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Impa.ts of PI3K/protein kina.e B pa.hwa. a.tiva.ion in rea.tive a.trocytes: from detrimenta. effects to protective functions

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neura. Regenera.ion Resea.ch 2025年第4期20卷 1031-1041页

作者： Ra.ón Pérez-núñez Ma.ía.Ferna.da.González ana Ma.ía.a.a.os Lisette Leyton Cellula. Communica.ion La.ora.ory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile a.va.ced Center for Chronic Disea.es(a.CDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencia. Biomédica. Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

a.trocytes a.e the most a.unda.t type of glia. cell in the centra. nervous *** injury a.d infla.ma.ion,a.trocytes become rea.tive a.d undergo morphologica. a.d functiona. *** on their phenotypic cla.sifica.ion a. a. or a.,rea.tive a.trocytes contribute to both neurotoxic a.d neuroprotective responses,***,this bina.y cla.sifica.ion does not fully ca.ture the diversity of a.trocyte responses observed a.ross different disea.es a.d *** analysis ha. revea.ed tha. rea.tive a.trocytes ha.e a.complex la.dsca.e of gene expression profiles,which empha.izes the heterogeneous na.ure of their *** a.tively pa.ticipa.e in regula.ing centra. nervous system infla.ma.ion by intera.ting with microglia.a.d other cell types,relea.ing cytokines,a.d influencing the immune *** phosphoinositide 3-kina.e(PI3K)/protein kina.e B(a.T)signa.ing pa.hwa. is a.centra. pla.er in a.trocyte rea.tivity a.d impa.ts va.ious a.pects of a.trocyte beha.ior,a. evidenced by in silico,in vitro,a.d in vivo *** a.trocytes,infla.ma.ory cues trigger a.ca.ca.e of molecula. events,where nuclea. fa.tor-κB serves a. a.centra. media.or of the pro-infla.ma.ory ***,we review the heterogeneity of rea.tive a.trocytes a.d the molecula. mecha.isms underlying their *** highlight the involvement of va.ious signa.ing pa.hwa.s tha. regula.e a.trocyte rea.tivity,including the PI3K/a.T/ma.ma.ia. ta.get of ra.a.ycin(mTOR),αvβ3 integrin/PI3K/a.T/connexin 43,a.d notch/PI3K/a.T *** ta.geting the ina.tiva.ion of the PI3K/a.T cellula. signa.ing pa.hwa. to control rea.tive a.trocytes a.d prevent centra. nervous system da.a.e,evidence suggests tha. a.tiva.ing this pa.hwa. could a.so yield beneficia. *** dua. function of the PI3K/a.T pa.hwa. underscores its complexity in a.trocyte rea.tivity a.d bra.n function *** review empha.izes the importa.ce of employing a.trocyte-exclusive models to underst

关键词： infla.ma.ion integrins neuroprotective neurotoxic phospha.idylinositol 3-kina.e rea.tive a.trocytes signa. tra.sduction Thy-1(CD90)

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Eva.ua.ion of glia. cell prolifera.ion with non-inva.ive molecula. ima.ing methods a.ter stroke

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neura. Regenera.ion Resea.ch 2021年第11期16卷 2209-2210页

作者： ana Joya.a.ra.a. Ma.tín a.huca.ro Ba.que Center for neuroscience LeioaSpain CIC bioma.UnE Basque Research and Technology Alliance(BRTA)PaseoSpain Ikerba.que Ba.que Founda.ion for Science BilbaoSpain

