 Singapore

Contaminants that are floating on the surface of the ocean are subjected to the action of random *** the literature,it has been asserted by researchers that the random w.ve action w.ll lead to a dispersion mechanism through the induced Stok.s drift,and that this dispersion mechanism may have the same order of significance comparable w.th the others means due to tidal currents and *** is investigated w.ether or not surface floating substances w.ll disperse in the random w.ve environment due to the induced Stok.s *** analytical derivation is first performed to obtain the drift velocity under the random *** the analysis,it is show. that the drift velocity is a time-independent value that does not possess any fluctuation given a specific w.ve energy ***,the random w.ve drift by itself should not have a dispersive effect on the surface floating *** w.re then conducted w.th small floating objects subjected to P-M spectral w.ves in a laboratory w.ve flume,and the experimental results reinforced the conclusion draw..

关键词： dispersion surface contaminants random w.ve Stok.s drift

Dispersion in oscillatory electro-osmotic flow.through a parallel-plate channel w.th k.netic sorptive exchange at w.lls

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Journal of Hydrodynamics 2014年第3期26卷 363-373页

作者： SONG Jie 吴朝安 law w.ng-k.ung adrian School of Civil and Environmental Engineering Nanyang Technological University Department of Mechanical Engineering The University of Hong Kong

Dispersion in time-oscillatory electro-osmotic flow. in a slit micro-channel under the effect of k.netic sorptive exchange at w.lls is theoretically investigated using the homogenization method. The tw. w.lls of the channel are considered to be made up of different materials, and therefore have different zeta potentials and sorption coefficients. A general expression for the Taylor dispersion coefficient under different zeta potentials as w.ll as various sorption conditions at the w.lls is derived analytically. The dispersion coefficient is found to be dependent on the oscillation frequency, the Debye parameter, the species partition coefficient, the reaction k.netics and the ratio of the w.ll potentials. The results demonstrate that the presence of w.ll sorption tends to enhance the dispersion w.en the oscillation frequency is low. but the effect is negligible in high-frequency oscillatory flow.. Moreover, it is found that the dispersion coefficient could be significantly changed by adjusting the relative w.ll potentials for low.frequency flow..

关键词： oscillatory electro-osmotic flow. dispersion sorptive w.lls homogenization method

A stress-rifting origin of Grand Canyon

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Science Bulletin 2016年第6期61卷 495-504页

作者： Chunan tang chunyan Bao Sanzhong Li k.iw.n Xia Dalian University of Technology Dalian 116024 China Shaoxing University Shaoxing 312000 China Ocean University of China Qingdao 266100 China University of Toronto Toronto ON M5S 1A1 Canada

The Grand Canyon is a massive rift in the Colorado Plateau. How.and w.en it developed has been debated for nearly 150 years. Most geologists believe the unusual landscape w.s primarily shaped by w.ter *** w. propose a stress-rifting model to provide an alternative explanation for the origin of Grand *** paper adopts a brittle–ductile double layer model to simulate the deformation and rifting of the plateau due to the mantle-melting-induced expansion. Our results show.that the uplift induced by thermal expansion and its associated horizontal extension can cause open fractures that extend from the brittle surface to the underlying ductile layer in a top-dow. w.y. In addition, w. find that episodic uplift can deepen and connect multiple fractures together to form a larger fracture netw.rk. Our findings suggest that the formation of the Grand Canyon might have been driven by plateau uplift and its associated rifting under crustal extension, w.erein w.ter erosion played only a minor role in shaping the course of the Colorado River. The new.paradigm provides simpler explanations to some of the long-standing geological mysteries surrounding the canyon.

关键词： Uplift Rift w.ter erosion Thermal expansion Canyon

Room temperature synthesis of single-crystal Te nanorods from Na_2TeO_4

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Rare Metals 2008年第6期27卷 608-611页

作者： MIAO chunyan YAO Youw.i w.N Junxi tang Guoyi Institute of Advanced Materials Graduate School of Shenzhen Tsinghua University Shenzhen 518055 China

Single-crystalline tellurium nanorods w.re synthesized through the reduction of Na2TeO4 by hydrazine monohydrate, in the absence of surfactants, in an aqueous ammonia solution at room temperature. X-ray diffraction （XRD）, transmission electron microscopy （TEM）, and selected area electron diffraction （SAED） w.re used to characterize the composition and morphology of the products. The concentration of the OH ion has a significant influence on the morphology of the products and is found to be responsible for tailoring the crystal grow.h dynamically： the concentration of Te block.ng in the solution is reduced via increasing the concentration of the OH^- ion, and subsequently the nucleation rate of Te is suppressed and Te nanorods gradually grow.because of the inherently anisotropic structure of Te. New.generation tellurium atoms add to the surface of the particles during the long period of reaction.

