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Toward implantable devices for angle-sensitive,lens-less,multifluorescent,single-photon lifetime imaging in the brain using Fabry-Perot and absorptive color filters

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Light(Science & Applications) 2022年第2期11卷 197-211页

作者： adriaan j.taal Changhyuk Lee jaebin Choi Björn Hellenkamp Kenneth L.Shepard Columbia University-Department of Electrical Engineering 500W.120th St.Mudd 1310New York 10027 NYUSA Korea Institute of Science and Technology-Brain Science Institute 5 Hwarang-ro 14-gilSeongbuk-guSeoul 02792Republic of Korea

Implantable image sensors have the potential to revolutionize *** to their small form factor requirements;however,conventional filters and optics cannot be *** limitations obstruct highresolution imaging of large neural *** advances in angle-sensitive image sensors and single-photon avalanche diodes have provided a path toward ultrathin lens-less fluorescence imaging,enabling plenoptic sensing by extending sensing capabilities to include photon arrival time and incident angle,thereby providing the opportunity for separability of fluorescence point sources within the context of light-field microscopy(LFM).However,the addition of spectral sensitivity to angle-sensitive LFM reduces imager resolution because each wavelength requires a separate pixel ***,we present a 1024-pixel,50μm thick implantable shank-based neural imager with color-filtergrating-based angle-sensitive *** angular-spectral sensitive front end combines a metal–insulator–metal(MIM)Fabry–Perot color filter and diffractive optics to produce the measurement of orthogonal light-field information from two distinct colors within a single *** result is the ability to add independent color sensing to LFM while doubling the effective pixel *** implantable imager combines angular-spectral and temporal information to demix and localize multispectral fluorescent *** this initial prototype,this is demonstrated with 45μm diameter fluorescently labeled beads in scattering *** lifetime imaging is exploited to further aid source separation,in addition to detecting pH through lifetime changes in fluorescent *** these initial fluorescent targets are considerably brighter than fluorescently labeled neurons,further improvements will allow the application of these techniques to in-vivo multifluorescent structural and functional neural imaging.

关键词： filters lifetime angle

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Outcome of direct-acting antiviral treatment for patients with chronic hepatitis C virus infection: clinical benefit proven?

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 257-259页

作者： Raoel Maan adriaan j.van der Meer Department of Gastroenterology and Hepatology Erasmus MC University Medical Center RotterdamRotterdamthe Netherlands

The highly effective direct-acting antivirals(DAAs)for the treatment of chronic hepatitis C virus(HCV)infection were well-received by both patients and physicians as sustained virological response(SVR)was associated with an improved overall survival in patients with stable liver disease,even in case of cirrhosis(1).Yet,at that time these results were derived from retrospective cohort studies with long-term follow-up after interferon-based *** patients with compensated liver disease there is confidence that SVR is a clinically relevant endpoint based on consistent positive results with smart use of statistics in numerous cohort ***,however,there remains a need for long-term follow-up data showing a clinical benefit of DAA-induced SVR,preferably with high-quality prospective *** results from the French ANRS CO22 Hepather cohort,as published by *** and colleagues in the April issue of the Lancet,thus bring an important contribution to the field(2).It’s the first prospective cohort study with reasonable follow-up time to assess all-cause mortality after DAA therapy.

关键词： patients infection clinical

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Hepatocellular carcinoma (HCC) risk stratification after virological cure for hepatitis C virus (HCV)-induced cirrhosis: time to refine predictive models

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 385-387页

作者： Raoel Maan adriaan j.van der Meer Department of Gastroenterology and Hepatology Erasmus MC University Medical Center RotterdamRotterdamThe Netherlands

Direct-acting antivirals(DAAs)have revolutionized antiviral treatment for chronic hepatitis C virus(HCV)infection,especially with the interferon-free regimens of the past 5 *** a cure for a virus that has been identified(only)30 years ago is unique in medical ***,even in case of advanced liver disease,cohort studies showed that patients attaining a sustained virological response(SVR)have a 3-to 4-fold reduced risk of hepatocellular carcinoma(HCC)(1-3).

