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Molecular Plant 2024年第7期17卷 1110-1128页

作者： Shen Zhang Devasantosh Mohanty adnan muzaffar Min Ni Department of Plant and Microbial Biology University of Minnesota at Twin CitiesSaint PaulMinnesota MN 55108United States of AmericaUSA

Spatiotemporal regulation of gene expression by polycomb repressive complex 2(PRc2)is critical for animal and plant *** Arabidopsis fertilization independent seed(FIS)-PRC2 complex functions specifically during plant reproduction from gametogenesis to seed *** a double fertilization event,triploid endosperm proliferates early,followed by the growth of a diploid embryo,which replaces the endosperm in Arabidopsis and many *** genes critical for endosperm proliferation such as IKkU2 and MINI3 are activated after *** we report that two MADS-box AGAMOUS-LIKE(AGL)proteins associate with the key endosperm proliferation loci and recruit the FIS-PRC2 repressive complex at 4-5 days after pollination(DAP).Interestingly,AGL9 and AGL15 only accumulate toward the end of endosperm proliferation at 4-5 DAP and promote the deposition of H3K27me3 marks at key endosperm proliferation *** of AGL9 and AGL15 or overexpression of AGL9 or AGL15 significantly influence endosperm proliferation and ***-wide analysis with cleavage Under Targets and tagmentation(CUT&Tag)sequencing and RNA sequencing revealed the landscape of endosperm H3K27me3 marks and gene expression profiles in Col-0 and agl9 ***&Tag qPCR also demonstrated the occupancy of the two MADS-box proteins and FIS-PRC2 on a few representative target *** studies suggest that MADS-box proteins could potentially recruit PRc2 to regulate many other developmental processes in plants or even in fungi and animals.

关键词： AGL9 AGL15 embryo endosperm IKU2 MEDEA MINI3

Strengthening a Comprehensive Strategic Partnership

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Beijing Review 2024年第3期67卷 24-25页

作者： muzaffar Kamilov the Embassy of Uzbekistan in China

In recent years,the quality of the Uzbekistan-China comprehensive strategic partnership has reached a new *** of the Republic of Uzbekistan Shavkat Mirziyoyev visited China twice in *** year 2024 will also be active f... 详细信息

关键词： Strategic strategic visited

Coleus forskohlii shows anti-psoriatic activity in imiquimod-induced psoriasis rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 382-390,I0002-I0007页

作者： Sagarika Majhi Iti Chauhan Deepak Kumar Md.Niyaz Alam Md.Sarfaraj Hussain muzaffar Iqbal Faculty of Pharmacy I.T.S College of PharmacyMuradnagarGhaziabadU.P.India Lord Buddha Koshi Pharmacy College of Pharmacy BaijanathpurNH 107Saharsa(Bihar)852201India Department of Pharmaceutical Chemistry College of PharmacyKing Saud UniversityP.O.Box 2457Riyadh 11451Saudi Arabia

Objective:To evaluate anti-psoriatic activity of Coleus forskohlii in rats with imiquimod-induced ***:Imiquimod was used to induce psoriasis in *** weight,skin thickness,erythema,scaling,spleen weight,and histological alternations were measured to assess the effect of Coleus ***,an emulgel formulation containing Coleus forskohlii 10%was prepared and characterized along with its ex vivo permeation ***:The emulgel formulation containing Coleus forskohlii 10%had a pH of 5.40±0.36,with optimum spreadability of(31.67±2.08)g/(cm·s)and viscosity of(15966.67±1274.10)cps,and enhanced both the rate and the extent of drug permeation through psoriatic *** an ex vivo study,the quantity of drug permeated(19.18%),deposited(52.38%),and drug remaining in the donor compartments(28.31%)was *** forskohlii significantly alleviated imiquimod-induced psoriasis by increasing glutathione and superoxide dismutase activity,decreasing malondialdehyde and nitric oxide levels,and alleviating histological alternations in rat ***:Coleus forskohlii can alleviate imiquimod-induced psoriasis,which may be used as a therapeutic candidate for the treatment of psoriasis.

