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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of Public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

What do we know about biological nitrogen fixation in insects? Evidence and implications for the insect and the ecosystem

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Insect Science 2020年第3期27卷 392-403页

作者： Nitsan bar-Shmuel adi Behar Michal Segoli Mitrani Department of Desert Ecology Jacob Blaustein Institutes for Desert ResearchBen-Gurion University of the NegevSede Boqer CampusIsrael Kimron Veterinary Institute Department of ParasitologyBet DaganIsrael

Many insects feed on a low‐nitrogen diet,and the origin of their nitrogen supply is poorly *** has been hypothesized that some insects rely on nitrogen‐fixing bacteria(diazotrophs)to supplement their *** fixation by diazotrophs has been extensively studied and convincingly demonstrated in termites,while evidence for the occurrence and role of nitrogen fixation in the diet of other insects is less ***,we summarize the methods to detect nitrogen fixation in insects and review the available evidence for its occurrence(focusing on insects other than termites).We distinguish between three aspects of nitrogen fixation investigations:(i)detecting the presence of potential diazotrophs;(ii)detecting the activity of the nitrogen‐fixing enzyme;and(iii)detecting the assimilation of fixed nitrogen into the insect *** show that although evidence from investigations of the first aspect reveals ample opportunities for interactions with potential diazotrophs in a variety of insects,demonstrations of actual biological nitrogen fixation and the assimilation of fixed nitrogen are restricted to very few insect groups,including wood‐feeding beetles,fruit flies,leafcutter ants,and a wood *** then discuss potential implications for the insect's fitness and for the ecosystem as a *** suggest that combining these multiple approaches is crucial for the study of nitrogen fixation in insects,and argue that further demonstrations are desperately needed in order to determine the relative importance of diazotrophs for insect diet and fitness,as well as to evaluate their overall impact on the ecosystem.

关键词： biological nitrogen fixation diazotrophs gut microbiome insect diet

The combined role of visual and olfactory cues in foraging by Cataglyphis ants in laboratory mazes

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Current Zoology 2023年第4期69卷 401-408页

作者： Tomer Gilad Ori Bahar Malak Hasan adi bar Aziz Subach Inon Scharf School of Zoology George S Wise Faculty of Life SciencesTel Aviv University69978 Tel AvivIsrael

Foragers use several senses to locate food,and many animals rely on vision and *** is beneficial not to rely on a single sense,which might fail under certain *** examined the contribution of vision and smell to foraging and maze exploration under laboratory conditions using Cataglyphis desert ants as a *** intensity,measured as the number of workers entering the maze and arriving at the target as well as target arrival time,were greater when food,blue light,or both were offered or presented in contrast to a *** trained to forage for a combined food and light cue elevated their foraging intensity with ***,foraging intensity was not higher when using both cues simultaneously than in either one of the two *** training,we split between the two cues and moved either the food or the blue light to the opposite maze *** manipulation impaired foraging success by either leading to fewer workers arriving at the target cell(when the light stayed and the food was moved)or to more workers arriving at the opposite target cell,empty of food(when the food stayed and the light was moved).This result indicates that ant workers use both senses when foraging for food and readily associate light with food.

关键词： binary-tree maze desert ants diet choice foraging sensual modality spatial learning

Role of colonoscopy in patients with persistent acute diverticulitis

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World Journal of Gastroenterology 2008年第17期14卷 2763-2766页

作者： adi Lahat Henit Yanai Emad Sakhnini Yoram Menachem Simon bar-Meir Department of Gastroenterology ChaimSheba Medical Center and Sackler School of Medicine Tel AvivUniversity

AIM： To identify patients with persistent acute diverticulitis who might benefit from an early colonoscopy during their first hospitalization. METHODS： All patients hospitalized between July 2000 and December 2006 for acute diverticulitis who underwent colonoscopy were included in the study. Patients were followed during hospitalization and after discharge. Patients were considered to have a persistent course of acute diverticulitis if symptoms continued after 1 wk of conventional treatment with 1V antibiotics, or if symptoms recurred within 2 mo after discharge. Patients were considered to benefit from an early colonoscopy if the colonoscopy was therapeutic or if it changed a patient＇s outcome. RESULTS： Three hundred and six patients were hospitalized between July 2000 and December 2006 with the diagnosis of acute diverticulitis. Two hundred and twenty four of these were included in the study group. Twenty three patients （10.3%） fulfilled the criteria for a persistent course of acute diverticulitis. Of them, four patients （17.4%） clearly benefited from an early colonoscopy; these patients＇ clinical course is described. None of the patients with a regular non-persistent course demonstrated any benefit from colonoscopy. CONCLUSION： Early colonoscopy detected other significant pathology, which accounted for the clinical presentation in 17% of patients with persistent acute diverticulitis. Therefore, we believe an early colonoscopy should be considered in all patients with a persistent clinical course.

