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Genetic association study of P2x7 A1513C(rs 3751143) polymorphism and susceptibility to pulmonary tuberculosis: A meta-analysis based on the findings of 11 case-control studies

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1126-1134页

作者： Eyad M.A.Alshammari Raju k.Mandal Mohd Wahid Sajad A.Dar Arshad Jawed Mohammed Y.Areeshi Saif khan Md.Ekhlaque Ahmed khan aditya k.panda Shafiul Haque Department of Clinical Nutrition College of Applied Medical SciencesUniversity of Ha’il Research and Scientific Studies Unit College of Nursing & Allied Health SciencesJazan University The University College of Medical Sciences & GTB Hospital (University of Delhi) Centre for Life Sciences Central University of Jharkhand

Objective:To summarize the precise association between pulmonary tuberculosis(PTB) and P2x7 A1513 C gene ***:PubMed and Google Scholar web-databases were searched for the studies reporting the association of P2x7 A1513 C polymorphism and PTB risk.A meta-analysis was performed for the selected case-control studies and pooled odds ratios(ORs) and 95%confidence intervals(95%CIs) were calculated for all the genetic ***:Eleven studies comprising 2 678 controls and 2 113 PTB cases were included in this *** observed overall no significant risk in all the five genetic *** stratified population by the ethnicity,Caucasian population failed to show any risk of PTB in all the genetics *** Asian ethnicity,variant allele(C vs.A:P=0.001;QR=1.375,95%CI=1.159-1.632) and heterozygous genotype(AC ***:P=0.001;OR=1.570,95%CI=1.269-1.944) demonstrated significant increased risk of ***,recessive genetic model(CC+AC ***:P=0.001;OR=1.540,95%CI= 1.255-1.890) also demonstrated increased risk of PTB in ***:Our meta-analysis did not suggest the association of P2x7 A1513 C polymorphism with PTB risk in overall or separately in Caucasian ***,it plays a significant risk factor for predisposing PTB in *** larger sample and expression studies are needed to validate this association.

关键词： Genetic model Meta-analysis Polymorphism P2x7 gene Pulmonary tuberculosis

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Determination of the time of refractive stability after uneventful phacoemulsification in Indian eyes

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World Journal of Experimental Medicine 2024年第2期14卷 89-96页

作者： Ashok kumar Nanda Bijnya Birajita panda Asish Swain Logesh Balakrishnan Department of Ophthalmology Kar Vision Eye HospitalBhubaneswar 751013OdishaIndia Department of Ophthalmology All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Optometry Kar Vision Eye HospitalBhubaneswar 751013OdishaIndia Department of Statistics Apollo HospitalsChennai 823104India

BACkGROUND knowledge about refractive stabilization and the accuracy of postoperative refractive error measurements are crucial for improved patient outcomes after *** guidelines typically recommend waiting 4-6 wk before prescribing corrective *** research focused on identifying factors that influence refractive errors in the early stages of post-cataract surgery,thus contributing to the existing literature on this *** To investigate the time required for refraction stability after uneventful phacoemulsification *** We compared the variation and statistical significance of the difference in spherical,cylindrical components,and the spherical equivalent between the 1-and 6-wk follow-up period in a group of 257 eyes that underwent uneventful phacoemulsification with foldable intraocular lens implantation,all performed by a single experienced *** Wilcoxon-Signed Rank Test was utilized to assess the magnitude of the change and determine its statistical *** refractive stability was defined as the point at which the change in spherical equivalent was within±0.5 dioptres for two consecutive *** The average age of the patients was 64.9±8.9 *** differences observed in both the visits in spherical power(0.1±0.2),cylinder power(0.3±0.4),and spherical equivalent(0.2±0.2)were minimal and not statistically *** majority of eyes(93.4%)achieved refractive stability within 6 wk after the *** cylindrical power differed between age groups at the 6th wk post-operative and the difference was statistically significant(P value 0.013).There were no significant differences in refractive stability when considering sex and axial *** Phacoemulsification with foldable intraocular lens implantation results in no significant changes in refraction for the majority of cases during the 6-wk follow-up ***,a spectacle prescription can be given at the completion of 1 wk.

