检索结果-南通市图书馆

Endotoxin-induced alterations of adipose tissue function:a pathway to bovine metabolic stress

Journal of Animal Science and Biotechnology 2024年第4期15卷 1391-1407页

作者： Miguel chirivi g.Andres contreras Department of Large Animal clinical Sciences Michigan State UniversityEast LansingMIUSA

During the periparturient period, dairy cows exhibit negative energy balance due to limited appetite and increased energy requirements for lactogenesis. The delicate equilibrium between energy availability and expenditure puts cows in a state of metabolic stress characterized by excessive lipolysis in white adipose tissues(AT), increased production of reactive oxygen species, and immune cell dysfunction. Metabolic stress, especially in AT, increases the risk for metabolic and inflammatory diseases. Around parturition, cows are also susceptible to endotoxemia. Bacterial-derived toxins cause endotoxemia by promoting inflammatory processes and immune cell infiltration in different organs and systems while impacting metabolic function by altering lipolysis, mitochondrial activity, and insulin sensitivity. In dairy cows, endotoxins enter the bloodstream after overcoming the defense mechanisms of the epithelial barriers, particularly during common periparturient conditions such as mastitis, metritis, and pneumonia, or after abrupt changes in the gut microbiome. In the bovine AT, endotoxins induce a pro-inflammatory response and stimulate lipolysis in AT, leading to the release of free fatty acids into the bloodstream. When excessive and protracted, endotoxin-induced lipolysis can impair adipocyte's insulin signaling pathways and lipid synthesis. Endotoxin exposure can also induce oxidative stress in AT through the production of reactive oxygen species by inflammatory cells and other cellular components. This review provides insights into endotoxins' impact on AT function, highlighting the gaps in our knowledge of the mechanisms underlying AT dysfunction, its connection with periparturient cows' disease risk, and the need to develop effective interventions to prevent and treat endotoxemia-related inflammatory conditions in dairy cattle.

关键词： Adipose tissue dysfunction Endotoxin Inflammation Insulin resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interpreting siliciclastic sedimentation in the upper Paleozoic Mulargia-Escalaplano Basin(Sardinia, Italy):influence of tectonics on provenance

引用

Journal of Palaeogeography 2024年第1期13卷 18-34页

作者： Luca g.costamagna Sara criniti Dipartimento di Scienze chimiche e geologiche Citadella UniversitariaBlocco A09042 Monserrato CAItaly Dipartimento di Ingegneria dell'Ambiente Universita della Calabria87036 Arcavacata di Rende CSItaly

Late to post-Variscan molassic basins of Late Pennsylvanian-Permian age are exposed in Sardinia(Italy). Here, the compositional and stratigraphic evolution of the Mulargia-Escalaplano sedimentary basin(central Sardinia) has been investigated to highlight how the tectono-magmatic processes have influenced the sedimentation. Ruditic and arenitic samples were collected along well-characterized stratigraphic sections to provide a new insight into the impact of the tectono-magmatic processes on siliciclastic sedimentation. As a result, the conglomerates are mainly clast-supported, petromictic, and thus immature, with no defined maturity trend upwards. Nevertheless, pebble composition changes in times from Variscan basement pebble-rich to volcanic rock-rich, as a consequence of the basin widening and the dismantling and reworking of the coeval volcanic activity. The sandstone composition clearly changes from quartzolithic to feldspatholithic upwards, as a response to the same change of feeding and reworking of the volcanic rocks. Occasionally, interbedded quartzolithic arenites suggest exceptional floods carrying debris from the far borders of the basin. Also, the immature sandstone composition has been interpreted as being controlled by a continuous supply of fresh debris and to a rapid burial rate. In addition, the disappearance of metaradiolarite(lydite AA) Paleozoic grains in the sandstone mineral suite could represent a distinctive marker of a progressive unroofing of the Variscan chain and a clastic supply from deeper tectonic units.