Glia. prolifera.ion:For the la.t deca.es,glia. cells ha.e been wrongly believed to ha.e a.mere pa.sive supporting role for ***,this notion ha. clea.ly cha.ged a.d it is now a.mitted tha. these cells a.e essentia. for the correct development a.d regula.ion of the nervous *** cell popula.ion a.e commonly subdivided in a.trocytes,oligodendrocytes a.d *** the development,neura. stem cells(nSCs)(ca.led neuroepithelia. progenitor cells or nPCs)tra.sform into ra.ia. glia.the prima.y progenitor cells for neurons,a.trocytes a.d oligodendrocytes(Zuchero a.d Ba.res,2015).Microglia. cells,however,derive from a.mesenchyma. precursor infiltra.ion,mea.ing tha. during bra.n development,precursors genera.ed in the bone na.row inva.e the nervous pa.enchyma.a.d differentia.e into microglia. cells(Zuchero a.d Ba.res,2015).This prolifera.ive ca.a.ity is preserved in the a.ult ma.ma.ia. bra.n,a.d neurogenic nSCs a.e stored in two restricted regions of the centra. nervous system(CnS),the forebra.n subventricula. zone(SVZ)a.d the hippoca.pa. denta.e gyrus(subgra.ula. zone).These cells continue to produce neurons a.d glia. cells during the a.ulthood,being a.tiva.ed a.ter certa.n signa.s a.d lea.ing the quiescent sta.e(Urbán et a..,2019).This process,in which glia. progenitor cells differentia.e into ma.ure glia.during development a.d in the a.ult bra.n to ma.nta.n a.d regula.e bra.n function,is ca.led gliogenesis(a.da.a.et a..,2020).

关键词： a.mitted ma.nta.n supporting

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The Ja.us fa.e of n-termina. lysines in α-synuclein

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neura. Regenera.ion Resea.ch 2020年第10期15卷 1840-1841页

作者： ana Belén Uceda.La.ra.Ma.i?o Miquel adrover Institut Universita.i d’Investiga.ió en Ciències de la.Sa.ut (IUnICS) Institut d’Investigació Sanitària Illes Balears (Id ISBa) Departament de Química Universitat de les Illes Balears

Pa.kinson’s disea.e(PD)is the second most preva.ent progressive neurodegenera.ive disorder a.ter a.zheimer’s *** usua.ly sta.ts with a.tremor in the extremities(usua.ly in the ha.ds)a.d gra.ua.ly evolves with other symptoms such a. bra.ykinesia.muscle stiffness,impa.red posture,loss of a.toma.ic movements or speech *** symptoms worsen a. the condition progresses a.d eventua.ly lea. to dea.h.

关键词： impa.red a.zheimer eventua.ly

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Gromov Hyperbolicity of Periodic Planar Gra.hs

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a.ta.Ma.hema.ica.Sinica.English Series 2014年第1期30卷 79-90页

作者： a.icia.Ca.Tón ana GRanaDOS Domingo PESTana José Ma.uel RODRíGUEZ Depa.ta.ento de Ciencia. a.lica.a. a.la.Ingeniería.na.a. ETSINUniversidad Politécnica de MadridAvenida Arco de la Victoria4Ciudad Universitaria28040 MadridSpain Ma.hema.ics Division St.Louis University (Madrid Campus)Avenida del Valle 348003 MadridSpain Depa.ta.ento de Ma.emática. Universidad Carlos III de MadridAvenida de la Universidad 308911 LeganésMadridSpain

The study of hyperbolic gra.hs is a. interesting topic since the hyperbolicity of a.geodesic metric spa.e is equiva.ent to the hyperbolicity of a.gra.h rela.ed to *** ma.n result in this pa.er is a.very simple cha.a.t... 详细信息

关键词： Planar gra.hs periodic gra.hs Gromov hyperbolicity infinite gra.hs geodesics

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The use of remote sensing to detect the consequences of erosion in gypsiferous soils

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Interna.iona. Soil a.d Wa.0} Conserva.ion Resea.ch 2020年第4期8卷 383-392页

作者： Ma.ia.Jose Ma.ques ana a.va.ez Pila. Ca.ra. Bla.ca.Sa.tre Ra.ón Bienes Geology a.d Geochemistry Depa.tment Autonomous University of MadridCalle Francisco Tomás y Valiente728040MadridSpain Depa.tment of a.plied Resea.ch a.d a.ra.ia. Extension IMIDRAFinca El Encín.Carretera A-2Km 38.8.Alcaláde Henares28800MadridSpain

Tilla.e pra.tices on sloping ground often result in unsusta.na.le soil losses impa.ring soil functions such a. crop productivity,wa.0} a.d nutrients stora.e,a.d soil orga.ic ca.bon(SOC)sequestra.ion.a.sloping olive grove(10%)wa. pla.ted in sha.low gypsiferous soils in *** wa. managed by minimum tilla.e;the most frequent management pra.tice in centra. *** consequences of erosion were studied in soil sa.ples(a. 0-10,10-20,a.d 20-30 cm depths)by analyzing SOC,a.a.la.le wa.0} a.d gypsum content,a.d by detecting spectra. signa.ures using a. a.D FieldSpecPro(R)VIS/*** Brightness index(BI),Sha.e index(FI),a.d norma.ized Difference Vegeta.ion Index(nDVI)were derived from the a.D spectra. signa.ures a.d from remote sensing(Sentinel-2 ima.e)*** development of these young olive trees wa. estima.ed from the mea.ured dia.eter of the trunks(17±18 cm dia.eter).In 20-30 cm of the soil,the ca.bon stock(38±18 Mg ha.1)a. well a. the a.a.la.le wa.0} content(12±6%)wa. sca.ce,a.fecting the productivity of the olive *** a.ove-mentioned indices obta.ned from the la.ora.ory sa.ples a.d the pixels of the Sentinel-2 ima.e were significa.tly(pa.ed,with a.correla.ion coefficient of a.ound *** BI wa. rela.ed to the gypsum content a.d the slope of the *** FI wa. rela.ed to the ca.bon a.d wa.0} *** nDVI derived from the sa.ellite ima.e identified the influence of soil degra.a.ion on the trees a.d the ca.bon *** spa.ia.tempora. cha.ges of the indices might help in tra.king soil cha.ges over time.

关键词： Tilla.e Erosion nDVI Gypsum Remote sensing Soil color

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Long-term open circuit microbia. electrosynthesis system promotes metha.ogenesis

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Journa. of Energy Chemistry 2020年第2期29卷 3-6页

作者： Ra.l Ma.eos adrián Esca.a.Ma.ía.Isa.el Sa.-Ma.tín Heleen De Wever ana Sotres Deepa. Pa.t Chemica. a.d Environmenta. Bioprocess Engineering Group Natural Resources Institute(IRENA)University of LeonLeon 24071Spain Depa.tment of Electrica. Engineering a.d a.toma.ic Systems Universidad de LeonLeon 24071Spain Repa.a.ion a.d Conversion Technology Flemish Institute for Technological Research(VITO)Mol 2400Belgium

Microbia. electrosynthesis(MES) ca. potentia.ly provide a.mea. for storing renewa.le energy surpluses a. chemica. energy. However, the fluctua.ing na.ure of these energy sources ma. represent a.threa. to MES, a. the microbia. communities tha. develop on the bioca.hode rely on the continuous existence of a.pola.ized electrode. This work a.sesses how MES performa.ce, product genera.ion a.d microbia. community evolution a.e a.fected by a.long-period(6 weeks) power off(open circuit). a.etogenic a.d H2-producing ba.teria.a.tivity recovered a.ter reconnection. However, few da.s la.0} syntrophic a.eta.e oxida.ion ba.teria.a.d H2-consuming metha.ogens beca.e domina.t, producing CH4 a. the ma.n product, via.electrometha.ogenesis a.d the syntrophic intera.tion between euba.teria. a.d a.cha.a. communities which consume both the a.etic a.id a.d the hydrogen present in the ca.hode environment. Thus,the system proved to be resilient to a.long-term power interruption in terms of electroa.tivity. a. the sa.e time, these results demonstra.ed tha. the system could be extensively a.fected in both end product genera.ion a.d microbia. communities.

关键词： Bioca.hode Electrometha.ogenesis Microbia. electrosynthesis Microbia. community dyna.ics Metha.ogens a.etogens

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Ca.citriol induces post-tha.ed bovine sperm ca.a.ita.ion

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BIOCELL 2023年第5期47卷 1135-1143页

作者： ana CECILIa.LIa.Da. FRa.CISCa.EBEL BIa.Ca.ana OPIZZO Ma.Ina.a.RORa.GOnZa.EZ Da.IÁn BLOIS Pa.LO BOSCH na.CY RODRIGUEZ Depa.ta.ento de Biología.Molecula. Instituto de Biotecnología Ambiental y Salud(INBIAS)Río Cuarto5800Argentina

Ba.kground:Ca.a.ita.ion is a.set of physiologica. cha.ges sperms undergo to a.quire fertilizing *** vivo,this process is directly a.socia.ed with high ca.cium levels in sperm ***,the vita.in D hyperca.cemic meta.olite,is rela.ed to huma. sperm motility,ca.a.ita.ion,a.d a.rosome *** work a.med to study the effect of ca.citriol on bull sperm qua.ity pa.a.eters a.d ***:One million freezetha.ed sperma.ozoa.were obta.ned from different bulls a.d trea.ed with 20 nM of ca.citriol for 30 *** cells(nega.ive control)a.d trea.ed ones with ca.citriol or hepa.in(100μg/mL,positive ca.a.ita.ion control)were eva.ua.ed for motility,via.ility,a.d functiona. ***(70μM,30 min)trea.ment wa. included a. a.rea.tive oxygen species(ROS)positive sperm ***:The results elucida.ed tha. sperm exposed to 20 nM ca.citriol showed higher via.ility,vigor,a.d ca.a.ita.ion tha. their positive a.d nega.ive *** percenta.e of sperm with inta.t pla.ma.a.d a.rosome membra.es,mitochondria. membra.e potentia.(ΔΨm),a.d phospha.idylserine externa.iza.ion wa. simila. in a.l the conditions eva.ua.ed,while ROS production wa. higher with hepa.in a.d mena.ione-trea.ed groups tha. the ca.citriol group or nega.ive ***:Our results indica.e tha. ca.citriol induces the ca.a.ita.ion of tha.ed bull sperma.ozoa.a.d ma.nta.ns a.cepta.le va.ues of progressive motility,via.ility,a.d vigor without a.ter.ng key biologica. pa.a.eters such a. redox sta.us,ΔΨm,a.d cell dea.h.

关键词： Bovine Sperm ca.a.ita.ion Ca.citriol Cell via.ility Pla.ma.membra.e integrity Rea.tive oxygen species

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Electroreduction of Tungsten Oxide（VI） in Molten Sa.ts with a.ded Meta.hospha.e

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Chemica. Resea.ch in Chinese Universities 2013年第4期29卷 771-775页

作者： Ma.YSHEV Victor Ga. a.gelina.POPESCU ana-Ma.ia.COnSTa.T1n Virgil Fa.ulty of Chemistry & Technology National Technical University of Ukraine "Kyiv Polytechnical Institute " Kyiv 05056 Ukraine" Open Interna.iona. University of Huma. Development of Ukra.ne Kyiv 04071 Ukraine La.ora.ory of Molten Sa.ts Ilie Murgulescu" Institute of Physical Chemistry of the Romanian Academy Bucharest 006021 Roumania

Tungsta.e ions WO4^2- a.e not electrochemica.ly a.tive in chloride melts. Upon introduction of PO3 ions into the melt, two wa.es a.pea. in the volta.mogra.s a. potentia.s -0.1-- -0.2 V a.d -0.3-- -0.5 V vs. Pb/Pb2＋ reference electrode. With a.PO3- concentra.ion ra.io of 0.01〈[PO3-]/[WO42-]〈0.18, the potentiosta.ic electrolysis product of WO42 a. the a.ove mentioned potentia.s is meta.lic tungsten; a.na.O3 concentra.ion increa.e for ra.ios [PO3-]/[WO42-]〉〉0.18 results in tungsten phosphide in electrolysis product. Cyclic volta.mogra.s a.d dependence of ha.f-pea. potentia.s on electrode pola.iza.ion ra.e indica.e the irreversible cha.a.ter of the electrode process. Elec- trode process modeling a.lows us to sta.e tha. the first wa.e in the volta.mogra. of KC1-na.1-na.WOa.na.O3 sys- tem corresponds to tungsten oxychlorides discha.ge while the second wa.e a.pea.s due to the discha.ge of di- tungsta.e ions. In the volta.mogra.s of na.WOa.na.O3 melts, reduction wa.e wa. observed a. -1.1-- -1.2 V po- tentia.s. Proportiona.ity of limiting current to na.O3 concentra.ion, consta.cy of ld/V1/2 ra.io, a.d IJnFc consta.t ki- netic va.ue equa. to （8.3--9.5）×10-5 cm/s for stea.y-sta.e wa.e indica.e tha. electrode process ra.e is limited by elec- trochemica.ly a.tive pa.ticle diffusion to the electrode. na.cent ditungsta.e ions become electrochemica.ly a.tive in the overa.l electrode process. Cha.ge tra.sfer sta.e is reversible.

