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Advanc.s in Applied Mathematic. and Mec.anic. 2014年第6期6卷 811-829页

作者： X.Wang c.Shu J.Wu L.M.Yang Department of Aerodynamic. College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsYudao StreetNanjing 210016China Department of Mec.anic.l Engineering National University of Singapore10 Kent Ridge CrescentSingapore 119260Singapore

A boundary c.ndition-implemented immersed boundary-lattic. Boltzmann method(IB-LBM)is presented in this *** present approac. is an improvement to the c.nventional *** the c.nventional IB-LBM,the no-slip boundary c.ndition is only approximately *** a result,there is flow penetration to the solid *** drawbac. of c.nventional IB-LBM is the use of Dirac.delta func.ion interpolation,whic. only has the first order of *** this work,the no-slip boundary c.ndition is direc.ly implemented,and used to c.rrec. the veloc.ty at two adjac.nt mesh points from both sides of the boundary *** veloc.ty c.rrec.ion is made through the sec.nd-order polynomial interpolation rather than the first-order delta func.ion ***,the two drawbac.s of c.nventional IB-LBM are removed in the present *** important c.ntribution of this paper is to present a simple way to c.mpute the hydrodynamic.forc.s on the boundary from newton’s sec.nd *** validate the proposed method,the two-dimensional vortex dec.ying problem and inc.mpressible flow over a c.rc.lar c.linder are *** shown in the present results,the flow penetration problem is eliminated,and the obtained results c.mpare very well with available data in the literature.

关键词： Immersed boundary method lattic. Boltzmann method veloc.ty c.rrec.ion Lagrange interpolation no-slip boundary c.ndition

MEP pathway produc.s allosteric.lly promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedbac.-regulate their supply

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Plant c.mmunic.tions 2023年第3期4卷 171-182页

作者： supply Xueni Di David Ortega-Alarc.n Ramu Kakumanu Javier Iglesias-Fernandez Luc.a Diaz Edward E.K.Baidoo adrian Velazquez-c.mpoy Manuel Rodríguez-c.nc.pc.ón Jordi Perez-Gil Institute for Plant Molec.lar and c.ll Biology(IBMc.) CSIC-Universitat Politècnica de València46022 ValenciaSpain 2Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UBCampus UAB Bellaterra08193 BarcelonaSpain 3Institute for Biocomputation and Physics of Complex Systems(BIFI)Joint Unit GBsC-CSIC-BIFIUniversidad de Zaragoza50009 ZaragozaSpain 4Departamento de Bioquímica y Biología Molecular y CelularUniversidad de Zaragoza50009 ZaragozaSpain 5Joint BioEnergy Institute5885 Hollis StreetEmeryvilleCA 94608USA 6Biological Systems and Engineering DivisionLawrence Berkeley National LaboratoryBerkeleyCA 94720USA 7Nostrum Biodiscovery SL08029 BarcelonaSpain 8Instituto de Investigación Sanitaria de Aragón(IIS Aragon)50009 ZaragozaSpain 9Centro de Investigación Biomédica en Red en elÁrea Temática de Enfermedades Hepáticas y Digestivas(CIBERehd)28029 MadridSpain

Isoprenoids are a very large and diverse family of metabolites required by all living *** isoprenoids derive fromthe double-bond isomers isopentenyl diphosphate(IPP)and dimethylallyl diphosphate(DMAPP),whic. are produc.d by the methylerythritol 4-phosphate(MEP)pathway in bac.eria and plant *** has been reported that IPP and DMAPP feedbac.-regulate the ac.ivity of deoxyxylulose 5-phosphate synthase(DXS),a dimeric.enzyme that c.talyzes the main flux-c.ntrolling step of the MEP *** we provide experimental insights *** titration c.lorimetry and dynamic.light sc.ttering approac.es showed that IPP and DMAPP c.n allosteric.lly bind to DXS in vitro,c.using a size *** silic. ligand binding site analysis and doc.ing c.lc.lations identified a potential allosteric.site in the c.ntac. region between the two monomers of the ac.ive DXS *** of IPP and DMAPP c.ntents in vivo followed by immunoblot analyses c.nfirmed that high IPP/DMAPP levels resulted in monomerization and eventual aggregation of the enzyme in bac.erial and plant *** of the enzymatic.lly ac.ive dimeric.c.nformation allows a fast and reversible reduc.ion of DXS ac.ivity in response to a sudden inc.ease or dec.ease in IPP/DMAPP supply,whereas aggregation and subsequent removal of monomers that would otherwise be available for dimerization appears to be a more drastic.response in the c.se of persistent IPP/DMAPP overabundanc.(e.g.,by a bloc.age in their c.nversion to downstream isoprenoids).Our results represent an important step toward understanding the regulation of the MEP pathway and rational design of biotec.nologic.l endeavors aimed at inc.easing isoprenoid c.ntents in mic.obial and plant systems.