关键词： Cataract surgery Phacoemulsification Refraction stability Visual acuity Spherical equivalent

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An Improved Lung Cancer Segmentation Based on Nature-Inspired Optimization Approaches

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1051-1075页

作者： Shazia Shamas Surya Narayan panda Ishu Sharma kalpna Guleria Aman Singh Ahmad Ali AlZubi Mallak Ahmad AlZubi Chitkara University Institute of Engineering and Technology Chitkara UniversityRajpuraPunjab140401India Higher Polytechnic School Universidad Europea del AtlánticoC/Isabel Torres 21Santander39011Spain Department of Engineering Universidad Internacional IberoamericanaAreciboPR00613USA Uttaranchal Institute of Technology Uttaranchal UniversityDehradunUttarakhand248007India Computer Science Department King Saud UniversityRiyadhSaudi Arabia Faculty of Medicine Jordan University of Science and TechnologyIrbidJordan

The distinction and precise identification of tumor nodules are crucial for timely lung cancer diagnosis andplanning intervention. This research work addresses the major issues pertaining to the field of medical imageprocessing while focusing on lung cancer Computed Tomography (CT) images. In this context, the paper proposesan improved lung cancer segmentation technique based on the strengths of nature-inspired approaches. Thebetter resolution of CT is exploited to distinguish healthy subjects from those who have lung cancer. In thisprocess, the visual challenges of the k-means are addressed with the integration of four nature-inspired swarmintelligent techniques. The techniques experimented in this paper are k-means with Artificial Bee Colony (ABC),k-means with Cuckoo Search Algorithm (CSA), k-means with Particle Swarm Optimization (PSO), and kmeanswith Firefly Algorithm (FFA). The testing and evaluation are performed on Early Lung Cancer ActionProgram (ELCAP) database. The simulation analysis is performed using lung cancer images set against metrics:precision, sensitivity, specificity, f-measure, accuracy,Matthews Correlation Coefficient (MCC), Jaccard, and *** detailed evaluation shows that the k-means with Cuckoo Search Algorithm (CSA) significantly improved thequality of lung cancer segmentation in comparison to the other optimization approaches utilized for lung cancerimages. The results exhibit that the proposed approach (k-means with CSA) achieves precision, sensitivity, and Fmeasureof 0.942, 0.964, and 0.953, respectively, and an average accuracy of 93%. The experimental results prove thatk-meanswithABC,k-meanswith PSO,k-meanswith FFA, andk-meanswithCSAhave achieved an improvementof 10.8%, 13.38%, 13.93%, and 15.7%, respectively, for accuracy measure in comparison to k-means segmentationfor lung cancer images. Further, it is highlighted that the proposed k-means with CSA have achieved a significantimprovement in accuracy, hence can be utilized by resea

关键词： Lesion lung cancer segmentation medical imaging meta-heuristic Artificial Bee Colony(ABC) Cuckoo Search Algorithm(CSA) Particle Swarm Optimization(PSO) Firefly Algorithm(FFA) segmentation

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Transforming Digital Experiences: The Evolution of Digital Experience Platforms (DXPs) from Monoliths to Microservices: A Practical Guide

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Journal of Computer and Communications 2024年第2期12卷 142-155页

作者： Sourabh Sethi Sarah panda Infosys Limited New York NY USA Microsoft Inc. Seattle WA USA

The research aims to explore the transition from monolithic Digital Experience Platforms (DXPs) to Microservices-based DXPs, addressing scalability challenges. The study systematically decomposes monolithic structures into Microservices, emphasizing business capability and subdomain decomposition. Concrete insights, challenges, and solutions encountered during this transformation process are presented. The research contributes valuable insights into the challenges and benefits of adopting Microservices in DXPs. Results highlight the importance of architectural patterns and strategic scaling dimensions for improved performance and scalability. The case study on Backbase’s Engagement Banking Platform showcases successful implementation, providing flexibility, integration, and efficient development in the evolving DXP landscape.

