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晚期上皮性卵巢癌腹膜播散模式及腹膜切除范围

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中国肿瘤临床 2022年第24期49卷 1291-1294页

作者： aditi bhatt Snita Sinukumar Praveen Kammar Loma Parikh Gaurav Goswami Shweta Thakkar Sakina Shaikh Sanket Mehta 张新静(翻译) 李雁(审校) 印度艾哈迈达巴德Zydus医院肿瘤外科印度普那Jehangir医院肿瘤外科印度孟买医院肿瘤外科印度艾哈迈达巴德Zydus医院病理科印度艾哈迈达巴德Zydus医院放射科不详

根据晚期上皮性卵巢癌(epithelial ovarian cancer,EOC)患者腹膜播散模式和腹膜切除范围的最新研究进展,分析评估肿瘤细胞减灭术(cytoreductive surgery,CRS)中行全壁腹膜切除术(total parietal peritonectomy,TPP)和内脏腹膜广泛切除... 详细信息

根据晚期上皮性卵巢癌(epithelial ovarian cancer,EOC)患者腹膜播散模式和腹膜切除范围的最新研究进展,分析评估肿瘤细胞减灭术(cytoreductive surgery,CRS)中行全壁腹膜切除术(total parietal peritonectomy,TPP)和内脏腹膜广泛切除术的前瞻性研究初步结果。在手术期间看似“正常”的腹膜中,隐匿性疾病的发生率较高,这可能是疾病复发的来源。腹腔热灌注化疗(hyperthermic intraperitoneal chemotherapy,HIPEC)主要作用于微小病灶和手术过程中脱落到腹腔内的游离癌细胞,从而降低复发风险;与单纯CRS相比,HIPEC联合CRS在无进展生存率和总生存率上均显示出优势。彻底根除这种隐匿性疾病的唯一方法为腹膜切除,TPP与内脏腹膜广泛切除术可能是治疗这种隐匿性疾病最有效的策略。TPP的术后并发症可接受,TPP可延长无进展生存率和总生存率,且TPP后铂类耐药复发的发生率远低于既往结果。

关键词：上皮性卵巢癌腹膜播散模式腹膜切除范围肿瘤细胞减灭术全壁腹膜切除

Salt Tolerance Mechanisms and Approaches:Future Scope of Halotolerant Genes and Rice Landraces

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Rice science 2020年第5期27卷 368-383页

作者： Tarun bhatt aditi Sharma Sanjeev Puri Anu Priya Minhas Department of Biotechnology University Institute of Engineering and TechnologySector-25Panjab UniversityChandigarh 160014India

All rice plant developmental stages are severely affected by soil salinity. Salinity-induced ionic and osmotic stresses affect stomata closure and gaseous exchange, and reduce transpiration and the rate of carbon assimilation, and hence decrease plant yield. Understanding the response of rice plants toward salinity stress at the genetic level and developing salt-tolerant varieties are the vital mandates for its effective management. This review described the present status of salt-tolerance achieved in rice by various mechanisms including the ion homeostasis(Na^+/H^+, OsNHX antiporters), compatible organic solutes(glycine betaine and proline), antioxidative genes(OsECS, OsVTE1, OsAPX and OsMSRA4.1), salt responsive regulatory elements(transcription factors, cis-acting elements and miRNAs) and genes ecoding protein kinases(MAPKs, SAPKs and STRKs). Further, the future perspective of developing salt-tolerant varieties lies in exploring halotolerant gene homologs from rice varieties, especially the landraces. Genetic diversity among rice landraces can serve as a valuable resource for future studies toward variety improvement through breeding and genome editing. Further, identification, multiplication, preservation and utilization of biodiversity among landraces are the urgent buffers to be saved as a heritage for future generations to come.

关键词： rice soil salinity ion homeostasis halotolerant landrace

Efficacy of a Diabetes Specific Nutritional Supplement (DSNS) on Glycemic Response in Prediabetic Adults: A Two-Armed, Open-Labelled Randomized Controlled Study

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Food and Nutrition Sciences 2024年第7期15卷 612-643页

作者： Deepti Khanna Kejal Joshi Reddy Hema S. Gopalan Jaladhi bhatt Jayanti Gupta Simran Sethi Parth Joshi Manoj Pareek Department of R&D Hindustan Unilever Limited Gurugram India Mumbai India Cliantha Research Ahmedabad India

