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Bridging the gap:Unveiling the crisis of physical inactivity in inflammatory bowel diseases

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World Journal of Gastroenterology 2024年第10期30卷 1261-1265页

作者： Remus Stafie Ana-Maria Singeap adrian Rotaru Carol Stanciu Anca trifan Department of Gastroenterology Faculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Institute of Gastroenterology and Hepatology “St.Spiridon”University HospitalIasi 700111Romania

In this editorial we comment on the article titled“Inflammatory bowel diseases patients suffer from significant low levels and barriers to physical activity:the BE-FIt-IBD study”published in a recent issue of the World Journal of Gastroen-terology 2023;29(41):*** bowel diseases(IBD)are emerging as a significant global health concern as their incidence continues to rise on a global scale,with detrimental impacts on quality of *** many advances have been made regarding the management of the disease,physical inactivity in these patients represents an underexplored issue that may hold the key for further and better understanding the ramifications of *** pain,fatigue,and fear of exacerbating symptoms promotes physical inactivity among IBD patients,while the lack of clear guidelines on safe exercise regimens contributes to a norm of physical *** activity(PA)is accepted to have a positive effect on disease outcomes and quality of life,while inactivity exacerbates comorbidities like cardiovascular disease and mental health ***“BE-FIt-IBD”study,focusing on PA levels and barriers in IBD patients of Southern Italy,revealed that a significant proportion(42.9%)were physically *** lack of PA is attributed to barriers such as fear of flare-ups and misconceptions about exercise exacerbating the *** study also highlighted the need for better communication between healthcare providers and patients regarding the benefits of PA and safe incorporation into ***,physical inactivity may also contribute to disability in IBD patients,having a great impact on employment *** note is the fact that IBD also comes with an important psychological burden with relevant evidence suggesting that regular PA can improve mood,reduce anxiety,and enhance mental ***“BE-FIt-IBD”study advocated for the integration of PA into IBD management,emphasizing the bidirectional link between PA and *** exe

关键词： Inflammatory bowel disease Physical activity Disability Psychological burden Body composition Quality of life

Pressure Measurements from Five Different Nosebands at Rest, and During Riding at Walk, a Collected Gait, Backing up and a Full Stop

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Open Journal of Veterinary Medicine 2024年第6期14卷 137-154页

作者： adrian Harrison Dept for Veterinary and Animal Sciences (IVH) Faculty of Health & Medical Sciences University of Copenhagen PAS Section for Physiology Frederiksberg Denmark

Background: Scientific procedures for addressing noseband fit and tightness, eliminating the risk of excessive and painful tightening, as well as quantitative measurements of pressures under the noseband while riding are either scarce or lacking. Purpose/Aim: to assess simple means of measuring pressure under different nosebands with a view to their adoption as scientific methodology. Method: Horses (n = 7) were fitted with five different bridles (A-E). Pressure distribution and intensity were measured using colour sensitive film (Fujifilm LLLW), assessing the level of pressure and distribution across the surface of the nosebands, as assessed and ranked by independent assessors. A CURO system was also used to measure pressure in real-time under nosebands whilst riding. Results: the colour-sensitive film for D & B were ranked 1st and 2nd, respectively. Regularity of pressure overall showed a statistical difference between nosebands (A & B significantly more unregular than the others). Pressure measurements revealed significantly different means (all P Conclusions: Pressures under nosebands can reach levels that appear capable of inflicting tissue damage, hence bridles and nosebands should be assessed using scientific methodology and not based on arbitrary and subjective criteria, as is currently the case.

关键词： Noseband Welfare Pain Bridle Fit Riding tölt FEI

Advanced wind turbine blade inspection with hyperspectral imaging and 3D convolutional neural networks for damage detection

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Energy and AI 2024年第2期16卷 528-537页