关键词： Petrography Stratigraphy Provenance Molassic basins Sardinia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

classification of conversational Sentences Using an Ensemble Pre-Trained Language Model with the Fine-Tuned Parameter

引用

computers, Materials & continua 2024年第2期78卷 1669-1686页

作者： R.Sujatha k.Nimala Department of Networking and communications SRM Institute of Science and TechnologyKattankulathurChengalpattuTamilnadu603203India

Sentence classification is the process of categorizing a sentence based on the context of the *** categorization requires more semantic highlights than other tasks,such as dependence parsing,which requires more syntactic *** existing strategies focus on the general semantics of a conversation without involving the context of the sentence,recognizing the progress and comparing *** ensemble pre-trained language model was taken up here to classify the conversation sentences from the conversation *** conversational sentences are classified into four categories:information,question,directive,and *** classification label sequences are for analyzing the conversation progress and predicting the pecking order of the *** of Bidirectional Encoder for Representation of Transformer(BERT),Robustly Optimized BERT pretraining Approach(RoBERTa),generative Pre-Trained Transformer(gPT),DistilBERT and generalized Autoregressive Pretraining for Language Understanding(XLNet)models are trained on conversation corpus with *** tuning approach is carried out for better performance on sentence *** Ensemble of Pre-trained Language Models with a Hyperparameter Tuning(EPLM-HT)system is trained on an annotated conversation *** proposed approach outperformed compared to the base BERT,gPT,DistilBERT and XLNet transformer *** proposed ensemble model with the fine-tuned parameters achieved an F1_score of 0.88.

关键词： Bidirectional encoder for representation of transformer conversation ensemble model fine-tuning generalized autoregressive pretraining for language understanding generative pre-trained transformer hyperparameter tuning natural language processing robustly optimized BERT pretraining approach sentence classification transformer models

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

controlled deployment of a long tether to operate as a partial space elevator

引用

Astrodynamics 2024年第2期8卷 311-321页

作者： Jinbang Huang Arun k.Misra Department of Mechanical Engineering McGill UniversityMontrealQCH3A 0C3Canada

The deployment of a long tether to operate as a partial space elevator,starting from a nucleus in geostationary orbit,is *** deployment is an inherently unstable process because the center of orbit gradually decreases from the geostationary altitude when deployment *** is also observed that the elasticity of the tether has an important effect on deployment *** is shown that the application of a transverse force on the main spacecraft,determined by using linear state feedback and appropriate gains,can stabilize the *** LQR controller is *** of the dynamics of the system are carried out using this controller for various parametric values of tether elasticity,deployment rates,etc.,to evaluate the efficacy of the controller.

关键词： tether space elevator deployment stability control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Trusted certified Auditor Using cryptography for Secure Data Outsourcing and Privacy Preservation in Fog-Enabled VANETs

引用

computers, Materials & continua 2024年第5期79卷 3089-3110页

作者： Nagaraju Pacharla k.Srinivasa Reddy School of computer Science and Engineering VIT-AP UniversityAmaravatiAndhra Pradesh522237India

With the recent technological developments,massive vehicular ad hoc networks(VANETs)have been established,enabling numerous vehicles and their respective Road Side Unit(RSU)components to communicate with *** best way to enhance traffic flow for vehicles and traffic management departments is to share thedata they *** needs to be more protection for the VANET *** effective and safe methodof outsourcing is suggested,which reduces computation costs by achieving data security using a homomorphicmapping based on the conjugate operation of *** research proposes a VANET-based data outsourcingsystem to fix the *** keep data outsourcing secure,the suggested model takes cryptography models *** will keep the generated keys for the purpose of vehicle *** controlling and overseeingthe outsourced data while preserving privacy,the suggested approach considers the Trusted certified Auditor(TcA).Using the secret key,TcA can identify the genuine identity of VANETs when harmful messages *** proposed model develops a TcA-based unique static vehicle labeling system using cryptography(TcA-USVLc)for secure data outsourcing and privacy preservation in *** proposed model calculatesthe trust of vehicles in 16 ms for an average of 180 vehicles and achieves 98.6%accuracy for data encryption toprovide *** proposedmodel achieved 98.5%accuracy in data outsourcing and 98.6%accuracy in privacypreservation in fog-enabled *** curve cryptography models can be applied in the future for betterencryption and decryption rates with lightweight cryptography operations.