关键词： Persistent acute diverticulitis Early colonoscopy Clinical course

Diverticulitis in the young patient-Is it different?

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World Journal of Gastroenterology 2006年第18期12卷 2932-2935页

作者： adi Lahat Yoram Menachem Benjamin Avidan Henit Yanai Emad Sakhnini Eytan bardan Simon bar-Meir Department of Gastroenterology Chaim Sheba Medical Center and Sackler School of MedicineTel Aviv UniversityTel AvivIsrael

AIM： To prospectively study the incidence and the natural history of acute diverticulitis in young patients. METHODS： A total of 207 patients hospitalized at our hospital between January 2000 to February 2005 with the diagnosis of acute diverticulitis were included. Their demographic characteristics, medical history, physical, radiographic and endoscopic findings as well as therapy were recorded. Patients were followed every 6 mo for the first year and later annually. RESULTS： The mean patients＇ age was 61 （range 27-92） years. Twenty- five patients （12%） were younger than 45 years. Acute diverticulitis was significantly more prevalent among male in the young age group as compared to the older age group （19/25, 76% vs 61/182, 33%, respectively, P = 0.0001）. Complications occurred more often in the young age group; 32% vs 13%, （P = 0.002）. During follow-up, 6 patients （28%） remained asymptomatic in the young age group as compared to 87 patients （55%） in the older age group （P = 0.024）. As a result, sigmoidectomies were performed twice as often in the young age group （38% vs 13%, P = 0.002）. CONCLUSION： Diverticulitis in young patients has a male predominance, a more aggressive course with a higher rate of complications and a higher recurrence rate. An earlier surgical approach might be considered in young patients with acute diverticulitis.

关键词： Diverticulitis Young patient Complications Sigmoidectomy

Low temperature upregulates cwp expression and modifies alternative splicing patterns,increasing the severity of cwp-induced tomato fruit cuticular microfissures

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Horticulture Research 2019年第1期6卷 183-194页

作者： noam Chechanovsky Ran Hovav Rina Frenkel adi Faigenboim Yelena Eselson Marina Petreikov Michal Moy Shmuel Shen Arthur A.Schaffer Department of Vegetable and Field Crops Institute of Plant SciencesAgricultural Research OrganizationRishon LeZionIsrael

The cwp(cuticular water permeability)gene controls the development of cuticular microfissuring and subsequent fruit dehydration in *** gene underwent silencing in the evolution of the fleshy cultivated tomato but is expressed in the primitive wild tomato *** introgression of the expressed allele from the wild ***(cwph)into the cultivated tomato(Solanum lycopersicum)leads to the phenotype of fruit water loss during and following *** this report,we show that low temperature impacts on the severity of the cuticular microfissure phenotype via a combination of effects on both expression and alternative splicing of *** cwp gene,comprising four exons and three introns,undergoes post-transcriptional alternative splicing processes,leading to seven alternative transcripts that differ in reading-frame *** plants expressing each of the alternative transcripts identified the longest reading frame(VAR1)as the functional splice *** temperature led to a strong upregulation of cwph expression,compounded by an increase in the relative proportion of the functional VAR1 transcript,leading to increased severity of microfissuring of the *** summary,we demonstrate the molecular mechanism behind the horticultural phenomenon of the low-temperature effect on cuticular microfissures in the dehydrating tomato.

关键词： severity expressing subsequent

Geochemistry of Rare Earth Elements(REE) in the Weathered Crusts from the Granitic Rocks in Sulawesi Island, Indonesia

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Journal of Earth Science 2014年第3期25卷 460-472页

作者： adi Maulana Kotaro Yonezu Koichiro Watanabe Department of Geology Engineering Faculty of Engineering Hasanuddin University Department of Earth Resources Engineering Kyushu University

We report for the first time the geochemistry of rare earth elements（REE） in the weathered crusts of I-type and calc-alkaline to high-K（shoshonitic） granitic rocks at Mamasa and Palu region, Sulawesi Island, Indonesia. The weathered crusts can be divided into horizon A（lateritic profile） and B（weathered horizon）. Quartz, albite, kaolinite, halloysite and montmorrilonite prevail in the weathered crust. Both weathered profiles show that the total REE increased from the parent rocks to the horizon B but significantly decrease toward the upper part（horizon A）. LREE are enriched toward the upper part of the profile as shown by La/YbN value. However, HREE concentrations are high in horizon B1 in Palu profile. The total REE content of the weathered crust are relatively elevated compared to the parent rocks, particularly in the lower part of horizon B in Mamasa profile and in horizon B2 in Palu profile. This suggests that REE-bearing accessory minerals may be resistant against weathering and may remain as residual phase in the weathered crusts. The normalized isocon diagram shows that the mass balance of major and REE components between each horizon in Mamasa and Palu weathering profile are different. The positive Ce anomaly in the horizon A of Mamasa profile indicated that Ce is rapidly precipitated during weathering and retain at the upper soil horizon.