It is well known that Diabetes Specific Nutritional Supplements (DSNSs) are linked to improved glycemic control in individuals with diabetes. However, data on efficacy of DSNSs in prediabetics is limited. This was a two-armed, open-labelled, randomized controlled six-week study on 199 prediabetics [30 - 65 years;Glycosylated Hemoglobin (HbA1c) 5.7% - 6.4% and/or Fasting Blood Glucose (FBG) 100-125 mg/dl]. Two parallel phases were conducted: Acute Blood Glucose Response (ABGR) and Intervention phase. Prediabetic participants were randomized into test (n = 100) and control (n = 99). The primary objective was to assess the ABGR of DSNS versus an isocaloric snack, measured by incremental Area under the Curve (iAUC). Test and control received 60 g of DSNS and 56 g of isocaloric snack (cornflakes) respectively, both in 250 ml double-toned milk on visit days 1, 15, 29 and 43. Postprandial Blood Glucose (PPG) was estimated at 30, 60, 90, 120, 150 and 180 minutes. During the 4 weeks intervention phase, the test group received DSNS with lifestyle counselling (DSNS + LC) and was compared with the control receiving lifestyle counselling alone (LC alone). Impact was studied on FBG, HbA1C, anthropometry, body composition, blood pressure, nutrient intake, and physical activity. The impact of DSNS was also studied using CGM between two 14-day phases: CGM1 baseline (days 1 - 14) and CGM2 endline (days 28 - 42). DSNS showed significantly lower PPG versus isocaloric snack at 30 (p 12, and chromium were reported by DSNS + LC versus LC alone. No other significant changes were reported between groups. It may be concluded that DSNS may be considered as a snack for prediabetic or hyperglycemic individuals requiring nutritional support for improved glycemic control.

关键词： Diabetes Specific Nutritional Supplement Prediabetes Acute Blood Glucose Response Incremental Area under Curve Lifestyle Counselling

Evaluation of Human Impacts on Bartlett Pond Ecosystem, Laredo, Southern Texas, USA, through Empirical Modeling

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Journal of Environmental Protection 2024年第4期15卷 497-526页

作者： Maya P. bhatt Amede Rubio Ganesh B. Malla Cristobal Lopez Virginia Morales Erick Vazquez Cano David Marquez Orlando Berumen Alvarez Alfred Addo-Mensah Department of Biology and Chemistry Texas A&M International University Laredo USA Department of Mathematics Computer Geology and Physics University of Cincinnati-Clermont College Batavia USA

The trace elements chemistry of Bartlett Pond, a small shallow wetland pond in Laredo, Southern Texas, was sampled to evaluate the dynamics of trace elements impacts on water quality and ecosystems ecology of the pond. Two types of fish (bass and tilapia) were also sampled to see the trace element accumulation in different parts of their body. The concentrations of trace elements in water samples were found in the following order: Fe ≫Sb > Pb > As ≫Co > Tl > Cr > Cd within Bartlett Pond. Overall, the water quality of the pond is unacceptable for drinking and any other purposes as trace element concentrations (e.g. As, Cd, Co, Cr, Pb, Fe, Sb and Tl) are exceedingly higher (several fold) than the WHO and US EPA guidelines. Predictive and correlation analysis shows that most trace elements exhibit a strong positive correlation among them indicating the same anthropogenic sources and biogeochemical processes regulate these trace elements within the pond. Distributions of the trace elements in water exhibit different shapes mostly as positively skewed distribution for As, Cd, Co, Cr, and Tl, symmetrical distribution for Fe and almost symmetrical distribution for Pb and Sb. Concentrations of As, Co and Tl accumulated much higher in different parts of the Bass than Tilapia fish. The concentrations of As, Tl, Co, and Sb appeared significantly higher in different parts of the body of both Bass and Tilapia than the maximum SRM certified values. Accumulation of these contaminants in fish tissues pose increased health risks to humans who consume these contaminated fish although fishing is prohibited. Anthropogenic activities in the region primarily degrade the whole pond ecosystem ecology of the Bartlett Pond and waters of this pond to be not recommended for any use. These findings may be useful for the scientific community and concerned authorities to improve understanding about these precious natural resources and conservation of the ecosystem ecology.