关键词： sustained interferon hepatitis

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Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review

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World journal of Gastroenterology 2016年第40期22卷 9012-9021页

作者： Berrie Meijer Chris jj Mulder Godefridus j Peters adriaan A van Bodegraven Nanne KH de Boer Department of Gastroenterology and Hepatology VU University Medical Center Department of Medical Oncology VU University Medical Center Department of Gastroenterology Geriatrics Internal and Intensive Care Medicine (Co-MIK) Zuyderland Medical Center

AIM To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease(IBD) patients, irrespective of the(hepato-) toxicity *** A systematic literature search of the MEDLINE database using Pub Med was performed using the keywords "thioguanine", "6-TG", "thioguanine", "inflammatory bowel disease", "IBD", "Crohn's disease", "Ulcerative colitis" and "effectiveness" in order to identify relevant articles published in English starting from 2000. Reference lists of the included articles were crosschecked for missing articles. Reviewed manuscripts concerning the effectiveness of thioguanine treatment in IBD were reviewed by the authors and the data were extracted. Data were subsequently analyzed with descriptive statistics. Due to the lack of standardized outcomes, a formal meta-analysis was not *** A total of 11 applicable studies were found that involved the effectiveness of thioguanine therapy in IBD. Eight studies were conducted in a prospectivemanner, in the remaining three studies, data was collected retrospectively. In total, 353 IBD-patients(225 patients with Crohn's disease, 119 with ulcerative colitis and nine with unclassified IBD) with prior azathioprine/mercaptopurine resistance and/or intolerance(n = 321) or de novo thioguanine administration(n = 32) were included for analysis, of which 228(65%) had clinical improvement on thioguanine therapy, based on standard IBD questionnaires, biochemical parameters or global physician assessments. Short-term results were based on 268 treatment years(median follow-up 9 mo, range 3-22 mo) with a median daily dose of 20 mg(range 10-80 mg). Discontinuation, mostly due to adverse events, was reported in 72 patients(20%). CONCLUSION The efficacy of thioguanine therapy in IBD patients intolerant to conventional thiopurine therapy is observed in 65%, with short term adverse events in 20% of patients.

关键词： Thiopurines Thioguanine Inflammatory bowel disease Crohn’s disease Ulcerative colitis

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Can liver stiffness measurement accurately predict disease progression and clinical outcome in patients with metabolic dysfunction-associated steatotic liver disease and bridging fibrosis or cirrhosis?

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 912-915页

作者： Diederick j.van Doorn adriaan G.Holleboom R.Bart Takkenberg joanne Verheij Marten A.Lantinga Department of Gastroenterology and Hepatology Amsterdam UMCUniversity of AmsterdamAmsterdam Gastroenterology Endocrinology MetabolismAmsterdamThe Netherlands Department of Vascular Medicine Internal MedicineAmsterdam UMCUniversity of AmsterdamAmsterdam Gastroenterology Endocrinology MetabolismAmsterdamThe Netherlands Department of Hepatopancreatobiliary Pathology Amsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands

Diederick *** Doorn1,adriaan ***2,*** Takkenberg1,joanne Verheij3,Marten ***11Department of Gastroenterology and Hepatology,Amsterdam UMC,University of Amsterdam,Amsterdam Gastroenterology Endocrinology Metabolism,Amsterdam,The Netherlands;2Department of Vascular Medicine,Internal Medicine,Amsterdam UMC,University of Amsterdam,Amsterdam Gastroenterology Endocrinology Metabolism,Amsterdam,The Netherlands;3Department of Hepatopanc Metabolic dysfunction-associated steatotic liver disease(MASLD)-until recently termed non-alcoholic fatty liver disease(NAFLD)-is a rising cause of chronic liver disease with an estimated global prevalence of 30%(1).

