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Parallel Implicit-Explicit General Linear Methods

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Communications on Applied Mathematics and Computation 2021年第4期3卷 649-669页

作者： Steven Roberts Arash Sarshar adrian Sandu Computational Science Laboratory Virginia Polytechnic Institute and State UniversityBlacksburgVA 24060USA

High-order discretizations of partial differential equations(PDEs)necessitate high-order time integration schemes capable of handling both stiff and nonstiff operators in an efficient ***-explicit(IMEX)integration based on general linear methods(GLMs)offers an attractive solution due to their high stage and method order,as well as excellent stability *** IMEX characteristic allows stiff terms to be treated implicitly and nonstiff terms to be efficiently integrated *** work develops two systematic approaches for the development of IMEX GLMs of arbitrary order with stages that can be solved in *** first approach is based on diagonally implicit multi-stage integration methods(DIMSIMs)of types 3 and *** second is a parallel generalization of IMEX Euler and has the interesting feature that the linear stability is independent of the order of *** experiments confirm the theoretical rates of convergence and reveal that the new schemes are more efficient than serial IMEX GLMs and IMEX Runge-Kutta methods.

关键词： Parallel Time integration IMEX methods General linear

Endoscopic ultrasound-guided elastography in the nodal staging of oesophageal cancer

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World Journal of Gastroenterology 2012年第9期18卷 889-895页

作者： Stuart Paterson Fraser Duthie adrian J Stanley Department of Gastroenterology Forth Valley Royal Hospital Department of Pathology Glasgow Royal Infirmary Department of Gastroenterology Glasgow Royal Infirmary

AIM： To assess quantitative endoscopic ultrasound （EUS）- guided elastography in the nodal staging of oesophago- gastric cancers.METHODS： This was a single tertiary centre study as- sessing 50 patients with established oesophago-gastric cancer undergoing EUS-guided fine needle aspiration biopsy （FNAB） of lymph nodes between July 2007 and July 2009. EUS-guided elastography of lymph nodes was performed before EUS-FNAB. Standard EUS charac- teristics were also described. Cytological determination of whether a lymph node was malignant or benign was used as the gold standard for this study. Comparisons of elastography and standard EUS characteristics were made between the cytologically benign and malignant nodes. The main outcome measure was the accuracy of elastography in differentiating between benign and malignant lymph nodes in oesophageal cancers.

关键词： Endoscopic ultrasound Oesophageal cancerLymph nodes Elastography Tumour staging

Sound Foundations (Methodology S.)

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The Space Infrastructure Vulnerability Cadastre:Orbital Debris Critical Loads

2005年

作者： adrian Underhill

来源：畅想之星图书光盘版（南... 评论

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International Journal of Disaster Risk Science 2015年第4期6卷 359-371页

作者： adrian V.Gheorghe Daniel E.Yuchnovicz Department of Engineering Management and Systems Engineering Old Dominion University

Orbital debris from over 50 years of human activity in space are threatening the operations of existing and future satellites and the sustainability of high-value satellite orbits. This technical memorandum calls for the development of a cadastre that depicts the vulnerability of critical satellite orbits to accumulating orbital debris. A space infrastructure vulnerability cadastre could serve as a governance tool for use by developers and operators of critical space infrastructures to better communicate the current and future vulnerability of high-value orbits to the accumulation of orbital debris. These high-value orbits are susceptible to 'loss' for decades or centuries if generation of orbital debris continues unabated. The concept of environmental critical loads is applied to heavily used orbits as a way to indicate acceptable debris density for satellite operations, and when debris density/risk thresholds approach unacceptable levels that reduce the probability of sustaining spacecraft operations in those orbits.

关键词： Orbital debris Satellite orbits Space cadastre Space infrastructure

Resilience Quantification and Its Application to a Residential Building Subject to Hurricane Winds

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International Journal of Disaster Risk Science 2013年第3期4卷 105-114页

作者： Berna Eren Tokgoz adrian V.Gheorghe Department of Engineering Management and Systems Engineering Old Dominion UniversityNorfolkVA 23529USA

In order to overcome negative consequences of a disaster, buildings and infrastructures need to be resilient. After a disaster occurs, they must get back to their normal operations as quickly as possible. Buildings and infrastructures should incorporate both pre-event(preparedness and mitigation) and post-event(response and recovery) resilience activities to minimize negative effects of a disaster. Quantitative approaches for measuring resilience for buildings and infrastructures need to be developed. A proposed methodology for quantification of resilience of a given building type based on different hurricane categories is presented. The formulation for the resilience quantification is based on a model embedding several distinct parameters(for example, structural loss ratios, conditional probabilities of exceeding for damage states, estimated and actual recovery times, wind speed probability). The proposed resilience formulation is applied to a residential building type selected from *** results of resilience for the selected residential building type against Category 1, 2, and 3 hurricanes are presented in a dashboard representation. Resilience performance indicators between different types of buildings, which are identical except for their roof types, have been evaluated in order to present applicability of the proposed methodology.