关键词： Trace Elements Bartlett Pond Laredo Southern Texas Wetlands Ecosystem Ecology

Efficacy of a Diabetes Specific Nutrition Supplement on Glycemic, Anthropometric, Dietary and Gut Health Markers in Adults with Type 2 Diabetes: An RCT

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Food and Nutrition Sciences 2024年第8期15卷 846-867页

作者： Deepti Khanna Hema S. Gopalan Kuzhandaivelu Abirami Vasudevan Sudha Rajagopal Gayatri Kejal Joshi-Reddy Jaladhi bhatt Raman Ganesh Jeevan Karthikeyan Parkavi Vadivel Deepika Manoj Pareek Ranjit Mohan Anjana Viswanathan Mohan R&D Department Hindustan Unilever Limited Gurugram India Department of Foods Nutrition & Dietetics Research Madras Diabetes Research Foundation Chennai India Department of Diabetology Dr. Mohans Diabetes Specialities Centre Chennai India

With increasing incidence of diabetes, use of diabetes specific nutrition supplements (DSNS) is common for better management of the disease. To study effect of 12-week DSNS supplementation on glycemic markers, anthropometry, lipid profile, SCFAs, and gut microbiome in individuals with diabetes. Markers studied were glycemic [Fasting Blood Glucose (FBG), Post Prandial Glucose (PPG), HbA1c, Incremental Area under curve (iAUC), Mean Amplitude of Glycemic Excursions (MAGE), Time in/above Range (TIR/TAR)], anthropometry [weight, Body Mass Index (BMI), waist circumference (WC)], lipid profile, diet and gut health [plasma short chain fatty acids (SCFAs)]. N = 210 adults were randomized to receive either DSNS with standard care (DSNS + SC;n = 105) or standard care alone (SC alone;n = 105). After 12 weeks, significant differences between DSNS + SC versus SC alone was observed in FBG [−3 ± 6 vs 14 ± 6 mg/dl;p = 0.03], PPG [−35 ± 9 vs −3 ± 9 mg/dl;p = 0.01], weight [−0.6 ± 0.1 vs 0.2 ± 0.1 kg;p = 0.0001], BMI [−0.3 ± 0.1 vs 0.1 ± 0.1 kg/m2;p = 0.0001] and WC [−0.3 ± 0.2 vs 0.2 ± 0.2 cm;p = 0.01]. HbA1C and low-density lipoprotein (LDL) were significantly reduced in DSNS + SC [−0.2 ± 0.9;p = 0.04 and −5 mg/dl;p = 0.03] respectively with no change in control. Continuous Glucose Monitoring (CGM) reported significant differences between DSNS + SC versus SC alone for mean glucose [−12 ± 65 vs 28 ± 93 mg/dl;p < 0.01], TAR 180 [−9 ± 42 vs 7 ± 45 mg/dl;p = 0.04], TAR 250 [−3 ± 27 vs 9 ± 38 mg/dl;p = 0.05], iAUC [−192 (1.1) vs −48 (1.1) mg/dl;p = 0.03]. MAGE was significantly reduced for both DSNS + SC (−19 ± 67;p < 0.001) and SC alone (−8 ± 70;p = 0.04), with reduction being more pronounced for DSNS + SC. DSNS + SC reported a decrease in carbohydrate energy % [−9.4 (−11.3, −7.6) %;p < 0.0001] and amount [−47.4 (−67.1, −27.7) g;p < 0.0001], increased dietary fiber [9.5 (7.2, 11.8) g;p < 0.0001] and protein energy % [0.9 (0.5, 1.3) %;p < 0.0001] versus SC alone. DSNS + SC reported signi

关键词： Diabetes Specific Nutrition Supplement Standard of Care Diabetes Glycemic Markers HbA1C

Ion Conduction in Superionic Glassy Electrolytes:An Overview

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Journal of Materials Science & Technology 2013年第3期29卷 193-208页

作者： Angesh Chandra Alok bhatt Archana Chandra Department of Applied Physics Shri Shankaracharya Institute of Prof.Manag.& Tech.Raipur 492015C.G.India Department of Applied Physics M.P Christian College of Engg.& Tech.Bhilai 490026C.G.India

The various theoretical and experimental models for ion conduction mechanism of fast ion conducting （FIC） glass electrolytes have been reported in the present review paper. Some characterization techniques of FIC glasses are presented. The experimental methods for determination of some ion transport parameters viz ionic conductivity （σ）, ionic mobility （μ）, mobile ion concentration （n）, ionic drift velocity （Vd）, ionic transference number （tion） and activation energies of FIC glasses are explained. The solid state battery fabrication by using some FIC glasses is also reported.

