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Potential of a COX-2 inhibitor in lowering chemotherapy-induced neutropenia

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中华乳腺病杂志（电子版） 2010年第5期4卷 8-13页

作者： Louis Wing-Cheong Chow adrian yun-san yip Eleanor Yuen-Yuen Ong Chi-Kei Lam Masakazu Toi Clinical Trials Centre Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Organisation for Oncology and Translational Research Comprehensive Centre for Breast Diseases UNI MED Medical Institute Department of Surgery Kyoto UniversityJapan

Objective This study was initially designed to evaluate the effect of celecoxib on the regimen of 5-fluorouracil,epirubicin,and cyclophosphamide(FEC)combination,followed by docetaxel(T)in neoadjuvant *** unplanned preliminary review on safety was conducted after a halt of the study due to the concerned potential cardiovascular risk of using COX-2 *** We studied 23 consecutive cases of operable breast cancer having received four cycles of FEC(500 mg/m2,100 mg/m2,500 mg/m2)followed by four cycles of T(100 mg/m2)with concurrent celecoxib(400 mg twice daily)(group A)or same chemotherapy regimen but without concurrent celecoxib(group B).These combined chemotherapies were administered every 3 *** Chi-square test or Fisher's exact test were used to assess the difference in incidence of limiting hematological toxicites between *** 23 patients(group A:n=12;group B,n=11)received a total of 183 out of 184 planned treatment cycles;one(4%,1/23)of them omitted the fourth cycle of FEC owing to repeated incidences of febrile *** dose intensity(RDI)for FEC in group A(90%±11%)was higher than that in group B(80%±8%)while RDI for T was similar between group A(93%±8%)and group B(96%±9%).Of the first 91 treatment cycles of FEC,limiting hematological toxicity,severe neutropenia including febrile neutropenia,was significantly different between group A and B [(10.4%,5/48)vs.(32.6%,14/43),P=0.009].Other toxicities commonly observed in chemotherapy receiving patients were *** Neoadjuvant use of FEC followed by T with concurrent celecoxib appeared to be safe for treatment of operable invasive breast *** observed lower incidence of chemotherapy-induced neutropenia is possibly contributed by the administration of *** believe that further investigation might provide more evidence on the use of COX-2 inhibitors in breast cancer.

关键词：血疗法乳腺癌治疗临床

Application of biomarkers in sentinel lymph node biopsy for the management of breast cancer

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中华乳腺病杂志（电子版） 2012年第6期6卷 11-15页

作者： Qing Liu Wings Tjing yung Loo adrian yun san yip Louis Wing Cheong Chow Elizabeth Lam Yan Ng Mary Ngan Bing Cheung UNIMED Medical Institute Organization for Oncology and Translational Research

Objective Sentinel lymph node in breast cancer is a predictor of the tumor's metastatic *** emerging from antitumor immune response might also target sentinel lymph node (SLN).In this study,we evaluated the cytokine profile including interleukin-8 (IL-8),interleukin-12 (IL-12),interferon-gamma (IFN-γ),and tumor necrosis factor alpha (TNF-α) for the T-cell *** From January 2008 to August 2010,35 patients with breast mass underwent SLN biopsy in UNIMED Medical *** specimens were formalin-fixed and paraffin-embedded for hematoxylin and eosin staining and immunohistochemistry with following markers:IL-8,IL-12,IFN-γ and TNF-α.The staining intensity was scored according to four grades:negative (-),weak expression (+),moderately positive expression (+ +),strong positive expression (+ + +).The correlation between the expression of cytokines and pathological characteristics were also analyzed using the Spearman Rank Correlation *** Out of 35 patients,SLN metastases were observed in 20 patients and among them,75% (15 /20) were strongly stained (+ + +) with IL-8 and moderately stained (+ +) with IL-12,but only 25% (5 /20) were strongly stained (+ + +) with IFN-γ and TNF-α.The expression of IL-8 was significantly associated with all tumor grades (r=0.639,P=0.00),estrogen receptor (r=0.778,P=0.01),progesterone receptor (r=0.759 P=0.00) and HER-2 /neu receptor (r=0.863 P=0.00).Conclusion The strong association between IL-8 expression and SLN metastases might highlight the prognostic significance of IL-8 in SLN.

关键词：临床治疗乳腺疾病医学

Effect of Tai Chi Chuan on serotonin and cortisol for monitoring stress and quality of life in post-treatment breast cancer patients

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中华乳腺病杂志（电子版） 2014年第4期8卷 34-40页

作者： William Wai Nam Tsang Wings Tjing yung Loo Louis Wing Cheong Chow Elizabeth Lam Yan Ng adrian yun san yip Jianping Chen Department of Rehabilitation Sciences Hong Kong Polytechnic University UNIMED Medical Institute and Organisation for Oncology and Translational Research School of Chinese Medicine Li Ka Shing Faculty of MedicineUniversity of Hong Kong

Objective Immediate physical exercise has been recommended for patients in the recovery phase to improve survival and quality of life(QOL)and reduce recurrence of *** new NCCN Guidelines for Survivorship also highlighted the role of exercise in post-cancer health,encouraging patients to perform light physical activity following *** aim of our study is to effect of Tai Chi Chuan(TCC)on serotonin and cortisol for monitoring stress and QOL in post-treatment breast cancer *** Totally85 post-treatment breast cancer patients were enrolled in this study to observe the effects of practicing TCC on recovery,as well as stress and happiness which are indicators of QOL of in *** blood was drawn from study subjects to analyze the levels of serotonin,cortisol and high sensitive C-reactive protein(HSCRP)at baseline,and at 3,6 and 12 months of TCC *** was drawn from healthy subjects only at baseline.A QOL questionnaire was administered to study subjects at three time points throughout the study,and once for healthy *** data were processed by analysis of variance of repeated *** At 3,6 and 12 months time points following regular TCC exercise,WBC,RBC,hemoglobin in blood samples showed a statistically significant difference(F=161.55,172.14,289.73;all P=0.00);the level of serotonin(biomarker for well-being),cortisol(indicator of stress)and HS-CRP(biomarker for inflammation)showed a statistical improvement(F=307.46,182.85,102.23;all P=0.00).After 3,6 and 12 months of regular TCC exercise,according to the results of QOL questionnaire,the indicators including quality of sleep,perceived hunger,fatigue,contentment,stress and social interaction presented a significant difference(F=312.98,222.64,543.90,46.05,28.10,78.92,all P<0.05),while there was no statistical difference in life dissatisfaction(F=56.61,P=0.166)Conclusions TCC physical activity for post-treatment breast cancer patients improved QOL and overall

关键词：乳腺病患者临床分析治疗方法