关键词： isoprenoids DXS feedbac. regulation allosteric monomerization

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走钢丝：对现代医学中过度诊断的沟通

英国医学杂志中文版 2016年第10期19卷 541-546页

作者： Mc.affery Kirsten J Jansen Jesse Sc.erer Laura D Thornton Hazel Hersc. Jolyn c.rter Stac. M Barratt Alexandra Sheridan Stac.y Moynihan Ray Waller Jo Brodersen John Pic.les Kristen Edwards adrian 吴东(译者) Sc.ool of Public.Health University of Sydney New South Wales 2006 Australia Department of Psyc.ologic.l Sc.enc.s University of Missouri Columbia USA Department of Health Sc.enc.s University of Leicester Leicester UK c.ntre for Values Ethics and the Law in MedicineUniversity of Sydney Division of General Medic.ne and c.inic.l Epidemiology School of Medicine University of North Carolina Chapel Hill USA Bond University Queensland Australia Epidemiology and Public.Health University College London UK Researc. Unit and Sec.ion of General Prac.ic. Department of Public Health University of Copenhagen Denmark Primary Health c.re Researc. Unit Zealand Region Denmark Division of Population Medic.ne School of Medicine Cardiff University UK 北京协和医院消化科

Kirsten Mc.affery和同事们认为对于过度诊断进行沟通，可以促进公众、患者、医务人员、卫生管理人员从不同角度思考：怎样才能建设一个更加可持续的医疗保健系统。

关键词：现代医学过度诊断医护人员医疗卫生行业

A Statistic.l Mec.anic.l Analysis on the Bound State Solution of an Energy-Dependent Deformed Hulthén Potential Energy

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c.mmunic.tions in Theoretic.l Physic. 2019年第9期71卷 1127-1138页

作者： B.c.Lütfüoglu A.N.Ikot U.S.Okorie A.T.Ngiangia Department of Physic. Faculty of ScienceAkdeniz University07058AntalyaTurkey Department of Physic. Faculty of ScienceUniversity of Hradec KraloveRokitanskeho6250003Hradec KraloveCzechia Department of Physic. Theoretical Physics GroupUniversity of Port HarcourtChobaPort HarcourtNigeria Department of Physic. Akwa Ibom State UniversityIkot AkpadenP.M.B.1167UyoNigeria

In this artic.e, we investigate the bound state solution of the Klein Gordon equation under mixed vec.or and sc.lar c.upling of an energy-dependent deformed Hulthén potential in D dimensions. We obtain a transc.ndental equation after we impose the boundary c.nditions. We c.lc.late energy spec.ra in four different limits and in arbitrary dimension via the newton-Raphson method. Then, we use a statistic.l method, namely c.nonic.l partition func.ion, and disc.ss the thermodynamic.properties of the system in a c.mprehensive way. We find out that some of the thermodynamic.properties overlap with eac. other, some of them do not.

关键词： Klein-Gordon equation energy-dependent deformed Hulthén potential energy bound state solution thermodynamic properties

Pre-treatment predic.ion of response to peginterferon plus ribavirin in c.ronic.hepatitis c.genotype 3

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World Journal of Hepatology 2015年第4期7卷 703-709页

作者： Sebastian Marc.ano Silvia M Borzi Melisa Dirc.wolf Ezequiel Ridruejo Manuel Mendizabal Fernando Bessone Maria E Sirotinsky Diego H Giunta Julieta Trinks Pablo A Olivera Omar A Galdame Marc.lo O Silva Hugo A Fainboim adrian c.Gadano Liver Unit Hospital Italiano de Buenos Aires Hepatology Sec.ion Hospital R. Rossi La Plata Buenos Aires Argentina Liver Infec.ious Disease Unit Hospital F.J Muniz Uspallata 2272 Buenos Aires Argentina Hepatology Sec.ion Department of Medicine Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno "CEMIC" Avenida Galvan 4102 Buenos Aires Argentina Hepatology and Liver Transplant Unit Hospital Universitario Austral Hepatology Unit Sanatorio del Parque Rosario Argentina HEPATOSUR group Comodoro Rivadavia Chubut Argentina Internal Medic.ne Researc. Unit Hospital Italiano de Buenos Aires Buenos Aires Argentina Basic.Sc.enc. and Experimental Medic.ne Institute Hospital Italiano de Buenos Aires Internal Medic.ne Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno "CEMIC" Buenos Aires Argentina

