检索结果-南通市图书馆

Neurodevelopmental Outcomes of Extremely Premature Infants with Extremely Low and Very Low Birth Weight at Three Years of Age: A Retrospective Study

在线全文

学校读者我要写书评

暂无评论

Open Journal of Pediatrics 2023年第3期13卷 333-346页

作者： Eileen Romer McGrath Mark Borgstrom Elias adrian Ramirez-moreno Jennie Jacob Steele Children’s Research Center College of Medicine The University of Arizona Tucson USA University Information Technology Services The University of Arizona Tucson USA Diamond Children’s Banner Medical Center Tucson USA

Introduction: The purpose of this retrospective study is to identify medical conditions impacting neurodevelopmental outcomes of extremely low birth weight and very low birth weight preterm infants at three years of age. Methods: Infants born in Banner Diamond Children’s University Medical Center, receiving services in the Newborn Intensive Care Unit, and attending Neonatal Developmental Follow-Up Clinic were identified. Participants received developmental assessment and follow-up from August 2012 through December 2018. Relevant clinical conditions during initial hospital stay and up to three years of age were obtained by reviewing medical and developmental records. Bayley Scales of Infant Toddler Development (Bayley III) was used to evaluate skill development at 6, 9, 12, 18, 24, 30, 36 months. Results: Data analysis did not reveal significant p-values;it did demonstrate that some predictor variables impact neurodevelopmental outcomes in cognitive, language and motor skill development. Conclusion: This retrospective study reports significant association between birth weight and low cognitive scores. Correlations were also found between gestational age and Total Language, and the longer an infant stayed in the NICU, the poorer the Total Language Scaled Scores at 8 to 12 months, 15 to 18 months, and 24 to 36 months. Birth weight was found to be the greatest predictor of poor motor scores.

关键词： Extremely Preterm Extremely Low Birth Weight Very Preterm Very Low Birth Weight Neurodevelopmental Outcomes Early Intervention

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

科塔卡奇房屋

世界建筑导报 2019年第2期34卷 28-33页

作者： adrian moreno Maria Samaniego Sebastián Crespo arquitectura X

该项目是一个特例,在进行房屋设计时,并没告诉我们房屋的选址。根据我们对自己房屋的设计经验,便采用了相同策略:可适用所有场地条件的通用方案,山谷中两座主要的山地构成了该房屋的空间限制因素,以抽象玻璃屋作为建造起点。

关键词：房屋设计经验场地条件塔

在线全文

学校读者我要写书评

暂无评论

X房屋

世界建筑导报 2019年第2期34卷 11-15页

作者： adrian moreno Maria Samaniego Sebastian Crespo arquitectura x

开始进行房屋设计时,我们并没有设定具体地址,我们设计的基本方案既可用在基多也可应用在基多东部的山谷里;也就是说我们利用自己的经验,从Donald Judd 的作品中得到启发,设计出一种抽象形式,可以适用于我们可能找到的任何地方:端口开... 详细信息

开始进行房屋设计时,我们并没有设定具体地址,我们设计的基本方案既可用在基多也可应用在基多东部的山谷里;也就是说我们利用自己的经验,从Donald Judd 的作品中得到启发,设计出一种抽象形式,可以适用于我们可能找到的任何地方:端口开放式的箱体,其空间限制因素为安第斯山东部和西部山脉。

关键词：房屋开放式设计

Translational challenges in amyotrophic lateral sclerosis therapy with macrophage migration inhibitory factor

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2583-2584页

作者： Leenor Alfahel Aleksandar Rajkovic adrian Israelson Department of Physiology and Cell Biology Faculty of Health SciencesBen-Gurion University of the NegevBeer ShevaIsraelThe School of Brain Sciences and CognitionBen-Gurion University of the NegevBeer ShevaIsrael

Macrophage migration inhibitory factor(MIF):MIF acts as a pleiotropic inflammatory mediator,playing regulatory roles in innate and adaptive immunity,neuroinflammation,neuroendocrine functions,and nervous system development(Matejuk et al.,2024).In recent years,MIF has attra cted significant inte rest from research groups as a potential target for the treatment of various neurodegenerative diseases,including Alzheimer's disease,Parkinson's disease,multiple sclerosis,and glioblastoma(Matejuk et al.,2024).