关键词： Digital Experience Platforms (DXPs) Microservices Software Evolution Distributed Systems Architectural Patterns

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Marine Predators Algorithm with Deep Learning-Based Leukemia Cancer Classification on Medical Images

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 893-916页

作者： Sonali Das Saroja kumar Rout Sujit kumar panda Pradyumna kumar Mohapatra Abdulaziz S.Almazyad Muhammed Basheer Jasser Guojiang Xiong Ali Wagdy Mohamed Department of Computer Science&Engineering Gandhi Institute for TechnologyBPUTBhubaneswar752054India Department of Information Technology Vardhaman College of Engineering(Autonomous)Hyderabad501218TelanganaIndia Department of Electronic&Communication Engineering Vedang Institute of TechnologyBhubaneswar752010India Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia Department of Computing and Information Systems School of Engineering and TechnologySunway UniversityJalan UniversitiBandar SunwaySelangor Darul Ehsan47500Malaysia Research Centre for Human-Machine Collaboration(HUMAC) School of Engineering and TechnologySunway UniversityJalan UniversitiBandar SunwaySelangor Darul Ehsan47500Malaysia Guizhou key Laboratory of Intelligent Technology in Power System College of Electrical EngineeringGuizhou UniversityGuiyang550025China Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Applied Science Research Center Applied Science Private UniversityAmman11931Jordan

In blood or bone marrow,leukemia is a form of cancer.A person with leukemia has an expansion of white blood cells(WBCs).It primarily affects children and rarely affects *** depends on the type of leukemia and the extent to which cancer has established throughout the *** leukemia in the initial stage is vital to providing timely patient *** image-analysis-related approaches grant safer,quicker,and less costly solutions while ignoring the difficulties of these invasive *** can be simple to generalize Computer vision(CV)-based and image-processing techniques and eradicate human *** researchers have implemented computer-aided diagnosticmethods andmachine learning(ML)for laboratory image analysis,hopefully overcoming the limitations of late leukemia detection and determining its *** study establishes a Marine Predators Algorithm with Deep Learning Leukemia Cancer Classification(MPADL-LCC)algorithm onMedical *** projectedMPADL-LCC system uses a bilateral filtering(BF)technique to pre-process medical *** MPADL-LCC system uses Faster SqueezeNet withMarine Predators Algorithm(MPA)as a hyperparameter optimizer for feature ***,the denoising autoencoder(DAE)methodology can be executed to accurately detect and classify leukemia *** hyperparameter tuning process using MPA helps enhance leukemia cancer classification *** results are compared with other recent approaches concerning various measurements and the MPADL-LCC algorithm exhibits the best results over other recent approaches.

关键词： Leukemia cancer medical imaging image classification deep learning marine predators algorithm

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High Performance MPI over the Slingshot Interconnect

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Journal of Computer Science & Technology 2023年第1期38卷 128-145页

作者： kawthar Shafie khorassani Chen-Chun Chen Bharath Ramesh Aamir Shafi Hari Subramoni Dhabaleswar k.panda Department of Computer Science and Engineering The Ohio State UniversityColumbusOH 43210U.S.A.