关键词： Cirrhosis liver stiffness steatotic liver disease

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SOIL CARBON CHECK:A TOOL FOR MONITORING AND GUIDING SOIL CARBON SEQUESTRATION IN FARMER FIELDS

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Frontiers of Agricultural Science and Engineering 2023年第2期10卷 248-261页

作者： jan adriaan REIjNEVELD Martijn jasper van OOSTRUM Karst Michiel BROLSMA Oene OENEMA Eurofins International Agro Competence Center Binnenhaven 56709 PD Wageningenthe Netherlands Wageningen Environmental Research Wageningen University&ResearchP.O.Box 476700 AA Wageningenthe Netherlands

In 2015,17 Sustainable Development Goals(SDGs)were approved,including SDG13,which addresses actions to increase carbon capture(CO_(2)-C storage)for climate change ***,no analytical procedures have been defined for quantifying soil organic carbon(SOC)*** paper presents a rapid tool for guiding farmers and for monitoring SOC sequestration in farmer *** tool consists of multiconstituent soil analyses through near-infrared spectroscopy(NIRS)and an SOC mineralization *** tool provides forecasts of SOC sequestration over *** analyses by NIRS have been calibrated and validated for farmer fields in European countries,China,New Zealand,and *** indicate a high accuracy of determination for SOC(R^(2)≥0.93),and for inorganic C,soil texture,and soil bulk *** oxidizable soil C is used as proxy for active SOC,to detect early management-induced changes in SOC contents,and is also quantified by NIRS(R^(2)=0.92).A pedotransfer function is used to convert the results of the soil analyses to SOC sequestration in kg·ha^(-1)C as well as CO_(2).In conclusion,the tool allows fast,quantitative,and action-driven monitoring of SOC sequestration in farmer fields,and thereby is an essential tool for monitoring progress of SDG13.

关键词： 4 per 1000 initiative carbon sequestration climate action farmer fields SDG13 soil organic carbon soil testing

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Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population

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World journal of Gastroenterology 2008年第20期14卷 3183-3187页

作者： Muhammed Hadithi Marcel Cazemier Gerrit A Meijer Elisabeth Bloemena Richel j Felt-Bersma Chris j Mulder Stephan GM Meuwissen Amado Salvador Pea adriaan A van Bodegraven Department of Gastroenterology VUmcUniversity Medical Center Department of Pathology VUmc University MedicalCenter

AIM： To describe the characteristics of Dutch patients with *** bowel disease （IBD） first diagnosed above 60 years of age-a disease also known as old-age colitis （OAC） and to highlight a condition that has a similar appearance to IBD, namely segmen- tal colitis associated with diverticular disease （SCAD）. METHODS： A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years. RESULTS： Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 （50） [median age 82 years （range 64-101）; 25 male （42%）] were identified. These patients were diagnosed with ulcerative colitis （n = 37, 61%）, Crohn＇s disease （n = 14, 24%）, and indeterminate colitis （n = 8, 15%）. Remission was induced in 40 （68%） patients within a median interval of 6 mo （range 1-21） and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five （8%） patients. CONCLUSION： OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical features suggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli.

关键词： Inflammatory bowel disease Old-age colitis Segmental colitis

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Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the MR CLEAN Registry

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Stroke & Vascular Neurology 2021年第4期6卷 572-580,I0037-I0048页

作者： Luuk Dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart j Emmer Ivo G H jansen Maxim j H L Mulder Robin Lemmens Robert-jan B Goldhoorn Marieke j H Wermer jelis Boiten Geert j LycklamaàNijeholt Yvo B W E M Roos adriaan C G M van Es Hester F Lingsma Diederik W j Dippel Wim H van Zwam Robert j van Oostenbrugge Ido R van den Wijngaard on behalf of the MR CLEAN Registry investigators Neurology Leiden University Medical CentreLeidenThe Netherlands Neurology Erasmus MCRotterdamThe Netherlands Public Health Erasmus MCRotterdamThe Netherlands Neurology Maastricht University Medical Centre+MaastrichtThe Netherlands Radiology and Nuclear Medicine Amsterdam University Medical CentreLocation AMCAmsterdamThe Netherlands Neurology University Hospitals LeuvenLeuvenBelgium Neurosciences Experimental Neurology and Leuven Brain InstituteUniversity of LeuvenLeuvenBelgium VIB Center for Brain&Disease ResearchLaboratory of NeurobiologyLeuvenBelgium Neurology Haaglanden Medical CentreDen HaagThe Netherlands Radiology Haaglanden Medical CentreDen HaagThe Netherlands Neurology Amsterdam University Medical CentreLocation AMCAmsterdamThe Netherlands Radiology Leiden University Medical CentreLeidenThe Netherlands Radiology Maastricht University Medical Centre+MaastrichtThe Netherlands