关键词： Vehicular ad-hoc networks data outsourcing privacy preservation cryptography keys trusted certified auditors data security

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

化石有机碳风化及其生物地球化学循环效应

引用

中国科学：地球科学 2024年第6期54卷 2098-2102页

作者：李高军 gen k.LI 南京大学地球与行星科学系南京210023 Department of Earth Science University of CaliforniaSanta BarbaraCA 93106USA

生命过程是地球物质循环有别于其他行星最重要的特征之一.生命过程的重要一环是碳基生物通过光合作用将大气cO_(2)转化为有机形式的碳化合物,并释放氧气(Derry, 2014).化石有机碳,亦称为岩石有机碳,是一类在漫长地质历史时期积累并石化... 详细信息

生命过程是地球物质循环有别于其他行星最重要的特征之一.生命过程的重要一环是碳基生物通过光合作用将大气cO_(2)转化为有机形式的碳化合物,并释放氧气(Derry, 2014).化石有机碳,亦称为岩石有机碳,是一类在漫长地质历史时期积累并石化在岩石圈中的独特有机碳.化石有机碳与碳酸盐为主的无机形式碳一起成为固体地球去气作用cO_(2)释放最主要的汇,共同组成地球系统的两大核心碳储库.

关键词：固体地球碳化合物生物地球化学循环物质循环去气作用有机碳漫长地质历史碳储库

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal cOVID-19

引用

World Journal of gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus k Jacobs Steven D Morley kay Samuel katie Morgan Lyndsey Boswell Timothy J kendall David A Dorward Jonathan A Fallowfield Peter c Hayes John N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish National Blood Transfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BAckgROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and *** injury(LI)is also frequently reported in patients hospitalised with coronavirus disease 2019(cOVID-19),while preexisting MASLD increases the risk of LI and the development of cOVID-19-associated *** of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory syndrome coronavirus 2(SARS-coV-2)which causes cOVID-19,uses angiotensin-converting expression enzyme 2(AcE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and host cell *** To determine if hepatic AcE2 levels are altered during progression of MASLD and in patients who died with severe *** AcE2 protein levels and localisation,and histological fibrosis and lipid droplet accumulation as markers of MASLD were determined in formalin-fixed liver tissue sections across the MASLD pathological spectrum(isolated hepatocellular steatosis,metabolic dysfunction-associated steatohepatitis(MASH)+/-fibrosis,end-stage cirrhosis)and in post-mortem tissues from patients who had died with severe cOVID-19,using AcE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of total collagen and lipid droplet areas,followed by quantification using machine learning-based image pixel *** AcE2 staining is primarily intracellular and concentrated in the cytoplasm of centrilobular hepatocytes and apical membranes of bile duct ***,AcE2 protein levels are elevated in non-fibrotic MASH compared to healthy controls but not in the progression to MASH with fibrosis and in ***2 protein levels and histological fibrosis are not associated,but AcE2 and liver lipid droplet content are significantly correlated across the MASLD *** A

关键词： Metabolic dysfunction-associated steatotic liver disease Angiotensin-converting enzyme 2 Immunohistochemistry cOVID-19 cOVID-19-associated cholangiopathy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Empirical Wavelet Transform Based Method for Identification and Analysis of Sub-synchronous Oscillation Modes Using PMU Data

引用

Journal of Modern Power Systems and clean Energy 2024年第1期12卷 34-40页

作者： Joice g.Philip Jaesung Jung Ahmet Onen the Department of Energy Systems Research Ajou UniversitySuwonSouth Korea the Department of Electrical and Electronic Engineering Abdullah Gul UniversityKayseri38080Turkey the Department of Electrical and computer Engineering College of EngineeringSultan Qaboos UniversityAl-KhoudMuscatOman

