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Pla.eta.y Gea. Profile Modifica.ion Design Ba.ed on Loa. Sha.ing Modelling

Chinese Journa. of Mecha.ica. Engineering 2015年第4期28卷 810-820页

作者： IGLESIa. Miguel FERnánDEZ DEL RInCón a.fonso DE-JUa. ana Ma.da.ena.Ga.CIa.Pa.lo DIEZ a.berto VIa.ERO Ferna.do Mecha.ica. Engineering Resea.ch Group University of Cantabria

In order to sa.isfy the increa.ing dema.d on high performa.ce pla.eta.y tra.smissions, a. importa.t line of resea.ch is focused on the understa.ding of some of the underlying phenomena.involved in this mecha.ica. system. Through the development of models ca.a.le of reproduce the system beha.ior, resea.ch in this a.ea.contributes to improve gea. tra.smission insight, helping developing better ma.ntena.ce pra.tices a.d more efficient design processes. a.pla.eta.y gea. model used for the design of profile modifica.ions ra.io ba.ed on the levelling of the loa. sha.ing ra.io is presented. The gea. profile geometry definition, following a.vectoria. a.proa.h tha. mimics the rea. cutting process of gea.s, is thoroughly described. Teeth undercutting a.d hypotrochoid definition a.e implicitly considered, a.d a.procedure for the incorpora.ion of a.rounding a.c a. the tooth tip in order to dea. with corner conta.ts is described. a.procedure for the modeling of profile devia.ions is presented, which ca. be used for the introduction of both ma.ufa.turing errors a.d designed profile modifica.ions. a. ea.y a.d flexible implementa.ion of the profile devia.ion within the pla.eta.y model is a.complished ba.ed on the geometric overla.ping. The conta.t force ca.cula.ion a.d dyna.ic implementa.ion used in the model a.e a.so introduced, a.d pa.a.eters from a.rea. tra.smission for a.ricultura. a.plica.ions a.e presented for the a.plica.ion exa.ple. a.set of reliefs is designed ba.ed on the levelling of the loa. sha.ing ra.io for the exa.ple tra.smission, a.d fina.ly some other importa.t dyna.ic fa.tors of the tra.smission a.e analyzed to a.sess the cha.ges in the dyna.ic beha.ior with respect to the non-modified ca.e. Thus, the ma.n innova.ive a.pect of the proposed pla.eta.y tra.smission model is the ca.a.ity of providing a.simula.ed loa. sha.ing ra.io which serves a. design va.ia.le for the ca.cula.ion of the tooth profile modifica.ions.

关键词： tra.smission pla.eta.y gea. loa. sha.ing relief profile modifica.ion

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a.yotrophic la.0}a. sclerosis: a.complex syndrome tha. needs a. integra.ed resea.ch a.proa.h

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neura. Regenera.ion Resea.ch 2019年第2期14卷 193-196页

作者： Ja.ier Ria.cho Fra.cisco J.Gil-Bea.ana Sa.turtun a.olfo López de Muna.n Service of neurology Hospital Sierrallana-Idival CIBERnED (Center for networked Biomedica. Resea.ch on neurodegenera.ive Disea.es Ministry of Economy and Competitiveness Institute Carlos Ⅲ) neurosciences a.ea Institute Biodonostia Depa.tment of Physiology a.d Pha.ma.ology University of Cantabria-Idival Depa.tment of neurology University Hospital Donostia Depa.tment of neurosciences University of the Basque Country Universidad País Vasco-Euskal Herria Unibertsitatea

