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A techno-economic and life cycle assessment for the production of green methanol from CO_(2): catalyst and process bottlenecks

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Journal of Energy chemistry 2022年第5期31卷 255-266页

作者： Tomas Cordero-Lanzac adrian Ramirez Alberto Navajas Lieven Gevers Sirio brunialti Luis mGandía Andrés T.Aguayo S.mani Sarathy Jorge Gascon Department of chemical Engineering University of the Basque Country(UPV/EHU)PO Box 64448080 BilbaoSpain King Abdullah University of Science and Technology KAUST Catalysis Center(KCC)Advanced Catalytic MaterialsThuwal 23955Saudi Arabia Department of Science Public University of Navarre(UPNA)Arrosadía Campus s/n31006 PamplonaSpain Institute for Advanced materials and mathematics(Inamat2) Universidad Pública de Navarra(UPNA)Edificio Jerónimo de AyanzCampus de ArrosadiaPamplona-Iruña 31006Spain King Abdullah University of Science and Technology Clean Combustion Research Center(CCRC)Thuwal 23955Saudi Arabia

The success of catalytic schemes for the large-scale valorization of CO_(2) does not only depend on the development of active,selective and stable catalytic materials but also on the overall process *** we present a multidisciplinary study(from catalyst to plant and techno-economic/lifecycle analysis)for the production of green methanol from renewable H2 and CO_(2).we combine an in-depth kinetic analysis of one of the most promising recently reported methanol-synthesis catalysts(InCo)with a thorough process simulation and techno-economic *** then perform a life cycle assessment of the simulated process to gauge the real environmental impact of green methanol production from CO_(2).Our results indicate that up to 1.75 ton of CO_(2) can be abated per ton of produced methanol only if renewable energy is used to run the process,while the sensitivity analysis suggest that either rock-bottom H2 prices(1.5$kg1)or severe CO_(2) taxation(300$per ton)are needed for a profitable methanol ***,we herein highlight and analyze some critical bottlenecks of the *** attention has been paid to the contribution of H2 to the overall plant costs,ch4 trace formation,and purity and costs of raw *** addition to providing important information for policy makers and industrialists,directions for catalyst(and therefore process)improvements are outlined.

关键词： CO_(2) methanol Kinetic modeling Process simulation Life cycle assessment

Synthesis of Tenoltrifluoroacetone Composite Doped with Terbium, Dysprosium and Europium Encapsulated in Silica Oxide matrix

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Journal of Surface Engineered materials and Advanced Technology 2020年第4期10卷 63-74页

作者： Yazmin Francisco Dulce medina miguel barron Joan Reyes Pedro adrian martinez Angel de Jesus morales Elizabeth Garfias Universidad Autónoma metropolitana Departamento de Materiales Ciencias Básicas e Ingeniería Reynosa Tamaulipas México Instituto Politécnico Nacional ESIQIE UPALM S/N Mexico City México

The synthesis of the thenoyltrifluoroacetone compound doped with terbium, dysprosium and europium encapsulated in a silica matrix (TTA:Tb:Dy:Eu@SiO2) were performed by the sol-gel method. The precursors to obtain the ... 详细信息

The synthesis of the thenoyltrifluoroacetone compound doped with terbium, dysprosium and europium encapsulated in a silica matrix (TTA:Tb:Dy:Eu@SiOb>2b>) were performed by the sol-gel method. The precursors to obtain the vitreous phase (SiOb>2b>) were: Tetraethylorthosilicate (TEOS, Cb>8b>Hb>2b>Ob>4b>Si, 98%, Aldrich), and ethyl alcohol (chb>3b>chb>2b>OH, 99.5%, meyer), distilled water and 0.05 ml of hydrochloric acid (HCl, meyer). The sample with molar ratio 20:80 TTA:Tb:Dy:Eu@SiOb>2b> has the best emission intensity. Thermogravimetric analysis (TGA) shown that silica encapsulated samples decompose at lower temperatures than pure TTA:Tb:Dy:Eu luminescent material. Fourier Transform Infrared (IR-TF) shown the characteristic Si-O-Si bands that are presented at a wavelength of 1049, 853 and 440 cmǃ confirming that the luminescent material is encapsulated in a silica matrix, finally X-ray diffraction (XRD) shown that TTA:Tb:Dy:Eu@SiO2 composite is amorphous.

关键词： Synthesis Luminescence Composite Sol-Gel Terbium Dysprosium and Europium

mEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply

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Plant Communications 2023年第3期4卷 171-182页

作者： supply Xueni Di David Ortega-Alarcon Ramu Kakumanu Javier Iglesias-Fernandez Lucia Diaz Edward E.K.baidoo adrian Velazquez-Campoy manuel Rodríguez-Concepción Jordi Perez-Gil Institute for Plant molecular and Cell biology(IbmCP) CSIC-Universitat Politècnica de València46022 ValenciaSpain 2Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UBCampus UAB Bellaterra08193 BarcelonaSpain 3Institute for Biocomputation and Physics of Complex Systems(BIFI)Joint Unit GBsC-CSIC-BIFIUniversidad de Zaragoza50009 ZaragozaSpain 4Departamento de Bioquímica y Biología Molecular y CelularUniversidad de Zaragoza50009 ZaragozaSpain 5Joint BioEnergy Institute5885 Hollis StreetEmeryvilleCA 94608USA 6Biological Systems and Engineering DivisionLawrence Berkeley National LaboratoryBerkeleyCA 94720USA 7Nostrum Biodiscovery SL08029 BarcelonaSpain 8Instituto de Investigación Sanitaria de Aragón(IIS Aragon)50009 ZaragozaSpain 9Centro de Investigación Biomédica en Red en elÁrea Temática de Enfermedades Hepáticas y Digestivas(CIBERehd)28029 MadridSpain

