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Acta Metallurgica Sinica(English Letters) 2016年第10期29卷 902-910页

作者： Rizwan Bajwa Zulfiqar Khan H.Nazir Vivek Chacko adil saeed NanoCorr Energy and Modelling Research GroupBournemouth University

This paper presents research findings on the tribological performance of electrodeposited coatings subject to nano-lubricants with the addition of nano-Al2O3 and graphene and Ni/nano-Al2O3 composite coatings. Electrodeposited coatings were produced by using a pulse electrodeposition method. Tribological experiments were conducted by using a linear reciprocating ball on fiat sliding tribometer. Experimental results confirmed that the wear and friction resistance properties were significantly enhanced by doping of nano-effects in the lubricating oil and composite coating. The addition of Al2O3 nanoparticles in the lubricating oil showed the best tribological properties, followed by Ni-Al2O3 composite coatings and nano-oil with graphene. The surface morphology and microstructure of electrodeposited coatings were examined by scanning electron microscopy, energy-dispersive spectroscopy and X-ray diffraction. The wear mechanisms of these coatings subjected to tribological testing were investigated by post-test surface analyses. This research provides a novel approach to design durable nano-coatings for tribological applications in various industries such as automotive, aerospace, locomotive and renewable energy technologies.

关键词： Tribology Nanoparticles Graphene Nano-additives Nano-coatings

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纳米复合涂层往复磨损行为的试验分析与建模

现代涂料与涂装 2019年第1期 72-72页

作者： Mian Hammad Nazir Zulfiqar Ahmad Khan adil saeed 王志强

当前汽车、国防和精密制造业对纳米复合涂层提出了高耐磨性和低摩擦系数的特殊要求,本文针对以下几种纳米复合涂层进行了微动磨损的试验研究,它们分别为:镍-氧化铝(Ni/Al2O3)、镍-矽碳化物(Ni/SiC)、镍-氧化锆(Ni/ZrO2)及镍/石墨烯。通... 详细信息

当前汽车、国防和精密制造业对纳米复合涂层提出了高耐磨性和低摩擦系数的特殊要求,本文针对以下几种纳米复合涂层进行了微动磨损的试验研究,它们分别为:镍-氧化铝(Ni/Al2O3)、镍-矽碳化物(Ni/SiC)、镍-氧化锆(Ni/ZrO2)及镍/石墨烯。通过扫描电镜(SEM)显微照片、晶粒尺寸、硬度、气孔率、表面应力、摩擦系数行为和

关键词：纳米复合涂层气孔率石墨烯磨损模型

Supramolecular Nanohelix Fabricated by Pillararene-Based Host–Guest System for Chirality Amplification, Transfer, and Circularly Polarized Luminescence in Water

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CCS Chemistry 2022年第10期4卷 3426-3439页

作者： Krishnasamy Velmurugan adil Murtaza Azhar saeed Jianing Li Kaiya Wang Minzan Zuo Qian Liu Xiao-Yu Hu College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106 School of Physics MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed MatterXi’an Jiaotong UniversityXi’an 710049 State Key Laboratory for Mechanical Behaviour of Materials Shaanxi International Research Center for Soft MatterXi’an Jiaotong UniversityXi’an 710049

Amplified chirality and Förster resonance energy transfer(FRET)-assisted chirality transfer frommolecular to nanoscale level have been shown to play a vital role in co-assembled nanohelix for potential energy transfer in biological ***,we have constructed a chiral host–guest complex donor system for chiral amplification via induced chirality of pillar[5]arene host and loaded it with an achiral dye acceptor to demonstrate how chirality-assisted excitation energy transfer occurred in the supramolecular nanohelix system in an aqueous medium.