关键词： Psoriasis Coleus forskohlii Emulgel Ex vivo Imiquimod Carbopol

Trust-based Intelligent Scheme for Mitigating Black Hole Attacks in IoT

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Journal of Harbin Institute of Technology(New Series) 2024年第3期31卷 39-50页

作者： Feroz Khan A.B Weslin D Dilli Babu M Mohammed muzaffar Hussain Department of Computer Science Syed Hameedha Arts and Science CollegeKilakarai 623806Tamil NaduIndia Department of Information Technology Mohamed Sathak AJ College of EngineeringSiruseriChennai 603103India Department of Information Technology Panimalar Engineering CollegeChennai 600123India Department of Information Technology C.Abdul Hakeem College of Engineering and TechnologyMelvisharam 632509India

Internet of Things(IoT)networks are characterized by a multitude of wireless,interconnected devices that can dynamically join or exit the network without centralized administration or fixed infrastructure for *** multipath routing in IoT networks can improve data transmission reliability and load balancing by establishing multiple paths between source and destination nodes,these networks are susceptible to security threats due to their wireless *** security solutions developed for conventional networks are often ill-suited to the unique challenges posed by IoT *** response to these challenges,this paper proposes the integration of the Ad hoc On-demand Multipath Distance Vector(AOMDV)routing protocol with a trust model to enhance network *** findings from this research demonstrate the successful fusion of AOMDV with a trust model,resulting in tangible improvements in network *** assessment of trustworthiness bolsters both security and routing capabilities in IoT *** trust model plays a crucial role in mitigating black hole attacks in IoT networks by evaluating the trustworthiness of nodes and helping in the identification and avoidance of malicious nodes that may act as black *** results validate the efficacy of the proposed trust-based routing mechanism in achieving its *** plays a pivotal role in decision-making and in the creation of secure distribution *** assessing the trustworthiness of nodes,both network security and routing efficiency can be *** effectiveness of the proposed trust-based routing mechanism is scrutinized through simulations,offering insights into its potential advantages in terms of improved network security and routing performance in the context of the IoT.

关键词： Mobile ad-hoc network(MANET) routing Ad hoc On-demand Multipath Distance Vector(AOMDV) trust model security

Sepsis during short bowel syndrome hospitalizations:Identifying trends,disparities,and clinical outcomes in the United States

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 26-36页

作者： Dushyant Singh Dahiya Jennifer Wachala Shantanu Solanki Dhanshree Solanki Asim Kichloo Samantha Holcomb Uvesh Mansuri Khwaja Saad Haq Hassam Ali Manesh Kumar Gangwani Yash R Shah Teresa Varghese Hafiz muzaffar Akbar Khan Simon Peter Horslen Thomas D Schiano Syed-Mohammed Jafri Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Internal Medicine Samaritan Medical CenterWatertownNY 13601United States Division of Gastroenterology Hepatology&Nutrition The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Medicine Institute for Foreign Medical Graduate EducationHoustonTX 77030United States Department of Internal Medicine MedStar Harbor HospitalBaltimoreMD 21225United States Department of Internal Medicine WellStar Spalding Regional HospitalGriffinGA 30224United States Division of Gastroenterology Hepatology and NutritionEast Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Gastroenterology and Hepatology University of Arkansas for Medical SciencesLittle RockAR 72205United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology SUNY Upstate Medical UniversitySyracuseNY 13210United States Department of Pediatrics School of Medicine and UPMC Children’s Hospital of PittsburghUniversity of PittsburghPittsburghPA 15219United States Division of Liver Diseases Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Division of Gastroenterology and Hepatology Henry Ford HospitalDetroitMI 48202United States

