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Uncovering genetic and metabolite markers associated with resistance against anthracnose fruit rot in northern highbush blueberry

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Horticulture Research 2023年第10期10卷 25-36页

作者： MacKenzie Jacobs Samantha thompson adrian E.Platts Melanie J.A.Body Alexys Kelsey Amanda Saad Patrick Abeli Scott J.teresi Anthony Schilmiller Randolph Beaudry Mitchell J.Feldmann Steven J.Knapp Guo-qing Song timothy Miles Patrick P.Edger Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingMI 48824USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Molecular Plant Science Program Michigan State UniversityEast LansingMI 48824USA Department of Plant Soil and Microbial SciencesMichigan State UniversityEast LansingMI 48824USA Department of Horticulture and Natural Resources Kansas State UniversityOlatheKS 66061USA Genetics and Genome Sciences Program Michigan State UniversityEast LansingMI 48824USA Mass Spectrometry&Metabolomics Core Michigan State UniversityEast LansingMI 48824USA Department of Plant Sciences University of CaliforniaDavisCA 95616USA

Anthracnose fruit rot(AFR),caused by the fungal pathogen Colletotrichum fioriniae,is among the most destructive and widespread fruit disease of blueberry,impacting both yield and overall fruit *** cultivars have highly variable resistance against *** date,this pathogen is largely controlled by applying various fungicides;thus,a more cost-effective and environmentally conscious solution for AFR is *** we report three quantitative trait loci associated with AFR resistance in northern highbush blueberry(Vaccinium corymbosum).Candidate genes within these genomic regions are associated with the biosynthesis of flavonoids(***)and resistance against ***,we examined gene expression changes in fruits following inoculation with Colletotrichum in a resistant cultivar,which revealed an enrichment of significantly differentially expressed genes associated with certain specialized metabolic pathways(*** biosynthesis)and pathogen *** non-targeted metabolite profiling,we identified a flavonol glycoside with properties consistent with a quercetin rhamnoside as a compound exhibiting significant abundance differences among the most resistant and susceptible individuals from the genetic mapping *** analysis revealed that this compound exhibits significant abundance differences among the most resistant and susceptible individuals when analyzed as two ***,individuals within each group displayed considerable overlapping variation in this compound,suggesting that its abundance may only be partially associated with resistance against *** findings should serve as a powerful resource that will enable breeding programs to more easily develop new cultivars with superior resistance to AFR and as the basis of future research studies.

关键词： applying resistance specialized

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Potential of a COX-2 inhibitor in lowering chemotherapy-induced neutropenia

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中华乳腺病杂志（电子版） 2010年第5期4卷 8-13页

作者： Louis Wing-Cheong Chow adrian Yun-San Yip Eleanor Yuen-Yuen Ong Chi-Kei Lam Masakazu toi Clinical trials Centre Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Organisation for Oncology and translational Research Comprehensive Centre for Breast Diseases UNI MED Medical Institute Department of Surgery Kyoto UniversityJapan

Objective this study was initially designed to evaluate the effect of celecoxib on the regimen of 5-fluorouracil,epirubicin,and cyclophosphamide(FEC)combination,followed by docetaxel(t)in neoadjuvant *** unplanned preliminary review on safety was conducted after a halt of the study due to the concerned potential cardiovascular risk of using COX-2 *** We studied 23 consecutive cases of operable breast cancer having received four cycles of FEC(500 mg/m2,100 mg/m2,500 mg/m2)followed by four cycles of t(100 mg/m2)with concurrent celecoxib(400 mg twice daily)(group A)or same chemotherapy regimen but without concurrent celecoxib(group B).these combined chemotherapies were administered every 3 *** Chi-square test or Fisher's exact test were used to assess the difference in incidence of limiting hematological toxicites between *** 23 patients(group A:n=12;group B,n=11)received a total of 183 out of 184 planned treatment cycles;one(4%,1/23)of them omitted the fourth cycle of FEC owing to repeated incidences of febrile *** dose intensity(RDI)for FEC in group A(90%±11%)was higher than that in group B(80%±8%)while RDI for t was similar between group A(93%±8%)and group B(96%±9%).Of the first 91 treatment cycles of FEC,limiting hematological toxicity,severe neutropenia including febrile neutropenia,was significantly different between group A and B [(10.4%,5/48)vs.(32.6%,14/43),P=0.009].Other toxicities commonly observed in chemotherapy receiving patients were *** Neoadjuvant use of FEC followed by t with concurrent celecoxib appeared to be safe for treatment of operable invasive breast *** observed lower incidence of chemotherapy-induced neutropenia is possibly contributed by the administration of *** believe that further investigation might provide more evidence on the use of COX-2 inhibitors in breast cancer.

