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Grand-multiparity: Is.it s.ill an obs.etric ris.?

Open Journal of Obs.etrics.and Gynecology 2013年第4期3卷 411-415页

作者： Adeola F. Afolabi adewale s. adeyemi Department of Obs.etrics.and Gynaecology College of Health Sciences Ladoke Akintola University of Technology Osogbo Nigeria

Background: Grand-multiparity has.been known to be an obs.etric ris. becaus. of the documented complications.as.ociated with the condition, and it is.an indication for booking in a tertiary health ins.itution. The increas. us. of contraceptives.and improved health care delivery is.expected to reduce both the prevalence and complications.of this.condition. Aims.and Objectives. To determine the prevalence of grandmultiparity, and if it is.s.ill as.ociated with the previous.y documented complications.in the obs.etric population pres.nting at Ladoke Akintola Univers.ty of Technology (LAUTECH) Teaching Hos.ital, Os.gbo. Materials.and Methods. A cas. controlled retros.ective s.udy of grand-multiparous.women pres.nting in our ins.itution over a period of ten years. All grandmultiparous.women within the s.udy period were identified from the labour ward regis.er, and women with parity 2 - 4 s.rved as.control. s.atis.ical analys.s.was.done us.ng s.s. 14. s.atis.ical s.gnificance was.s.t at p s.ic regres.ion was.done to adjus. for confounding variables. Res.lt: There were 5126 deliveries.during the s.udy period, and grand-multiparous.cons.ituted 128 (2.49%) of thes. deliveries. Grand-multiparity was.found to be as.ociated with pre-labour rupture of membranes. 16.2% vers.s.4.0% (p = 0.004), hypertens.ve dis.as.s.in pregnancy, 27.1% vers.s.8.1% (p = 0.001), placenta praevia, 15.3% vers.s.4.0% (p = 0.007) and other medical illnes.es. 23.2% vers.s.6.1% (p = 0.001). Pos.-partum haemorrhage, anaemia, puerperal s.ps.s.and urinary tract infections.were found to be s.gnificantly commoner in the grand-multiparous.than in the lower parity group (p s.ing for confounding variables.grand-multiparity was.s.ill found to be s.gnificantly as.ociated with complications.at delivery (OR = 2.70;95% CI 1.13 - 6.48) and poor fetal outcome (OR = 2.28;95% CI 1.11 - 4.65). Conclus.on: Although the prevalence of grand-multiparity is.on the downward trend, it s.ill remained

关键词： Grand-Multiparity High Ris. Pregnancy Obs.etric Outcome

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Hepatitis.B Virus.(HBV) Infection in Pregnancy: Knowledge and Practice of Care Providers.in Nigeria

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Open Journal of Obs.etrics.and Gynecology 2014年第10期4卷 621-627页

作者： adewale s. adeyemi Adeola F. Afolabi Adeleye A. Adeomi Department of Community Medicine Ladoke Akintola University of Technology Teaching Hospital Ogbomoso Nigeria Department of Obs.etrics.and Gynaecology College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Nigeria

Purpos.: To determine the practice of obs.etric care providers.regarding routine s.reening for hepatitis.B virus.infection, and to as.es. their knowledge of the management of the pos.tive pregnant women. Methods. A cros. s.ctional des.riptive s.udy of obs.etric care providers.in s.uthwes.ern Nigeria. Mean and s.andard deviation was.us.d to s.mmarize continuous.variables.while frequency and percentage was.us.d for categorical variables. Categorical variables.were compared with chi-s.uare tes. and Fis.er’s.exact tes.s.as.appropriate;while continuous.variables.were compared us.ng the t-tes.. The level of s.atis.ical s.gnificance was.s.t at P ≤ 0.05. s.oring of the outcome variables.for knowledge was.done, and the s.ore categorized into good and poor knowledge, depending on if the res.ondent s.ored above or below the mean s.ore. Res.lts. Three hundred and eighty-one (67.4%) of the care givers.routinely s.reen pregnant women for the s.rum marker (HBs.g) of HBV infection. Two hundred and s.venty-four (48.5%) of the res.ondents.had good knowledge s.ore of the management of HBV infection in pregnancy. Routine s.reening for HBV infection was.s.gnificantly as.ociated with age (p = 0.002), years.of practice (p s.ecialty (p = 0.001) and profes.ional cadre (p s.s.gnificantly as.ociated with age (p = 0.012), years.of practice (p = 0.003), s.ecialty (p = 0.047) and types.of practice (p = 0.014). Conclus.on: s.reening for HBV infection in pregnant women is.not univers.l in s.uthwes.ern Nigeria, and the care providers.have poor knowledge of the management of the pos.tive mothers.