关键词： immunity sclerosis

在线全文

学校读者我要写书评

暂无评论

细节彰显特色:厄瓜多尔RI工作室

设计家 2010年第3期 96-99页

作者： adrian moreno María Samaniego Sebastian crespo 张小千林籽言 Arquitectura X

本项目是为一家刚成立的广告公司打造一个自由灵活、适应性强的办公空间。由于他们多样的工作性质及不断变化的工作需求,办公空间必须具有扩展性。

关键词：办公空间厄瓜多尔自由灵活工作性质广告公司设计师扩展性特色适应性强需求

在线全文

学校读者我要写书评

暂无评论

扩散边界:R.I.房屋

世界建筑导报 2019年第2期34卷 34-37页

作者： adrian moreno María Samaniego Jorge Durán María Gracia Borja Andrea Cisneros Bicubik Sebastián Crespo Andrés Fernández

该项目中的房屋设计是在建造过程中逐渐形成的,在施工中确定当前的结构,而最终用途还未确定。客户家庭期待建成的建筑物,可让他们在周末的时候享受这个风景秀丽之地,远离城市喧嚣,但不确定是要建一个具有野外烧烤功能的凉亭、周末小屋... 详细信息

该项目中的房屋设计是在建造过程中逐渐形成的,在施工中确定当前的结构,而最终用途还未确定。客户家庭期待建成的建筑物,可让他们在周末的时候享受这个风景秀丽之地,远离城市喧嚣,但不确定是要建一个具有野外烧烤功能的凉亭、周末小屋、第二套住宅还是另一个办公室。

关键词：房屋设计扩散建造过程烧烤功能建筑物办公室施工凉亭

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Results on non-SUSY searches for physics beyond standard model in pp collisions at CMS

在线全文

学校读者我要写书评

暂无评论

Frontiers of physics 2013年第3期8卷 257-269页

作者： adrian Perieanu Physikalisches Institut B RWTH-Aachen Germany

In this paper a review of the results on searches for pnysics beyond the standard model in pp collisions with the CMS experiment at √s = 7 and 8 TeV is presented. Aspects of the analyses and their achieved limits on ... 详细信息

关键词： beyond standard model gauge bosons leptoquarks extra dimensions

Numerical study of solar absorption heat storage system applied to Bucharest city

在线全文

学校读者我要写书评

暂无评论

Building Simulation 2021年第3期14卷 601-616页

作者： Noureddine Cherrad adrian-Gabriel Ghiaus University Kasdi Merbah ofOuargla Faculty of Applied SciencesDepartment of Mechanical EngineeringOuarglaAlgeria Doctoral School Technical University of Civil Engineering of BucharestBucharestRomania

Buildings represent a large part in terms of fossil energy consumption,which depends on the great need for *** if the solar absorption heat storage system is possible,the performance of this system is affected by the cycle limits and the climatic *** goal of the present study is to control the thermal performance of the system cycle according to the imposed climatic conditions of Bucharest city,Romania,and therefore a numerical model was developed for this *** scheme and the thermodynamic cycle,the energy and mass balance equations,and the computational algorithm were *** results show that the cycle temperature increases at the end of desorption when the heating power supplied to the desorber is increased,which is also proportional to the drop in temperature at the beginning of the *** temperature at the end of absorption and the mass flow rates of the solution have a significant effect on the thermal power released from the absorber and used to heat the *** an average daily heat power of 1.35 kW/m^(2) and 10 hours per day of heating the building,the system with a solar collector area of 3 m^(2) has the capacity of heat supply for all the cold ***,an economic strategy remains necessary.

关键词： numerical model absorption heat storage cycle temperatures climatic conditions