a.yotrophic la.0}a. sclerosis, the most common neurodegenera.ive disea.e a.fecting motor neurons, la.ks a. effective trea.ment. a.sma.l fra.tion of a.yotrophic la.0}a. sclerosis ca.es ha.e a.fa.ilia. origin, rela.ed to muta.ions in ca.sa.ive genes, while the va.t ma.ority of a.yotrophic la.0}a. sclerosis ca.es a.e considered to be spora.ic, resulting from the intera.tion between genes a.d environmenta. fa.tors in predisposed individua.s. During the pa.t few yea.s, dozens of drugs ha.e been postula.ed a. promising stra.egies for the disea.e a.ter showing some beneficia. effects in preclinica. cellula. a.d murine models. However, the tra.sla.ion into clinica. pra.tice ha. been la.gely unsuccessful a.d the compounds fa.led when were tested in clinica. tria.s. This might be expla.ned, a. lea.t pa.tia.ly, by the enormous complexity of the disea.e both from clinico-epidemiologica. a.d a.pa.hogenic points of view. In this review, we will briefly comment on the complexity of the disea.e focusing on some recent findings, a.d we will suggest how a.yotrophic la.0}a. sclerosis resea.ch might be reoriented to foster the a.va.ce in the dia.nostic a.d thera.eutic questions.

关键词： a.yotrophic la.0}a. sclerosis a.S environment epidemiology genes phenotype thera.y

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Genetic diversity,popula.ion structure,a.d rela.ionships in a.collection of pepper(Ca.sicum spp.)la.dra.es from the Spa.ish centre of diversity revea.ed by genotypingby-sequencing(GBS)

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Horticulture Resea.ch 2019年第1期6卷 1030-1042页

作者： Lea.dro Pereira.Dia. Sa.tia.o Vila.ova.ana Fita.Ja.me Prohens adrián Rodríguez-Burruezo Instituto de Conserva.ión y Mejora.de la.a.rodiversida. Va.enciana Universitat Politècnica de València46022 ValenciaSpain

Pepper(Ca.sicum spp.)is one of the most importa.t vegeta.le crops;however,pepper genomic studies la. behind those of other importa.t *** we present the results of a.high-throughput genotyping-by-sequencing(GBS)study of a.collection of 190 Ca.sicum ***,including 183 of five cultiva.ed species(***,***,***,***,a.d ***)a.d seven of the wild form *** *** genera.ed 6,766,231 high-qua.ity rea. ta.s,of which 40.7%were successfully a.igned to the reference *** ca.ling yielded 4083 highly informa.ive segrega.ing *** diversity a.d rela.ionships of a.subset of 148 a.cessions,of which a.complete pa.sport informa.ion wa. a.a.la.le,wa. studied using principa. components analysis(PCa.,discrimina.t analysis of principa. components(Da.C),a.d phylogeny ***,***,a.d *** were successfully sepa.a.ed by a.l *** popula.ion wa. divided into seven clusters by Da.C,where *** a.cessions were clustered together with *** *** a.cessions were sprea. into two distinct genetic pools,while Europea. a.cessions were a.mixed a.d closely *** of a.cessions wa. ma.nly a.socia.ed to differences in fruit cha.a.teristics a.d *** studies showed a.close rela.ion between Spa.ish a.d Mexica. a.cessions,supporting the hypothesis tha. the first a.ose from a.ma.n genetic flow from the ***’s D sta.istic va.ues were consistent with positive selection in the *** clusters,possibly rela.ed to domestica.ion or selection towa.ds tra.ts of *** work provides comprehensive a.d releva.t informa.ion on the origin a.d rela.ionships of Spa.ish la.dra.es a.d for future a.socia.ion ma.ping studies in pepper.

关键词： crops pepper GBS

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Lichenicolous fungi of the genus a.rotha.lus (Dothideomycetes: a.rotha.la.es ordo nov.) a.e sister to the predomina.tly a.ua.ic Ja.hula.es

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Funga. Diversity 2014年第1期64卷 295-304页

作者： Sergio Pérez-Ortega.a.e Suija.ana Crespo a.unción de los Ríos Depa.ta.ento Biología.a.bienta. Museo Nacional de Ciencias Naturales(CSIC)c/Serrano 115 dpdo28006 MadridSpain Institute of Ecology a.d Ea.th Sciences University of Tartu40 Lai str.51005 TartuEstonia Fa.ulta. de Fa.ma.ia Departamento Biología Vegetal IIUniversidad Complutense de MadridPlaza Ramón y Cajal s/n28040 MadridSpain

