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Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma

World Journal of Gastroenterology 2018年第24期24卷 2537-2554页

作者： Esther Llop Pedro E Guerrero adriàduran Sílvia Barrabés Anna Massaguer María JoséFerri Maite Albiol-Quer Rafael de Llorens Rosa Peracaula Department of Biology Biochemistry and Molecular Biology UnitUniversity of GironaGirona 17003Spain Biomedical Research Institute of Girona(IdIBGi).Parc Hospitalari Martíi Julià-Edifici M2 Salt 17190Spain Clinic Laboratory University Hospital Dr Josep TruetaGirona 17007Spain Department of Surgery Hepato-biliary and Pancreatic Surgery UnitUniversity Hospital Dr Josep TruetaGirona 17007Spain

Pancreatic cancer(Pa C) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers. It focuses on the anomalous glycosylation process and its role in PaC. Glycan structures of glycoconjugates such as glycoproteins are modified in tumors and these modifications can be detected in biological fluids of the cancer patients. Several studies have found serum glycoproteins with altered glycan chains in PaC patients, but they have not shown enough specificity for PaC. To find more specific cancer glycoproteins we propose to analyze the glycan moieties of a battery of glycoproteins that have been reported to increase in PaC tissues and that can also be found in serum. The combination of these new candidate glycoproteins with their aberrant glycosylation together with the existing biomarkers could result in a panel, which would expect to give better results as a new tool for early diagnosis of PaC and to monitor the disease.

关键词： Pancreatic cancer Aberrant glycosylation Glycoproteins Biomarkers Diagnosis

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Patent foramen ovale closure in non-lacunar cryptogenic ischemic stroke:where are we now?

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Journal of Geriatric Cardiology 2021年第1期18卷 67-74页

作者： adriàARBOIX Olga PARRA Josefina ALIÓ Cerebrovascular Division Department of NeurologyHospital Universitari del Sagrat CorUniversitat de BarcelonaBarcelonaCataloniaSpain Department of Pneumology Hospital Universitari del Sagrat CorUniversitat de BarcelonaBarcelonaCataloniaSpain Department of Cardiology Hospital Universitari de BellvitgeL’Hospitalet de LlobregatBarcelonaCataloniaSpain

Patent foram ovale(PFO)is the most common anatomical cause of an interarterial *** is usually asymptomatic but may cause paradoxical embolism and is a risk factor for non-lacunar cryptogenic cerebral ischemia in young *** the first clinical trials did not show a significant superiority of PFO closure in the secondary prevention of cerebral ischemia as compared with standard antithrombotic treatment,six subsequent randomized clinical trials(CLOSURE I,PC Trial,RESPECT,CLOSE,REDUCE,and DEFENSE-PFO)performed in a sample of cryptogenic stroke in patients aged 60 years or younger provided evidence of a significant reduction of recurrent cerebral ischemia after percutaneous PFO ***,the use of percutaneous PFO closure cannot be generalized to the entire population of patients with cerebral ischemia and PFO,but it is indicated in highly selected patients with non-lacunar cryptogenic cerebral infarction with a large right-to-left shunt,an atrial septal aneurysm and no evidence of atrial fibrillation,as well as in association with antithrombotic treatment for an optimal secondary prevention of cerebral ischemia.

关键词： PFO Patent foramen ovale closure in non-lacunar cryptogenic ischemic stroke where are we now

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Using mixed integer programming and airborne laser scanning to generate forest management units

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Journal of Forestry Research 2022年第1期33卷 217-226页

作者： adrián Pascual Sándor FTóth Forest Research Centre School of AgricultureUniversity of LisbonTapada da Ajuda1349-017 LisboaPortugal School of Forest Sciences University of Eastern FinlandP.O.Box 11180101 JoensuuFinland School of Environmental and Forest Sciences University of WashingtonSeattleWAUSA

Airborne laser scanning(ALS)has been widely applied to estimate tree and forest attributes,but it can also drive the segmentation of forest *** algorithms are the dominant technique in segmentation but spatial optimization using exact methods remains *** study presents a novel approach to segmentation based on mixed integer programming to create forest management units(FMUs).This investigation focuses on using raster information derived from ALS *** mainstream clustering algorithms were compared to the new MIP formula that simultaneously accounts for area and adjacency restrictions,FMUs size and homogeneity in terms of vegetation *** optimal problem solution was found when using less than 150 cells,showing the problem formulation is *** results for MIP were better than for the clustering algorithms;FMUs were more compact based on the intravariation of canopy height and the variability in size was *** MIP model allows the user to strictly control the size of FMUs,which is not possible in heuristic optimization and in the clustering algorithms *** definition of forest management units based on remote sensing data is an important operation and our study pioneers the use of MIP ALS-based optimal segmentation.

