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Colorectal cancer screening and surveillance in patients with inflammatory bowel disease in 2021

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World Journal of Gastroenterology 2022年第5期28卷 502-516页

作者： Jose Maria Huguet luis ferrer-Barceló Patrícia Suárez Eva Sanchez Jose David Prieto Victor Garcia Javier Sempere Department of Digestive Disease General University Hospital of ValenciaValencia 46014Spain

The detection of dysplasia in patients with inflammatory bowel disease(IBD)continues to be important given the increased risk of colorectal cancer in this ***,in 2017,we performed a review and update of the recommendations for the management and follow-up of patients with IBD based on the clinical practice guidelines of various scientific *** present manuscript focuses on new aspects of the detection,follow-up,and management of dysplasia according to the latest studies and *** chromoendoscopy with targeted biopsy continues to be the technique of choice for the screening and detection of dysplasia in IBD,the associated difficulties mean that it is now being compared with other techniques(virtual chromoendoscopy),which yield similar results with less technical ***,the emergence of new endoscopy techniques that are still being researched but seem promising(e.g.,confocal laser endomicroscopy and full-spectrum endoscopy),together with the development of devices that improve endoscopic visualization(e.g.,Endocuff Vision),lead us to believe that these approaches can revolutionize the screening and follow-up of dysplasia in patients with ***,further studies are warranted to define the optimal follow-up strategy in this patient population.

关键词： Colitis surveillance Colitis screening Chromoendoscopy Colorectal cancer Inflammatory bowel disease Ulcerative colitis

Catch per unit effort-environmental variables relations in the fishery of white shrimp(Litopenaeus schmitti)from the Gulf of Venezuela

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Agricultural Sciences 2013年第6期4卷 83-90页

作者： Angel Antonio Díaz Lugo Orlando José ferrer Montano Rodolfo Alvarez luis González Jesús Méndez Manuel Corona Instituto nacional de Investigaciones Agropecuarias(InIA) Punto FijoVenezuela Departamento de Biología Universidad del ZuliaMaracaiboVenezuela Instituto Socialista de la Pesca y la Acuicultura(InSOPESCA) CaracasVenezuela

During 15 months the white shrimp (Litopenaeus schmitti) fishing zone was characterized ecologically through the obtaining, compilation and analysis of environmental and physicochemical variables, and modeled the distribution of the relative abundance (CPUE) obtained in 21 fishing sites according to the environmental structure defined by the studied variables. A two-way factorial AnOVA with interaction was used to examine the spatial (fishing sites) and temporal (months) dynamics of CPUE, and a principal component analysis (PCA) was used to discern the environmental structure of the study area. To determine if the environmental structure modeled the distribution of white shrimp, the CPUE values were superimposed on maps of the study area showing strata of the most important physicochemical variables identified by PCA. AnOVA confirmed that the CPUE differed significantly among months (F = 15.6;GL = 11;P P = 0.1979);the interaction term was also not significant (F = 0.52;GL = 10;P = 0.8561). The superimposing of the CPUE on temperature and depth strata confirmed that white shrimp showed greater preference for intermediate temperatures and depths. Petróleos de Venezuela, S.A (PDVSA) contemplates the construction of a multiuse pipeline traversing the study area, by which the current environmental structure of the study area is prone to disturbance. Given the precedent effects represented by an aqueduct construction, it seems PDVSA should anticipate measures to minimize its impact on the fisheries of the zone, particularly on the white shrimp fishery.

