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发现利润区 how strategic business design will lead you to tomorrow 6版

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Report of the first international workshop on onchocerciasis-associated epilepsy

2018年

作者：（美）亚德里安·斯莱沃斯基（adrian j. Slywotzky）（美）大卫·莫里森（David j. Morrison）（美）鲍勃·安德尔曼（Bob Andelman）

本书总结了22种盈利模式，并详细地介绍了12家拥有持续创造优异业绩能力的公司及其管理者的利润策略和企业设计经验，以帮助读者能够超越经济周期和技术周期，避免无利润区这个黑洞，是公司始终处在利润区之内。

ISBN: (数字)9787508681719

ISBN: (纸本)9787508681719

关键词：企业利润研究

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Infectious Diseases of Poverty 2018年第1期7卷 238-242页

作者： Robert Colebunders Michel Mandro Alfred K.Njamnshi Michel Boussinesq An Hotterbeekx joseph Kamgno Sarah O’Neill adrian Hopkins Patrick Suykerbuyk Maria-Gloria Basanez Rory j.Post Belen Pedrique Pierre-Marie Preux Wilma A.Stolk Thomas B.Nutman Richard Idro Global Health Institute University of AntwerpAntwerpBelgium Provincial Health Division of Ituri BuniaDemocratic Republic of the Congo Department of Neurology Yaounde Central Hospital/University of Yaounde 1Brain Research Africa Initiative(BRAIN)YaoundeCameroon Institut de Recherche pour le Developpement(IRD) MontpellierFrance Centre for Research on Filariasis and other Tropical Diseases(CRFilMT) and Faculty of Medicine and Biomedical SciencesUniversity of Yaounde 1YaoundeCameroon Department of Public Health Institute of Tropical MedicineAntwerpBelgium Neglected and Disabling Diseases of Poverty Consultant KentUK London Centre for Neglected Tropical Disease Research Imperial College LondonLondonUK London School of Hygiene&Tropical Medicine and Liverpool john Moores University LondonUK Drugs for Neglected Diseases initiative GenevaSwitzerland Preux Pierre-Marie INSERMUniversity LimogesCHU LimogesUMR_S 1094Tropical NeuroepidemiologyInstitute of Neuroepidemiology and Tropical NeurologyCNRS FR 3503 GEIST87000 LimogesFrance Department of Public Health Erasmus MCUniversity Medical Centre RotterdamRotterdamThe Netherlands Laboratory of Parasitic Diseases National Institutes of HealthBethesdaMarylandUSA Makerere University College of Health SciencesKampalaUganda

Background:Recently,several epidemiological studies performed in Onchocerca volvulus-endemic regions have suggested that onchocerciasis-associated epilepsy(OAE)may constitute an important but neglected public health problem in many countries where onchocerciasis is still *** text:On October 12-14th 2017,the first international workshop on onchocerciasis-associated epilepsy(OAE)was held in Antwerp,*** workshop was attended by 79 participants from 20 different *** research findings strongly suggest that *** is an important contributor to epilepsy,particularly in meso-and hyperendemic areas for *** with *** is associated with a spectrum of epileptic seizures,mainly generalised tonic-clonic seizures but also atonic neck seizures(nodding),and stunted *** is characterised by an onset of seizures between the ages of 3-18 *** working groups discussed topics such as how to 1)strengthen the evidence for an association between onchocerciasis and epilepsy,2)determine the burden of disease caused by OAE,3)prevent OAE,4)improve the treatment/care for persons with OAE and affected families,5)identify the pathophysiological mechanism of OAE,and 6)deal with misconceptions,stigma,discrimination and gender violence associated with *** OAE Alliance was created to increase awareness about OAE and its public health importance,stimulate research and disseminate research findings,and create partnerships between OAE researchers,communities,advocacy groups,ministries of health,non-governmental organisations,the pharmaceutical industry and funding ***:Although the exact pathophysiological mechanism underlying OAE remains unknown,there is increasing evidence that by controlling and eliminating onchocerciasis,OAE will also ***,OAE constitutes an additional argument for strengthening onchocerciasis elimination *** the high numbers of people with epilepsy

关键词： Onchocerciasis Epilepsy Nodding syndrome Nakalanga syndrome Prevalence Burden of disease Africa

MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply

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Plant Communications 2023年第3期4卷 171-182页

