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Comparative effectiveness of medical treatment *** surgery for histologically proven non-alcoholic steatohepatitis and fibrosis:a matched network meta-analysis

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 696-708,I0008-I0011页

作者： adrian t.billeter Beatrice Reiners Svenja E.Seide Pascal Probst Eva Kalkum Christian Rupp Beat P.Müller-Stich Department of General Visceral and Transplant SurgeryUniversity of HeidelbergHeidelbergGermany Institute of Medical Biometry and Informatics University of HeidelbergHeidelbergGermany the Study Center of the German Surgical Society(SDGC) HeidelbergGermany Department of Gastroenterology and Hepatology University of HeidelbergHeidelbergGermany

Background:Non-alcoholic steatohepatitis(NASH)comprises a major healthcare problem affecting up to 30%of patients with obesity and the associated risk for cardiovascular and liver-related *** new drugs for NASH-treatment are currently *** study thus far directly compared surgical and non-surgical therapies for *** network meta-analysis compares for the first time the effectiveness of different therapies for NASH using a novel statistical ***:the study was conducted according to the PRISMA guidelines for network ***,CENtRAL and Web of Science were searched without restriction of time or language using a validated search *** investigating therapies for NASH in adults with liver biopsies at baseline and after at least 12 months were *** with liver cirrhosis were *** of bias was assessed with ROB-2 and ROBINS-I-tools.A novel method for population-adjusted indirect comparison to include and compare single-arm trials was *** outcomes were NASH-resolution and improvement of ***:Out of 7,913 studies,twelve randomized non-surgical studies and twelve non-randomized surgical trials were ***-resolution after non-surgical intervention was 29%[95%confidence interval(CI):23-40%]and 79%(95%CI:72-88%)after *** network meta-analysis showed that surgery had a higher chance of NASH-resolution than medication[odds ratio(OR)=2.68;95%CI:1.44-4.97]while drug treatment was superior to placebo(OR=2.24;95%CI:1.55-3.24).Surgery(OR=2.18;95%CI:1.34-3.56)and medication(OR=1.79;95%CI:1.39-2.31)were equally effective to treat fibrosis compared to placebo without difference between *** results did not change when only new drugs specifically developed for the treatment of NASH were ***:Metabolic surgery has a higher effectiveness for NASH-therapy than medical therapy while both were equally effective regarding improvement of *** d

关键词： Non-alcoholic fatty liver disease(NAFLD) non-alcoholic steatohepatitis(NASH) metabolic surgery fatty liver

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Combined non-alcoholic fatty liver disease and type 2 diabetes in severely obese patients-medium term effects of sleeve gastrectomy versus Roux-en-Y-gastric bypass on disease markers

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Hepatobiliary Surgery and Nutrition 2022年第6期11卷 795-807页

作者： Franck Billmann Sherehan El Shishtawi tom Bruckner Mostafa ElSheikh Beat Peter Muller-Stich adrian billeter Department of Surgery University Hospital of HeidelbergHeidelbergGermany Institut für Medizinische Biometrie und Informatik Universität HeidelbergHeidelbergGermany Department of General Surgery El-Gharbia GovenorateTantaEl gash St.Medical CampusThe Faculty of MedicineTantaEgypt