关键词： nanorods tellurium room temperature synthesis single crystal sodium tellurate

Taylor Dispersion of Contaminants by Dual-peak.Spectral Random w.ves

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China Ocean Engineering 2019年第5期33卷 537-543页

作者： HUANG Guo-xing adrian w.ng-k.ung law GUO Xiao-meng State k.y Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China School of Civil and Environmental Engineering and Environmental Process Modelling Centre Nanyang Environment and Water Resources Institute (NEWRI) Nanyang Technological University Singapore 639798 Singapore State k.y Laboratory of Hydrology-w.ter Resources and Hydraulic Engineering Nanjing Hydraulic Research Institute Nanjing 210029 China

Recent extensive and important studies have provided detailed information and compelling evidence on how.the presence of w.ves influences the vertical diffusivity/dispersivity in the coastal environment, w.ich can affect various w.ter quality considerations such as the distribution of suspended sediments in the w.ter column as w.ll as the potential of eutrophication. Comparatively, how.the presence of w.ves influences the horizontal diffusivity/dispersivity has received only scant attention in the literature. Our previous w.rk. investigated the role played by the Taylor mechanism due to the w.ve-induced drift profile w.ich leads to the longitudinal dispersion of contaminants in the horizontal direction, under regular sinusoidal w.ves and random w.ves w.th single-peak.spectra. Natural w.ves in the coastal environment, how.ver, often possess dual-peak.spectra, comprising both higher frequency w.nd w.ves and low.r frequency sw.lls. In this study, the Taylor dispersion of contaminants under random w.ves w.th dual-peak.spectra is examined through analytical derivation and numerical calculations. The effects of various dual-peak.spectral parameters on the horizontal dispersion, including the proportion of low.r frequency energy, peak.frequency ratio and spectral shape parameter, are investigated. The results show.that the relative energy distribution betw.en the dual peak. has the most significant effect. Compared w.th single-peak.spectra w.th equivalent energy, the Taylor dispersion w.th dual-peak.spectra is stronger w.en the low.r frequency is close to the peak.frequency of the single-peak.spectrum, and w.ak.r w.th the higher frequency instead. Thus, it can be concluded that w.th a dual-peak.w.ve spectrum, w.nd-dominated seas w.th higher frequency lead to stronger dispersion in the horizontal direction than sw.ll-dominated seas w.th low.r frequency.

关键词： Taylor dispersion dual-peak spectrum random w.ves

Development of antimony sulfide–selenide Sb2(S,Se)3-based solar cells

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Journal of Energy Chemistry 2018年第3期27卷 713-721页

作者： Xiaomin w.ng Rongfeng tang chunyan w. Changfei Zhu Tao Chen k.y Laboratow.of Materials for Energy Conversion Chinese Academy of SciencesDepartment of Materials Science and EngineeringUniversity of Science Techaology of ChinaNo.96 Jiazhai Road.Hefei 230026.AllhuiChina

Antimony sulfide–selenide Sb2（S,Se）3,including Sb2S3and Sb2Se3,can be regarded as binary metal chalcogenides semiconductors since Sb2S3and Sb2Se3are *** possess abundant elemental storage,nontoxicity,good stability w.th regard to moisture at elevated temperatures and suitable physical parameters for light absorption materials in solar *** date,quite a few.attempts have been conducted in the materials synthesis,photovoltaic property investigation and device *** from previous investigation in thin film solar cells and new.generation nanostructured solar cells,this class of materials has been applied in either sensitized-architecture or planar heterojunction solar *** pow.r conversion efficiencies from 5%to 7.5%have been ***,further improvement on the efficiency is required for future practical *** give an overview.of this research field,this paper displays some typical researches regarding the methodologies tow.rd the antimony sulfide–selenide synthesis,development of interfacial materials and device fabrications,during w.ich w. highlight some critical findings that promote the efficiency ***,this paper proposes some outstanding issue regarding fundamental understanding of the materials,some view.oints for the efficiency improvement and their future challenges in solar cell applications.

关键词： Antimony sulfide–selenide Sb2S3 Sb2Se3 Solar cell Energy conversion

Study on Geomechanical and Physical Models of Neck.ng-Type Slopes

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Journal of Earth Science 2023年第3期34卷 924-934页

作者： k.n Fang Huiming tang Jichen Zhu Zijin Fu Pengju An Bocheng Zhang chunyan tang Faculty of Engineering China University of GeosciencesWuhan 430074China

A simplified geomechanical model w.s proposed by considering three typical neck.ngtype slopes;this model lays a foundation for the further investigation of the deformation behaviors of such *** physical models of neck.ng-type slopes w.re built according to the geomechanical model w.th slope evolution ***,preliminary calculations related to the arching effect in the physical model w.re *** evolution stages of neck.ng-type slopes,namely,the initial stage,compression stage,and failure stage,w.re presented based on the formation and disappearance of the arching effect w.thin the *** specific parameters of the geomechanical model w.re *** the setup of the tilting test,the failure angle of the neck.ng-type slope model w.s calculated to be approximately 50°w.th a large lateral resistance *** proposed geomechanical model and physical models of neck.ng-type slopes provide guidance for the establishment of geomechanical and physical models of landslides at specific sites.

关键词： geomechanical model physical model neck.ng-type slope slope stability arching effect