关键词：血疗法乳腺癌治疗临床

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Why some tumours trigger neovascularisation and others don't:the story thus far

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Chinese Journal of Cancer 2016年第2期35卷 69-79页

作者： Omanma Adighibe Russell D.Leek Marta Fernandez-Mercado Jiangting Hu Cameron Snell Kevin C.Gatter adrian L.Harris Francesco Pezzella Radcliffe Department of Medicine Nuffield Division of Laboratory ScienceJohn Radcliffe HospitalUniversity of Oxford Radcliffe Department of Medicine Leukaemia and Lymphoma Research Molecular Haematology UnitNuffield Division of Laboratory ScienceJohn Radcliffe Hospital Biodonostia Research Institute Department of Medical Oncology Molecular Oncology LaboratoriesWeatherall Institute of Molecular MedicineJohn Radcliffe Hospital

Background:Angiogenesis is not essential for tumours to develop and expand,as cancer can also grow in a nonangiogenic fashion,but why this type of growth occurs is ***,our data from mRNA transcription profiling did not show any differences in the classical angiogenic pathways,but differences were observed in mitochondrial metabolic pathways,suggesting a key role for metabolic *** then validated these results with mRNA profiling by investigating differential protein expression via immunohistochemistry in angiogenic and non-angiogenic non-small cell lung cancers(NSCLCs).Methods:Immunohistochemical staining for 35 angiogenesis- and hypoxia-related biomarkers were performed on a collection of 194 angiogenic and 73 non-angiogenic NSCLCs arranged on tissue *** of P53 was performed with frozen tissue samples of ***:the non-angiogenic tumours were distinguished from the angiogenic ones by having higher levels of proteins associated with ephrin pathways,mitochondria,cell biogenesis,and hypoxia-inducible factor 1(HIF1) regulation by oxygen and transcription of HIF-controlled genes but lower levels of proteins involved in the stroma,cell-cell signaling and adhesion,integrins,and Delta-Notch and epidermal growth factor(EGF)-related ***,proteins classically associated with angiogenesis were present in both types of tumours at very comparable *** expression of P53 was strongly associated with non-angiogenic tumours.A pilot investigation showed that P53 mutations were observed in 32.0%of angiogenic cases but in 71.4%of non-angiogenic ***:Our observations thus far indicate that both angiogenic and non-angiogenic tumours experience hypoxia/HIF and vascular endothelial growth factor(VEGF) pathway protein expression in a comparable ***,angiogenesis does not ensue in the non-angiogenic ***,metabolic reprogramming seems to distinguish these two types of ne

关键词： Cancer, Angiogenesis, Hypoxia, Blood vessels

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嗓音质量评价与测量(2)

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听力学及言语疾病杂志 2008年第5期16卷 439-442页

作者： adrian Fourcin 张家騄伦敦大学学院语音学系中国科学院声学研究所

抖动的不同定义(Huber.2000,Baken&.Orlikoff.2000)抖动(jitter)这个参数最常用的形式是利用声带振动周期的时长得出来的.即在图2和公式(2)中的t.为得出百分数表示,要把公式(2)得出的数值乘以100.这称为百分数抖动(%jitter)。[第一段]

关键词：质量评价测量嗓音声带振动

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真空渗透法转化植物的研究

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生物技术 1999年第2期9卷 35-36页

作者：张钰 adrian J.Calter 哈尔滨医科大学生物及医学遗传学教研室加拿大国家研究院植物生物技术研究所

以拟南芥为材料介绍一种不需组培的原位植物转化方法—真空渗透法。将含有Ｔ—ＤＮＡ载体的农杆菌细胞悬液，用真空渗透的方式转化愈伤的完整植株，从而直接获得转化的种子。该法快速简便、重复性好，不需经过组培阶段即可获得转化植株。

关键词：真空渗透转化拟南芥植物

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Physical and damping properties of kenaf fibre filled natural rubber/thermoplastic polyurethane composites

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Defence technology（防务技术） 2020年第1期16卷 29-34页

作者： A.M.Noor Azammi S.M.Sapuan Mohamad R.Ishak Mohamed t.H.Sultan Advanced Engineering Materials and Composite Research Centre(AEMC) Department of Mechanical and Manufacturing EngineeringUniversity Putra Malaysia43400UPM SerdangSelangorMalaysia Automotive Engineering technology Section Universiti Kuala Lumpur Malaysian France Institute(UniKL-MFI)43650Bandar BaruBangiSelangorMalaysia Laboratory of Biocomposite technology Institute of Tropical Forestry and Forest Products(INTROP)Universiti Putra Malaysia43400UPM SerdangSelangorMalaysia Department of Aerospace Engineering Universiti Putra Malaysia43400UPM SerdangSelangorMalaysia

the paper presents the investigation of the effect of alkaline treatment of sodium hydroxide(NaOH) on physical and dynamic mechanical analysis(DMA) viscoelastic properties of kenaf fibre filled natural rubber(NR)/thermoplastic polyurethane(tPU) *** treated kenaf fiber,NR and tPU were weighed and proportioned according to the required compositions and were blended using hot mixed Brabender *** polymer composites were then fabricated using the hot press to form a sample *** sample was cut and prepared and water absorption,density,thickness swelling and DMA tests were *** far as physical properties are concerned,composites with the highest NR amount of shows the best results,which indicates good fiber bonding *** polymer composites with the highest amount of tPU shows the highest damping properties at high temperature.