关键词： disaster formulation consequences

Imaging techniques used for the real-time assessment of angiogenesis in digestive cancers

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World Journal of Gastroenterology 2011年第1期17卷 7-8页

作者： adrian Sǎftoiu Peter Vilmann Research Center of Gastroenterology and Hepatology Gastroenterology DepartmentUniversity of Medicine and Pharmacy CraiovaCraiovaDolj200349Romania Department of Surgical Gastroenterology Copenhagen University Hospital HerlevEndoscopic Unit at Gentofte Hospital2900 HellerupDenmark

Angiogenesis has a critical role in primary tumor growth and the development of *** angiogenesis inhibitors were recently developed,being a very attractive target for digestive tumor ***,individualized therapy should not only be based on the pre-treatment imaging evaluation,but also on sensitive monitoring of microvascular changes during ***-of-theart imaging techniques have the potential to visualize and characterize angiogenesis,although the technology and methodologies employed are recent and need further *** aim of this series of reviews was to analyze and enhance current knowledge and future perspectives about the real-time assessment of angiogenesis in digestive cancers,used for the longitudinal monitoring of the effects of chemo-radiotherapy(including anti-angiogenic therapies),as well as for the precise targeting of drugs through molecular-based drug-delivery systems.

关键词： Angiogenesis Digestive cancers Chemoradiotherapy

Heme in intestinal epithelial cell turnover, differentiation, detoxification, inflammation, carcinogenesis, absorption and motility

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World Journal of Gastroenterology 2006年第27期12卷 4281-4295页

作者： Phillip S Oates adrian R West Physiology M311 School of Biomedical Biomolecular and Chemical SciencesUniversity of Western Australia35 Stirling HighwayNedlands 6009Australia

The gastrointestinal tract is lined by a simple epithelium that undergoes constant renewal involving cell division, differentiation and cell death. In addition, the epithelial lining separates the hostile processes of digestion and absorption that occur in the intestinal lumen from the aseptic environment of the internal milieu by defensive mechanisms that protect the epithelium from being breached. Central to these defensive processes is the synthesis of heme and its catabolism by heme oxygenase （HO）. Dietary heme is also an important source of iron for the body which is taken up intact by the enterocyte. This review describes the recent literature on the diverse properties of heme/HO in the intestine tract. The roles of heme/HO in the regulation of the cell cycle/ apoptosis, detoxification of xenobiotics, oxidative stress, inflammation, development of colon cancer, hemeiron absorption and intestinal motility are specifically examined.

关键词： Absorption Heme Uptake Release Heme oxygenase Oxidant Cytoprotection Inflammation Cancer Detoxification

Mechanisms of heme iron absorption:Current questions and controversies

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World Journal of Gastroenterology 2008年第26期14卷 4101-4110页

作者： adrian R West Phillip S Oates M311 Physiology School of BiomedicalBiomolecular and Chemical SciencesThe University of Western Australia35 Stirling HighwayCrawley 6009 Australia

Iron is a critical micronutrient, and iron derived from heme contributes a large proportion of the total iron absorbed in a typical Western diet. Heme iron is absorbed by different mechanisms than non-heme iron, but despite considerable study over many years these mechanisms remain poorly understood. This review provides an overview of the importance of heme iron in the diet and discusses the two prevailing hypotheses of heme absorption; namely receptor mediated endocytosis of heme, and direct transport into the intestinal enterocyte by recently discovered heme transporters. A specific emphasis is placed on the questions surrounding the site of heme catabolism and the identity of the enzyme that performs this task. Additionally, we present the hypothesis that a non-heme iron transport protein may be required for heme iron absorption and discuss the experiences of our laboratory in examining this hypothesis.

关键词： Iron Heme absorption Receptor mediatedendocytosis Heine transporter Heine oxygenase

The effect of mining face＇s direction on the observed seismic activity

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International Journal of Coal Science & Technology 2016年第3期3卷 322-329页

作者： Witold Pytel Joanna Switon adrian Wojcik KGHM Cuprum Ltd. Research and Development Centre 53-659 Wroclaw Poland KGHM Polish Copper Ltd. O/ZG Rudna Department 59-100 Polkowice Poland

A major natural hazard associated with LGOM （Legnica-Glogow Copper Mining） mining is the dynamic phenomena occurrence, physically observed as seismic tremors. Some of them generate effects in the form of relaxations or bumps. Long-term observations of the rock mass behaviour indicate that the degree of seismic hazard, and therefore also seismic activity in the LGOM area, is affected by the great depth of the copper deposit, high-strength rocks as well as the ability of rock mass to accumulate elastic energy. In this aspect, the effect of the characteristics of initial stress tensor and the orientation of considered mining panel in regards to its components must be emphasised. The primary objective of this study is to answer the question, which of the factors considered as ＂influencing＂ the dynamic phenomena occurrence in copper mines have a statistically significant effect on seismic activity and to what extent. Using the general linear model procedure, an attempt has been made to quantify the impact of different parameters, including the depth of deposit, the presence of goaf in the vicinity of operating mining panels and the direction of mining face advance, on seismic activity based on historical data from 2000 to 2010 concerned with the dynamic phenomena recorded in different mining panels in Rudna mine. The direction of mining face advance as well as the goaf situation in the vicinity of the mining panel are of the greatest interest in the case of the seismic activity in LGOM. It can be assumed that the appropriate manipulation of parameters of mining systems should ensure the safest variant of mining method under specific geological and mining conditions.

关键词： Induced seismicity Polish copper mines General linear model procedure