作者： Patrick Rizk Frederic Rizk Sasan Sattarpanah Karganroudi adrian Ilinca Rafic Younes Jihan Khoder Department of Mechanical Engineering Universitédu QuébecàTrois-RivièresDrummondvilleQCCanada Centre national intégrédu manufacturier intelligent(CNIMI) Universitédu QuébecàTrois-RivièresDrummondvilleQCCanada Department of Mathematics Computer Science and EngineeringUniversitédu QuébecàRimouski300 allée des UrsulinesRimouskiQCG5L3A1Canada the Center for Advanced Computer Studies University of Louisiana at LafayetteLafayetteLAUSA t3E Industrial Research Group Mechanical Engineering DepartmentÉcole de Technologie Supérieure1100 Notre-Dame St WMontréalQC H3C 1K3Canada Faculty of Engineering Third BranchLebanese UniversityHadathBeirutLebanon LISV Laboratory University of Versailles Saint-Quentin-en-Yvelines10-12 Avenue de l'Europe78140VélizyFrance

In the context of global efforts to mitigate climate change by pursuing sustainable energy sources, wind energy has emerged as a critical contributor. However, the wind energy industry faces substantial challenges in maintaining and preserving the integrity of wind turbine blades. timely and accurate detection and classification of blade faults, encompassing issues such as cracks, erosion, and ice buildup, are imperative to uphold wind turbines' ongoing efficiency and safety. this study introduces an inventive approach that amalgamates hyperspectral imaging and 3D Convolutional Neural Networks (CNNs) to augment the precision and efficiency of wind turbine blade fault detection and classification. Hyperspectral imaging is harnessed to capture comprehensive spectral information from blade surfaces, facilitating exact fault identification. the process is streamlined through Incremental Principal Component Analysis (IPCA), reducing data dimensions while maintaining integrity. the 3D CNN model demonstrates remarkable performance, achieving high accuracy in detecting all fault categories in full-band hyperspectral images. the model retains high accuracy even with dimensionality reduction to 20 spectral bands. the reduced processing time of the 20-band image enhances the practicality of real-world applications, thereby reducing downtime and maintenance expenditures. this research represents a significant advancement in wind turbine blade inspection, contributing to the sustainability and dependability of wind energy systems and furthering the cause of a cleaner and more sustainable energy future as part of the broader fight against climate change.

关键词： blade thereby turbine

IFN-γ^(+) cytotoxic CD4^(+) t lymphocytes are involved in thepathogenesis of colitis induced by IL-23 and the foodcolorant Red 40

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Cellular & Molecular Immunology 2022年第7期19卷 777-790页

作者： Lili Chen Zhengxiang He Bernardo S.Reis Jesse D.Gelles Jerry Edward Chipuk adrian t.ting Julie A.Spicer Joseph A.trapani Glaucia C.Furtado Sergio A.Lira Precision Immunology Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA Laboratory of Mucosal Immunology The Rockefeller UniversityNew YorkNY 10065USA Department of Oncological Sciences Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA the tisch Cancer Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA the Diabetes Obesityand Metabolism InstituteIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA Department of Immunology Mayo ClinicRochesterMN 55905USA Auckland Cancer Society Research Centre Faculty of Medical and Health SciencesThe University of AucklandPrivate Bag 92019Auckland 1142New Zealand Cancer Immunology Program Peter MacCallum Cancer Centre305 Grattan StreetMelbourneVIC 3000Australia

the food colorant Red 40 is an environmental risk factor for colitis development in mice with increased expression of interleukin(IL)-*** immune response is mediated by CD4^(+)t cells,but mechanistic insights into how these CD4^(+)t cells trigger andperpetuate colitis have remained ***,using single-cell transcriptomic analysis,we found that several CD4^(+)t-cell subsetsare present in the intestines of colitic mice,including an interferon(IFN)-γ-producing *** vivo challenge of primed mice withRed 40 promoted rapid activation of CD4^(+)t cells and caused marked intestinal epithelial cell(IEC)apoptosis that was attenuated bydepletion of CD4^(+)cells and blockade of IFN-γ.Ex vivo experiments showed that intestinal CD4^(+)t cells from colitic mice directlypromoted apoptosis of IECs and intestinal ***4^(+)t cell-mediated cytotoxicity was contact-dependent and required FasL,which promoted caspase-dependent cell death in target *** ablation of IFN-γconstrained IL-23-and Red 40-inducedcolitis development,and blockade of IFN-γinhibited epithelial cell death in *** results advance the understanding of themechanisms regulating colitis development caused by IL-23 and food colorants and identify IFN-γ^(+)cytotoxic CD4^(+)t cells as a newpotential therapeutic target for colitis.

关键词： Allura Red IL23 Cytotoxic CD4^(+)t cells CD4^(+)CtL Inflammation Epithelium damage Colitis

Novel sediment source fingerprinting quantifying erosion-induced total nitrogen and total phosphorus outputs from an intensive agricultural catchment,North China

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International Soil and Water Conservation Research 2023年第3期11卷 494-506页

作者： Hanqing Yu Joseph Adu-Gyamfi Suarau Odutola Oshunsanya adrian Chappell Wenxiang Liu Yu Zheng tingting Xue Lee Heng Agricultural Clean Watershed Research Group Institute of Environment and Sustainable Development in AgricultureChinese Academy of Agricultural Sciences(CAAS)Haidian District100081BeijingChina International Atomic Energy Agency ViennaAustria Department of Agronomy University of IbadanNigeria School of Earth and Environmental Sciences Cardif UniversityCardifUK Chongqing Branch Institute Changjiang River Scientific Research InstituteChongqing400026China

Intensive farming is a primary cause of increased sediment and associated nitrogen(N)and phosphorus(P)loads in surface water *** their contributing sources,pathways and loads present major challenges in the high-intensity agricultural ***,we quantify the sediment sources and magnitude of sediment total N and total P from different sources using a novel application of compound-specific stable isotope(CSSI)and fallout radionuclides(FRNs)of^(137)cs and^(210)pbex in an intensive agricultural catchment in North *** sources from surface and sub-surface soils were estimated from FRNs fingerprint and accounted for 62±7%and 38±7%respectively,while surface soil from land uses that originated from hillslope were identified by CssI *** a novel application of FRNs and CSSI sediment fingerprinting techniques,the dominant sediment source was derived from maize farmland(44±0.1%),followed by channel bank(38±7%).the sedimentation rate(13.55±0.30 t ha^(-1)yr^(-1))was quantifed by the^(137)cs cores(0-60 cm)at the outlet of this *** total N and total P in sediment were both mostly derived from maize farmland and least from channel *** channel banks are significant sediment sources but contribute little to the input of sediment N and P for *** implies that chemically-applied farmlands are the main hotspots for catchment erosion control and pollution *** novel application of FRNs and CSSI techniques cost-effectively quantified sediment N and P loads from different sources with a single visit to the catchment,enabling rapid assessment for optimizing soil conservation strategies and land management practices.

关键词： Sediment sources Land use N and P loads Compound-specific stable isotope Falloutradionuclides

Grammar Without Pron... Is Like Food Without taste （Ⅱ）

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基础教育外语教学研究 2018年第8期 27-29页

作者： adrian Underhill

St-Segment Depression in Leads I and aVL: Artifactual or Pathophysiological Findings ?

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Cardiovascular Innovations and Applications 2021年第4期6卷 109-111页

作者： Sharen Lee Gary tse Xin Wang adrian Baranchuk tong Liu Cardiovascular Analytics Group Laboratory of Cardiovascular PhysiologyHong KongChina tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjinChina Department of Medicine Kingston General HospitalQueen’s UniversityKingstonOntarioCanada

the 12-lead electrocardiogram(ECG)is a routinely performed test but is susceptible to misinterpretation even by experienced *** report a case of a 72-year-old lady with no prior cardiac history presented to our hospital with atypical chest *** initial electrocardiogram shows an initial St depression followed by positive defl ections leads I and ***-physiological St segment and t-wave changes are also observed in the precordial leads V2 to *** contrast,these abnormalities are notably absent in lead II.A repeat of the ECG taken 30 minutes later reveals the resolution of most abnormalities seen in the initial ECG on a background of high-frequency noise in the limb *** was referred to the cardiology department for further *** urgent echocardiogram revealed no regional wall motion abnormalities with preserved ejection fraction,and her coronary angiogram revealed no signifi cant coro-nary *** case illustrates the importance of understanding different factors that can cause St segment abnor-malities,notably artifactual changes that can mimic St segment myocardial infarction.

关键词： St segment artifact

Methanotrophy-driven accumulation of organic carbon in four paddy soils of Bangladesh

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Pedosphere 2022年第2期32卷 348-358页

作者： Nasrin SULtANA Jun ZHAO Yuanfeng CAI G.K.M.Mustafizur RAHMAN Mohammad Saiful ALAM Mohammad FAHEEM adrian HO Zhongjun JIA State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Agroforestry and Environmental Science Faculty of AgricultureSher-e-Bangla Agricultural University(SAU)Sher-e-Bangla NagarDhaka-1207Bangladesh Department of Soil Science Faculty of AgricultureBangabandhu Sheikh Mujibur Rahman Agricultural University(BSMRAU)Gazipur-1706Bangladesh Institute for Microbiology Leibniz Universität HannoverHerrenhäuser Straße 2Building 4104Hannover D-30419Germany

Biological methane oxidation is a crucial process in the global carbon cycle that reduces methane emissions from paddy fields and natural wetlands into the ***,soil organic carbon accumulation associated with microbial methane oxidation is poorly ***,to investigate methane-derived carbon incorporation into soil organic matter,paddy soils originated from different parent materials(Inceptisol,Entisol,and Alfisol) were collected after rice harvesting from four major rice-producing regions in *** microcosm incubation with 5%(volume/volume)^(13) CH_(4),soil^(13) C-atom abundances significantly increased from background level of 1.08% to 1.88%–2.78%,leading to a net methane-derived accumulation of soil organic carbon ranging from 120 to 307 mg kg^(-1).Approximately 23.6%–60.0% of the methane consumed was converted to soil organic carbon during microbial methane *** phylogeny of^(13) C-labeled pmoA(enconding the alpha subunit of the particulate methane monooxygenase) and 16 S rRNA genes further revealed that canonical α(type II) and γ(type I) Proteobacteria were active methane *** within the Methylobacter-and Methylosarcina-affiliated type Ia lineages dominated active methane-oxidizing communities that were responsible for the majority of methane-derived carbon accumulation in all three paddy soils,while Methylocystis-affiliated type IIa lineage was the key contributor in one paddy soil of Inceptisol *** results suggest that methanotroph-mediated synthesis of biomass plays an important role in soil organic matter *** study thus supports the concept that methanotrophs not only consume the greenhouse gas methane but also serve as a key biotic factor in maintaining soil fertility.

关键词： 16S rRNA gene DNA-based stable-isotope probing(DNA-SIP) methane oxidation methanotroph pmoA rice soil soil organic carbon soil organic matter

the Use of Far Infrared treatment Prior to Exercise in Horses: An mfBIA and Acoustic Myography three Case Study

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Open Journal of Veterinary Medicine 2024年第4期14卷 69-89页

作者： adrian Harrison D.Phil Department for Veterinary and Animal Sciences (IVH) Faculty of Health & Medical Sciences University of Copenhagen K&#248benhavn Denmark

Background: Acute effects of Far Infrared (FIR) treatment in horses are unknown, especially short periods of 30 minutes, as is any effect on such muscle parameters as warm-up balance, overall exercise balance and laterality asymmetries. Aim: this study examines three equine cases in detail to measure any effects of a short period of FIR treatment. Methods: Multi-frequency bioimpedance (mfBIA) and acoustic myography (AMG), non-invasive techniques, were applied pre- and post-treatment with FIR to the back (t5-L4/5) and for *** dorsi and *** medius was recorded during a 15-minute warm-up regimen. mfBIA parameters included extracellular resistance (Re), centre frequency (fc), membrane capacitance (Mc), intracellular resistance (Ri) and phase angle (PA) which indicates level of training and health status. Results: FIR treatment responses for mfBIA parameters were found to be horse-specific and different, whilst in terms of AMG, FIR treatment for 30 minutes had a beneficial effect on overall balance in all three horses (5 out of 6 muscles), and a beneficial effect on the AMG parameter St (force symmetry) in all three horses (6 out of 6 muscles). An overall improvement for combined balance and St values for both muscles and all three horses of 86% was noted with FIR treatment, compared to 56% without. Conclusions: this preliminary study of FIR treatment in three horses, has been found to result in an overall improvement in combined balance and St values for both muscles. FIR has potential as a promising treatment to reduce the risk of warm-up-related injuries in athletic horses.

关键词： Equine FIR Muscle Balance Muscle Force Injury Prevention