关键词： Segmentation Precision forestry Optimization Mathematical programming Airborne laser scanning

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On the Maximal Operator Associated with Certain Rotational Invariant Measures

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Acta Mathematica Sinica,English Series 2010年第6期26卷 993-1004页

作者： adrián INFANTE Fernando SORIA Department of Mathematics Universidad Simn Bolívar Department of Mathematics Universidad Autnoma de Madrid

The aim of this work is to investigate the integrability properties of the maximal operator Mu,associated with a non-doubling measure μ defined on Rn. We start by establishing for a wide class of radial and increasing measures μ that Mu is bounded on all the spaces Lu^p（R^n）,P〉***,we show that there is a radial and increasing measure p for which Mμ does not map Lμ^p（R^n） into weak Lμ^p（R^n）,1≤p〈∞.

关键词： maximal operator non-doubling measures

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Cardiovascular risk factors for acute stroke: Risk profiles in the different subtypes of ischemic stroke

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World Journal of Clinical Cases 2015年第5期3卷 418-429页

作者： adrià Arboix Unit of Cerebrovascular Diseases Service of Neurology Hospital Universitari del Sagrat Cor University of Barcelona E-08029 Barcelona Catalonia Spain

Timely diagnosis and control of cardiovascular risk factors is a priority objective for adequate primary and secondary prevention of acute stroke. Hypertension, atrial fibrillation and diabetes mellitus are the most common risk factors for acute cerebrovascular events, although novel risk factors, such as sleep-disordered breathing, inflammatory markers or carotid intima-media thickness have been identified. However, the cardiovascular risk factors profile differs according to the different subtypes of ischemic stroke. Atrial fibrillation and ischemic heart disease are more frequent in patients with cardioembolic infarction, hypertension and diabetes in patients with lacunar stroke, and vascular peripheral disease, hypertension, diabetes, previous transient ischemic attack and chronic obstructive pulmonary disease in patients with atherothrombotic infarction. This review aims to present updated data on risk factors for acute ischemic stroke as well as to describe the usefulness of new and emerging vascular risk factors in stroke patients.

关键词： Cardiovascular risk factors Hypertension Atrial fibrillation Diabetes mellitus Ischemic stroke Transient ischemic attack Sleep apnea

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Liaison between natural killer cells and dendritic cells in human gestation

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Cellular & Molecular Immunology 2014年第5期11卷 449-455页

作者： Ester Leno-duran Instituto de Biopatologfa y Medicina Regenerativa Centro de Investigaci6n Biomedica Universidad de Granada Armilla Granada Spain Instituto deParasitologfa y Biomedicina 'Lopez Neyra' Centro superior de investigaciones cientfficas Armilla Granada spain Hospital Universitario San Cecilio Granada Spain Medicine University of Berlin Charit6 Centre 12 Internal Medicine and Dermatology Berlin Germany These authors contributed equally to this work.

A successful pregnancy relies on immunological adaptations that allow the fetus to grow and develop in the uterus, despite being recognized by maternal immune cells. Among several immunocompetent cell types present within the human maternal/fetal interface, DC-SIGN~ dendritic cells （DCs） and CD56＋ natural killer （NK） cells are of major importance for early pregnancy maintenance, not only generating maternal immunological tolerance but also regulating stromal cell differentiation. Previous reports show the presence of NK-DC cell conjugates in first trimester human decidua, suggesting that these cells may play a role in the modulation of the local immune response within the uterus. While effective immunity is necessary to protect the mother from harmful pathogens, some form of tolerance must be activated to avoid an immune response against fetal antigens. This review article discusses current evidence concerning the functions of DC and NK cells in pregnancy and their liaison in human decidua.

关键词： cross-talk dendritic cells natural killer cells pregnancy

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Using GEDI lidar data and airborne laser scanning to assess height growth dynamics in fast-growing species:a showcase in Spain

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Forest Ecosystems 2021年第1期8卷 182-198页

作者： Juan Guerra-Hernández adrián Pascual 3edata Centro de iniciativas empresariaisFundación CEL.O Palomar s/n27004 LugoSpain Forest Research Centre School of AgricultureUniversity of LisbonTapada da Ajuda1349-017 LisbonPortugal Center for Global Discovery and Conservation Science Arizona State UniversityHiloHA 96720USA