Background:We aimed to evaluate the medium-term efficacy of sleeve gastrectomy(SG)***-en-Y gastric bypass(RYGB)on remission of non-alcoholic fatty liver disease(NAFLD)in patients with type 2 diabetes mellitus(t2DM).Methods:We identified severely obese patients[body mass index(BMI)>35 kg/m^(2)]with NAFLD(as defined by the Longitudinal Assessment of Bariatric Surgery Study)and t2DM(as defined by the American Association of Clinical Endocrinologists and the American College of Endocrinology)who underwent SG or RYGB in a single university surgical *** cohorts were match-paired and data were analysed after at least 3 years of follow *** key outcomes measured were:(I)the improvement of liver function tests and NAFLD markers;(II)glycemic control and insulin ***:Ninety-six patients were investigated;44(45.8%)were *** mean pre-operative BMI was 45.2 kg/m2 in the SG and 42.0 kg/m^(2) in the RYGB *** and RYGB both significantly reduced serum liver enzyme *** markers resolved 2 years after SG in all *** contrast,only 78%and 80%of patients achieved remission of NAFLD 2 and 3 years after RYBG *** procedures resulted in comparable rates of remission of ***:Bariatric surgery with SG may be preferable to RYGB for obese patients with NAFLD and t2DM based on the rates of remission of markers of these ***,our results need to be confirmed in prospective *** the metabolic effects of specific bariatric surgical procedures may facilitate the development of a personalised approach to weight-loss surgery.

关键词： Bariatric surgery morbid obesity complications non-alcoholic fatty liver disease(NAFLD) type 2 diabetes mellitus(t2DM) gastric bypass sleeve gastrectomy(SG) transaminases

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Unmasking the mask:the role of personal protective equipment for ophthalmologists caring for asymptomatic patients during the COVID-19 pandemic

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1841-1843页

作者： adrian t.Fung Westmead and Central Clinical Schools Discipline of Clinical Ophthalmology and Eye HealthUniversity of SydneySydney 2145NSWAustralia Department of Ophthalmology Faculty of Medicine and Health SciencesMacquarie UniversitySydney 2109NSWAustralia

the use of personal protective equipment(PPE)for ophthalmologists caring for asymptomatic patients remains *** commentary reviews the latest emerging *** is paramountly important in shaping health policies in countrie... 详细信息

关键词： COVID-19 personal protective equipment mask

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testing discrete symmetries at a super τ-charm factory

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Frontiers of physics 2016年第1期11卷 17-25页

作者： adrian John Bevan Particle Physics Research Centre Queen Mary University of London Mile End Road London E1 4NS UK

tests of discrete symmetry violation have played an important role in understanding the structure of weak interactions in the Standard Model of particle physics. Historically, these measurements have been extensively performed in experiments with large samples of K and B mesons. A high luminosity τ-charm facility presents physicists with the opportunity to comprehensively explore discrete symmetry violation and test the Standard Model using τ leptons, charm mesons, and charmed baryons. this paper discusses several possible measurements for a future t-charm factory.

关键词： discrete symmetries P C t CP CPt violation

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Novel transparent MgGa_(2)O_(4) and Ni^(2+)-doped MgGa_(2)O_(4) ceramics

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Journal of Advanced Ceramics 2022年第3期11卷 470-481页

作者： Guangran ZHANG adrian GOLDStEIN Yiquan WU Kazuo Inamori School of Engineering New York State College of CeramicsAlfred UniversityAlfredNew York 14802USA Israel Ceramic and Silicate Institute HaifaIsrael

In this study we fabricated, for the first time, magnesium gallate (MgGa_(2)O_(4), a partially inverted spinel) transparent ceramics, both undoped and doped with 1 at% Ni. the specimens were derived from in-house prepared powder, with a crystallite size of ∼10 nm (by wet chemistry) and densified by pulsed electric current sintering (PECS;peak temperature 950 ℃ for 90 min). Densification levels of 99.84% and 99.52% of theoretical density were attained for doped and undoped materials, respectively. Doping with Ni was seen to marginally improve the densification level. Quite transparent specimens were produced: the best showing transmission of ∼89% of the theoretical level (thickness t = 0.85 mm). the absorption spectra revealed that the dopant was accumulated as Ni^(2+) in the octahedral sites of the lattice, as occurs in single-crystal specimens. After excitation at 980 nm, the doped disks exhibited a wide fluorescence band centered at 1264 nm.