关键词： host–guest interaction supramolecular chirality chirality transfer circularly polarized luminescence supramolecular self-assembly

Dependency of Torque on Aerofoilcamber Variation in Vertical Axis Wind Turbine

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World Journal of Mechanics 2016年第11期6卷 472-486页

作者： adil Loya Muhammad Zia Ullah Khan Rumeel Ahmad Bhutta Muhammad saeed Department of Mechatronic Engineering PAF Karachi Institute of Information Technology Sahiwal Pakistan Department of Mechanical Engineering COMSATS Institute of Information Technology Islamabad Pakistan Department of Mechanical Civil and Aerospace Engineering Manchester UK

The advancements in the wind turbine technology specially associated with Vertical Axis Wind Turbines (VAWT), has been improved for last couple of years. This is due to extensive use of computational techniques. This paper investigates dependency of torque on aerofoil geometry by performing numerical simulation on Darrieustype VAWT with fix pitch blades. Coordinate points for aerofoil was generated using Java Foil software. Reynolds-Averaged Navier Stokes (RANS) turbulence modelling was used for predicting the flow and efficiency of the three blades VAWT. The unsteady flow condition was considered to make simulation as realistic as possible. In order to visualize high strain flow and separation, we used two equation models i.e. k-ε with RNG. NACA 0012 aerofoil was used and camber variations were carried out for developing samples of aerofoil to check the enhancement in performance of VAWT. Results demonstrate the torque and power along with its coefficients. It has been investigated that the performance efficiency was significantly improved by changing the aerofoil camber, demonstrating highest torque with camber (C3) aerofoil and the least performance was observed using camber (C0).

关键词： Co-Efficient of Moment CFD Torque Power Fluent Java Foil

Seroprevalence of Human Brucellosis in Kuku Dairy Scheme, Khartoum State, Sudan

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Journal of Life Sciences 2014年第10期8卷 811-814页

作者： Tamador-Elkhansaa Elnour Angara adil Abdel Rahman Ali Ismail Nageeb Suliman saeed Department of Development Studies & Extension Sudan University of Science and Technology (SUST) Khartoum 11111 Sudan Department of Preventive Veterinary Medicine University of Bahri Khartoum 11111 Sudan Department of Microbiology Faculty of Medicine University of Khartoum Khartoum 11111 Sudan

A seroprevalence investigation of human brucellosis was carried out in Kuku Dairy Scheme, Sudan. A total of 176 serum samples were collected and screened by Rose Bengal Plate Test （RBPT）. The positive sera vqere further examined using Tube Agglutination Test （TAT） and c-Elisa. The seropositivity was 15.9%, 14.8% and 11.4% using RBPT, TAT and c-Elisa respectively. Whereas, the active infection based on seropositivity and clinical signs were 4.6%, 4.6% and 2.3% in case of RBPT, TAT and c-Elisa respectively. Based on c-Elisa result the infected individuals were further subjected to clinical examination and treated with streptomycin and doxocycline for six weeks.

关键词： Malta fever in contact persons agricultural workers Kuku Scheme.

A Comparative Evaluation of Polystyrene Divinylbenzene Copolymer HPLC Columns on the Chromatographic Performance of the Compendial Method for Doxycycline Hyclate Capsules: Implications for Method Implementation of a Medical Countermeasure Medication

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Journal of Analytical Sciences, Methods and Instrumentation 2015年第3期5卷 23-34页

作者： Firat Yerlikaya adil Mohammad Patrick J. Faustino Mansoor A. Khan saeed R. Khan Division of Product Quality Research Office of Testing and Research Office of Pharmaceutical Quality Center for Drug Evaluation and Research Food and Drug Administration Silver Spring MD USA