关键词： Distribution CPUE Litopenaeus schmitti Gulf of Venezuela

Precision medicine in sepsis and septic shock:From omics to clinical tools

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World Journal of Critical Care Medicine 2022年第1期11卷 1-21页

作者： Juan Carlos Ruiz-Rodriguez Erika P Plata-Menchaca luis Chiscano-Camón Adolfo Ruiz-Sanmartin Marcos Pérez-Carrasco Clara Palmada Vicent Ribas Mónica Martínez-Gallo Manuel hernández-González Juan J Gonzalez-Lopez nieves Larrosa Ricard ferrer Intensive Care Department Vall d’Hebron Hospital UniversitariVall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Shock Organ Dysfunction and Resuscitation Research GroupVall d’Hebron Institut de Recerca(VHIR)Vall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Departament de Medicina Universitat Autònoma de BarcelonaBellaterra 08193Spain Department of Intensive Care Hospital Clínic de BarcelonaBarcelona 08036Spain Data Analytics in Medicine Digital Health UnitEurecatCentre Tecnològic de CatalunyaBarcelona 08005Spain Immunology Division Vall d’Hebron Hospital UniversitariVall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Diagnostic Immunology Research Group Vall d’Hebron Institut de Recerca(VHIR)Vall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Department of Cell Biology Physiology and ImmunologyUniversitat Autònoma de BarcelonaBellaterra 08193Spain Department of Clinical Microbiology Vall d’Hebron Hospital UniversitariVall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Department of Microbiology and Genetics Universitat Autònoma de BarcelonaBellaterra 08193Spain

Sepsis is a heterogeneous disease with variable clinical course and several clinical *** it is associated with an increased risk of death,patients with this condition are candidates for receipt of a very well-structured and protocolized *** patients should receive the fundamental pillars of sepsis management,which are infection control,initial resuscitation,and multiorgan ***,specific subgroups of patients may benefit from a personalized approach with interventions targeted towards specific pathophysiological ***,we will review the framework for identifying subpopulations of patients with sepsis,septic shock,and multiorgan dysfunction who may benefit from specific *** of these approaches are still in the early stages of research,while others are already in routine use in clinical practice,but together will help in the effective generation and safe implementation of precision medicine in sepsis.

关键词： Sepsis Septic shock Organ dysfunction Precision medicine Biomarkers Phenotype Endotype

Co-occurrence of germline pathogenic variants for different hereditary cancer syndromes in patients with Lynch syndrome

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Cancer Communications 2021年第3期41卷 218-228页

作者： Rosario ferrer-Avargues Maria Isabel Castillejo Estela Damaso Virginia Diez-Obrero noemi Garrigos Tatiana Molina Alan Codoner-Alejos Angel Segura Ana Beatriz Sanchez-Heras Adela Castillejo Jose luis Soto Foundation for the Promotion of Health and Biomedical Research of Valencia Region(FISABIO) FISABIO-Elche Health DepartmentElche 032303Spain Molecular Genetics Unit.Elche University Hospital Elche 032303Spain Department of Molecular Biopathology Immunological Center of AlicanteSan Juan-Alicante 03550Spain Medical Oncology Department Cancer Genetic Counseling Unit.La Fe University HospitalValencia 46026Spain Medical Oncology Department Cancer Genetic Counseling Unit.Elche University HospitalElche 03203Spain

Background:Lynch syndrome(LS)is a hereditary condition characterized by a high risk of colorectal cancer,endometrial cancer,and other neoplasia associated with germline alterations in DnA mismatch repair *** classical genetic diagnostic strategy for LS consists of the Sanger sequencing of genes associated with the suspected ***-generation sequencing(nGS)enables the simultaneous sequencing of a large number of hereditary cancer ***,we aimed to study whether other germline pathogenic variants of hereditary cancer genes are present in patients with ***:A cohort of 84 probands with a previous genetic diagnosis of LS by Sanger sequencing was reanalyzed using nGS via a commercial panel of 94 hereditary cancer genes by hybrid *** American College of Medical Genetics and Genomics criteria were used to classify the clinical significance of the *** findings of nGS were confirmed by Sanger *** possible,genetic analyses of the new findings in the proband’s relativeswere also performed by Sanger ***:We identified five families(6%),out of 84,with at least two germline pathogenic variants conferring to high or moderate risk in different dominant cancer-predisposing genes:[MLH1-BRCA2-nBn],[MLH1-BRCA1],[MSH2-ATM],[MSH6-nF1],and[MLH1-FAnCA].Interestingly,only one out of these five families exhibited a clinical phenotype associated with the new pathogenic *** family with three pathogenic variants of the[MLH1-BRCA2-nBn]genes showed a high aggregation of tumors associated with LS and breast and ovarian cancer ***:Our results showed that the co-occurrence of more than one pathogenic variant in cancer-predisposing genes was remarkable among cases of *** cases,no clinicial manifestations were associated with the secondary pathogenic *** studies are needed to confirm these findings and elucidate their clinical *** of LS families should be considered only in fa