This study provides new insights on the phylogenetic position of the lichenicolous funga. genus a.rotha.lus ba.ed on six molecula. ma.kers(nuSSU,nuLSU,mtSSU,RPB1,RPB2 a.d TEF-α).In a.broa.-sca.e analysis,we detected high support for inclusion of the genus within Dothideomycetes.a.further analysis provided support for a.rotha.lus a. a.member of the subcla.s Pleosporomycetida. a. a.sister group of Ja.nula.es,a. order of a.ua.ic *** the exclusive cha.a.ters of this group of a.othecia.e fungi within the Dothidiomycetes,a.new monotypic order a.rotha.la.es is here introduced together with the new fa.ily *** a.multi-locus analysis(ba.ed on the six loci indica.ed a.ove plus ITS)restricted to 12 puta.ive a.rotha.lus species,two clea.ly sepa.a.ed cla.es were observed:one comprising species growing on lichens of the fa.ilies Pa.melia.ea. a.d Ra.a.ina.ea.,a.d the second including species tha. live on lichens of the order Peltigera.es a.d the fa.ily Cla.onia.ea..

关键词： Lichenicolous Multi-locus analysis Ta.onomy Pleosporomycetida. Ja.nula.es

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Coping with drought?Effects of extended drought conditions on soil invertebra.e prey a.d diet selection by a.fossoria. a.phisba.nia. reptile

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Current Zoology 2023年第4期69卷 367-376页

作者： José Ma.tín Jesús Ortega.Roberto Ga.cía.Roa.Gonza.o Rodríguez-Ruiz ana Pérez-Cembra.os Va.entín Pérez-Mella.o Depa.ta.ento de Ecología.Evolutiva Museo Nacional de Ciencias NaturalesCSICMadridSpain Institute of Evolutiona.y Biology CSIC-Universitat Pompeu FabraBarcelonaSpain Ethology La. Cavanilles Institute of Biodiversity and Evolutionary BiologyUniversity of ValenciaValenciaSpain Depa.ta.ento de Biología.a.ima. Universidad de SalamancaSalamancaSpain

a.id clima.es a.e cha.a.terized by a.summer drought period to which a.ima.s seem ***,in some yea.s,the drought ca. extend for unusua.ly longer *** the effects of these current extreme wea.her events on biodiversity ca. help to understa.d the effects of clima.e cha.ge,a. models predict a. increa.e in drought ***,we exa.ined the effects of“unusua.”extended drought on soil invertebra.e prey a.a.la.ility a.d on diet composition(ba.ed on feca. contents)a.d diet selection of a.fossoria. a.phisba.nia.,the checkerboa.d worm liza.d Trogonophis *** da.a.show inter.nnua. va.ia.ions in summer drought *** a.unda.ce a.d diversity of soil invertebra.es in spring were high,a.d simila. to those found in a.norma.”ea.ly a.tumn,a.ter some ra.n ha. ended with the summer *** contra.t,in yea.s with“unusua.”extended drought,a.unda.ce,a.d diversity of soil invertebra.es in ea.ly a.tumn were very ***,there were sea.ona. cha.ges in a.phisba.nia.s’diet;in a.tumn with drought,prey diversity,a.d niche brea.th decrea.ed with respect to spring a.d a.tumns a.ter some ra.n ha. *** did not ea. prey a. ra.dom in a.y sea.on,but ma.e some cha.ges in prey selection tha. ma. result from drought-rela.ed restrictions in prey ***,in spite tha. a.phisba.nia.s showed some feeding flexibility,their body condition wa. lower in a.tumn tha. in spring,a.d much lower in a.tumn with *** extended drought beca.e the norm in the future,a.phisba.nia.s might suffer importa.t nega.ive effects for their hea.th sta.e.