The purpose of this study was to evaluate the impact of polystyrene divinylbenzene copolymer HPLC columns on the chromatographic performance of the USP compendial method for doxycycline hyclate. The compendial method was implemented based on the assessment of the chromatographic performance of six USP defined L21 polystyrene divinylbenzene HPLC columns. Modifications to the method were based on USP for chromatography. The method was validated for the determination of doxycycline hyclate and its impurities in commercially available drug products. A number of different polystyrene-divinylbenzene columns were tested and failed to provide selectivity for the resolution of doxycycline and its impurities. Separation was optimally achieved on an Agilent PLPR-S column (250 × 4.6 mm, 8 μm) by using an Agilent 1260 series HPLC system. Doxycycline hyclate and its impurities were eluted isocratically at a flow rate of 1 mL/min with mobile phase and detected at 270 nm. The column temperature was maintained at 60oC. The method was validated according to USP category I requirements for Assay. Validation acceptance criteria were met in all cases. The analytical range for doxycycline hyclate was 50 - 250 μg/mL and the linearity was r2 > 0.999 over three days. The method was determined to be specific. Both accuracy (95.1% - 102.4%) and precision (0.50% - 4.8%) were established across the analytical range for low, intermediate and high QC concentrations. Method applicability was demonstrated by analyzing marketed products of doxycycline hyclate, in which results showed potency meeting USP acceptance criteria. In conclusion, this study described the remarkable differences in selectivity that were encountered during the implementation phase for the compendial methods for doxycycline and its impurities in marketed products and it could be used in the future to assss the product quality of doxycycline hyclate capsules stored in the National stockpiles.

关键词： Doxycycline 4-Epidoxycycline 6-Epidoxycycline Metacycline Polystyrene-Divinylbenzene

Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients:a randomised,double-blinded,placebo-controlled phase-II trial

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Translational Neurodegeneration 2023年第1期12卷 849-871页

作者： Burak Yulug Ozlem Altay Xiangyu Li Lutfu Hanoglu Seyda Cankaya Simon Lam Halil Aziz Velioglu Hong Yang Ebru Coskun Ezgi Idil Rahim Nogaylar Ahmet Ozsimsek Cemil Bayram Ismail Bolat Sena Oner Ozlem Ozdemir Tozlu Mehmet Enes Arslan Ahmet Hacimuftuoglu Serkan Yildirim Muhammad Arif saeed Shoaie Cheng Zhang Jens Nielsen Hasan Turkez Jan Borén Mathias Uhlén adil Mardinoglu Department of Neurology and Neuroscience Faculty of MedicineAlanya Alaaddin Keykubat UniversityAntalyaTurkey Science for Life Laboratory KTH-Royal Institute of TechnologyStockholmSweden Department of Neurology Faculty of MedicineIstanbul Medipol UniversityIstanbulTurkey Centre for Host-Microbiome Interaction’s Faculty of DentistryOral and Craniofacial SciencesKing’s College LondonLondonUK Department of Women’s and Children’s Health Karolinska InstituteStockholmSweden Functional Imaging and Cognitive-Affective Neuroscience Lab Istanbul Medipol Univer-sityIstanbulTurkey Department of Medical Pharmacology Faculty of Medi-cineAtatürk UniversityErzurumTurkey Department of Pathology Veterinary FacultyAtaturk UniversityErzurumTurkey Department of Molecular Biology and Genetics Faculty of ScienceErzurum Technical UniversityErzurumTur-key School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhouPeople’s Republic of China Department of Biology and Biological Engineering Chalmers University of TechnologyGothenburgSweden Department of Medical Biology Faculty of MedicineAtatürk UniversityErzurumTurkey Department of Molecular and Clinical Medicine University of Gothenburg and Sahlgrenska University HospitalGothenburgSweden.