关键词： cancer panel hereditary cancer lynch syndrome moderate penetrance genes multilocus inherited neoplasia alleles syndrome next-generation sequencing secondary findings

Endoscopic recommendations for colorectal cancer screening and surveillance in patients with inflammatory bowel disease:Review of general recommendations

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World Journal of Gastrointestinal Endoscopy 2017年第6期9卷 255-262页

作者： Jose María Huguet Patricia Suárez luis ferrer-Barceló Lucía Ruiz Ana Monzó Ana Belén Durá Javier Sempere Digestive Disease Department General University Hospital of Valencia46014 ValenciaSpain

Screening for colorectal cancer(CRC) in patients with inflammatory bowel disease(IBD) is recommended by all scientific societies. However, there are differences in the recommendations they make regarding screening and surveillance. We address a series of questions that come up in the daily clinical practice of a physician. The first two questions that are raised are:(1) Who should be offered screening for CRC? and(2) When should the first colonoscopy be performed? The next step is to decide who should undergo endoscopic surveillance and at what intervals they should be performed. Chromoendoscopy is emerging as the recommended endoscopic technique for screening and surveillance. The terminology for describing lesions detected with endoscopy is also changing. The management of visible lesions or non-visible dysplasia is also a motive for the review. We end the review by addressing the followup for endoscopically resected lesions. These questions often cannot be answered easily due to the varying degrees of evidence available; therefore, we have made some general recommendations based on those made by the various guidelines and consensuses. The first screening colonoscopy should be offered 8 years after a IBD diagnosis and we recommend that patients be stratified according to the individual risk for each for endoscopic surveillance intervals.

关键词： Colitis surveillance Colitis screening Chromoendoscopy Colorectal cancer Inflammatory bowel disease

Diagnostic-therapeutic management of bile duct cancer

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World Journal of Clinical Cases 2019年第14期7卷 1732-1752页

作者： José María Huguet Miriam Lobo José Mir Labrador Carlos Boix Cecilia Albert luis ferrer-Barceló Ana B Durá Patricia Suárez Isabel Iranzo Mireia Gil-Raga Celia Baez de Burgos Javier Sempere Digestive Disease Department General University Hospital of ValenciaValencia 46014Spain Medical Oncology Department General University Hospital of ValenciaValencia 46014Spain Unidad Hepática Avanzada Servicio de Cirugía General y DigestivaGeneral University Hospital of ValenciaValencia 46014Spain Medical Oncology Department Hospital de RequenaRequena 46340Spain

Biliary tract cancer, or cholangiocarcinoma, comprises a heterogeneous group of malignant tumors that can emerge at any part of the biliary tree. This group is the second most common type of primary liver cancer. Diagnosis is usually based on symptoms, which may be heterogeneous, and nonspecific biomarkers in serum and biopsy specimens, as well as on imaging techniques. Endoscopy-based diagnosis is essential, since it enables biopsy specimens to be taken. In addition, it can help with locoregional staging of distal tumors. Endoscopic retrograde cholangiopancreatography is a key technique for the evaluation and treatment of malignant biliary tumors. Correct staging of cholangiocarcinoma is essential in order to be able to determine the degree of resectability and assess the results of treatment. The tumor is staged based on the TnM classification of the American Joint Committee on Cancer. The approach will depend on the classification of the tumor. Thus, some patients with early-stage disease could benefit from surgery;complete surgical resection is the cornerstone of cure. However, only a minority of patients are diagnosed in the early stages and are suitable candidates for resection. In the subset of patients diagnosed with locally advanced or metastatic disease, chemotherapy has been used to improve outcome and to delay tumor progression. The approach to biliary tract tumors should be multidisciplinary, involving experienced endoscopists, oncologists, radiologists, and surgeons.

