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Far-infrared absorption studies of Be acceptors in δ-doped GaAs/AlAs multiple quantum wells

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Science China(Physics,Mechanics & Astronomy) 2006年第6期49卷 702-708页

作者： M. P. Halsall P. harrison M. J. Steer School of Physics and Astronomy the University of ManchesterManchester M60 1QD U. K. School of Electronic and Electrical Engineering University of LeedsLS2 9JT U. K. EPSRC Ⅲ-V Semiconductor Central Facility Department of Electronic and Electrical Engineering University of SheffieldS1 3JD U. K.

We report a far-infrared absorption study of internal transitions of shallow Be acceptors in both bulk GaAs and a series of δ-doped GaAs/AlAs multiple quantum well samples with well thicknesses of 20,15 and 10 nm. Low temperature far-infrared absorp-tion measurements clearly show three principal absorption lines due to transitions of Be-acceptor states from the ground state to the first three odd-parity excited states,respec-tively. Using a variational principle,the 2p-1s transition energies of quantum confined Be acceptors are calculated as a function of the well width. It is found that the theoretical calculation of the 2pz → 1s transitions is in good agreement with the D-like line experi-mental data.

关键词： shallow acceptor impurities,δ-doped,GaAs/AlAs multiple quantum wells,far-infrared absorptions.

Lipid mediators of inflammation in neurological injury： shifting the balance toward resolution

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Neural Regeneration Research 2016年第1期11卷 77-78页

作者： Jordan L.harrison Rachel K.Rowe Jonathan Lifshitz BARROW Neurological Institute at Phoenix Children's Hospital Phoenix AZ USA Interdisciplinary Graduate Program in Neuroscience Arizona State University Tempe AZ USA Department of Child Health University of Arizona College of Medicine - Phoenix Phoenix AZ USA Phoenix Veteran Affairs Healthcare System Phoenix AZ USA

Acquired neurological injuries initiate a pathological cascade of secondary injury processes,including inflammation,which continue for days to weeks following ***-induced neuroinflammation acts as a host defense mechanism contributing to the neutralization of the insult（removing offending factors）and restoring structure and function of the brain（establish homeostasis）.The timing of these protective functions of the immune response is vital,since chronic inflammation

关键词： inflammation neurological homeostasis initiate protective removing vital toward contributing cascade

Skeletal muscle atrophy,regeneration,and dysfunction in heart failure:Impact of exercise training

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Journal of Sport and Health Science 2023年第5期12卷 557-567,F0003页

作者： harrison Gallagher Paul W.Hendrickse Marcelo G.Pereira T.Scott Bowen School of Biomedical Sciences Faculty of Biological SciencesUniversity of LeedsLeeds LS29JTUK

This review highlights some established and some more contemporary mechanisms responsible for heart failure(HF)-induced skeletal muscle wasting and *** first describe the effects of HF on the relationship between protein synthesis and degradation rates,which determine muscle mass,the involvement of the satellite cells for continual muscle regeneration,and changes in myofiber calcium homeostasis linked to contractile *** then highlight key mechanistic effects of both aerobic and resistance exercise training on skeletal muscle in HF and outline its application as a beneficial ***,HF causes multiple impairments related to autophagy,anabolic-catabolic signaling,satellite cell proliferation,and calcium homeostasis,which together promote fiber atrophy,contractile dysfunction,and impaired *** both wasting and weakness are partly rescued by aerobic and resistance exercise training in HF,the effects of satellite cell dynamics remain poorly explored.

关键词： Calcium Exercise training Heart failure Satellite cells Skeletal muscle wastingTagedAPTARAEnd

Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system

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Translational Neurodegeneration 2022年第1期11卷 667-689页

作者： Douglas M.Lopes Sophie K.Llewellyn Ian F.harrison Division of Medicine Department of ImagingCentre for Advanced Biomedical ImagingFaculty of Medical SciencesUniversity College LondonPaul O’Gorman Building72 Huntley StreetLondon WC1E 6DDUK

