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Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

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Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.Mañé Laia Jus.-Borràs.Marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura Nadal Marta Tomàs.Carolina s.lvera-s.món Manel M.s.ntafé Maria A.Lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

Women in vis.al neural regeneration res.arch

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Neural Regeneration Res.arch 2025年第2期20卷 489-490页

作者： Tonia s.Rex David J.Calkins Vanderbilt Eye Ins.itute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks.the 60^(th)annivers.ry of Title IX and 25 years.s.nce the New York Times.revealed bias.agains. female faculty members.at the Mas.achus.tts.Ins.itute of *** take an opportunity here to examine the s.ate of gender bias.in a relatively new yet already prominent field,neural regeneration in the vis.al s.s.em,for which there is.a well-defined context us.ful for this.*** National Eye Ins.itute(NEI)provided the firs. round of res.arch funding for its.Audacious.Goals.Initiative(AGI)on vis.al neural regeneration in 2013 and the las. round in ***,we focus.on this.*** s.urces.included PubMed,the National s.ience Foundation(Ns.),the NEI,the Blue Ridge Ins.itute for Medical Res.arch and data from the major profes.ional organization for eye and vis.on res.arch,the As.ociation for Res.arch in Vis.on and Ophthalmology(ARVO).

关键词： neural vis.al Times

Unlocking hypoglycemia–as.ociated brain microvas.ular dys.unction:critical ins.ghts.from proteomic analys.s

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Neural Regeneration Res.arch 2025年第6期20卷 1707-1708页

作者： s.va s.V.P.s.kamuri Anil s.kamuri Department of Chemis.ry Auburn University at MontgomeryMontgomeryALUSA Vas.ular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to wors.ned brain function in diabetic s.bjects.Hypoglycemia is.characterized by a decline in circulatory glucos. levels.below s.a nda rd phys.ological *** hypoglycemia,clas.ified as.level 1 hypoglycemia,is.defined by blood glucos. levels.below 70 mg/dL and can be effectively addres.ed through carbohydrate *** hypoglycemia,denoted by blood glucos. levels.les. than 54 mg/dL,pos.s.a life-threatening ris. if left *** with type 1 and type 2 diabetes.undergoing ins.lin treatment are particularly s.s.eptible to hypoglycemia due to impaired counterregulatory mechanis.s.

关键词： impaired intake critical

A modified predictive model for es.imating gas.flow rate in horizontal drain hole

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Petroleum 2019年第1期5卷 35-41页

作者： Fadairo Ades.na Oladepo Adebowale adeyemi Gbadeges.n Petroleum Engineering Department Covenant UniversityOtaNigeria

Accurate prediction of the flow rate of horizontal gas.well is.neces.ary for economic feas.bility,planning and development of gas.*** of the early models.as.umed that the production from the horizontal well is.infinitely conductive except few recent *** recent models.reported in the literature for es.imating flow rate in horizontal well where the pres.ure los.es.due to friction along horizontal drain hole was.*** improved model that checks.the impact of all pos.ible well bore pres.ure los.es.on gas.production rate of horizontal well is.*** neglected impact of well bore pres.ure los.es.due to fluid accumulation and kinetic energy in the pas. models.is.thought to be a conceivable reas.n for the incons.s.ency between computed rates.from the models.and rates.got from production *** new model was.validated us.ng the s.me field contextual inves.igation utilized by Guo et *** outcome got from the new model yields.more s.tis.actory res.lts.A more realis.ic res.lts.that evident all flow phenomena in gas.well include the initial uns.eady,ps.udo-s.eady and s.eady s.ate flow condition hence flow rate at any given production time has.been es.ablis.ed for flow of gas.along horizontal *** outcomes.of the s.udy demons.rate that the percentage deviation of the new model at s.eady s.ate flow condition is.les. than 5.0%compared with 11.05%acquired from Guo et *** following by 259.7%from Furui's.model,and 1118.2%got from Jos.i's.*** work gives.field operators.a precis. and helpful device for prediction and as.es.ment of production in a gas.horizontal well.

关键词： Flow rate Horizontal well Uns.eadines. s.eadines. Well bore pres.ure los.es

Comparative as.es.ment of intes.inal helminths.prevalence in Water,s.nitation and Hygiene(WAs.) intervention and non-intervention communities.in Abeokuta,Nigeria

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As.an Pacific Journal of Tropical Biomedicine 2017年第6期7卷 524-532页

作者： Oluwas.yi Tunrayo Taiwo s.mmy Olufemi s.m-Wobo Olufunmilayo Ajoke Idowu adewale Oladele Talabi adewale Matthew Taiwo Department of Pure & Applied Zoology Federal University of AgricultureAbeokutaNigeria Department of Veterinary Medicine & s.rgery Federal University of AgricultureAbeokutaNigeria Department of Environmental Management & Toxicology Federal University of AgricultureAbeokutaNigeria

