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Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing Strengths,Limitations,and Its Therapeutic Landscape Position

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Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： VICTOR Abiola adepoju OKECHUKWU Innocent Onyezue SAFAYET Jamil OLALEKAN John Okesanya DON Eliseo Lucero-Prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria Department of Public Health Daffodil International UniversityDhaka-1216Bangladesh Department of Public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

Classification, Tectonic Setting, and Mineralization Potential of Ayetoro and Sasaro Syenitic Plutons in Igarra Schist Belt, Southwestern Nigeria

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International Journal of Geosciences 2024年第6期15卷 493-510页

作者： Mohammed Olatoye adepoju Yinusa Ayodele Asiwaju-Bello Department of Applied Geology Federal University of Technology Akure Nigeria

Petrographic and geochemical studies of syenite-looking Ayetoro and Sasaro plutons within Igarra Schist Belt were carried out in order to classify them and determine their tectonic setting and mineralization potential. Petrographic study and geochemical classification revealed that while Ayetoro boss is microgranite constituting an aggregate of medium grained muscovite, quartz and biotite minerals, Sasaro stock is micromonzonite made up of medium grained albite, orthoclase, biotite, hornblende and pyroxene. Geotectonic setting showed the boss and stock are orogenic, probably derived from the same upper mantle magma as Igarra batholith that got contaminated by crustal materials responsible for their difference in lithology. Their mineralization potential showed that the massive Ayetoro microgranite with no appreciable trace-element contents cannot serve as host of any metallic deposit, and should be suitable for industrial applications. Whereas, the silicified, highly sheared Sasaro monzonite, with elevated level of some trace elements contents as Ag, Au and Cu, could harbor Ag-Au-Cu deposit.

关键词： ICP-MS Microgranite Micromonzonite Orogenic Ag-Au-Cu Deposit Igarra Schist Belt

Congenital Bilateral Proximal Radio-Ulnar Synostosis in a Nigerian Child

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Open Journal of Pediatrics 2024年第1期14卷 101-107页

作者： Alabi Ayobami Oyetunji Joel-Medewase Victor Idowu Olalere Ayankemi adenike Joel Iretiayo Titilolu Sayomi Bukola Adetutu Oladibu Olanike Taiye Adetoye Mayowa Mary Ashaolu Oluwakayode Joseph Department of Paediatrics and Child Health Ladoke Akintola University of Technology Ogbomoso Nigeria Department of Radiology Ladoke Akintola University of Technology Ogbomoso Nigeria Department of Radiology University College Hospital Ibadan Nigeria Department of Paediatrics and Child Health LAUTECH Teaching Hospital Ogbomoso Nigeria

Congenital radio-ulnar synostosis (CRUS) is a rare skeletal malformation of the upper limb and the most common congenital functional disorder of the elbow joint, causing limitation in forearm rotational movements, which may lead to difficulties with some activities of daily living. We reported a 4-year-old girl with congenital bilateral proximal radio-ulnar synostosis who presented with functional discomfort due to limitation of the prono-supination movements of the forearms and abnormal gestures when handling objects. She has clinical and radiological features of congenital radio-ulnar synostosis (CRUS). However, the parents declined corrective surgery because of wrong perception of the condition to be normal. This case highlighted the poor health seeking behavior and wrong illness perception prevalent in the developing countries.

关键词： Congenital Radio-Ulnar Synostosis Upper Limb Congenital Anomalies Pro-no-Supination

Formulation factors affecting the binding properties of Chinese yam(Dioscorea oppositifolia) and corn starches

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Asian Pacific Journal of Tropical Medicine 2009年第6期2卷 1-7页

作者： adenike Okunlola Oluwatoyin A.Odeku Department of Pharmaceutics and Industrial Pharmacy University of IbadanIbadanNigeria

Objective:The quantitative effects of formulation and processing variables affecting the binding properties of Chinese yam starch（Dioscorea oppositifolia） in chloroquine phosphate tablet formulations have been investigated in comparison with corn starch using a 23 factorial experimental ***:Chinese yam starch,representing the "low" level,and corn starch,representing the "high" level were used as binders at concentrations of 2.5%w/w and 10%w/w in chloroquine phosphate tablet *** mechanical properties of the tablets,measured by the tensile strength（T） and brittle fracture index（BFI） as well as the release properties measured by the disintegration time（DT） and dissolution time(t80- time for 80%drug release),were used as assessment ***:The ranking of the individual coefficient values for the formulations on T was D > N >>C,on BFI was N > D >>C,on DT was D > N > C and on t80 was C > N > D while the ranking of the interaction coefficient on T was N-D > C-D >> N-C,on BFI was N-D > N-C = C-D,on DT and t80 was N-C > N-D > *** the binding agent from Chinese to corn starch,led to a decrease in T,DT and t80 but increase in BFI of the *** were significant（P < 0.001 ） interactions between the nature of binder,N and the other two variables,C and ***:The result showed that Chinese yam possessed stronger binding capacity than corn starch and could be useful as an alternative binder when tablets with high mechanical strength with minimal problems of lamination,and slow release are required.