Background Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen ***,outcomes after EVT in these late window patients without perfusion imaging are largely *** assessed their characteristics and outcomes in routine clinical *** The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and *** perfusion was no standard imaging *** used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified Rankin Scale(mRS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous *** included 3-month mRS score,functional independence(defined as mRS 0-2),and *** Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQR 6.9-10.6),of whom 93(87.7%)had unknown time of stroke *** perfusion was not performed in 87/106(80.2%)late window *** window patients were younger(mean 67 vs 70 years,pjusted common OR for 1 point improvement in mRS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/C

关键词： treatment beyond Registry

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Clinical nutrition in the hepatogastroenterology curriculum

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World journal of Gastroenterology 2016年第5期22卷 1729-1735页

作者： Chris jj Mulder Geert jA Wanten Carol E Semrad Palle B jeppesen Hinke M Kruizenga Nicolette j Wierdsma Matthijs E Grasman adriaan A van Bodegraven Department of Gastroenterology and Hepatology VU University Medical Center Amsterdam1007 MD AmsterdamThe Netherlands Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Center6500 HB NijmegenThe Netherlands Department of Medicine GI Section The University of ChicagoChicagoIL 60637United States Department of Medical Gastroenterology Rigshospitalet University Hospital of Copenhagen2100 KHB CopenhagenDenmark Department of Dietetic VU University Medical Center Amsterdam1081 HZ AmsterdamThe Netherlands Department of Internal Medicine Gastroenterologyand GeriatricsORBIS Medical Center6130 MB Sittard-GeleenThe Netherlands

Gastroenterology(GE) used to be considered a subspecialty of internal medicine. Today, GE is generally recognized as a wide-ranging specialty incorporating capacities, such as hepatology, oncology and interventional endoscopy, necessitating GEexpert differentiation. Although the European Board of Gastroenterology and Hepatology has defined specific expertise areas in Advanced endoscopy, hepatology, digestive oncology and clinical nutrition, training for the latter topic is lacking in the current hepatogastroenterology(HGE) curriculum. Given its relevance for HGE practice, and being at the core of gastrointestinal functioning, there is an obvious need for training in nutrition and related issues including the treatment of disease-related malnutrition and obesity and its associated metabolic derangements. This document aims to be a starting point for the integration of nutritional expertise in the HGE curriculum, allowing a central role in the management of malnutrition and obesity. We suggest minimum endpoints for nutritional knowledge and expertise in the standard curriculum and recommend a focus period of training in nutrition issues in order to produce well-trained HGE specialists. This article provides a road map for the organization of such a training program. We would highly welcome the World Gastroenterology Organisation, the European Board of Gastroenterology and Hepatology, the American Gastroenterology Association and other(inter)national Gastroenterology societies support the necessary certifications for this item in the HGE-curriculum.

关键词： Gastroenterology Training Clinical nutrition Malnutrition Metabolism Curriculum Targeted therapy Enteral feeding Parenteral feeding Obesity

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万桥园

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建筑学报 2011年第8期 40-41页

作者： adriaan Geuze 王晓京(译) 张广源(摄影) 荷兰West8城市规划与景观设计事务所 West 8城市规划与景观设计事务所

一座园林就是一个故事,像一首诗、一部小说。万桥园就像是一段人生,一段旅程,有许多未知甚至坎坷,也有许多欢乐和荣耀。万桥园的设计带你走过这一段蜿蜒的人生之路,就像穿过一座充满惊奇的迷宫,它将带领你穿越自然,跨过万座桥梁。

关键词：园林设计建筑万桥园设计理念

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