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Ten-year multicentric retrospective analysis regarding postoperative complications and impact of comorbidities in hemorrhoidal surgery with literature review

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World Journal of Clinical Cases 2023年第2期11卷 366-384页

作者： Cosmin Moldovan Elena Rusu Daniel Cochior Madalina Elena Toba Horia Mocanu Razvan Adam Mirela Rimbu adrian ghenea Florin Savulescu Daniela Godoroja Florin Botea Department of Medical Surgical Disciplines Faculty of MedicineTitu Maiorescu University of BucharestBucharest 031593Romania Department of General Surgery Witting Clinical HospitalBucharest 010243Romania Department of Preclinic Disciplines Faculty of MedicineTitu Maiorescu University of BucharestBucharest 031593Romania Department of General Surgery Sanador Clinical HospitalBucharest 010991Romania Department of General Surgery Monza Clinical HospitalBucharest 021967Romania Department of Ear Nose and ThroatIlfov County Clinical Emergency HospitalBucharest 022104Romania Department of Orthopedics and Traumatology Elias Emergency University HospitalBucharest 011461Romania Medical Doctoral School Titu Maiorescu University of BucharestBucharest 040317Romania Department of Coloproctology MedLife SA Băneasa HyperclinicBucharest 013693Romania nd Department of Surgery Carol Davila Central Military Emergency University HospitalBucharest 010242Romania Department of Anesthesia Ponderas Academic HospitalBucharest 014142Romania Florin Botea 2nd Department of SurgeryFundeni Clinical InstituteBucharest 022328Romania

BACKGROUND Hemorrhoidal disease(HD)is considered a low-severity pathology by both general population and physicians,but the lengthy conservative therapy and postoperative complications suggest *** To assess the effectiveness of different treatment options,both conservative and surgical,in contrast with some preexisting *** We conducted a retrospective,10-yearlong study between January 2011 and December 2021 in two surgical centers,a private and a state-owned *** compared the efficacy and safety of several treatment options,such as open hemorrhoidectomy,stapled hemorrhoidopexy,rubber band ligation and infrared coagulation in terms of complication rates and types and their correlation with different preexisting comorbidities such as inflammatory bowel disease(IBD),use of anticoagulant medication(AM)and liver *** also conducted a 20-years long PubMed research(1.263 articles)for relevant *** Our study recorded 10940 patients with HD,10241 with conservative and 699 with surgical *** of these,the male-to-female ratio of 1.3,and a peak in age distribution between 59 and 68 years old(32%of patients).For the entire study,we recorded a 90%incidence of immediate pain,immediate bleeding in 1.5%(11 cases),delayed bleeding in 1.0%(7 cases),and 0.6%surgical site *** retention was also present,with 0.2%of patients,anal stricture in 1%and fecal incontinence for 0.5%of patients(4 cases).We recorded no severe complications such as Fournier`s gangrene or rectovaginal *** accounted for 6%of the patients,with ulcerative colitis in 12%and Chron`s disease in 10.5%.6.6%of the patients had AM,determining 4%immediate and 2%delayed bleeding,in surgically treated *** Our study determined that most common complications(pain,urinary retention,bleeding,and stricture)are correlated with each surgical technique and pre-existing comorbidities.

关键词： Retrospective Hemorrhoidal Postoperative Complications Comorbidities

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Translational challenges in amyotrophic lateral sclerosis therapy with macrophage migration inhibitory factor

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Neural Regeneration Research 2025年第9期20卷 2583-2584页

作者： Leenor Alfahel Aleksandar Rajkovic adrian Israelson Department of Physiology and Cell Biology Faculty of Health SciencesBen-Gurion University of the NegevBeer ShevaIsraelThe School of Brain Sciences and CognitionBen-Gurion University of the NegevBeer ShevaIsrael

Macrophage migration inhibitory factor(MIF):MIF acts as a pleiotropic inflammatory mediator,playing regulatory roles in innate and adaptive immunity,neuroinflammation,neuroendocrine functions,and nervous system development(Matejuk et al.,2024).In recent years,MIF has attra cted significant inte rest from research groups as a potential target for the treatment of various neurodegenerative diseases,including Alzheimer's disease,Parkinson's disease,multiple sclerosis,and glioblastoma(Matejuk et al.,2024).