关键词： rare earth element geochemistry weathered crust granitic rock Sulawesi Indonesia.

Analysis of aflatoxin B1 in contaminated feed,media,and serum samples of Cyprinus carpio *** high-performance liquid chromatography

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Food Quality and Safety 2018年第4期2卷 199-204页

作者： Pradeepkiran Jangampalli adi Bhaskar Matcha Division of Animal Biotechnology Department of ZoologySri Venkateswara UniversityTirupati 517502India Garrison Institute on Aging Texas Tech University of Health Science CentreLubbockUSA

Objectives:Enzyme-linked immunosorbent assay(ELISA)-,thin-layer chromatography(TLC)-,and highperformance liquid chromatography(HPLC)-sensitive methods were used for the identification of aflatoxin B1(AFB1)contaminated fish feed,media,and fish serum *** and Methods:The ELISA,TLC,and HPLC methods were validated by the quantitative and qualitative determination of AFB1 in contaminated fish feed,media,and fish blood serum ***:The primary identification of AFB1 was carried out with a DOA-ELISA test kit ELISA followed by TLC with RF values 0.81,0.79,0.81,and 0.80 of AFB1-contaminated fish feed,media,and serum samples,respectively,compared with AFB1 *** results show that the AFB1 levels in contaminated fish feed,media,and serum samples were 2.6,2.6,and 2.7 ng/mL,concentrations *** level of concentrations of AFB1 was almost similar in all three samples,but slightly higher in the fish serum sample with,2.7 ng/***,the present method is strongly recommended for monitoring AFB1 contamination in feed stuffs,especially in fisheries where the feed is under continuous exposure to ***:This method is accurate and more sensitive when compared with routine conventional AFB1 detection methods,and is highly applicable in aquaculture and fisheries to screen the mycotoxins in fish feed.

关键词： enzyme-linked immunosorbent assay TLC HPLC aflatoxin B1 analysis

Comparative transcriptome analyses shed light on carotenoid production and plastid development in melon fruit

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Horticulture Research 2021年第1期8卷 1229-1241页

作者： noam Chayut Hui Yuan Yuval Saar Yi Zheng Tianhu Sun Xuesong Zhou Anna Hermanns Elad Oren adi Faigenboim Maixia Hui Zhangjun Fei Michael Mazourek Joseph Burger Yaakov Tadmor Li Li Department of Vegetable Research ARONewe Ya’ar Research CenterP.O.Box 1021Ramat Yishay 30095Israel Robert W.Holley Center for Agriculture and Health USDA-Agricultural Research ServiceCornell UniversityIthacaNY 14853USA Plant Breeding and Genetics Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA Boyce Thompson Institute IthacaNY 14853USA State Key Laboratory of Crop Genetics&Germplasm Enhancement Nanjing Agricultural UniversityNanjing 210095China Present address:John Innes Centre Norwich Research ParkNorwichUK

Carotenoids,such asβ-carotene,accumulate in chromoplasts of various fleshy fruits,awarding them with colors,aromas,and *** Orange(CmOr)gene controlsβ-carotene accumulation in melon fruit by posttranslationally enhancing carotenogenesis and repressingβ-carotene turnover in *** isomerase(CRTISO)isomerizes yellow prolycopene into red lycopene,a prerequisite for further metabolism intoβ-*** comparatively analyzed the developing fruit transcriptomes of orange-colored melon and its two isogenic EMS-induced mutants,low-β(Cmor)and yofi(Cmcrtiso).The Cmor mutation in low-βcaused a major transcriptomic change in the mature *** contrast,the Cmcrtiso mutation in yofi significantly changed the transcriptome only in early fruit developmental *** findings indicate that melon fruit transcriptome is primarily altered by changes in carotenoid metabolic flux and plastid conversion,but minimally by carotenoid composition in the ripe *** of the differentially expressed genes into functional groups revealed an association between fruit carotenoid metabolic flux with the maintenance of the photosynthetic apparatus in fruit ***,large numbers of thylakoid localized photosynthetic genes were differentially expressed in low-β.CmOR family proteins were found to physically interact with light-harvesting chlorophyll a–b binding proteins,suggesting a new role of CmOR for chloroplast maintenance in melon *** study brings more insights into the cellular and metabolic processes associated with fruit carotenoid accumulation in melon fruit and reveals a new maintenance mechanism of the photosynthetic apparatus for plastid development.

关键词： apparatus orange metabolism