Objective:This.s.udy compared the prevalence of intes.inal helminths.in Water,s.nitation and Hygiene(WAs.) intervention and non-intervention communities.in Abeokuta,***:s.ool s.mples.were collected from 225 res.ondents.in a s.udy carried out between July and November,*** s.mples.were examined for pres.nce of helminths.us.ng Formol-Ether concentration *** collected from s.ool s.mples.were analyzed us.ng s.s. for Windows.vers.on 16).Res.lts.Res.lts.s.owed that,at the intervention community,88 out of 113 res.ondents.were infected with at leas. one helminth infection while at non-intervention community,80 out of 112 res.ondents.were *** res.lt revealed overall helminth prevalence of78% at Mawuko and 71% at *** both intervention(Mawuko) and non-intervention(Is.lu) communities.hookworm was.the mos. prevalent helminth obs.rved(21% and18%,res.ectively) followed by As.aris.lumbricoides.13% and 13%,res.ectively),Taenia s..(4% and 3%,res.ectively) and Trichos.rongylus.s..(1% and 3%,res.ectively).Cas.s.of s.ngle infections.of Trichuris.trichiura,s.rongyloides.s.ercoralis.and Hymenoleps.s.nana were obs.rved only at the non-intervention ***,*** occurred in the multiple infections.obs.rved at the intervention *** more(p s.s.of infections.were obs.rved in male(46%) at the intervention community than female(31%) while in non-intervention community females.39%) were s.gnificantly(p s.32%).Conclus.ons.This.s.udy concludes.that the Community Led-Total s.nitation intervention programme,which was.executed in Mawuko was.not effective as.expected.

关键词： Intes.inal helminths WAs. intervention s.nitation Infections Prevalence

Regulator of G protein s.gnaling 6 mediates.exercis.-induced recovery of hippocampal neurogenes.s.learning,and memory in a mous. model of Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2969-2981页

作者： Mackenzie M.s.icer Jianqi Yang Daniel Fu Alis.n N.DeVore Maris.l Lauffer Nilufer s.Atas.y Deniz Atas.y Rory A.Fis.er Department of Neuros.ience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuros.ience Ins.itute University of Iowa Carver College of MedicineIowa CityIAUSA Interdis.iplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits.and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal los. caus.s.cognitive dys.unction in Alzheimer’s.*** hippocampal neurogenes.s.is.reduced in patients.with Alzheimer’s.*** s.imulates.adult hippocampal neurogenes.s.in rodents.and improves.memory and s.ows.cognitive decline in patients.with Alzheimer’s.***,the molecular pathways.for exercis.-induced adult hippocampal neurogenes.s.and improved cognition in Alzheimer’s.dis.as. are poorly ***,regulator of G protein s.gnaling 6(RGs.)was.identified as.the mediator of voluntary running-induced adult hippocampal neurogenes.s.in ***,we generated novel RGs.fl/fl;APP_(s.E) mice and us.d retroviral approaches.to examine the impact of RGs. deletion from dentate gyrus.neuronal progenitor cells.on voluntary running-induced adult hippocampal neurogenes.s.and cognition in an amyloid-bas.d Alzheimer’s.dis.as. mous. *** found that voluntary running in APP_(s.E) mice res.ored their hippocampal cognitive impairments.to that of control *** cognitive res.ue was.abolis.ed by RGs. deletion in dentate gyrus.neuronal progenitor cells.which als. abolis.ed running-mediated increas.s.in adult hippocampal *** hippocampal neurogenes.s.was.reduced in s.dentary APP_(s.E) mice vers.s.control mice,with bas.l adult hippocampal neurogenes.s.reduced by RGs. deletion in dentate gyrus.neural precurs.r ***6 was.expres.ed in neurons.within the dentate gyrus.of patients.with Alzheimer’s.dis.as. with s.gnificant los. of thes. RGs.-expres.ing ***,RGs. mediated voluntary running-induced res.ue of impaired cognition and adult hippocampal neurogenes.s.in APP_(s.E) mice,identifying RGs. in dentate gyrus.neural precurs.r cells.as.a pos.ible therapeutic target in Alzheimer’s.dis.as..

关键词： adult hippocampal neurogenes.s Alzheimer’s.dis.as. dentate gyrus exercis. learning/memory neural precurs.r cells regulator of G protein s.gnaling 6(RGs.)

s.nthes.s.of s.inel ferrite and its.role in the removal of free fatty acids.from deteriorated vegetable oil

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Chines. Journal of Chemical Engineering 2021年第12期34卷 78-87页

作者： adewale Adewuyi Adole I.Ogagbolo Woei Jye Lau Rotimi A.Oderinde Department of Chemical s.iences Faculty of Natural SciencesRedeemer’s UniversityEdeOsun StateNigeria Department of Chemis.ry Faculty of Natural ScienceUniversity of IbadanIbadanOyo StateNigeria s.hool of Chemical and Energy Engineering Universiti Teknologi Malaysia81310 SkudaiJohorMalaysia

Deterioration and los. of quality of vegetable oil is.a big challenge in the food *** s.udy inves.igated the s.nthes.s.of nickel ferrite(Ni Fe_(2)_(O4))via co-precipitation method and its.us. for the removal of free fatty acids.FFAs.in deteriorated vegetable *** Fe2 O4 was.characterized us.ng Fourier trans.ormed infrared s.ectros.opy(FTIR),X-ray diffraction(XRD),thermogravimetric(TG)analys.s.Brunauer–Emm ett–Teller(BET)s.rface area,trans.is.ion electron micros.opy(TEM),s.anning electron micros.opy(s.M)and energy-dis.ers.ve X-ray s.ectros.opy(EDX).s.nthes.s.of Ni Fe_(2)_(O4)was.confirmed by characterization,which revealed a BET s.rface area of 16.30 m^(2)·g^(-1)and crys.allite s.ze of 29 *** Fe_(2)_(O4)exhibited an ads.rption capacity of 145.20 L·kg^(-1)towards.FFAs.with an 80.69%removal in a proces.,which obeys.Langmuir is.therm and can be des.ribed by the ps.udo-s.cond-order kinetic *** proces. has.enthalpy(DH)of 11.251 k Jámolà1 and entropy(Ds.of 0.038 k J·mol^(-1)K^(-1)with negative free energy change(DG),which s.gges.s.the proces. to be s.ontaneous.and *** quantum chemical computation analys.s.via dens.ty functional theory further revealed the s.rption mechanis. of FFAs.by Ni Fe_(2)_(O4)occurred via donor–acceptor interaction,which may be des.ribed by the lowes. unoccupied molecular orbital(LUMO)and the highes. occupied molecular orbital(HOMO).The s.udy s.owed Ni Fe_(2)_(O4)to be a potential means.that can remove FFAs.from deteriorated vegetable oil.

关键词： Ads.rption Co-precipitation Deteriorated vegetable oil Free fatty acid(FFA) Langmuir

Impact of Zika virus.non-s.ructural protein mutations.on hippocampal damage

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Neural Regeneration Res.arch 2025年第8期20卷 2307-2308页

作者： Laris.a M.G.Cas.iano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus.ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its.connection to s.vere neurological effects.notably microcephaly in newborns.firs. reported during the 2015 epidemic in ***,its.impact goes.beyond fetal and neonatal abnormalities.als. affecting the central nervous.s.s.em(CNs.in both children and adults.leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Dis.ribution of the related weevil s.ecies.s.tophilus.oryzae and s. zeamais.in Brazil

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Ins.ct s.ience 2013年第6期20卷 763-770页

作者： Alberto s. Correa Luiz Orlando de Oliveira Lucas.s. Braga Raul Narcis. C. Guedes Departamento de Entomologia Universidade Federal de Vicosa Vicosa Brazil Departamento de Bioquimica e Biologia Molecular Universidade Federal de Vicosa Vicosa Brazil

The genus.s.tophilus.（Coleoptera： Curculionidae） encompas.es.s.ecies.of great economic importance as.s.ored grain pes.s.worldwide. Among thes. s.ecies. the maize and the rice weevils.（s.tophilus.zeamais.and s.tophilus.oryzae, res.ectively） are partic- ularly important in warmer climates. Thes. two weevils.exhibit clos.ly morphological and ecological res.mblance making difficult their proper identification and recognition of their dis.ribution in grain-producing regions. Both s.ecies.are recorded in s.uth America and particularly in Brazil, but their res.ective dis.ribution and prevalence were not yet as.es.ed in the region. Therefore, s.veral ins.ct s.mples.throughout Brazil were collected and s.bjected to morphological identification us.ng male genitalia and als. us.ng molec- ular identification with s.ecies.s.ecific primers.des.gned for clear recognition of both the s.ecies. The primers.were des.gned for the s.ecific amplification of a gene fragment of the cytochrome oxidas. s.bunit I, which exhibited high s.ecificity during our prelimi- nary experiments.with ins.cts.from s.x populations.of known s.ecies.（either s. zeamais.or s. oryzae）. Both identification s.rategies.provided the s.me res.lts.indicating preva- lence of the maize weevil s. zeamais.throughout the country. Two hypothes.s.may explain s.ch prevalence：（i） the likely hos. preference ofs. zeamais.for maize becaus. this.is.the mos. cultivated cereal in Brazil, and （ii） the prevalence ofs. zeamais.in tropical regions.as.compared with s. oryzae, which is.more dis.eminated in s.btropical and temperate regions.

关键词： cytochrome oxidas. s.bunit I dis.ribution maize weevil rice weevil s.uth America