Background Alzheimer’s disease(AD)is associated with metabolic abnormalities linked to critical elements of *** recently administered combined metabolic activators(CMA)to the AD rat model and observed that CMA improves the AD-associated histological parameters in the *** promotes mitochondrial fatty acid uptake from the cytosol,facilitates fatty acid oxidation in the mitochondria,and alleviates oxidative *** Here,we designed a randomised,double-blinded,placebo-controlled phase-II clinical trial and studied the effect of CMA administration on the global metabolism of AD ***-dose CMA included 12.35 g L-serine(61.75%),1 g nicotinamide riboside(5%),2.55 g N-acetyl-L-cysteine(12.75%),and 3.73 g L-carnitine tartrate(18.65%).AD patients received one dose of CMA or placebo daily during the first 28 days and twice daily between day 28 and day *** primary endpoint was the difference in the cognitive function and daily living activity scores between the placebo and the treatment *** secondary aim of this study was to evaluate the safety and tolerability of CMA.A comprehensive plasma metabolome and proteome analysis was also performed to evaluate the efficacy of the CMA in AD *** We showed a significant decrease of AD Assessment Scale-cognitive subscale(ADAS-Cog)score on day 84 vs day 0(P=0.00001,29%improvement)in the CMA ***,there was a significant decline(P=0.0073)in ADAS-Cog scores(improvement of cognitive functions)in the CMA compared to the placebo group in patients with higher ADAS-Cog *** cognitive functions in AD patients were supported by the relevant alterations in the hippocampal volumes and cortical thickness based on imaging ***,the plasma levels of proteins and metabolites associated with NAD+and glutathione metabolism were significantly improved after CMA *** Our results indicate that treatment of AD patients with CMA can lead to enhanced cognit

关键词： Alzheimer’s disease Combined metabolic activators Multi-omics Systems biology Systems medicine

Development and Application of a Validated UHPLC Method for the Determination of Atropine and Its Major Impurities in Antidote Treatment Nerve Agent Auto-Injectors (ATNAA) Stored in the Strategic National Stockpiles

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Pharmacology & Pharmacy 2017年第1期8卷 15-31页

作者： Cheng H.Yen adil Mohammad Miah Schneider Salwa K.Poole Bryan Lowry Brenda W.Mc Curdy Patrick J.Faustino saeed R.Khan Office of Regulatory Affairs Detroit LaboratoryFood and Drug AdministrationDetroitMIUSA Division of Product Quality Research Office of Testing and ResearchOffice of Pharmaceutical QualityCenter for Drug Evaluation and ResearchFood and Drug AdministrationSilver SpringMDUSA

The development and implementation of advanced analytical technologies is essential for extending the expiry for complex drug products stored in the Strategic National Stockpiles. Consequently, a novel Ultra High-Performance Liquid Chromatographic (UHPLC) method has been developed for the analysis of atropine and its respective impurities to support the analytical research platform for auto-injectors. This study is part of a larger research effort to improve the efficiency and broaden the applicability of advanced analytical methods for medical counter-measure medications. The current HPLC compendial methodology for atropine sulfate injection requires an analysis time of 40 minutes for atropine. In comparison, the novel gradient UHPLC method required only 8 minutes to evaluate both atropine and its major pharmaceutical impurities. Improved separation was achieved on a Waters Acquity UHPLC BEH C18 1.7 μm, 2.1 × 100 mm column employing gradient elution of mobile phase solvent A (0.1% H3PO4) and solvent B (0.1% H3PO4, 90% ACN, and 10% H2O). The method was validated according to USP Category I requirements for assay. The daily standard calibration curves were linear over a concentration range from 50 μg/mL to 250 μg/mL with a correlation coefficient of >0.999. The detection limit (LOD) and quantitation limit (LOQ) were 3.9 μg/ml and 13.1 μg/ml, respectively. Resolution results indicate that atropine and the following impurities, degradants and a preservative can also be separated and analyzed using this proposed method: noratropine, 4,4’-di-hy-droxydiphenyl ether, 2,4’-dihydroxydiphenyl ether, 4-bromophenol, 4-hydro-xyatropine, tropic acid, apoatropine HCl, atropic acid, hydroquinone, nitroethane, phenol and catechol. The UHPLC method demonstrated enhanced selectivity and significantly reduced the analysis time when compared with the traditional USP compendial HPLC method. The method was successfully applied to the evaluation of atropine in ATNAA auto-injectors lots fro

关键词： Atropine Sulfate Atropine ATNAA SLEP UHPLC Impurities