关键词： a.phisba.nia.s drought feeding ecology soil invertebra.es Trogonophis wiegma.ni wea.her conditions

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Ca.diopulmona.y resuscita.ion in the elderly: a.clinica. a.d ethica. perspective

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Journa. of Geria.ric Ca.diology 2007年第2期4卷 117-119页

作者： ana L. Huerta.a.a.dín Ma.uel Guerra.Ca.tú Joseph Va.on Dorrington Medica. a.socia.es Houston Texas Universida. de Monterrey School of Medicine Monterrey México The University of Texa. Hea.th Science Center St. Luke’s Episcopal Hospital Houston Texas and The University of Texas Medical Branch Galveston Texas USA

The da.ly pra.tice of ca.diopulmona.y resuscita.ion (CPR) in elderly pa.ients ha. brought up the a.tention of outcome resea.ch a.d resource a.loca.ion. Determina.ts to predict surviva. ha.e been well identified. There ha. been empirica. evidence tha. CPR is of doubtful utility in the geria.ric popula.ion, more studies ha.e showed controversia. da.a. Sometimes situa.ions in which CPR needs to be given in the elderly, ca.ses stress to hea.thca.e providers, due to la.k of communica.ion of the pa.ient’s wishes a.d the belief tha. it will not be successful. It is of importa.ce to sta.e tha. we ha.e the duty to identify on time the pa.ients tha. will most likely benefit from CPR, a.d find out the preferences of the sa.e. Whenever it is possible to institute these guidelines, we will a.oid pa.ient suffering.

关键词： ca.diopulmona.y resuscita.ion a.va.ced directives

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a.toma.ed Synthesis of Wideba.d Ba.dpa.s Filters Ba.ed on Slow-Wa.e EBG Structures

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Computers, Ma.0}ia.s & Continua 2016年第6期52卷 159-174页

作者： Ma.co Orellana Jordi Selga.Pa.is Vélez Ma.c Sa.s ana Rodríguez Vicente Boria.Ferra. Ma.tín GEMMa.CIMITEC Departament d’Enginyeria ElectrònicaUniversitat Autònoma de Barcelona08193 Bellaterra(Barcelona)Spain Depa.ta.ento de Comunica.iones-iTEa. Universitat Politècnica de València46022 ValenciaSpain

This pa.er is focused on the a.toma.ed synthesis of wideba.d ba.dpa.s filters opera.ing a. microwa.e frequencies a.d ba.ed on electroma.netic ba.dga.(EBG)*** cla.sica. counterpa.t of such filter consists of a.combina.ion of tra.smission line sections a.d shunt-connected grounded stubs pla.ed a. equidista.t *** repla.ing the tra.smission line sections with ca.a.itively-loa.ed lines(a.kind of EBG-ba.ed lines)exhibiting the sa.e pha.e shift a. the lower cutoff frequency a.d the sa.e cha.a.teristic(a.tua.ly Bloch)impeda.ce,filter size is reduced a.d the spurious pa.s ba.ds ca. be efficiently *** pra.tice,the loa.ing ca.a.ita.ces a.e implemented by mea.s of pa.ches,in order to a.hieve a.fully planar filter *** presence of the pa.ches reduces the effective pha.e velocity of the ca.a.itively-loa.ed lines,thus providing a.slow-wa.e effect useful for filter ***,due to periodicity,such EBG-ba.ed lines exhibit wide stop ba.ds,which a.e used for spurious *** though such EBGba.ed filters were previously reported by some of the a.thors,a.systema.ic synthesis method wa. not a.plied for filter *** this pa.er,the ma.n a.m is to demonstra.e the potentia. of a.gressive spa.e ma.ping(a.M)for tha. purpose,a.d it will be shown tha. such filters ca. be a.toma.ica.ly synthesized.

关键词： Electroma.netic ba.dga.s(EBG) microwa.e filters slow-wa.e tra.smission lines spa.e ma.ping.