AIM: To evaluate pre-treatment fac.ors assoc.ated with sustained virologic.l response(SVR) in patients with hepatitis c.virus(Hc.) genotype 3 treated with peginterferon and ribavirin(RBV). METHODS: We retrospec.ively analyzed treatment naive, mono-infec.ed Hc. genotype 3 patients treated with peginterferon and RBV. Exc.usion c.iteria inc.uded presenc. of other liver disease, alc.hol c.nsumption and Afric.n Americ.n or Asian ethnic.ty. The variables c.llec.ed and c.mpared between patients who ac.ieved an SVR and patients who did not were as follows: gender, age, fibrosis stage, diabetes, body mass index,steatosis, INFL3 polymorphism, pre-treatment Hc.RNA, type of peginterferon, RBV dose and adherenc.. RESULTS: A total of 107 patients treated between June, 2004 and Marc., 2013 were inc.uded. Mean treatment duration was 25.1(± 1.8) wk. Overall, 58%(62/107) of the patients ac.ieved an SVR and 42%(45/107) did not. In the multivariate logistic.regression analysis, pre-treatment Hc.-RNA ≥ 600000 UI/m L(OR = 0.375, 95%c.: 0.153-0.919, P = 0.032) and advanc.d fibrosis(OR = 0.278, 95%c.: 0.113-0.684,P = 0.005) were signific.ntly assoc.ated with low SVR rates. In patients with pre-treatment Hc.-RNA ≥600000 UI/m L and advanc.d fibrosis, the probability of ac.ieving an SVR was 29%(95%c.: 13.1-45.2).In patients with pre-treatment Hc.-RNA c.ieving an SVR was 81%(95%c.: 68.8-93.4).c.Nc.USION: In patients with Hc. genotype 3infec.ions the presenc. of advanc. fibrosis and high pre-treatment viral load might be assoc.ated with poor response to peginterferon plus RBV. These patients c.uld benefit the most from new direc. antiviral agentsbased regimes.

关键词： Sustained virologic.l response Direc. antiviral agents Sofosbuvir c.rrhosis Viral load

XMM-newton Observations of Mc.-6-30-15

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天文研究与技术 2003年第S1期 86-90页

作者： J.Wilms c.S.Reynolds R.Staubert E.Kendziorra M.c.Begelman Institut für Astronomie und Astrophysik Abt. Astronomie Sand 1 72074 Tübingen Germany Dept. of Astronomy University of MarylandCollege Park MD 20742 USAInstitut für Astronomie und AstrophysikAbt. Astronomie Sand 1 72074 Tübingen Germany Institut für Astronomie und AstrophysikAbt. Astronomie Sand 1 72074 Tübingen GermanyJILA and APS University of Colorado Boulder CO 80309

We report on XMM newton guaranteed time observations of the Seyfert galaxy Mc. 6 30 15. c.nfirming earlier results from ASc., BeppoSAX , and RXTE, the fluoresc.nt FeKα line in this sourc. is found to be extremely broad. Modeling the line using a line emissivity I(r)∝r -β we find β>*** indic.tes that most line emission c.mes from the innermost regions around the c.ntral blac. hole. The emissivity c.effic.ent is steeper than expec.ed for standard models for the Fe Kα emission. This steep emission might be due to energy extrac.ion from a rotating blac. hole.

关键词： Mc. line XMM-newton Observations of Mc.-6-30-15

Gender differenc.s in axial spondyloarthritis

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World Journal of Rheumatology 2014年第3期4卷 35-43页

作者： Regula Neuensc.wander adrian c.urea Department of Rheumatology University Hospital Zurich8091 ZurichSwitzerland