BACKGROUND Short bowel syndrome(SBS)hospitalizations are often complicated with *** is a significant paucity of data on adult SBS hospitalizations in the United States and across the *** To assess trends and outcomes of SBS hospitalizations complicated by sepsis in the United *** The National Inpatient Sample was utilized to identify all adult SBS hospitalizations between *** study cohort was further divided based on the presence or absence of *** were identified,and hospitalization characteristics and clinical outcomes were *** of mortality for SBS hospitalizations complicated with sepsis were *** Of 247097 SBS hospitalizations,21.7%were complicated by *** SBS hospitalizations had a rising trend of hospitalizations from 20.8%in 2005 to 23.5%in 2014(P trend<0.0001).Compared to non-septic SBS hospitalizations,septic SBS hospitalizations had a higher proportion of males(32.8%vs 29.3%,P<0.0001),patients in the 35-49(45.9%vs 42.5%,P<0.0001)and 50-64(32.1%vs 31.1%,P<0.0001)age groups,and ethnic minorities,i.e.,Blacks(12.4%vs 11.3%,P<0.0001)and Hispanics(6.7%vs 5.5%,P<0.0001).Furthermore,septic SBS hospitalizations had a higher proportion of patients with intestinal transplantation(0.33%vs 0.22%,P<0.0001),inpatient mortality(8.5%vs 1.4%,P<0.0001),and mean length of stay(16.1 d vs 7.7 d,P<0.0001)compared to the non-sepsis cohort.A younger age,female gender,White race,and presence of comorbidities such as anemia and depression were identified to be independent predictors of inpatient mortality for septic SBS *** Septic SBS hospitalizations had a rising trend between 2005-2014 and were associated with higher inpatient mortality compared to non-septic SBS hospitalizations.

关键词： Short bowel syndrome Sepsis Outcomes Mortality Trends

*** Intelligent Scheme for Mitigating Black Hole Attacks in IoT

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The Re-embodiment of the Silk Road and the Impact of Transportation on Economic Development——A Case Study of Central Asia and Uzbekistan

哈尔滨工业大学学报（英文版） 2024年第3期 39页

作者： Feroz Khan A.B Weslin D Dilli Babu M Mohammed muzaffar Hussain

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The Re-embodiment of the Silk Road and the Impact of Transpo...

作者： muzaffar Nadjimkhodjaev 山东大学

学位级别：硕士

中国经济经过三十多年的快速发展,国内生产面临着能源短缺的问题。恢复新丝绸之路项目的活动是确保获得来自中亚的廉价提供的资源。尽管中亚国家了解利用自然资源的风险,但他们将从中方获得投资,预计随着这些国家过去25年的发展缓慢,中...

中国经济经过三十多年的快速发展,国内生产面临着能源短缺的问题。恢复新丝绸之路项目的活动是确保获得来自中亚的廉价提供的资源。尽管中亚国家了解利用自然资源的风险,但他们将从中方获得投资,预计随着这些国家过去25年的发展缓慢,中国将根据世界市场调整其经济。无论在乌兹别克斯坦和中亚地区有多种发展投资,本论文的研究中心都是围绕中亚地区各共和国的交通基础设施和跨境发展问题展开的,通过界定可能存在的障碍以及实现这些障碍的前景。实践中的思考。假设的证据将有助于通过提供真实的案例来评估这些风险。本文研究的“一带一路”活动纲要,在展现中国和中亚国家日益增长的共同经济优势的潜在结果的同时,提供了对倡议背后目标的理解。所谓潜在成果,就是说这个项目对中国和CA地区在经济上是有利的,因为整个世界都与中国有关(进出口繁荣)。通过在自然资源丰富的地区修建新的公路、铁路、油气管道,中国正在努力实现经济稳定。这反过来将为中亚共和国提供发展经济的机会,同时帮助中国从这些地区进口自然资源。乌兹别克斯坦的交通发展项目通过减少该国的贫困而在经济改善中发挥着重要作用。

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Developing Engagement in the Learning Management System Supported by Learning Analytics

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Computer Systems Science & Engineering 2022年第7期42卷 335-350页

作者： Suraya Hamid Shahrul Nizam Ismail muzaffar Hamzah Asad W.Malik Department of Information System Faculty of Computer Science and Information TechnologyUniversiti MalayaKuala LumpurMalaysia Faculty of Computing and Informatics Universiti Malaysia SabahSabahMalaysia Department of Computing School of Electrical Engineering and Computer Science(SEECS)National University of Sciences and Technology(NUST)IslamabadPakistan

Learning analytics is an emerging technique of analysing student par-ticipation and *** recent COVID-19 pandemic has signiﬁcantly increased the role of learning management systems(LMSs).LMSs previously only complemented face-to-face teaching,something which has not been possible between 2019 to *** date,the existing body of literature on LMSs has not analysed learning in the context of the pandemic,where an LMS serves as the only interface between students and ***,productive results will remain elusive if the key factors that contribute towards engaging students in learning are notﬁrst identiﬁ***,this study aimed to perform an exten-sive literature review with which to design and develop a student engagement model for holistic involvement in an *** required data was collected from an LMS that is currently utilised by a local Malaysian *** model was validated by a panel of experts as well as discussions with *** is our hope that the result of this study will help other institutions of higher learning determine factors of low engagement in their respective LMSs.