Many neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are characterised by the accumulation of misfolded protein deposits in the brain, leading to a progressive destabilisation of the neuronal network and neuronal death. Among the proteins that can abnormally accumulate are tau and α-synuclein, which can propagate in a prion-like manner and which upon aggregation, represent the most common intracellular proteinaceous lesions associated with neurodegeneration. For years it was thought that these intracellular proteins and their accumulation had no immediate relationship with extracellular homeostasis pathways such as the glymphatic clearance system;however, mounting evidence has now suggested that this is not the case. The involvement of the glymphatic system in neurodegenerative disease is yet to be fully defined;however, it is becoming increasingly clear that this pathway contributes to parenchymal solute clearance. Importantly, recent data show that proteins prone to intracellular accumulation are subject to glymphatic clearance, suggesting that this system plays a key role in many neurological disorders. In this review, we provide a background on the biology of tau and α-synuclein and discuss the latest findings on the cell-to-cell propagation mechanisms of these proteins. Importantly, we discuss recent data demonstrating that manipulation of the glymphatic system may have the potential to alleviate and reduce pathogenic accumulation of propagation-prone intracellular cytotoxic proteins. Furthermore, we will allude to the latest potential therapeutic opportunities targeting the glymphatic system that might have an impact as disease modifiers in neurodegenerative diseases.

关键词： Glymphatic Propagation Tauopathy Synucleinopathy Clearance Aquaporin-4

Organic Solar Cells at Stratospheric Condition for High Altitude Platform Station Application

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Chinese Journal of Chemistry 2022年第24期40卷 2927-2932页

作者： Ram Datt harrison Ka Hin Lee Guichuan Zhang Hin-Lap Yip Wing Chung Tsoi SPECIFIC Faculty of Science and EngineeringSwansea UniversityBay CampusFabian WaySwanseaSA18EN United Kingdom Department of Physics City University of Hong KongKowloonHong KongSARChina School of Semiconductor Science and Technology South China Normal UniversityFoshanGuangdong528225 China State Key Laboratory of Luminescent Materials and Devices South China University of Technology381 Wushan RoadGuangzhouGuangdong510640 China Department of Materials Science and Engineering City University of Hong KongKowloonHong KongChina School of Energy and Environment City University of Hong KongKowloonHong KongChina Hong Kong Institute for Clean Energy City University of Hong KongKowloonHong KongChina

High specific power or power to mass ratio is a critical concern of photovoltaic(PV)for aerospace *** solar cells(OSCs)have advantages such as high absorption coefficient,compatibility with flexible substrate,light-weight,***,recently OSCs achieved power conversion efficiency(PCE)over 20%with the incorporation of the non-fullerene based small molecule acceptor and high specific power is believed to be *** enter the market,high-altitude platform station(HAPS)is perhaps the first place to start *** this work,we explore and compare the in-situ performance of two high performing OSCs,using the same donor but different acceptors,in mimic HAPS environment where the pressure,temperature and the illumination conditions are *** found that the use of acceptor can result in substantial difference in the performance at low temperatures.

关键词： Organic solar cells Stratosphere High-altitude platform station Low-temperature physics Donor-acceptor systems

Spatial and seasonal variation in soil respiration along a slope in a rubber plantation and a natural forest in Xishuangbanna, Southwest China

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Journal of Mountain Science 2018年第4期15卷 695-707页

作者： ZHAO Yong-li Stefanie D.GOLDBERG XU Jian-chu Rhett D.harrison Center for Mountain Ecosystem Studies Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 China University of Chinese Academy of Sciences Beijing 100039 China World Agroforestry Centre East and Central Asia Kunming 650201 China World Agroforestry Centre East & Southern Africa Region 13 Elm Road Woodlands Lusaka Zambia

Soil respiration is a key component of the global carbon cycle, and even small changes in soil respiration rates could result in significant changes in atmospheric CO_2 levels. The conversion of tropical forests to rubber plantations in SE Asia is increasingly common, and there is a need to understand the impacts of this land-use change on soil respiration in order to revise CO_2 budget calculations. This study focused on the spatial variability of soil respiration along a slope in a natural tropical rainforest and a terraced rubber plantation in Xishuangbanna, Southwest(SW) China. In each land-use type, we inserted 105 collars for soil respiration *** was conducted over one year in Xishuangbanna during May, June, July and October 2015(wet season) and January and March 2016(dry season). The mean annual soil respiration rate was 30% higher in natural forest than in rubber plantation and mean fluxes in the wet and dry season were 15.1 and 9.5 Mg C ha^(-1) yr^(-1) in natural forest and 11.7 and 5.7 Mg C ha^(-1) yr^(-1) in rubber plantation. Using a linear mixedeffects model to assess the effect of changes in soil temperature and moisture on soil respiration, we found that soil temperature was the main driver of variation in soil respiration, explaining 48% of its seasonal variation in rubber plantation and 30% in natural forest. After including soil moisture, the model explained 70% of the variation in soil respiration in natural forest and 76% in rubber plantation. In the natural forest slope position had a significant effect on soil respiration, and soil temperature and soil moisture gradients only partly explained this correlation. In contrast, soil respiration in rubber plantation was not affected by slope position, which may be due to the terrace structure that resulted in more homogeneous environmental conditions along the slope. Further research is needed to determine whether or not these findings hold true at a landscape level.