关键词： Bile duct cancer Cholangiocarcinoma Management Diagnosis Incidence Multidisciplinary treatment

Endoscopic evaluation of immunotherapy-induced gastrointestinal toxicity

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World Journal of Gastrointestinal Endoscopy 2018年第12期10卷 392-399页

作者： Isabel Iranzo Jose María Huguet Patricia Suárez luis ferrer-Barceló Vega Iranzo Javier Sempere Digestive Disease Department General University Hospital of Valencia Oncology Department General University Hospital of Valencia

Immunotherapy is any treatment aimed at boosting or enhancing the immune system. It includes a wide range of options, from vaccines to treatment for conditions such as allergy and cancer. In the case of cancer, unlike other available treatments, immunotherapy is not aimed at destroying the tumor cells but at stimulating the patient's immune system so that it attacks the tumor. In cancer,immunotherapy provides a series of advantages. nevertheless, immunotherapy administered for treatment of cancer is associated with immune-mediated enterocolitis. Colitis mediated by monoclonal anti-cytotoxic T lymphocyte–associated antigen 4 and to programmed cell death protein 1 and its ligand PDL1 shares characteristics with chronic inflammatory bowel disease(IBD), and similar findings have been reported for both the endoscopy images and the segment involved. The most frequent lesions on endoscopy are ulcer and erythema, and the most frequently affected site is the sigmoid colon. A segmental pattern has been reported to be slightly more frequent than a continuous *** addition, upper gastrointestinal lesions have been reported in up to half of patients, with the most frequent findings being gastritis and erosive *** is the case in IBD, systemic corticosteroids and immunosuppressive treatment(anti-TnF agents) are the approaches used in patients with a more unfavorable progression. Immunotherapy must be suspended completely in some cases.

关键词： Enterocolitis Ipilimumab Immunotherapy Immune-related adverse event nivolumab Toxicity Endoscopy

Screening for colorectal cancer in patients with inflammatory bowel disease. Should we already perform chromoendoscopy in all our patients?

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World Journal of Gastrointestinal Endoscopy 2018年第11期10卷 322-325页

作者： Jose María Huguet Patrícia Suárez luis ferrer-Barceló Isabel Iranzo Javier Sempere Digestive Disease Department Hospital General Universitario de Valencia

Patients with inflammatory bowel disease(commonly known as IBD) have a greater risk of colorectal cancer than the general population. Therefore, they are included in special programs for screening and followup. Chromoendoscopy, which has a high diagnostic yield in the detection of neoplasia, is generally the recommended endoscopy technique. However, this procedure does have some disadvantages(long examination time, need for optimal bowel preparation, specialist training), which increase its cost. How then can we overcome these barriers? First, it is necessary to educate hospital managers and directors of the advantages of chromoendoscopy in patients with IBD. Second, at least one endoscopist per center should be a specialist in the technique. Third, we should train nursing staff in the preparation of the dye. Finally, each examination should be given the time it needs. Even though clinical practice guidelines do not yet recommend the use of virtual imaging techniques such as narrow band imaging, a recent study reported no differences between the two approaches for the detection of tumors. Therefore, we believe that all patients should undergo chromoendoscopy. In the future, centers without access to dyes or where other barriers exist should at least perform narrow band imaging.

关键词： Colorectal Cancer Inflammatory bowel disease Chromoendoscopy Surveillance narrow band imaging

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta ferrer Teresa ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez luis Martín-Villén JoséMolina Aurora Morillo María Dolores navarro-Amuedo Dolores nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain neurology and Clinical neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFn-α).In COVID-19 there is a deficit in DC numbers and IFn-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID