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ITPK1 is an InsP_(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis.

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Molecular Plant 2021年第11期14卷 1864-1880页

作者： Esther Riemer Danye Qiu Debabrata Laha Robert K.Harmel Philipp Gaugler Verena Gaugler Michael Frei Mohammad-Reza Hajirezaei Nargis Parvin Laha Lukas Krusenbaum Robin Schneider adolfo Saiardi Dorothea Fiedler Henning J.Jessen Gabriel Schaaf Ricardo F.H.Giehl Department of Plant Nutrition Institute of Crop Science and Resource ConservationRheinische Friedrich-Wilhelms-Universitat Bonn53115 BonnGermany Department of Chemistry and Pharmacy and CIBSS-Centre for Integrative Biological Signalling Studies Albert-Ludwigs University Freiburg79104 FreiburgGermany Medical Research Council Laboratory for Molecular Cell Biology(MRC-LMCB) University College LondonLondon WC1E 6BTUK Department of Biochemistry Indian Institute of ScienceBengaluruKarnataka 560012India Leibniz-Forschungsinstitut fur Molekulare Pharmakologie 13125 BerlinGermany Department of Chemistry Humboldt Universitat zu Berlin12489 BerlinGermany Institute of Agronomy and Crop Physiology Justus-Liebig University Giessen35392 GiessenGermany Department of Physiology&Cell Biology Leibniz-lnstitute of Plant Genetics and Crop Plant Research06466 GaterslebenGermany

In plants, phosphate (Pi) homeostasis is regulated by the interaction of PHR transcription factors with stand-alone SPX proteins, which act as sensors for inositol pyrophosphates. Here, we combined different methods to obtain a comprehensive picture of how inositol (pyro)phosphate metabolism is regulated by Pi and dependent on the inositol phosphate kinase ITPK1. We found that inositol pyrophosphates are more responsive to Pi than lower inositol phosphates, a response conserved across kingdoms. With CE-ESI-MS we could separate different InsP7 isomers in Arabidopsis and rice, and identify 4/6-InsP7 and a PP-InsP4 isomer hitherto not reported in plants. We found that the inositol pyrophosphates 1/3-InsP7, 5-InsP7 and InsP8 increase severalfold in shoots after Pi resupply and that tissue-specific accumulation of inositol pyrophosphates relies on ITPK1 activities and MRP5-dependent InsP6 compartmentalization. Notably, ITPK1 is critical for Pi-dependent 5-InsP7 and InsP8 synthesis in planta and its activity regulates Pi starvation responses in a PHR-dependent manner. Furthermore, we demonstrate that ITPK1-mediated conversion of InsP6 to 5-InsP7 requires high ATP concentrations and that Arabidopsis ITPK1 has an ADP phosphotransferase activity to dephosphorylate specifically 5-InsP7 under low ATP. Collectively, our study provides deeper insights into Pi-dependent changes in nutritional and energetic states with the synthesis of regulatory inositol pyrophosphates.

关键词： diphosphoinositol pentakisphosphate kinase inositol 1,3,4-trisphosphate 5/6-kinase 1 inositol phosphates inositol pyrophosphates phosphate homeostasis phosphate signaling

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马略卡王国文献馆

世界建筑导报 2021年第3期36卷 60-61页

作者：无 adolfo Gosálvez(摄影) HAND建筑师事务所不详

在西班牙帕尔马(Palma de Mallorca)的历史中心进行建造意味着需要寻找与这座城市独特性格相契合的方式。这里的街道被完整地保留,展示出一种均质和永恒的特性。交替开合的空间使街道在私人与公共领域之间变换。大大小小的庭院为市民提... 详细信息

在西班牙帕尔马(Palma de Mallorca)的历史中心进行建造意味着需要寻找与这座城市独特性格相契合的方式。这里的街道被完整地保留,展示出一种均质和永恒的特性。交替开合的空间使街道在私人与公共领域之间变换。大大小小的庭院为市民提供了悠闲生活节奏,同时形成了通透的街道景观。

关键词：文献馆街道景观公共领域生活节奏西班牙

Antifungal Potential of Beauveria bassiana on Solanum lycopersicum L. Infected with Fusarium oxysporum f. sp. lycopersici

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Phyton-International Journal of Experimental Botany 2023年第4期92卷 1235-1255页

作者： Henry López-López Nancy Ruiz-Lau Rocío Meza-Gordillo Víctor Manuel Ruiz-Valdiviezo Joseph Galthier Robledo-Luchetti Carlos Alberto Lecona-Guzmán Juan JoséVillalobos-Maldonado Luc Dendooven Joaquín adolfo Montes-Molina Laboratorio de Biotecnología vegetal Tecnológico Nacional de Mexico/Campus Tuxtla GutiérrezTuxtla Gutiérrez29050Mexico CONACYT-Tecnológico Nacional de Mexico/Campus Tuxtla Gutiérrez Tuxtla Gutiérrez29050México ABACUS CinvestavCiudad de México07360México

The objective of this work was to evaluate the effect of Beauveria bassiana(Bb 1205)on controlling Fusarium oxysporum ***(Fol 17108)in tomato plants in greenhouse *** of Bb 1205 was the most promising among the agronomic variables and expression of the activity of the enzymesβ-1,3-glucanases and *** of Bb 1205 occurred at a concentration of 1×108 conidia·mL−1,which was administered onto the leaves,directly into the soil and via *** with Fol 17108 occurred with 1×106 spores·mL−1,which were added directly to the *** was used for measuring agronomic parameters,namely activity of chitinases andβ-1,3-glucanases in foliage and *** Bb 1205 was added to the soil,the chlorophyll index and aerial part length showed significant *** addition,it was determined that root length,fresh weight of foliage,flower,and fruit count increased 82 days after inoculation(dai).Chitinase activity induced by Bb 1205 in leaves and roots of tomato plants infected with Fol 17108 was observed when injected into the stem at 32 dai(41.8 and 11.6-fold,respectively).Inoculation on the foliage showed a 10-fold increase ofβ-1,3-glucanases in the roots after 82 *** for leaves,a 3.8-fold increase was found when the stem was *** the different in vivo applications,Bb 1205 activated its defenses by expressing the chitinase enzymes andβ-1,3-glucanase,thus reducing the damage caused by Fol 17108,demonstrating increase plant growth thereafter.

关键词： Mycoparasitism agronomic parameters chitinases β-1,3-glucanases

Grape Phenolic Extract Potentially Useful in the Control of Antibiotic Resistant Strains of <i>Campylobacter</i>

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Advances in Microbiology 2014年第2期4卷 73-80页

作者： Elisa Mingo Alfonso V. Carrascosa Sonia de Pascual-Teresa adolfo J. Martinez-Rodriguez Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN) CSIC Departamento de Metabolismo y Nutrición-C/Jose Antonio Novais Madrid Spain Instituto de Investigación en Ciencias de la Alimentación (CIAL) CSIC-UAM Departamento de Biotecnología y Microbiología. C/Nicolás Cabrera 9. Cantoblanco Campus Universidad Autónoma de Madrid Madrid Spain

In this work, a grape phenolic extract obtained by methanol extraction has been demonstrated to be effective in inhibiting the growth of different strains and species of Campylobacter, one of the most important bacterial foodborne pathogens causing gastroenteritis worldwide. Noteworthily, it was particularly effective against several strains presenting multiple antibiotic resistances. In all cases, the minimum inhibitory concentration (MIC) was lower than 300 mg GAE/L, being of 60 mg GAE/L for one of the most resistant strains (C. coli LP2), while the others were between 120 mg GAE/L and 180 mg GAE/L. The analytical study of the main phenolic compounds in the grape extract revealed that it was mainly constituted by catechins (85.7%) and phenolic acids (13.7%). However, experiments developed using pure standards demonstrate that phenolic acids (such as gallic, p-hidroxibenzoic, vanillic, and homovanillic acids) were the most active, provoking a Campylobacter growth decrease between 6.7 and 7.6 log, while epicatechin was the only catechin with activity as pure compound (1 log of growth decrease).

关键词： Campylobacter Food-Borne Pathogen Antibiotic Resistance Grape Phenolic Extract Phenolic Acids Flavanols

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马德里EMV60户社会集合住宅

世界建筑导报 2021年第3期36卷 62-63页

作者：无 adolfo Gosálvez(摄影) HAND建筑师事务所不详

考虑到场地周边的城市现状,该方案通过一种直接的抽象方式--限制体量--来占据场地的中心位置。我们必须将这座建筑放置在改造过的场地中,而土地将不可避免地承受建筑重压。因此,我们希望通过为体量“减重”,并以此为基础寻求将功能,立... 详细信息

考虑到场地周边的城市现状,该方案通过一种直接的抽象方式--限制体量--来占据场地的中心位置。我们必须将这座建筑放置在改造过的场地中,而土地将不可避免地承受建筑重压。因此,我们希望通过为体量“减重”,并以此为基础寻求将功能,立面表达,采光和建筑朝向结合在一起的方法。简言之,我们需要创造一种可以高效使用的计划。我们首先将这座建筑视为一块巨型大理石,接下来通过从中逐步削减体量,而非添加,创造出最后的建筑形体。

关键词：建筑朝向集合住宅建筑形体大理石采光体量高效使用城市现状

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用能量法计算拖拉机防翻安全架

拖拉机与农用运输车 1982年第4期 14-16页

作者： adolfo Marsili ,曹文堂

在超静定结构的设计中,人们不仅致力于提高其安全程度,也需要对造成损坏的能量作出估计。设想有一拖拉机防倾翻安全架,要保证它受力后变形量不超过预定值,同时并能吸收外力,如果只考虑有关静态值是还不够的。我们作这项研究,首先要确定