关键词： Kenaf fiber Alkaline treatment thermoplastic polyurethane Natural rubber Dynamic mechanical analysis

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SoC内部电路验证

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电子质量 2005年第9期 1-2页

作者： adrian M.Hernández Agilent technologies

本文介绍了基于FPGA和Soc内部电路观察二个方面的Soc验证,并论证了FPGA验证方法能够帮助仿真期间未找到的缺陷。通过内部Soc验证,你会发现模型和测试设计工程师不能有理解的细节。

关键词： Soc 内部验证 FPGA 观察

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和你喜欢的鼓手一起打鼓

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2014年

作者：（英）阿德里安·霍普金斯（adrian Hopkins）

本书主要内容包括：一定要相信、现在好了、活在祈祷中、超越这感觉、阿拉巴马甜蜜的家、自从你离开之后等。……

ISBN: (数字)9787549548668

ISBN: (纸本)9787549548668

本书主要内容包括：一定要相信、现在好了、活在祈祷中、超越这感觉、阿拉巴马甜蜜的家、自从你离开之后等。……

关键词：爵士鼓器乐曲

来源：畅想之星图书光盘版（南... 评论

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Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy

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Cancer Communications 2024年第4期44卷 508-513页

作者： Andrés Pastor-Fernández Manuel Montero Gómez de las Heras Jose Ignacio Escrig-Larena Marta Barradas Cristina Pantoja adrian Plaza Jose Luis Lopez-Aceituno Esther Durán Alejo Efeyan Maria Mittelbrunn Lola Martinez Pablo Jose Fernandez-Marcos Metabolic Syndrome Group(BIOPROMEt) Madrid Institute for Advanced Studies(IMDEA)FoodE28049MadridSpain Molecular Biology Center Severo Ochoa(CBMSO) Spanish National Research Council(CSIC)Madrid Autonoma University(UAM)MadridSpain Department of Basic Medical Sciences Institute of Applied Molecular MedicineSchool of MedicineUniversity Studies Center(CEU)-San Pablo UniversityMadridSpain Metabolism and Cell Signaling Laboratory Spanish National Cancer Research Centre(CNIO) MadridSpain 5Flow Cytometry UnitBiotechnology ProgrammeSpanish National Cancer Research Centre(CNIO)MadridSpain

Fasting reduces chemotherapy toxicity[1],enhances immunogenic tumor cell death[2,3]and increases CD8^(+)t cell infiltration in tumors,particularly when combined with chemotherapy[2,3]or immunotherapy[4].More-over,fast... 详细信息

关键词： chemotherapy fasting immune

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Application of single and combination therapy of clarithromycin and tamoxifen to suppress breast cancer cell proliferation and metabolism

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中华乳腺病杂志（电子版） 2012年第1期6卷 26-31页

作者： Wings t.Y.Loo Louis W.C.Chow adrian Y.S Yip Mary N.B.Cheung UNIMED Medical Institute Organization for Oncology and translational Research Hong Kong Organization for Oncology and translational Research School of Chinese Medicine Li Ka Shing Faculty of MedicineUniversity of Hong Kong Clinical trial Center Li Ka Shing Faculty of MedicineUniversity of Hong Kong

Objective this study compares the anti-tumor effects of single and combination use of clarithromycin and tamoxifen on estrogen receptor (ER) positive breast cancer cell lines,Bt-483 and MCF-7 as well as triple negative cell line,MBA-MD-231,which acts as a negative *** effect of solid breast tumor inhibition by clarithromycin is also *** Bt-483,MCF-7 and MBA-MD-231 were cultured in 6-well plates in a 37 ℃ humidified incubator without CO2 for 24 h prior to the addition of the test *** test groups were clarithromycin (Group 1),tamoxifen (Group 2),clarithromycin and tamoxifen (Group 3),and control (Group 4).Group 3 was prepared in 1 to 1 ratio at a concentration of 1.5 mmol/L clarithromycin and 25 μmol/L *** the other hand,1 mm3 solid breast tumors were submerged into various groups as above for 24 *** the harvest day,the proliferation of cancer cells and solid breast tumor samples were measured by WSt-1 proliferation reagent while AtP bioluminescence assay was employed to measure the metabolic rate of the three cell *** the proliferation of Bt-483 and MCF-7 was suppressed most by combination use of clarithromycin and tamoxifen with statistical *** two drugs did not have an inhibitory effect on the hormonal negative cancer *** solid breast tumor samples,all the test groups showed reduced metabolic rate as compared with the control group (Ption use of tamoxifen and clarithromycin are effective in suppressing cell proliferation and metabolism rate of breast cancer cells while single use of clarithromycin effectively inhibits the proliferation of solid breast tumor.

关键词：摘要编辑部编辑工作读者

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