关键词： immunity sclerosis

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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Results on non-SUSY searches for physics beyond standard model in pp collisions at CMS

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Frontiers of physics 2013年第3期8卷 257-269页

作者： adrian Perieanu Physikalisches Institut B RWTH-Aachen Germany

In this paper a review of the results on searches for pnysics beyond the standard model in pp collisions with the CMS experiment at √s = 7 and 8 TeV is presented. Aspects of the analyses and their achieved limits on ... 详细信息

关键词： beyond standard model gauge bosons leptoquarks extra dimensions

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Numerical study of solar absorption heat storage system applied to Bucharest city

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Building Simulation 2021年第3期14卷 601-616页

作者： Noureddine Cherrad adrian-Gabriel Ghiaus University Kasdi Merbah ofOuargla Faculty of Applied SciencesDepartment of Mechanical EngineeringOuarglaAlgeria Doctoral School Technical University of Civil Engineering of BucharestBucharestRomania

Buildings represent a large part in terms of fossil energy consumption,which depends on the great need for *** if the solar absorption heat storage system is possible,the performance of this system is affected by the cycle limits and the climatic *** goal of the present study is to control the thermal performance of the system cycle according to the imposed climatic conditions of Bucharest city,Romania,and therefore a numerical model was developed for this *** scheme and the thermodynamic cycle,the energy and mass balance equations,and the computational algorithm were *** results show that the cycle temperature increases at the end of desorption when the heating power supplied to the desorber is increased,which is also proportional to the drop in temperature at the beginning of the *** temperature at the end of absorption and the mass flow rates of the solution have a significant effect on the thermal power released from the absorber and used to heat the *** an average daily heat power of 1.35 kW/m^(2) and 10 hours per day of heating the building,the system with a solar collector area of 3 m^(2) has the capacity of heat supply for all the cold ***,an economic strategy remains necessary.

关键词： numerical model absorption heat storage cycle temperatures climatic conditions

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Relating thermal conductivity of soil skeleton with soil texture by the concept of“local thermal conductivity fluctuation”

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第1期14卷 262-271页

作者： adrian Rózanski Faculty of Civil Engineering Wroclaw University of Science and TechnologyWybrzeze Wyspia_nskiego 2750-370WrocławPoland

The thermal conductivity of the soil skeletonλ;is an essential parameter from the point of view of the correct assessment of soil overall/effective *** work introduces the concept of“local thermal conductivity fluctuation”which characterizes the microscale variation of conductivity within the solid *** is proposed to link the“local fluctuation”of thermal conductivityλwith the soil texture-the information that is available at the scale of engineering *** was possible to relate the skeleton thermal conductivity with the grain size distribution of the ***,based on a large series of numerical simulations,the paper provides four triangle diagrams(at different organic matter contents:0%,2%,4%and 6%)relating the value ofλ;with volume fraction of individual soil *** result is extremely important from the practical point of *** can quickly evaluateλ;value provided that information on the grain size distribution and organic matter content is available.

关键词： Soil skeleton Probability density function(PDF) Computational micromechanics Local fluctuation Soil texture

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Testing discrete symmetries at a super τ-charm factory

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Frontiers of physics 2016年第1期11卷 17-25页

作者： adrian John Bevan Particle Physics Research Centre Queen Mary University of London Mile End Road London E1 4NS UK

Tests of discrete symmetry violation have played an important role in understanding the structure of weak interactions in the Standard Model of particle physics. Historically, these measurements have been extensively performed in experiments with large samples of K and B mesons. A high luminosity τ-charm facility presents physicists with the opportunity to comprehensively explore discrete symmetry violation and test the Standard Model using τ leptons, charm mesons, and charmed baryons. This paper discusses several possible measurements for a future T-charm factory.