关键词： Soil respiration Tropical rain forest Rubber plantation Land-use change Carbon cycle Transect

Dual-energy X-ray absorptiometry scans accurately predict differing body fat content in live sheep

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Journal of Animal Science and Biotechnology 2019年第1期10卷 248-253页

作者： David W Miller Ellen J Bennett Joanne L harrison Fiona Anderson Clare L Adam School of Veterinary and Life Sciences Murdoch University Scotland’s Rural College (SRUC) Peter Wilson Building The Faculty of Health University of Tasmania School of Biological Sciences University of Aberdeen Rowett Institute of Nutrition and Health University of Aberdeen

Background: There is considerable interest in implementing mobile scanning technology for on-farm body composition analysis on live *** experiments evaluated the use of dual energy X-ray absorptiometry(DXA) as an accurate method of total body fat measurement in live ***: In Exp.1,visceral and whole body fat analysis was undertaken in sheep with body condition scores(BCS)in the range 2 to 3.25(scale 1: thin to 5: fat).The relationship of BCS was moderately correlated with visceral fat depot mass(r = 0.59,P 0.05,n = 9).There was a moderate correlation between DXA body fat and BCS(r = 0.70,P < 0.01,n = 17),and DXA body fat was highly correlated with chemical body fat(r = 0.81,P < 0.001,n = 9).In Exp.3,a series of five DXA scans,at 8-week intervals,was performed on growing sheep over a 32-week *** average BCS ranged from 2.39 ± 0.07(S.E.M.) to 3.05 ± 0.11 and the DXA body fat(%) ranged from 16.8 ± 0.8 to 24.2 ± *** was a moderate correlation between DXA body fat and BCS over the 32 weeks(r = 0.61,P < 0.001,n = 24).Conclusions: Overall,these experiments indicated that there was good agreement between BCS,DXA and chemical analysis for measuring total body fat in sheep,and that DXA scanning is a valid method for longitudinal measurement of total body fat in live sheep.

关键词： BCS DEXA Fat Leptin Longitudinal Sheep

Management of intestinal failure in inflammatory bowel disease:Small intestinal transplantation or home parenteral nutrition?

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World Journal of Gastroenterology 2014年第12期20卷 3153-3163页

作者： Elizabeth harrison Philip Allan Amrutha Ramu Anil Vaidya Simon Travis Simon Lal Intestinal Failure Unit Salford Royal NHS Foundation Trust Translational Gastroenterology Unit Oxford University Hospitals NHS Trust Transplant Centre Oxford University Hospitals NHS Trust

Inflammatory bowel disease and Crohn’s disease in particular, is a common cause of intestinal failure. Current therapeutic options include home parenteral nutrition and intestinal transplantation. For most patients, home intravenous therapy including parenteral nutrition, with a good probability of long-term survival, is the favoured choice. However, in selected patients, with specific features that may shorten survival or complicate home parenteral nutrition, intestinal transplantation presents a viable alternative. We present survival, complications, quality of life and economic considerations that currently influence individualised decision-making between home parenteral nutrition and intestinal transplantation.

关键词： Inflammatory bowel disease, Crohn’ s disease, Intestinal failure, Intestinal transplantation, Home parenteral nutrition, Survival, Complications, Quality of life

Cellular signaling in sinecatechins-treated external genital and perianal warts: unraveling the mechanism of action of a botanical therapy

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Virologica Sinica 2015年第3期30卷 214-217页

作者： harrison P Nguyen Hung Q Doan Peter Rady Stephen K Tyring Department of Dermatology Baylor College of Medicine Department of Dermatology University of Texas Houston Health Science Center Center for Clinical Studies

Dear Editor,Derived from green tea leaves,sinecatechins(Veregen)ointment,15%is a topical therapy that is FDA-approved to treat human papillomavirus(HPV)-induced external genital and perianal warts(EGW)in immunocompetent patients aged 18 years and *** two phase 3 trials enrolling over 1,000 participants with EGW,a 16-week treatment regimen with sinecatechins ointment resulted in higher rates of complete clearance of all warts—both

关键词： genital papillomavirus clearance older regimen approved signaling transcriptase salient biopsy