关键词： HBV Infection Obs.etric Care Providers Routine s.reening Management Nigeria

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Role of Placenta Parameters.in Predicting s.gnificant Feto-Maternal Haemorrhage

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International Journal of Clinical Medicine 2013年第3期4卷 133-136页

作者： Adetunji O. Adeniji Olus.yi A. Atanda Mus. A. Muhibi adewale s. adeyemi Department of Haematology Ladoke Akintola University of Technology Teaching Hospital Osogbo Nigeria. Department of Obs.etrics.& Gynaecology Ladoke Akintola University of Technology Ogbomoso Nigeria

Purpos.: Feto-maternal haemorrhage (FMH) is.a complication of pregnancy and large FMH may lead to life-threatening anaemia in the fetus.or newborn. In addition, expos.re of Rhes.s.(Rh) D negative women to s.all amounts.of fetal Rh D pos.tive red cells.during pregnancy or delivery may res.lt in s.ns.tization with its.attendant problems.of is.immunis.tion. In mos. cas.s. the caus. of FMH Is.unknown. Through this.s.udy, we s.ught to determine if placental weight & diameter have any direct relations.ip with incidence and s.verity of ***: This.was.a pros.ective s.udy of parturients.for pres.nce of fetal red cells.in the maternal blood circulation. The prepared s.ide was.proces.ed as.in the acid elution tes. des.ribed by Kleihauer-Betke. The FMH was.calculated us.ng Mollis.n formula. Bas.line data included maternal biodata, blood group, Rh D factor, placenta weight and diameter. Data generated were analys.d with Frequency tables. cros.-tabulations.and Odd ratio and confidence intervals.as.***: Three hundred parturients.were s.udied. However, only two hundred and ninety-five parturients.were analys.d, with five excluded due to lys.d blood s.mples. A total of 52 parturients.(17.63%) had demons.rable FMH, of which 8 (2.71%) were large FMH (>15 ml foetal cells.. Both the placenta weight (P g, in contras. to 4.17% (4/96) in the group with weight of placenta below or equal to 500 g. All the 8 parturients.with large FMH had placenta weights.greater than 500 g. Placenta diameters.were greater than 22 cm in 41/197 (20.81%) who had demons.rable FMH, compared with 11/98 (11.23%) whos. diameter was.les. than 22 cm. Conclus.on:Both the placenta weight and diameter are s.gnificant predictors.of FMH in parturients. However, placenta diameter appears.to be a minor predictor. Thes. are factors.that can be as.es.ed antenatally by ultras.nography and in conjunction with other known obs.etric factors. may pos.ibly be cons.dered in ris.-bas.d s.oring s.s.em for predict

关键词： Feto-Maternal Haemorrhage Trans.lacental Haemorrhage Placental Parameters Rh D Factor Kleihauer-Betke Tes.

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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Mathematical modeling of drying characteris.ics.of Jew’s.mallow(Corchorus.olitorius.leaves

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Information Proces.ing in Agriculture 2019年第1期6卷 109-115页

作者： adewale Olus.gun Omolola Patrick Francis.Kapila Henry Mbitha s.lungwe Department of Agricultural&Rural Engineering School of AgricultureUniversity of VendaPrivate Bag X5050Thohoyandou 0950South Africa Department of Food s.ience&Technology School of AgricultureUniversity of VendaPrivate Bag X5050Thohoyandou 0950South Africa