关键词： Engagement analysis learning analytics learning management system student engagement

Impact on Transportation Cost after CPEC

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Impact on Transportation Cost after CPEC

作者： M Mehtab muzaffar 中北大学

学位级别：硕士

本论文研究了通过中巴经济走廊CPEC的中国货物的运输问题,特别是通过实际评估针对其中的运输费用和运输时间进行了研究。本研究的重点在于发现在与运输成本和运输成本相关的阶段内,进口和价格是否会受到任何好的甚至是不利的影响,并找... 详细信息

本论文研究了通过中巴经济走廊CPEC的中国货物的运输问题,特别是通过实际评估针对其中的运输费用和运输时间进行了研究。本研究的重点在于发现在与运输成本和运输成本相关的阶段内,进口和价格是否会受到任何好的甚至是不利的影响,并找出与运输成本和运输时间的影响路径,主要目的是找出CPEC对中国制造产品的进口和成本的影响。这项研究使用了各种来源的成本数据,如航运企业和货运代理数据等。数据调查包括分类拆分、配送成本和行程周期等方面,并考察了企业对供应链的功能、活动和流程的了解是用来提取成本信息。本文首先综述了运输费用在供应链管理中的重要性和运输时间在供应链管理中的重要性。分析了巴基斯坦的地理、气候、经济和政府政策等多个因素,并将这些因素合并成一个整体描述,描述它们如何影响出口成本和时间周期。在分析货物路径时,CPEC项目的初始目标也考虑在内,讨论中还考虑了中国的贸易量和目前的航线过境时间。研究结果表明包括对德国、法国、沙特阿拉伯、阿曼和其他8个港口的供应链效益中大大节省了成本和时间,同时CPEC在运输时间和成本方面肯定会给供应链系统和台湾等地区带来巨大的利益。

关键词： CPEC 供应链

OffSig-SinGAN: A Deep Learning-Based Image Augmentation Model for Offline Signature Verification

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Computers, Materials & Continua 2023年第7期76卷 1267-1289页

作者： M.muzaffar Hameed Rodina Ahmad Laiha Mat Kiah Ghulam Murtaza Noman Mazhar Faculty of Computer Science and Information Technology University of MalayaKuala Lumpur46400Malaysia Department of Computer Science Bahauddin Zakariya UniversityMultan60000Pakistan Department of Computer Science Sukkur Institute of Business Administration UniversitySukkur65200Pakistan

Offline signature verification(OfSV)is essential in preventing the falsification of *** learning(DL)based OfSVs require a high number of signature images to attain acceptable ***,a limited number of signature samples are available to train these models in a real-world *** researchers have proposed models to augment new signature images by applying various ***,on the other hand,have used human neuromotor and cognitive-inspired augmentation models to address the demand for more signature ***,augmenting a sufficient number of signatures with variations is still a challenging *** study proposed OffSig-SinGAN:a deep learning-based image augmentation model to address the limited number of signatures problem on offline signature *** proposed model is capable of augmenting better quality signatures with diversity from a single signature image *** is empirically evaluated on widely used public datasets;*** quality of augmented signature images is assessed using four metrics like pixel-by-pixel difference,peak signal-to-noise ratio(PSNR),structural similarity index measure(SSIM),and frechet inception distance(FID).Furthermore,various experiments were organised to evaluate the proposed image augmentation model’s performance on selected DL-based OfSV systems and to prove whether it helped to improve the verification accuracy *** results showed that the proposed augmentation model performed better on the GPDSsyntheticSignature dataset than other augmentation *** improved verification accuracy rate of the selected DL-based OfSV system proved the effectiveness of the proposed augmentation model.

关键词： Signature forgery detection offline signature verification deep learning image augmentation generative adversarial networks