Isoprenoids are a very large and diverse family of metabolites required by all living *** isoprenoids derive fromthe double-bond isomers isopentenyl diphosphate(IPP)and dimethylallyl diphosphate(DmAPP),which are produced by the methylerythritol 4-phosphate(mEP)pathway in bacteria and plant *** has been reported that IPP and DmAPP feedback-regulate the activity of deoxyxylulose 5-phosphate synthase(DXS),a dimeric enzyme that catalyzes the main flux-controlling step of the mEP *** we provide experimental insights *** titration calorimetry and dynamic light scattering approaches showed that IPP and DmAPP can allosterically bind to DXS in vitro,causing a size *** silico ligand binding site analysis and docking calculations identified a potential allosteric site in the contact region between the two monomers of the active DXS *** of IPP and DmAPP contents in vivo followed by immunoblot analyses confirmed that high IPP/DmAPP levels resulted in monomerization and eventual aggregation of the enzyme in bacterial and plant *** of the enzymatically active dimeric conformation allows a fast and reversible reduction of DXS activity in response to a sudden increase or decrease in IPP/DmAPP supply,whereas aggregation and subsequent removal of monomers that would otherwise be available for dimerization appears to be a more drastic response in the case of persistent IPP/DmAPP overabundance(e.g.,by a blockage in their conversion to downstream isoprenoids).Our results represent an important step toward understanding the regulation of the mEP pathway and rational design of biotechnological endeavors aimed at increasing isoprenoid contents in microbial and plant systems.

关键词： isoprenoids DXS feedback regulation allosteric monomerization

Inhibition of N-myc down regulated gene 1 in in vitro cultured human glioblastoma cells

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world Journal of Clinical Oncology 2012年第7期3卷 104-110页

作者： Harun m Said buelent Polat Susanne Stein mathias Guckenberger Carsten Hagemann adrian Staab Astrid Katzer Jelena Anacker michael Flentje Dirk Vordermark Department of Radiation Oncology University of Wuerzburg 97080 Würzburg Germany Department of Hematology and Oncology Johannes Gutenberg University Ⅲ Medical School 55101 Mainz Germany Department of Neurosurgery Tumorbiology Laboratory University of Wuerzburg 97080 Würzburg Germany Department of Radiation Oncology Paul Scherer Institute CH-5100 Villingen Switzerland Department of Gynaecology and Obstetrics University of Wuerzburg 97080 Würzburg Germany Department of Radiation Oncology University-Halle-Wittenberg 06110 Halle Germany

AIm: To study short ds RNA oligonucleotides(si RNA)as a potent tool for artificially modulating gene expression of N-myc down regulated gene 1(NDRG1) gene induced under different physiological conditions(Normoxia and hypoxia) modulating NDRG1 transcription, m RNA stability and translation. mETHODS: A cell line established from a patient with glioblastoma multiforme. Plasmid DNA for transfections was prepared with the Endofree Plasmid maxi kit. From plates containing 5 × 107 cells, nuclear extracts were prepared according to previous protocols. The p SUPERNDRG1 vectors were designed, two sequences were selected from the human NDRG1 c DNA(5'-GCATTATTGGCATGGGAAC-3' and 5'-ATGCAGAGTAACGTGGAAG-3'. reverse transcription polymerase chain reaction was performed using primers designed using published information on β-actin and hypoxia-inducible factor(HIF)-1α m RNA sequences in Gen bank. NDRG1 m RNA and protein level expression results under different conditions of hypoxia or reoxygenation were compared to aerobic control conditions using the mann-whitney U test. Reoxygenation values were also compared to the NDRG1 levels after 24 h of hypoxia(P was considered significant).RESULTS: si RNA- and iodoacetate(IAA)-mediated downregulation of NDRG1 m RNA and protein expression in vitro in human glioblastoma cell lines showed a nearly complete inhibition of NDRG1 expression when compared to the results obtained due to the inhibitory role of glycolysis inhibitor IAA. Hypoxia responsive elements bound by nuclear HIF-1 in human glioblastoma cells in vitro under different oxygenation conditions and the clearly enhanced binding of nuclear extracts from glioblastoma cell samples exposed to extreme hypoxic conditions confirmed the HIF-1 western blotting results. CONCLUSION: NDRG1 represents an additional diagnostic marker for brain tumor detection, due to the role of hypoxia in regulating this gene, and it canrepresent a potential target for tumor treatment in human glioblastoma. T

关键词： N-myc down regulated gene 1 Short dsRNA oligonucleotides Human cancer diseases brain cancer Radiotherapy