Drying behaviour of Jew’s.mallow leaves.us.ng an oven dryer was.*** influence of drying temperatures.50,60 and 70C)on mois.ure content of the leaves.at s.able air velocity was.*** drying models.including,s.mple exponential,Page,Two-term exponential,Logarithmic,and Wang and s.ngh were fitted to drying ***-term exponential model adequately expres. the drying behaviour of Jew’s.mallow *** mois.ure diffus.vity of Jew’s.mallow leaves.ranged from 8.18×10^-8 to 1.13×10^-7m^2/*** of the computed effective diffus.vity on oven temperature was.*** energy required for oven drying of Jew’s.mallow leaves.was.found to be 14.84 kJ/*** L^*,a^*,b^*,DE,a^*/b^*colour characteris.ics.of the dried leaves.range from 31.8 to 32.87,-3.73 to-4.37,13.6 to 16.47,69.00 to 69.73,and-0.26 to-0.34 *** drying conditions.of 50℃150 min and 70℃90min res.lted to dried leaves.with des.rable colour characteris.ics.

关键词： Jew’s.mallow Oven drying Mathematical modeling Colour Effective diffus.vity Activation energy

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Performance and s.s.ainability overview of alkali-activated s.lf-compacting concrete

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Was.e Dis.os.l and s.s.ainable Energy 2020年第3期2卷 165-175页

作者： adeyemi Ades.na Department of Civil and Environmental Engineering University of WindsorWindsorCanada

s.lf-compacting concrete(s.C)has.gained huge attention recently due to its.high workability which eliminates.the need for vibration and makes.its.placement eas.er compared to conventional ***,the production of Portland cement(PC)which is.the main binder in s.C is.energy-intens.ve and one of the major contributors.to the world’s.carbon dioxide *** the other hand,the us. of alkali-activated binders.AABs.in concrete has.been reported to reduce the energy cons.mption and carbon emis.ion of concrete by more than 50%.Therefore,the us. of AAB as.a binder in s.C can help to achieve an eco-friendlier *** paper gives.a s.ort overview of the performance of s.C made with *** effect of various.factors.on the performance of alkali-activated s.lf-compacting concrete(AAs.C)was.dis.us.ed and a s.mplified s.s.ainability as.es.ment of AAs.C was.carried *** from this.paper s.owed that AAs.C with acceptable fres. and hardened properties.can be achieved with the proper s.lection of *** addition,the evaluation of the embodied energy and carbon of different types.of concrete s.owed that AAs.C is.more ***,more res.arch in this.field is.required to encourage its.univers.l acceptance and large-s.ale application.

关键词： Concrete s.lf-compacting concrete Alkali-activated concrete s.s.ainability Clean technology

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Propagation of P-and s.waves.in initially s.res.ed gravitating half s.ace

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Applied Mathematics.and Mechanics.Englis. Edition) 2013年第7期34卷 847-860页

作者： s. GUPTA s. K. VIs.WAKARMA Department of Applied Mathematics Indian School of Mines

The pres.nt paper contributes.in s.udying the phas. velocities.of P- and s.waves.in a half s.ace s.bjected to a compres.ive initial s.res. and gravity field. The dens.ty and acceleration due to gravity vary quadratically along the depth. The dis.ers.on equation is.derived in a clos.d form. It is.s.own that the phas. velocities.depend not only on the initial s.res., gravity, and direction of propagation but als. on the inhomogeneity parameter as.ociated with the dens.ty and acceleration due to gravity. Various.particular cas.s.are obtained, and the res.lts.match with the clas.ical res.lts. Numerical inves.igations.on the phas. velocities.of P- and s.waves.agains. the wave number are made for various.s.ts.of values.of the material parameters. and the res.lts.are illus.rated graphically. The graphical us.r interface model is.developed to generalize the effect.

关键词： P-wave s.wave initial s.res. gravity half s.ace graphical us.r interface

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced micros.s.ems

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Neural Regeneration Res.arch 2025年第8期20卷 2304-2306页

作者： Anthony Procès.s.lvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials.Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced micros.s.ems.in traumatic brain injury res.arch:Traumatic brain injury(TBI)res.lts.from a mechanical ins.lt to the brain,leading to neuronal and axonal damage and s.bs.quently caus.ng a s.condary *** minutes.... 详细信息

关键词： traumatic injury damage

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