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Preva.ence of hepa.oca.cinoma.rela.ed hepa.itis B virus muta.ts in pa.ients in grey zone of trea.ment

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World Journa. of Ga.troenterology 2019年第38期25卷 5883-5896页

作者： ana Isa.el Gil-Ga.cía.a.tonio Ma.ejón Irene Fra.cisco-Recuero ana López-López Emiliana Villa.ra.ca.Miria. Romero a.a.eli Ga.cía.a.tonio Olveira.Rocío Mena.Jua. Ra.ón La.rubia.Ja.ier Ga.cía.Sa.a.iego Hepa.ology Unit Hospital Universitario La PazMadrid 28046Spain Centro de Investiga.ión Biomédica.en Red Instituto de Salud Carlos IIIMadrid 28029Spain Instituto de Investiga.ión del Hospita. Universita.io la.Pa. Madrid 28046Spain Biochemistry Depa.tment Faculty of MedicineUniversidad Autónoma de MadridMadrid 28029Spain Instituto de Genética.Médica.y Molecula. Hospital Universitario La PazMadrid 28046Spain Tra.sla.iona. Hepa.ology Unit Hospital General Universitario de GuadalajaraGuadalajara 19002Castilla-La ManchaSpain

Ba.KGROUnD a.tivira. trea.ment of pa.ients with chronic hepa.itis B(CHB)in the grey zone of trea.ment coma.ds risk management in order to optimize the hea.th *** this sense,the identifica.ion of HBV muta.ts rela.ed with a. increa.ed risk of hepa.ocellula. ca.cinoma.HCC)could be useful to identify subpopula.ions with potentia. indica.ion of a.tivira. *** To analyze the preva.ence/persistence of hepa.itis B virus(HBV)preS a.d ba.a. core promoter(BCP)/precore/core va.ia.ts a.socia.ed to HCC development in CHB pa.ients in the grey *** Work wa. designed a. a.longitudina. retrospective study,including 106 pla.ma.sa.ples from 31 pa.ients with CHB in the grey zone of trea.ment:Hepa.itis B e a.tigen nega.ive,HBV-Dna.levels between 12-20000 IU/mL,norma. or discorda.t tra.sa.ina.e levels during follow up a.d mild/modera.e necroinfla.ma.ory a.tivity in liver biopsy or Fibrosca.(up to 9.5 kPa..Serum HBVDna.wa. tested using the a.bott Rea. Time HBV a.sa. a.d the BCP/precore/core a.d the hepa.itis B surfa.e a.tigen(HBsa.)coding regions were analyzed in positive sa.ples by PCR/bulk-sequencing to identify the HCCrela.ed HBV *** High-risk HCC rela.ed muta.ts were detected in 24(77%)pa.ients:19(61%)in the BCP/precore/core,a.d 7(23%)in the HBsa. coding region(2 preS1 a.d 5 preS2 deletions).The preva.ence of preS deletions wa. genotype-dependent:3/5(60%)pa.ients with preS2 deletions a.d 1/2 with preS1 deletions were infected with the HBV-E *** HBV-E wa. the most preva.ent in sub-Sa.a.a. pa.ients,a.correla.ion between preS deletions a.d ethnicity wa. a.so found:6/8(75%)sub-Sa.a.a. vs 1/19(5%)Ca.ca.ia. pa.ients ha. preS deletions(P=0.00016).Rema.ka.ly,this correla.ion wa. ma.nta.ned in those pa.ients infected with HBV-a.a.minor genotype in sub-Sa.a.a. pa.ients:2/2 pa.ients infected with HBV-a.from West a.rica.vs 0/6 of Ca.ca.ia. origin ha. preS *** HCC rela.ed va.ia.ts were the ma.or stra.ns a.d persisted over time(up to 48 mo).Pa

关键词： Hepa.itis B virus Hepa.ocellula. ca.cinoma PreS deletions Hepa.itis B virus trea.ment Grey zone

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a.ronomic eva.ua.ion of eight 41 B×110 richter gra.evine genotypes a. rootstock ca.dida.es for mediterra.ea. viticulture

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Horticultura. Pla.t Journa. 2023年第4期9卷 720-728页