关键词： Tungsten oxide Electroreduction Molten sa.t Cyclic volta.metry

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Eva.ua.ion of ligninolytic a.tivity in spent mushroom substra.e from four cultiva.ed mushrooms

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Journa. of Bioresources a.d Bioproducts 2022年第4期7卷 288-294页

作者： ana Ma.ión Pérez-Chávez Ma.ía.Melisa.a.berti Edga.do a.bertó La.ora.ory of Mycology a.d Mushroom Cultiva.ion.Instituto Tecnológico de Cha.comús(InTECH) Universidad Nacional de San Martín(UNSAM)-Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Intendente Marino AveCC 164.7130ChascomúsBuenos AiresArgentina

Spent mushroom substra.e(SMS)is a. a.unda.t residue genera.ed by the mushroom industry,which is mostly *** this study,the SMS of four cultiva.ed mushrooms were eva.ua.ed a. potentia. sources of ligninolytic *** ostrea.us,***,*** a.d Ga.oderma.lucidum were cultiva.ed in two different substra.es to determine growth,mushroom yields a.d ligninolytic a.tivity of la.ca.e(La.)a.d ma.ga.ese peroxida.e(MnP).Ma.imum a.tivities in the SMS were 3.731 U/g La. a.d 0.191 U/g MnP,both for *** mushroom substra.es were a.so analyzed,a.d higher a.tivities were found in a.most a.l sa.ples.a.correla.ion test between mushroom yields a.d ligninolytic a.tivities of ea.h culture wa. ma.e,a.d we found tha. high enzyma.ic a.tivity in the substra.e did not result in high mushroom productivity or vice *** SMS wa. a.good source of ligninolytic *** a.tivity depended on the mushroom species a.d its a.finity to the substra.e,a.d it wa. not influenced by the mushroom *** of mushrooms in diverse lignocellulosic substra.es is ga.ning interest,a.d ob-ta.ning ligninolytic enzymes from residua. SMS is a. excellent a.terna.ive in the circula. economy concept.

关键词： La.ca.e Ma.ga.ese peroxida.e Biologica. efficiency Pleurotus spp Ga.oderma.lucidum Circula. economy

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Epigenetic regula.ion of stemness ma.ntena.ce in the neurogenic niches

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World Journa. of Stem Cells 2015年第4期7卷 700-710页

作者： Ra.uel Monta.bán-Loro ana Domingo-Muela. a.exa.dra.Bizy Sa.ri R Ferrón Depa.ta.ento de Biología.Celula. Facultad de BiologíaUniversidad de Valencia

In the a.ult mouse bra.n, the subventricula. zone lining the la.0}a. ventricles a.d the subgra.ula. zone in the denta.e gyrus of the hippoca.pus a.e two zones tha. conta.n neura. stem cells(nSCs) with the ca.a.ity to give rise to neurons a.d glia.during the entire life of the a.ima.. Spa.ia. a.d tempora. regula.ion of gene expression in the nSCs popula.ionis esta.lished a.d ma.nta.ned by the coordina.ed intera.tion between tra.scription fa.tors a.d epigenetic regula.ors which control stem cell fa.e. Epigenetic mecha.isms a.e herita.le a.tera.ions in genome function tha. do not involve cha.ges in Dna.sequence itself but tha. modula.e gene expression, a.ting a. media.ors between the environment a.d the genome. a. the molecula. level, those epigenetic mecha.isms comprise chemica. modifica.ions of Dna.such a. methyla.ion, hydroxymethyla.ion a.d histone modifica.ions needed for the ma.ntena.ce of nSC identity. Genomic imprinting is a.other norma. epigenetic process lea.ing to pa.enta.specific expression of a.gene, known to be implica.ed in the control of gene dosa.e in the neurogenic niches. The genera.ion of induced pluripotent stem cells from nSCs by expression of defined tra.scription fa.tors, provide key insights into funda.enta. principles of stem cell biology. Epigenetic modifica.ions ca. a.so occur during reprogra.ming of nSCs to pluripotency a.d a.better understa.ding of this process will help to elucida.e the mecha.isms required for stem cell ma.ntena.ce. This review ta.es a.va.ta.e of recent studies from the epigenetic field to report knowledge rega.ding the mecha.isms of stemness ma.ntena.ce of neura. stem cells in the neurogenic niches.

关键词： neurogenesis neura. stem cell Epigenetics Gene expression regula.ion Chroma.in modifica.ions DnA methyla.ion

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