Background:The NASA’s Global Ecosystem Dynamics Investigation(GEDI)satellite mission aims at scanning forest ecosystems on a multi-temporal short-rotation *** GEDI data can validate and update statistics from nationwide airborne laser scanning(ALS).We present a case in the Northwest of Spain using GEDI statistics and nationwide ALS surveys to estimate forest dynamics in three fast-growing forest ecosystems comprising 211,346 *** objectives were:i)to analyze the potential of GEDI to detect disturbances,ii)to investigate uncertainty source regarding non-positive height increments from the 2015–2017 ALS data to the 2019 GEDI laser shots and iii)to estimate height growth using polygons from the Forest Map of Spain(FMS).A set of 258 National Forest Inventory plots were used to validate the observed height ***:The spatio-temporal assessment from ALS surveying to GEDI scanning allowed the large-scale detection of *** mean annual height growths were 0.79(SD=0.63),0.60(SD=0.42)and 0.94(SD=0.75)m for Pinus pinaster,Pinus radiata and Eucalyptus spp.,*** median annual values from the ALS-GEDI positive increments were close to NFI-based growth values computed for Pinus pinaster and Pinus radiata,*** effect of edge border,spatial co-registration of GEDI shots and the influence of forest cover in the observed dynamics were important factors to considering when processing ALS data and GEDI ***:The use of GEDI laser data provides valuable insights for forest industry operations especially when accounting for fast ***,errors derived from positioning,ground finder and canopy structure can introduce uncertainty to understand the detected growth patterns as documented in this *** analysis of forest growth using ALS and GEDI would benefit from the generalization of common rules and data processing schemes as the GEDI mission is increasingly being utilized in the forest remote sensing community.

关键词： Forest inventory Productivity Multi-temporal LiDAR Full-waveform(FW) Satellite mapping

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Combining spatial and economic criteria in tree-level harvest planning

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Forest Ecosystems 2020年第2期7卷 234-246页

作者： Petteri Packalen Timo Pukkala adrián Pascual School of Forest Sciences University of Eastern FinlandPO Box 11180101 JoensuuFinland Forest Research Center School of AgricultureUniversity of LisbonTapada da Ajuda1349-017 LisboaPortugal

Background:Modern remote sensing methods enable the prediction of tree-level forest resource ***,the benefits of using tree-level data in forest or harvest planning is not clear given a relative paucity of *** particular,there is a need for tree-level methods that simultaneously account for the spatial distribution of trees and other *** this study,we developed a spatial tree selection method that considers tree-level(relative value increment),neighborhood related(proximity of cut trees)and global objectives(total harvest).Methods:We partitioned the whole surface area of the stand to trees,with the assumption that a large tree occupies a larger area than a small *** was implemented using a power *** also utilized spatially explicit tree-level growth models that accounted for competition by neighboring *** was conducted with a variant of cellular *** proposed method was tested in stone pine(Pinus pinea L.)stands in Spain where we implemented basic individual tree detection with airborne laser scanning ***:We showed how to mimic four different spatial distributions of cut trees using alternative weightings of objective *** Non-spatial selection did not aim at a particular spatial layout,the Single-tree selection dispersed the trees to be cut,and the Tree group and Clearcut selections clustered harvested trees at different ***:The proposed method can be used to control the spatial layout of trees while extracting trees that are the most economically mature.

关键词： Spatial optimization Tree selection Cellular automata Remote sensing Airborne laser scanning

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Cone Metric Spaces and Fixed Point Theorems in Diametrically Contractive Mappings

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Acta Mathematica Sinica,English Series 2010年第3期26卷 489-496页

作者： duran TURKOGLU Muhib ABULOHA Department of Mathematics Faculty of Science and Arts Gazi University Department of Mathematics Institute of Science and Technology Gazi University

In this paper, some topological concepts and definitions are generalized to cone metric spaces. It is proved that every cone metric space is first countable topological space and that sequentially compact subsets axe compact. Also, we define diametrically contractive mappings and asymptotically diametrically contractive mappings on cone metric spaces to obtain some fixed point theorems by assuming that our cone is strongly minihedral.

关键词： fixed point cone metric space diametrically contractive sequentially compact Lebesgue element totally bounded strongly minihedral

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Stroke and sleep-disordered breathing: A relationship under construction

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World Journal of Clinical Cases 2016年第2期4卷 33-37页

作者： Olga Parra adrià Arboix Service of Pneumology Hospital Universitari del Sagrat CorUniversity of Barcelona Cerebrovascular Division Service of NeurologyUniversity of Barcelona Hospital del Sagrat Cor

The association between sleep-disordered breathing(SDB) and cardiovascular risk has been the focus of attention in recent *** disorders are emerging risk factors for cardiovascular disease and have been related to the whole spectrum of stroke,including transient ischemic attack,ischemic cerebral infarction and intracerebral *** has been shown that lacunar stroke or lacunar infarctions affecting the internal capsule or the protuberance are associated with a higher frequency of *** stroke patients with associated SDB have a worse prognosis and a higher mortality as compared to patients with first-ever stroke without *** studies provide evidence of the usefulness of treatment with continuous positive airway pressure when SDB is present in stroke patients.

关键词： Apnea-hypopnea index Cardiovascular risk factors Continuous positive airway pressure Ischemic stroke Lacunar infarction Sleep disordered

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