关键词： magnesium gallate(MgGa_(2)O_(4)) spinel transparent ceramics pulsed electric current sintering(PECS)

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Concentration-Dependent Solar thermochemical CO_(2)/H_(2)O Splitting Performance by Vanadia-Ceria Multiphase Metal Oxide Systems

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Research 2020年第1期2020卷 522-533页

作者： Asim Riaz Muhammad Umair Ali t.Gabriel Enge takuya tsuzuki adrian Lowe Wojciech Lipinski Research School of Electrical Energy and Materials EngineeringThe Australian National UniversityCanberra ACT 2601Australia Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing 100871China Research School of Earth Sciences The Australian National UniversityCanberra ACT 2601Australia

the effects of V and Ce concentrations(each varying in the 0-100%range)in vanadia-ceria multiphase systems are investigated for synthesis gas production via thermochemical redox cycles of CO_(2) and H_(2)O splitting coupled to methane partial oxidation *** oxidation of prepared oxygen carriers is performed by separate and sequential CO_(2) and H_(2)O splitting *** and chemical analyses of the mixed-metal oxides revealed important information about the Ce and V interactions affecting their crystal phases and redox *** CeO_(2) and pure V_(2)O_(5) are found to offer the lowest and highest oxygen exchange capacities and syngas production performance,*** mixed-oxide systems provide a balanced performance:their oxygen exchange capacity is up to 5 times higher than that of pure CeO_(2) while decreasing the extent of methane *** addition of 25%V to CeO_(2) results in an optimum mixture of CeO_(2) and CeVO4 for enhanced CO_(2) and H_(2)O *** higher V concentrations,cyclic carbide formation and oxidation result in a syngas yield higher than that for pure CeO_(2).

关键词： pure methane splitting

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Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer

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World Journal of Gastroenterology 2018年第32期24卷 3583-3616页

作者： Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina tǎan adrian Goldis Department of Internal Medicine I University Medical ClinicUniversity of Medicine and Pharmacy"Victor Babes"Timisoara 300041Timis CountyRomania Department of Surgery X 1st Surgery ClinicUniversity of Medicine and Pharmacy"Victor Babes"Timisoara 300041Timis CountyRomania Department of Pathology University of Medicine and Pharmacy"Victor Babes"Timisoara 300041Timis CountyRomania Department of Gastroenterology and Hepatology University of Medicine and Pharmacy"Victor Babes"Timisoara 300041Timis CountyRomania

Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. the use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. these data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects.

关键词： immunotherapy prognostic significance tumor immune microenvironment immune checkpoint inhibitors gastric cancer

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NF-κB激活蛋白2(NAP2)诱导白细胞介素-12分泌的研究

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细胞与分子免疫学杂志 2003年第4期19卷 403-405页

作者：杨敏刘娜 adrian t tING 第四军医大学基础部生物化学与分子生物学教研室陕西西安710032 美国西奈山医学院免疫学系美国纽约10029

目的 :研究新克隆的编码NF κB激活蛋白 2 (NAP2 )基因的功能及作用机制。方法 :采用NF κB和IL 12启动子荧光素酶报告质粒及胞质内IL 12染色法 ,观察NAP2基因产物在巨噬细胞中对NF κB、IL 12启动子的激活及对IL 12合成的调控。结果 :N... 详细信息

目的 :研究新克隆的编码NF κB激活蛋白 2 (NAP2 )基因的功能及作用机制。方法 :采用NF κB和IL 12启动子荧光素酶报告质粒及胞质内IL 12染色法 ,观察NAP2基因产物在巨噬细胞中对NF κB、IL 12启动子的激活及对IL 12合成的调控。结果 :NAP2可激活NF κB和IL 12启动子 ,而IκBαDN则可抑制他们的活化。在巨噬细胞系J774中 ,NAP2也可诱导IL 12表达。结论 :NAP2基因产物可激活IL 12启动子并诱导IL 12的合成 ,提示NAP2可能是通过调控NF κB转录因子而调节IL

关键词： NAP2 白细胞介素—12 NF—κB

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A techno-economic and life cycle assessment for the production of green methanol from CO_(2): catalyst and process bottlenecks

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Journal of Energy Chemistry 2022年第5期31卷 255-266页

作者： tomas Cordero-Lanzac adrian Ramirez Alberto Navajas Lieven Gevers Sirio Brunialti Luis MGandía Andrés t.Aguayo S.Mani Sarathy Jorge Gascon Department of Chemical Engineering University of the Basque Country(UPV/EHU)PO Box 64448080 BilbaoSpain King Abdullah University of Science and technology KAUST Catalysis Center(KCC)Advanced Catalytic MaterialsThuwal 23955Saudi Arabia Department of Science Public University of Navarre(UPNA)Arrosadía Campus s/n31006 PamplonaSpain Institute for Advanced Materials and Mathematics(InaMat2) Universidad Pública de Navarra(UPNA)Edificio Jerónimo de AyanzCampus de ArrosadiaPamplona-Iruña 31006Spain King Abdullah University of Science and technology Clean Combustion Research Center(CCRC)Thuwal 23955Saudi Arabia

the success of catalytic schemes for the large-scale valorization of CO_(2) does not only depend on the development of active,selective and stable catalytic materials but also on the overall process *** we present a multidisciplinary study(from catalyst to plant and techno-economic/lifecycle analysis)for the production of green methanol from renewable H2 and CO_(2).We combine an in-depth kinetic analysis of one of the most promising recently reported methanol-synthesis catalysts(InCo)with a thorough process simulation and techno-economic *** then perform a life cycle assessment of the simulated process to gauge the real environmental impact of green methanol production from CO_(2).Our results indicate that up to 1.75 ton of CO_(2) can be abated per ton of produced methanol only if renewable energy is used to run the process,while the sensitivity analysis suggest that either rock-bottom H2 prices(1.5$kg1)or severe CO_(2) taxation(300$per ton)are needed for a profitable methanol ***,we herein highlight and analyze some critical bottlenecks of the *** attention has been paid to the contribution of H2 to the overall plant costs,CH4 trace formation,and purity and costs of raw *** addition to providing important information for policy makers and industrialists,directions for catalyst(and therefore process)improvements are outlined.

关键词： CO_(2) Methanol Kinetic modeling Process simulation Life cycle assessment

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Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis

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World Journal of Hepatology 2021年第11期13卷 1512-1533页

作者： Yunxia Ma Miljana Nenkov Yuan Chen adrian t Press Elke Kaemmerer Nikolaus Gassler Section Pathology Institute of Forensic MedicineJena University HospitalFriedrich Schiller University JenaJena 07747Germany Department of Anesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care Jena University HospitalFriedrich Schiller University JenaJena 07747Germany Department of Pediatrics Jena University HospitalFriedrich Schiller University JenaJena 07747Germany

Fatty acids are energy substrates and cell components which participate in regulating signal transduction,transcription factor activity and secretion of bioactive lipid *** acyl-CoA synthetases(ACSs)family containing 26 family members exhibits tissue-specific distribution,distinct fatty acid substrate preferences and diverse biological *** evidence indicates that dysregulation of fatty acid metabolism in the liver-gut axis,designated as the bidirectional relationship between the gut,microbiome and liver,is closely associated with a range of human diseases including metabolic disorders,inflammatory disease and carcinoma in the gastrointestinal tract and *** this review,we depict the role of ACSs in fatty acid metabolism,possible molecular mechanisms through which they exert functions,and their involvement in hepatocellular and colorectal carcinoma,with particular attention paid to long-chain fatty acids and small-chain fatty ***,the liver-gut communication and the liver and gut intersection with the microbiome as well as diseases related to microbiota imbalance in the liver-gut axis are ***,the development of potentially therapeutic small molecules,proteins and compounds targeting ACSs in cancer treatment is summarized.

关键词： Long-chain fatty acids Short-chain fatty acids Acyl-CoA synthetases Microbiota Liver-gut axis

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