关键词：拖拉机变形量受力牛顿弯曲应力

Effectiveness of Improved Cookstoves to Reduce Indoor Air Pollution in Developing Countries. The Case of the Cassamance Natural Subregion, Western Africa

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Journal of Geoscience and Environment Protection 2014年第1期2卷 1-5页

作者： Candela de la Sota Julio Lumbreras Javier Mazorra adolfo Narros Luz Fernández Rafael Borge Department of Chemical and Environmental Engineering Technical University of Madrid (UPM) Spain

The Spanish NGO “Alianza por la Solidaridad” has installed improved cookstoves in 3000 households during 2012 and 2013 to improve energy efficiency reducing fuelwood consumption and to improve indoor air quality. The type of cookstoves were Noflaye Jeeg and Noflaye Jaboot and were installed in the Cassamance Natural Subregion covering part of Senegal, The Gambia and Guinea-Bissau. The Technical University of Madrid (UPM) has conducted a field study on a sample of these households to assess the effect of improved cookstoves on kitchen air quality. Measurements of carbon monoxide (CO) and fine particle matter (PM2.5) were taken for 24-hr period before and after the installation of improved cookstoves. The 24-hr mean CO concentrations were lower than the World Health Organization (WHO) guidelines for Guinea-Bissau but higher for Senegal and Gambia, even after the installation of improved cookstoves. As for PM2.5 concentrations, 24-hr mean were always higher than these guidelines. However, improved cookstoves produced significant reductions on 24-hr mean CO and PM2.5 concentrations in Senegal and for mean and maximum PM2.5 concentration on Gambia. Although this variability needs to be explained by further research to determine which other factors could affect indoor air pollution, the study provided a better understanding of the problem and envisaged alternatives to be implemented in future phases of the NGO project.

关键词： Indoor Air Pollution Improved Cookstoves Biomass Burning Health Effects Western Africa

Strategies in secondary biliary fibrosis

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Journal of Biomedical Science and Engineering 2013年第8期6卷 10-18页

作者： José M. Hermosillo-Sandoval adolfo D. Rodríguez-Carrizález Alejandra G. Miranda-Díaz Department of Surgery Specialties Hospital of the National Occidental Medical Centre Social Security Institute of Mexico Guadalajara México University Health Sciences Centre University of Guadalajara Guadalajara México

The cellular and molecular mechanisms that mediate hepatic fibrosis have provided a framework of different therapeutic foci to prevent, delay or in such case revert fibrosis and cirrhosis. The fundamental event in development of hepatic fibrosis caused by secondary biliary cholestasis is based on activation of the hepatic stellar cells (HSC) which the primary function is forming fibrosis. The activated HSC cells transform into myofibroblasts with capacity to produce alpha smooth muscle actin (α-SMA). As a result, the HSC activates proliferation of the cholangiocytes and epithelial cells whose functions represent important anti-fibrotic objectives. Some strategies are described as targeting against molecule involved in fibrosis production;and some medications with anti-fibrotic functions that are actually available in the medical arsenal have been tested in experimental animal models and in few clinical studies, and their components act in relation to the fibrotic cascade. In the end, the treatment strategies for hepatic fibrosis can vary on an individual basis depending on the etiology, the risk of fibrosis progression and the predominant pathogenic medium, which indicates that a multi-factorial approach could be necessary. Orthotopic liver transplant continues being the last final alternative for hepatic insufficiency from any cause;however, in no way does it supersede healthy natural liver in survival and adequate function. The investigative arsenal continues to develop rapidly, giving rise to other possible objectives in pre-clinical studies of conceptual trials, such as the utilization of molecular, cellular, drugs therapy and Chinese herbs. Despite being aforementioned, there are no existing ideal alternatives that completely reverse fibrosis in humans. Future usefulness of the majority of management alternatives seems probable and could be feasible.

关键词： Bile Duct Lesion Bile Duct Injury Bile Duct Atresia Hepatic Cholestasis Secondary Biliary Fibrosis Hepatic Transplant

ITPK1 is an InsP_(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

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Molecular Plant 2024年第7期17卷 1151-1157页

(Molecular Plant 14,1864-1880;November 12021)We identified a mistake made when calculating the absolute concentrations of inositol(pyro)phosphates derived from CE-ESl-MS measurements reported in the originally published version of our *** to a calculation error when determining concentrations per fresh biomass,the absolute values shown in the manuscript are approximately 30-fold lower than they should *** mistake affects Figures 2D,3C,4C,and 7D and Figures S4,S11B,S13,and *** all conclusions made in the article referred to relative differences between genotypes and treatments,they remained unaffected by these mistakes.

关键词： ipt Arabidopsis absolute