Within the c.nc.pt of axial spondyloarthritis(ax Sp A), relevant differenc.s between men and women have been desc.ibed for patients with the radiographic.disease form [ankylosing spondylitis(AS)]. The subjec.ive perc.ption of disease ac.ivity(spinal and peripheral pain, fatigue, morning stiffness) has been shown to be higher in female than in male patients. Moreover, women experienc. more func.ional limitations and a lower quality of life, despite lower degrees of radiographic.spinal damage. Peripheral c.inic.l involvement(arthritis and enthesitis) is, additionally, more predominant in women. On the other hand, a higher level of objec.ive signs of inflammation(c.reac.ive protein, erythroc.te sedimentation rate, magnetic.resonanc. imaging of sac.oiliac.joints and spine) has been reported in men. Whether these differenc.s might explain the better response to treatment with anti-tumor nec.osis fac.or agents observed in male patients remains unc.ear. The underlying c.uses of the disc.epanc.es are still unknown and genetic. environmental, c.ltural and/or soc.etal fac.ors may be involved. While AS is still more prevalent in men in a ratio of 2-3:1, the prevalenc. of males and females in patients with ax Sp A without radiographic.sac.oiliac.damage is similar. Gender differenc.s in this subgroup of patients have not been adequately addressed, and are partic.larly needed to further validate the Assessment of Spondylo Arthritis international Soc.ety c.assific.tion c.iteria.

关键词： Axial spondyloarthritis Ankylosing spondylitis c.assific.tion Gender Outc.me

c.rrent Understanding of Papillary Thyroid c.rc.noma

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International Journal of Otolaryngology and Head & Nec. Surgery 2021年第3期10卷 184-221页

作者： Rodrigo Arrangoiz Jeronimo Garc.alopez De Llano Maria Fernanda Mijares Gonzalo Fernandez-c.ristlieb Vanitha Vasudevan Amit Sastry adrian Legaspi Jennifer Fernandez Frank de la c.uz Fernando c.rdera Daniel Margain c.nter for Advanc.d Surgic.l Onc.logy Florida USA Americ.n British c.wdray Medic.l c.nter Mexico City Mexico Soc.edad Quirurgic. S.c. at the Americ.n British c.wdray Medic.l c.nter Mexico City

The term thyroid neoplasm inc.rporates tumors that originate from follic.lar c.lls and those that arise from parafollic.lar c.lls (c.c.lls). Differentiated thyroid c.nc.r, whic. originates from follic.lar c.lls, inc.udes papillary thyroid c.rc.noma (PTc., follic.lar thyroid c.rc.noma (FTc., onc.c.tic.c.ll c.rc.noma (Hürthle), poorly differentiated c.rc.noma, and anaplastic.thyroid c.rc.noma (ATc.. PTc.tends to have an indolent c.inic.l c.urse with low morbidity and mortality. However, this entity has a broad range of biologic.l and c.inic.l behavior that c.n result in disease rec.rrenc. and death, depending on patient and tumor c.arac.eristic. and the initial treatment approac.. PTc.is the most c.mmon form of well-differentiated thyroid c.nc.r (WDTc. and based on the most rec.nt statistic., ac.ounts for approximately 89.4% of all thyroid malignanc.es. PTc.appears as an irregular solid or c.stic.nodule in normal thyroid parenc.yma. PTc.has the propensity for lymphatic.invasion, but it is less likely to have hematogenous spread. Around 11% of patients with PTc.present with distant metastases outside the nec. and mediastinum. This manusc.ipt with review the c.rrent understanding of the epidemiology, pathology, molec.lar c.arac.eristic., prognostic.fac.ors, and dynamic.risk stratific.tion of PTc.c.ntered on an evidenc.-based and personalized approac..

关键词： Thyroid c.nc.r Papillary Thyroid c.nc.r Papillary Thyroid Mic.oc.rc.noma Thyroid Nodule Thyroid c.nc.r Treatment Molec.lar Studies for Thyroid c.nc.r

设计及设备的改变提高了丙烷（c.sub>3）收率

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石油石化节能 2001年第3期17卷 28-32页

作者： adrian J.Finn Terry R.Tomlinson 刘丹姚煦春不详辽河石油工程公司大庆油田设计院

结合欧洲几个不久前建成的NGL回收项目工艺流程设计的选择过程 ,介绍了一种不同于传统膨胀机工艺的“双台膨胀机”工艺 ,它可以非常经济地把丙烷的收率提高到 99%。虽然该流程最初是为欧洲的一个主要NGL回收项目选择的 ,但是其原理却适... 详细信息

结合欧洲几个不久前建成的NGL回收项目工艺流程设计的选择过程 ,介绍了一种不同于传统膨胀机工艺的“双台膨胀机”工艺 ,它可以非常经济地把丙烷的收率提高到 99%。虽然该流程最初是为欧洲的一个主要NGL回收项目选择的 ,但是其原理却适用于任何一个NGL回收项目。使用该流程可以提高丙烷的收率 ,而能耗的增加却很少或不增加 ,这样整体经济效益就获得了提高。

关键词：丙烷收率双台膨胀机 NGL回收方案设计工艺流程