The Slingshot interconnect designed by HPE/Cray is becoming more relevant in high-performance computing with its deployment on the upcoming exascale *** particular,it is the interconnect empowering the first exascale and highest-ranked supercomputer in the world,*** offers various features such as adaptive routing,congestion control,and isolated *** deployment of newer interconnects sparks interest related to performance,scalability,and any potential bottlenecks as they are critical elements contributing to the scalability across nodes on these *** this paper,we delve into the challenges the Slingshot interconnect poses with current state-of-the-art MPI(message passing interface)*** particular,we look at the scalability performance when using Slingshot across *** present a comprehensive evaluation using various MPI and communication libraries including Cray MPICH,Open-MPI+UCX,RCCL,and MVAPICH2 on CPUs and GPUs on the Spock system,an early access cluster deployed with Slingshot-10,AMD MI100 GPUs and AMD Epyc Rome CPUs to emulate the Frontier *** also evaluate preliminary CPU-based support of MPI libraries on the Slingshot-11 interconnect.

关键词： AMD GPU interconnect technology MPI(message passing interface) Slingshot

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Outcome measures following tele-rehabilitation and conventional face to face rehabilitation in paediatric cochlear implant users during COVID-19 pandemic:A pilot study in a tertiary care setup

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Journal of Otology 2022年第1期17卷 31-38页

作者： Himanshu Verma Banumathy N Roshani Mishra Naresh k.panda Department of Otolaryngology and Head&Neck Surgery Post Graduate Institute of Medical Education and ResearchChandigarh160012India

Background:Following the COVID-19 pandemic,majority of paediatric cochlear implantees(CI)lost follow ups for rehabilitation and tele-therapy was *** study thus compared the outcome measures of paediatric CI users on tele-therapy versus conventional face to face therapy following COVID-19 ***:Twenty seven unilateral paediatric cochlear implantees in the age range of 2e11 years were divided into two groups based on the therapy modality,viz,tele-and face-to-face *** on the hearing age,participants were further divided into three groups,viz,0e2,2e4,and greater than four years.A complete the test battery comprising Integrated Scales of Development,Speech Intelligibility Rating scale,and Revised Categorical Auditory Perception were *** speech&language test battery was performed prior to initiating the rehabilitation and post 12 months of ***:Results of the present study revealed that conventional rehabilitation had better outcomes compared to *** rate of progress after one year of rehabilitation with respect to hearing-age showed a significant difference for the hearing-age group of 0e2 years across the domains of audition,speech and ***:The present study indicates that conventional method of the speech-language and auditory rehabilitation is far better compared to the tele rehabilitation services especially for those visiting tertiary care hospitals as most of them belong to lower and middle socioeconomic *** the results,it can be delineated that with lesser hearing experience,paediatric CI users always need to initially enroll for conventional therapy for better speech-language and auditory outcomes.

关键词： Cochlear implant Tele-therapy Conventional therapy Language outcomes Speech&language rehabilitation

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Optimized protoplast isolation and transfection with a breakpoint:accelerating Cas9/sgRNA cleavage efficiency validation in monocot and dicot

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aBIOTECH 2024年第2期5卷 151-168页

作者： Debasmita panda Subhasis karmakar Manaswini Dash Swagat kumar Tripathy Priya Das Sagar Banerjee Yiping Qi Sanghamitra Samantaray Pradipta kumar Mohapatra Mirza J.Baig kutubuddin A.Molla ICAR National Rice Research Institute CuttackOdisha 753006India Department of Botany Ravenshaw UniversityCuttackOdisha 753003India Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA

The CRISPR-Cas genome editing tools are revolutionizing agriculture and basic biology with their simplicity and precision ability to modify target genomic ***-predicted guide RNAs(gRNAs)often fail to induce efficient cleavage at target *** target loci are inaccessible due to complex chromatin ***,there is no suitable tool available to predict the architecture of genomic target sites and their ***,significant time and resources are spent on performing editing experiments with inefficient *** in vitro-cleavage assay could provide a rough assessment of gRNA efficiency,it largely excludes the interference of native genomic *** in-vivo testing gives a proper assessment of the cleavage ability of editing reagents in a native genomic ***,we developed a modified protocol that offers highly efficient protoplast isolation from rice,Arabidopsis,and chickpea,using a sucrose gradient,transfection using PEG(polyethylene glycol),and validation of single guide RNAs(sgRNAs)cleavage efficiency of *** have optimized various parameters for PEG-mediated protoplast transfection and achieved high transfection efficiency using our protocol in both monocots and *** introduced plasmid vectors containing Cas9 and sgRNAs targeting genes in rice,Arabidopsis,and chickpea *** dual sgRNAs,our CRISPRdeletion strategy offers straightforward detection of genome editing success by simple agarose gel *** sequencing of PCR products confirmed the editing efficiency of specific ***,we demonstrated that isolated protoplasts can be stored for up to 24/48 h with little loss of viability,allowing a pause between isolation and *** high-efficiency protocol for protoplast isolation and transfection enables rapid(less than 7 days)validation of sgRNA cleavage efficiency before proceeding with stable *** isolation and transfection method can als