关键词： Ion conduction Glassy solid electrolyte Fast ion conducting (FIC) glass Superionic solid Relaxation phenomenon

Quantum Cryptography for Internet of Things Security

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Journal of Electronic Science and Technology 2019年第3期17卷 213-220页

作者： Alekha Parimal bhatt Anand Sharma the Department of Computer Science and Engineering Mody University of Science and Technology

Internet of things (IoT) is a developing technology with a lot of scope in the future. It can ease various different tasks for us. On one hand, IoT is useful for us, on the other hand, it has many serious security threats, like data breaches, side-channel attacks, and virus and data authentication. Classical cryptographic algorithms, like the Rivest-Shamir-Adleman (RSA) algorithm, work well under the classical computers. But the technology is slowly shifting towards quantum computing, which has immense processing power and is more than enough to break the current cryptographic algorithms easily. So it is required that we have to design quantum cryptographic algorithms to prevent our systems from security breaches even before quantum computers come in the market for commercial uses. IoT will also be one of the disciplines, which needs to be secured to prevent any malicious activities. In this paper, we review the common security threats in IoT and the presently available solutions with their drawbacks. Then quantum cryptography is introduced with some of its variations. And finally, the analysis has been carried out in terms of the pros and cons of implementing quantum cryptography for IoT security.

关键词： Internet of things quantum computing quantum cryptography security

Immunotherapy for recurrent hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第15期29卷 2261-2271页

作者： Ahan bhatt Jennifer Wu Division of Hematology and Oncology Perlmutter Cancer Center of NYU Langone HealthNYU School of MedicineNew YorkNY 10016United States

Hepatocellular carcinoma(HCC)is presented frequently in late stages that are not amenable for curative *** for patients who can undergo resection for curative treatment of HCC,up to 50%*** patients who were not exposed to systemic therapy prior to recurrence,recurrence frequently cannot be subjected to curative therapy or local *** patients have several options of immunotherapy(IO).This includes programmed cell death protein 1(PD-1)and cytotoxic T-lymphocyte associated protein 4 treatment,combination of PD-1 and vascular endothelial growth factor inhibitor or single agent PD-1 therapy when all other options are deemed *** are also investigational therapies in this area that explore either PD-1 and tyrosine kinase inhibitors or a novel agent in addition to PD-1 with vascular endothelial growth factor *** minireview explored IO options for patients with recurrent HCC who were not exposed to systemic therapy at the initial *** also discussed potential IO options for patients with recurrent HCC who were exposed to first-line therapy with curative intent at diagnosis.

关键词： Liver neoplasms Immune checkpoint blockade Combination drug therapy PD-1-PD-L1 blockade CTLA-4 inhibitor

Analysis of silicon-based integrated photovoltaic–electrochemical hydrogen generation system under varying temperature and illumination

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Journal of Energy Chemistry 2017年第1期26卷 72-80页

作者： Vishwa bhatt Brijesh Tripathi Pankaj Yadav Manoj Kumar Department of Solar Energy School of TechnologyPandit Deendayal Petroleum UniversityGandhinagar 382007India Department of Science School of TechnologyPandit Deendayal Petroleum UniversityGandhinagar 382007India Department of Electrical Engineering Incheon National UniversityIncheon 406772Republic of Korea

Last decade witnessed tremendous research and development in the area of photo-electrolytic hydrogen generation using chemically stable nanostructured photo-cathode/anode materials. Due to intimately coupled charge separation and photo-catalytic processes, it is very difficult to optimize individual components of such system leading to a very low demonstrated solar-to-fuel efficiency (SFE) of less than 1%. Recently there has been growing interest in an integrated photovoltaic–electrochemical (PV–EC) system based on GaAs solar cells with the demonstrated SFE of 24.5% under concentrated illumination condition. But a high cost of GaAs based solar cells and recent price drop of poly-crystalline silicon (pc-Si) solar cells motivated researchers to explore silicon based integrated PV–EC system. In this paper a theoretical framework is introduced to model silicon-based integrated PV–EC device. The theoretical framework is used to analyze the coupling and kinetic losses of a silicon solar cell based integrated PV–EC water splitting system under varying temperature and illumination. The kinetic loss occurs in the range of 19.1%–27.9% and coupling loss takes place in the range of 5.45%–6.74% with respect to varying illumination in the range of 20–100 mW/cm2. Similarly, the effect of varying temperature has severe impact on the performance of the system, wherein the coupling loss occurs in the range of 0.84%–21.51% for the temperature variation from 25 to 50 °C. © 2016 Science Press

关键词： Electrochemical cells Electrochemical impedance spectroscopy Gallium arsenide Hydrogen production Nanostructured materials Polysilicon Semiconducting gallium Silicon Silicon solar cells Solar power generation