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Retrospective cohort study of statin therapy effect on resected colorectal liver metastases

World Journal of Gastrointestinal Surgery 2020年第2期12卷 34-44页

作者： Edward Alabraba Hussain Ibrahim adina olaru Iain Cameron Dhanny Gomez Nottingham HPB Surgery Group Department of Hepatobiliary Surgery and Pancreatic Surgery Queen’s Medical CentreNottingham University Hospitals NHS TrustNottingham NG72UHUnited Kingdom NIHR Nottingham Digestive Disease Biomedical Research Unit University of NottinghamNottingham NG72UHUnited Kingdom 不详

BACKGROUND Above and beyond their role in cardiovascular risk reduction,statins appear to have a chemopreventive role in some gastro-intestinal *** the quest for new chemopreventive agents,some existing established drugs such as statins have shown potential for re-purposing as *** existing drugs,whose pharmacodynamics are familiar,for novel beneficial effects offers a more cost-effective and less time-consuming strategy than establishing brand new drugs whose pharmacodynamic profile is *** studies show statins decrease the risk of developing colorectal cancer but there are no published studies exploring the potential impact of statins on carcinogenesis in colorectal liver metastases(CRLM).AIM To evaluate impact of statins on outcomes of CRLM resection,and secondarily to assess if statins influence CRLM *** We conducted a retrospective cohort study of patients operated for CRLM over a 13-year period from 2005 to *** were identified from a prospective database maintained in our Tertiary care *** 586 patients included the study had undergone resection of CRLM following discussion at multidisclipinary team meeting,some patients requiring neoadjuvant chemotherapy to downstage CRLM prior to *** analysed patient demographics,operative details,CRLM histopathology,Index of Deprivation,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio and chemotherapy use in relation to clinical *** were performed using SPSS version 16.0;significance taken at 5%.RESULTS Liver resection for CRLM was undertaken in 586 patients at a median age of 68(range 19 to 88)*** therapy was used by 181 *** follow-up time was 23(range 12-96)mo and further colorectal cancer metastases developed in 267 patients.A total of 131 patients ***-variate analysis identified 6 independent predictors of poorer disease-free survival:Synchronous presentation,multiple tumours,t

关键词： Colorectal liver metastases Statin Liver resection Chemoprevention Tumour biology Survival

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