This paper proposes an empirical wavelet transform(EWT)based method for identification and analysis of sub-synchronous oscillation(SSO)modes in the power system using phasor measurement unit(PMU)*** phasors from PMUs are preprocessed to check for the presence of *** the presence is established,the signal is decomposed using EWT and the parameters of the mono-components are estimated through Yoshida *** superiority of the proposed method is tested using test signals with known parameters and simulated using actual SSO signals from the Hami Power grid in Northwest *** show the effectiveness of the proposed EWT-Yoshida method in detecting the SSO and estimating its parameters.

关键词： Empirical wavelet transform(EWT) sub-synchronous oscillation Prony-based method Yoshida algorithm variational mode decomposition phasor measurement unit(PMU)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Supergravity effects on flame propagation and structure in hydrogen/air mixtures

引用

Acta Mechanica Sinica 2024年第6期40卷 31-38页

作者： Wenkai Liang chung k.Law center for combustion Energy Department of Energy and Power EngineeringTsinghua UniversityBeijing100080China Department of Mechanical and Aerospace Engineering Princeton UniversityPrinceton08544USA

In the current work,we investigated hydrogen/air flame propagation under supergravity *** show that when gravity is in the same/opposite direction as flame propagation,it leads to acceleration/deceleration of the flame,and that such an effect could substantially modify the flame propagation and structure at high gravity ***,for the absolute and relative flame propagation speeds,the gravity-affected flame speed shows opposite trends as the absolute flame speed is more affected by the local induced flow field,while the relative flame speeds are controlled by the super-adiabatic or sub-adiabatic flame *** gravity-affected thermal and chemical flame structures are also examined through the influence of the mixture equivalence ratio,pressure,and flame stretch.

关键词： Supergravity Flame acceleration Laminar flame speed Flame stretch Hydrogen

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical treatment of inflammatory bowel disease:From the gastroenterologist’s stand-point

引用

World Journal of gastrointestinal Surgery 2024年第5期16卷 1235-1254页

作者： John k Triantafillidis Inflammatory Bowel Disease Unit “Metropolitan General”HospitalHolargos 15562AtticaGreece Hellenic Society of gastrointestinal Oncology Haidari 12461AthensGreece

Treatment of ulcerative colitis(Uc)and crohn’s disease(cD)represents,in the majority of cases,a real challenge to the gastroenterologist’s abilities and skills as well as a clinical test concerning his/her levels of medical knowledge and *** the last two decades,our pharmaceutical arsenal was significantly strengthened,especially after the introduction of the so-called biological agents,drugs which to a large extent not only improved the results of conservative treatment but also changed the natural history of the ***,colectomy is still necessary for some patients with severe Uc although smaller compared to the past,precisely because of the improvements achieved in the available conservative ***,surgeries to treat colon dysplasia and cancer are increasing to some *** the same time,satisfactory improvements in surgical techniques,the pre-and post-operative care of patients,as well as the selection of the appropriate time for performing the surgery have been *** patients with cD,the improvement of conservative treatment did not significantly change the need for surgical treatment since two-thirds of patients need to undergo surgery at some point in the course of their *** the other hand,the outcome of the operation has improved through good preoperative care as well as the wide application of more conservative surgical techniques aimed at keeping as much of the bowel in situ as *** article discusses the indications for surgical management of Uc patients from the gastroenterologist’s point of view,the results of the emerging new techniques such as transanal surgery and robotics,as well as alternative operations to the classic ileo-anal-pouch *** author also discusses the basic principles of surgical management of patients with cD based on the results of the relevant *** self-evident is emphasized,that is,to achieve an excellent therapeutic result in patients with se

关键词： Inflammatory bowel disease Ulcerative colitis crohn’s disease Surgery Treatment Ileo-anal-pouch anastomosis Indications Techniques

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：