作者： supply Xueni Di David Ortega-Alarcon Ramu Kakumanu javier Iglesias-Fernandez Lucia Diaz Edward E.K.Baidoo adrian Velazquez-Campoy Manuel Rodríguez-Concepción jordi Perez-Gil Institute for Plant Molecular and Cell Biology(IBMCP) CSIC-Universitat Politècnica de València46022 ValenciaSpain 2Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UBCampus UAB Bellaterra08193 BarcelonaSpain 3Institute for Biocomputation and Physics of Complex Systems(BIFI)Joint Unit GBsC-CSIC-BIFIUniversidad de Zaragoza50009 ZaragozaSpain 4Departamento de Bioquímica y Biología Molecular y CelularUniversidad de Zaragoza50009 ZaragozaSpain 5Joint BioEnergy Institute5885 Hollis StreetEmeryvilleCA 94608USA 6Biological Systems and Engineering DivisionLawrence Berkeley National LaboratoryBerkeleyCA 94720USA 7Nostrum Biodiscovery SL08029 BarcelonaSpain 8Instituto de Investigación Sanitaria de Aragón(IIS Aragon)50009 ZaragozaSpain 9Centro de Investigación Biomédica en Red en elÁrea Temática de Enfermedades Hepáticas y Digestivas(CIBERehd)28029 MadridSpain

Isoprenoids are a very large and diverse family of metabolites required by all living *** isoprenoids derive fromthe double-bond isomers isopentenyl diphosphate(IPP)and dimethylallyl diphosphate(DMAPP),which are produced by the methylerythritol 4-phosphate(MEP)pathway in bacteria and plant *** has been reported that IPP and DMAPP feedback-regulate the activity of deoxyxylulose 5-phosphate synthase(DXS),a dimeric enzyme that catalyzes the main flux-controlling step of the MEP *** we provide experimental insights *** titration calorimetry and dynamic light scattering approaches showed that IPP and DMAPP can allosterically bind to DXS in vitro,causing a size *** silico ligand binding site analysis and docking calculations identified a potential allosteric site in the contact region between the two monomers of the active DXS *** of IPP and DMAPP contents in vivo followed by immunoblot analyses confirmed that high IPP/DMAPP levels resulted in monomerization and eventual aggregation of the enzyme in bacterial and plant *** of the enzymatically active dimeric conformation allows a fast and reversible reduction of DXS activity in response to a sudden increase or decrease in IPP/DMAPP supply,whereas aggregation and subsequent removal of monomers that would otherwise be available for dimerization appears to be a more drastic response in the case of persistent IPP/DMAPP overabundance(e.g.,by a blockage in their conversion to downstream isoprenoids).Our results represent an important step toward understanding the regulation of the MEP pathway and rational design of biotechnological endeavors aimed at increasing isoprenoid contents in microbial and plant systems.

关键词： isoprenoids DXS feedback regulation allosteric monomerization

Trait plasticity, not values, best corresponds with woodland plant success in novel and manipulated habitats

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journal of Plant Ecology 2013年第3期6卷 201-210页

作者： Robert j.Warren II jeffrey K.Lake Department of Biology SUNY Buffalo State1300 Elmwood AvenueBuffaloNY 14222USA Department of Biology Adrian CollegeAdrianMI49221USA

Aims The clustering of plants with similar leaf traits along environmental gradients may arise from adaptation as well as acclimation to het-erogeneous habitat *** the forces that shape plant leaf traits requires both linking variation in trait morphology with abiotic gradients and linking that trait variation with plant per-formance under varying abiotic *** the spectrum of plant types,shade-tolerant evergreen herbs are relatively low in trait plasticity,compared to deciduous and sun-adapted *** plants employ stress-tolerant strategies for survival,which coincide with relatively static trait morphologies,slow growth and hence a lower ability to adjust to changing environmental *** We investigate how the survival of two ecologically similar under-story evergreen species,Asarum arifolium and Hepatica nobilis,cor-responds with variation in six commonly measured functional traits(leaf area,specific leaf area,plant height,leaf number,leaf length and shoot mass)along natural and experimental abiotic *** examine temporal(the period 2007-9)and spatial(100 km)variations in these traits after(i)translocating 576 plants across a span from the southerm Appalachian Mountains in NC,USA,to the Piedmont,GA,USA,which includes north-and south-facing slope habitats and(ii)the experimental manipulation of diffuse light and soil *** findings We find that when translocated into a novel habitats,with novel environmental conditions that often are more extreme than the source habitat,both species appear capable of considerable mor-phological acclimation and generally converge to similar trait *** nobilis does not exhibit mean trait values particu-larly different from those of ***,but it demonstrates much greater phenotypic *** results indicate that relatively conservative plant species nonetheless acclimate and survive across heterogeneous environmental conditions.

关键词： Functional traits Asarum arifolium Hepatica nobilis niche specific leaf area understory

Bright,high-repetition-rate water window soft X-ray source enabled by nonlinear pulse self-compression in an antiresonant hollow-core fibre

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Light(Science & Applications) 2021年第3期10卷 313-319页

作者： M.Gebhardt T.Heuermann R.Klas C.Liu A.Kirsche M.Lenski Z.Wang C.Gaida j.E.Antonio-Lopez A.Schülzgen R.Amezcua-Correa j.Rothhardt j.Limpert Institute of Applied Physics Abbe Center of PhotonicsFriedrich-Schiller-Universitat JenaAlbert-Einstein-Str.1507745 JenaGermany Helmholtz-Institute jena Frobelstieg 307743 JenaGermany CREOL College of Optics and PhotonicsUniversity of Central FloridaOrlandoFL 32816USA Fraunhofer Institute for Applied Optics and Precision Engineering Albert-Einstein-Str.707745 JenaGermany Active Fiber Systems GmbH Ernst-Ruska-Ring 1707745 JenaGermany