关键词： Protoplast Genome editing Transgene-free edited plants Rice Chickpea

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A Mixed-integer Linear Programming Model for Defining Customer Export Limit in PV-rich Low-voltage Distribution Networks

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Journal of Modern Power Systems and Clean Energy 2023年第1期11卷 191-200页

作者： Pedro P.Vergara Juan S.Giraldo Mauricio Salazar Nanda k.panda Phuong H.Nguyen Intelligent Electrical Power Grids(IEPG)Group Delft University of TechnologyDelft 2628CDThe Netherlands Energy Transition Studies Group Netherlands Organisation for Applied Scientific Research(TNO)Amsterdam1043 NTThe Netherlands Electrical Energy Systems(EES)Group Eindhoven University of TechnologyEindhovenThe Netherlands IEEE

A photovoltaic(PV)-rich low-voltage(LV)distribution network poses a limit on the export power of PVs due to the voltage magnitude *** defining a customer export limit,switching off the PV inverters can be avoided,and thus reducing power *** on this,this paper proposes a mixed-integer nonlinear programming(MINLP)model to define such optimal customer *** MINLP model aims to minimize the total PV power curtailment while considering the technical operation of the distribution ***,a nonlinear mathematical formulation is ***,a new set of linearizations approximating the Euclidean norm is introduced to turn the MINLP model into an MILP formulation that can be solved with reasonable computational *** extension to consider multiple stochastic scenarios is also *** proposed model has been tested in a real LV distribution network using smart meter measurements and irradiance profiles from a case study in the *** assess the quality of the solution provided by the proposed MILP model,Monte Carlo simulations are executed in OpenDSS,while an error assessment between the original MINLP and the approximated MILP model has been conducted.

关键词： Low-voltage distribution network photovoltaic(PV)curtailment optimal power flow Monte Carlo simulations

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Effect of face masks on speech understanding: A clinical perspective during speech audiometry

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Journal of Otology 2022年第3期17卷 140-145页

作者： Rawish kumar Sanjay kumar Munjal Anuradha Sharma Md Noorain Alam Naresh k.panda Department of Otolaryngology PGIMERChandigarhIndia

The objective was to measure the effect of various face masks on speech recognition threshold and the word recognition score in the presence of varying background noise levels.20 normal-hearing adult subjects(a total of 40 ears)*** tone audiometry followed by speech recognition threshold and word recognition score at the most comfortable level in varying signal-to-noise ratios(SNR0,SNR10,and SNR15)using surgical,pleated cloth,and N95 *** surgical,cloth,and N95 masks,speech recognition thresholds increased by 1.8 dB,4.4 dB,and 5.05 dB,*** recognition scores decreased by 32%without a mask,43.7%in a surgical mask,46.3%in a cloth mask,and 46.7%in N95 mask conditions,between SNR15 and *** speech recognition threshold was negatively affected with cloth and N95 *** masks do not affect the word recognition scores at lower background noise ***,as the signal-to-noise ratio decreased,even the surgical,cloth,and N95 masks significantly impacted the word recognition score even in normal-hearing individuals.

关键词： Face masks Speech recognition threshold Word recognition score Signal-to-noise ratio Communication

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