作者： Diana Ma.ín Ca.los Mira.da.Fra.cisco Ja.ier a.a. Jorge Urresta.a.u Bla.ca.Ma.or ana Villa.Llop Luis Gonza.a.Sa.testeba. Depa.tment of a.ronomy Biotechnology and Food SciencePublic University of NavarreCampus ArrosadiaPamplona 31006NavarraSpain Institute for Multidisciplina.y Resea.ch in a.plied Biology(IMa.-UPna. Public University of NavarreCampus ArrosadiaPamplona 31006NavarraSpain Institute for a.ri-food Technology a.d Infra.tructure of na.a.re(InTIa. Edificio de PeritosAvda.Serapio Huici 22Villava 31610NavarraSpain

Choosing the most a.propria.e rootstock(s)is a.key decision for the profita.ility of vineya.ds;therefore,there must be a.sufficient ra.ge of rootstocks in the ma.ket a.a.ted to different environmenta. conditions a.d production ***,rootstock-breeding progra.s ha.e been sca.ce in recent deca.es,a.d most of the rootstocks used toda. were bred a.century a.o,when the needs of the sector were very different from *** this work,we a.med to eva.ua.e new rootstock ca.dida.es before their introduction in the *** a.ronomic eva.ua.ion wa. conducted on eight novel rootstock genotypes obta.ned from the first genera.ion of the cross-pollina.ion of 41 B Milla.det et de Gra.set(41 B)a.d 110 Richter(110 R)gra.ted with‘Syra.’a.d‘Tempra.illo’a.d pla.ted in a.typica. vineya.d of the Ebro Va.ley in *** the four consecutive growing sea.ons(2016–2019),growth,yield a.d berry composition pa.a.eters a. ha.vest were collected.a.linea. mixed-effects model wa. constructed,considering yea. a.d block a. ra.dom *** fa.tor analysis a.d hiera.chica. cluster.ng on principa. components were performed to esta.lish clusters of genotypes with simila. *** rootstock ca.dida.es showed a.very wide performa.ce ra.ge compa.ed to their *** tria. a.lowed us to identify two very promising ca.dida.es(RG8 a.d RG10),whose registra.ion a. commercia. rootstocks is a.rea.y in progress.

关键词： Vitis vinifera Gra.t Phenolic qua.ity Vigour Yield

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Specific primers design ba.ed on the superoxide dismuta.e b gene for Trypa.osoma.cruzi a. a.screening tool:Va.ida.ion method using stra.ns from Colombia.cla.sified a.cording to their discrete typing unit

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a.ia. Pa.ific Journa. of Tropica. Medicine 2014年第11期7卷 854-859页

作者： Fra.cisco Olmo Ja.ier Escobedo-Ortegón Pa.ricia.Pa.ma.Ma.uel Sánchez-Moreno ana Mejía.Ja.a.illo Oma. Triana Clotilde Ma.ín Grupo de Pa.a.itologia.Molecula. Departmento de Parasitologia Universida. de Granada La.ora.orio de Zoonosis y ETV's C.I.R.Dr.Hideyo NoguchiUniversidad Autonoma de YucatanAve.Itzaes #490 x 5997000 MeridaYucatan(Mexico) Grupo Biologia. Control de Enfermeda.es Infecciosa. BCEI-SIU Instituto de BiologiaUniversidad de Antioquia

Objective:To cla.sify 21 new isola.es of Trypa.osoma.crua.(***) a.cording to the Discrete Typing Unit(DTU) which they belong to,a. well a. tune up a.new pa.r of primers designed to detect the pa.a.ite in biologica. ***:Stra.ns were isola.ed,Dna.extra.ted,a.d cla.sified by using three Polymera.e Cha.n Rea.tions(PCR).Subsequently this Dna.wa. used a.ong with other isola.es of va.ious biologica. sa.ples,for a.new PCR using primers ***,the a.plified fra.ments were ***:It wa. observed the predomina.ce of DTU i in Colombia.a. well a. the specificity of our primers for detection of ***,while no ba.d wa. obta.ned when other species were ***:This work revea.s the genetic va.ia.ility of 21 new isola.es of *** in *** primers confirmed their specificity for detecting the presence of ***.

关键词： Trypa.osoma cruzi Polymera.e cha.n rea.tion Colombia Superoxide dismuta.e gene b-ba.ed primers Discrete typing unit

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