Bright,coherent soft X-ray radiation is essential to a variety of applications in fundamental research and life *** date,a high photon flux in this spectral region can only be delivered by synchrotrons,free-electron lasers or high-order harmonic generation sources,which are driven by kHz-class repetition rate lasers with very high peak ***,we establish a novel route toward powerful and easy-to-use SXR sources by presenting a compact experimentin which nonlinear pulse self-compression to the few-cycle regime is combined with phase-matched high-orderharmonic generation in a single,helium-illed antiresonant hollow-core *** enables the first 100 kHz-classrepetition rate,table-top soft X-ray source that delivers an application-relevant flux of 2.8×10^6 photon s^-1 eV^-1 around 300 *** fibre integration of temporal pulse self-compression(leading to the formation of the necessarystrong-field waveforms)and pressure-controlled phase matching will allow compact,high-repetition-rate lasertechnology,including commercially available systems,to drive simple and cost-effective,coherent high-flux softX-ray sources.

关键词： pulse repetition fibre

闪击战从入侵波兰到阿拉曼 1939-1943

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丛书名：二战重大战役系列

2002年

作者：（英）阿德里安·吉尔伯特（adrian Gilbert）孔娅妮等译

本书详细说明了20世纪30年代德国侵略战争的行动步骤，1939年德国与同盟国军队的有关情况以及使德国百战不败的“闪电”战术。书中配有各主要参战国的坦克、飞机、武器和士兵制服的图片，以及作战各方军事行动的详细地图。

ISBN: (纸本)7801730720

关键词：军事

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走钢丝：对现代医学中过度诊断的沟通

英国医学杂志中文版 2016年第10期19卷 541-546页

作者： Kirsten j McCaffery jesse jansen Laura D Scherer Hazel Thornton jolyn Hersch Stacy M Carter Alexandra Barratt Stacey Sheridan Ray Moynihan jo Waller john Brodersen Kristen Pickles adrian Edwards School of Public Health University of Sydney New South Wales 2006 Australia Department of Psychological Sciences University of Missouri Columbia USA Department of Health Sciences University of Leicester Leicester UK Centre for Values Ethics and the Law in Medicine University of Sydney Division of General Medicine and Clinical Epidemiology School of Medicine University of North Carolina Chapel Hill USA Bond University Queensland Australia Epidemiology and Public Health University College London UK Research Unit and Section of General Practice Department of Public Health University of Copenhagen Denmark Primary Health Care Research Unit Zealand Region Denmark Division of Population Medicine School of Medicine Cardiff University UK

Kirsten McCaffery和同事们认为对于过度诊断进行沟通，可以促进公众、患者、医务人员、卫生管理人员从不同角度思考：怎样才能建设一个更加可持续的医疗保健系统。

关键词：现代医学过度诊断医护人员医疗卫生行业

Identification of new genetic risk factors for prostate cancer

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Asian journal of Andrology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kote-jarai Graham G. Giles Ali Amin Al Olama Sarah K. jugurnauth Shani mulholland Daniel A. Leongamomlert Stephen M. Edwards jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-jones Amanda L. Hall Lynne T. O＇Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons＇ Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher j. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles jameson Colin S. Cooper Dallas R. English john L. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles Section of Cancer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer Epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Genetic Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic Epidemiology Laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Social Medicine University of Bristol Bristol BS8 2PR UK Academic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Royal Marsden NHS Foundation Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingham Medical School Queens Medical Centre Nottingham NG7 2UH UK Institute for Cancer Studies University of Sheffield Sheffield SIO 2RX UK Surgical Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list of authors is provided in the Supplementary Note online Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambridge Research Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence that a substantial part of genetic predisposition to prostate cancer （PCa） may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes： MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

关键词： prostate cancer genetics susceptibility loci SNPs relative risks

饱和与反式不饱和脂肪酸摄入与全因病死率、发生心血管疾病和2型糖尿病的风险：对观察性研究的系统性综述和荟萃分析

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英国医学杂志中文版 2016年第2期19卷 65-65页

作者： Russell j deSouza Andrew Mente adriana Maroleanu adrian I Cozma Vanessa Ha Teruko Kishibe Elizabeth Uleryk Patrick Budylowski Holger Schtinemann joseph Beyene Sonia S Anand 金奥铭朱一丹不详北京大学医学部乔治健康研究所

目的系统性综述饱和脂肪和反式不饱和脂肪的摄入与全因病死率、心血管疾病及其相关死亡、冠心病及其相关死亡、缺血性卒中及2型糖尿病的相关性。

关键词：心血管疾病糖尿病脂肪酸全因病死率