关键词： discrete symmetries P C T CP CPT violation

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A New Batch Verifying Scheme for Identifying Illegal Signatures

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Journal of Computer Science & Technology 2013年第1期28卷 144-151页

作者： adrian Atanasiu Faculty of Mathematics and Computer Science Bucharest University

The concept of batch verifying multiple digital signatures is to find a method by which multiple digital signatures can be verified simultaneously in a lower time complexity than separately verifying all the signatures. In this article, we analyze the complexity of the batch verifying schemes defined by Li, Hwang and Chen in 2010, and propose a new batch verifying multiple digital signature scheme, in two variants： one for RSA - by completing the Harn＇s schema with an identifying illegal signatures algorithm, and the other adapted for a modified Elliptic Curve Digital Siggnature Algorithm protocol.

关键词： digital signature batch verifying multiple signature RSA signature elliptic curve digital signature algorithm standard

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Automated recognition and mapping of building management system (BMS) data points for building energy modeling (BEM)

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Building Simulation 2021年第1期14卷 43-52页

作者： Sicheng Zhan adrian Chong Bertrand Lasternas Department of Building School of Design and EnvironmentNational University of Singapore4 Architecture DriveSingapore117566Singapore

With the advance of the internet of things and building management system(BMS)in modern buildings,there is an opportunity of using the data to extend the use of building energy modeling(BEM)beyond the design *** applications include retrofit analysis,measurement and verification,and operations and ***,while BMS is collecting a vast amount of operation data,different suppliers and sensor installers typically apply their own customized or even random non-uniform rules to define the metadata,i.e.,the point *** results in a need to interpret and manually map any BMS data before using it for energy *** mapping process is labor-intensive,error-prone,and requires comprehensive prior ***,BMS metadata typically has considerable variety and limited context information,limiting the applicability of existing interpreting *** this paper,we proposed a text mining framework to facilitate interpreting and mapping BMS points to EnergyPlus *** framework is based on unsupervised density-based clustering(DBSCAN)and a novel fuzzy string matching algorithm“X-gram”.Therefore,it is generalizable among different buildings and naming *** compare the proposed framework against commonly used baselines that include morphological analysis and widely used text mining *** two building cases from Singapore and two from the United States,we demonstrated that the framework outperformed baseline methods by 25.5%,with the measurement extraction F-measure of 87.2%and an average mapping accuracy of 91.4%.

关键词： building management system(BMS) building energy modeling(BEM) auto-mapping DBSCAN metadata interpretation

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Novel transparent MgGa_(2)O_(4) and Ni^(2+)-doped MgGa_(2)O_(4) ceramics

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Journal of Advanced Ceramics 2022年第3期11卷 470-481页

作者： Guangran ZHANG adrian GOLDSTEIN Yiquan WU Kazuo Inamori School of Engineering New York State College of CeramicsAlfred UniversityAlfredNew York 14802USA Israel Ceramic and Silicate Institute HaifaIsrael

In this study we fabricated, for the first time, magnesium gallate (MgGa_(2)O_(4), a partially inverted spinel) transparent ceramics, both undoped and doped with 1 at% Ni. The specimens were derived from in-house prepared powder, with a crystallite size of ∼10 nm (by wet chemistry) and densified by pulsed electric current sintering (PECS;peak temperature 950 ℃ for 90 min). Densification levels of 99.84% and 99.52% of theoretical density were attained for doped and undoped materials, respectively. Doping with Ni was seen to marginally improve the densification level. Quite transparent specimens were produced: the best showing transmission of ∼89% of the theoretical level (thickness t = 0.85 mm). The absorption spectra revealed that the dopant was accumulated as Ni^(2+) in the octahedral sites of the lattice, as occurs in single-crystal specimens. After excitation at 980 nm, the doped disks exhibited a wide fluorescence band centered at 1264 nm.

关键词： magnesium gallate(MgGa_(2)O_(4)) spinel transparent ceramics pulsed electric current sintering(PECS)

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