关键词： Starch Binder Chinese yam Tensile strength Brittle fracture index Chloroquine phosphate

Bioinhibition of diarrhogenic Gram-positive bacterial pathogens by potential indigenous probiotics

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Asian Pacific Journal of Tropical Medicine 2008年第2期1卷 7-11页

作者： adenike A.O.Ogunshe Applied Microbiology and Infectious Diseases Department of Botany & MicrobiologyUniversity of IbadanIbadanNigeria

High level infant mortality rates and onset of drug resistance has led into the possible development of indigenous probiotics as alternative bacteriotherapy in the control of infantile bacterial *** study was to determine the in vitro inhibitory potential of four probiotic candidates obtained from Nigerian indigenous fermented foods and beverages and from faecal specimens of healthy infants on infantile Gram-positive diarrhogenic bacterial *** probiotic candidates,AAOOL4,*** AAOOCH1,*** AA0025NN and *** AAOOT20 were assayed for in vitro bactericidal effects on diarrhogenic bacterial test strains-Bacillus cereus 25S,*** 32S,*** 26S and *** *** the test strains inoculated into an industrial infant weaning food already seeded with the probiotic strains were significantly inhibited within 96 *** AAOOL4,*** AAOOCH1,*** AAOO25NN and *** AAOOT20 had in vitro bactericidal effects on bacteri isolates implicated in infantile diarrhoea,indicating the probiotic potential of the candidates.

关键词： bactericidal biotherapy diarrhoea infantile probiotics tropics

Prediction and assessment of demand response potential with coupon incentives in highly renewable power systems

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Protection and Control of Modern Power Systems 2020年第1期5卷 124-137页

作者： Hao Ming Bainan Xia Ki-Yeob Lee Adekunle adepoju Srinivas Shakkottai Le Xie Electric Reliability Council of Texas 800 Airport RdTaylorTX 78664USA Intellectual Ventures BellevueWAUSA Department of Electrical and Computer Engineering Texas A&M UniversityCollege StationTXUSA

Demand Response(DR)provides both operational and financial benefits to a variety of stakeholders in the power *** example,in the deregulated market operated by the Electric Reliability Council of Texas(ERCOT),load serving entities(LSEs)usually purchase electricity from the wholesale market(either in day-ahead or real-time market)and sign fixed retail price contracts with their ***,incentivizing end-consumers’load shift from peak to off-peak hours could benefit the LSE in terms of reducing its purchase of electricity under high prices from the real-time *** the first-of-its-kind implementation of Coupon Incentive-based Demand Response(CIDR),the EnergyCoupon project provides end-consumers with dynamic time-of-use DR event announcements,individualized load reduction targets with EnergyCoupons as the incentive for meeting these targets,as well as periodic lotteries using these coupons as lottery tickets for winning dollar-value gifts.A number of methodologies are developed for this special type of DR program including price/baseline prediction,individualized target setting and a lottery *** paper summarizes the methodologies,design,critical findings,as well as the potential generalization of such an *** of the EnergyCoupon with a conventional Time-of-Use(TOU)price-based DR program is also *** results in the year 2017 show that by combining dynamic coupon offers with periodic lotteries,the effective cost for demand response providers in EnergyCoupon can be substantially reduced,while achieving a similar level of demand reduction as conventional DR programs.

关键词： EnergyCoupon Incentive-based demand response Critical peak pricing Electricity market Prospect theory

Classification, Tectonic Setting, and Mineralization Potential of Ayetoro and Sasaro Syenitic Plutons in Igarra Schist Belt, Southwestern Nigeria

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Evaluation of bacterial pathogens in paediatric polioviruspositive faecal specimens

International Journal of Geosciences（地球科学国际期刊） 2024年第6期 493页

作者： Mohammed Olatoye adepoju Yinusa Ayodele Asiwaju-Bello

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Asian Pacific Journal of Tropical Medicine 2009年第1期2卷 68-75页

作者： adenike A.O.Ogunshe Oluwafunmilayo G.Oyero Olalekan P.Olabode Applied Microbiology and Infectious Diseases Unit Department of Botany & MicrobiologyUniversity of IbadanIbadanNigeria. Science Laboratory Technology The PolytechnicIbadan/ Department of VirologyCollege of MedicineUniversity College HospitalIbadanNigeria.

Objective:To evaluate the in vitro inhibitory potential of commonly available antibiotic(discs) and paediatric suspensions against bacterial species from polio-positive faecal ***:Commonly available antibiotic (discs) and oral,paediatric suspensions were screened for in vitro inhibitory activities against bacterial species from infantile polio-positive faecal specimens,using agar disc-diffusion and modified agar well-diffusion ***:Isolated bacteria were Bacillus cereus,***,Staphylococcus aureus,Streptococcus pneumoniae,Aeromonas hydrophila,Citrobacter aerogenes,Escherichia coli,Enterobacter aerogenes,Klebsiella pneumoniae,Pseudomonas aeruginosa,Proteus mirabilis,***,Shigella dysenteriae,***,Sh. sonnei and Vibrio *** phenotypic antibiotic susceptibility rates among Gram-positive bacterial species were between 33.3%(augmentin) and 75.0%(chloramphenicol,erythromycin and gentamicin); higher susceptibility rates(48.6%-100.0%) were recorded among Gram-negative bacterial species, while between7.8%/ 10.1%(metronidazole / ampicillin) and 25.2%/28.1%(cotrimoxazole / septrin) were recorded towards paediatric ***:Bacterial species from polio-positive fecal specimens are minimally susceptible to commonly available oral paediatric antibiotic suspensions in Nigeria.

关键词： Antibiotics Co-infection Diarrhoea Infant mortality Paediatric Polio

Liveability experience of mountain-base residents:the case of Idi-Ori-Shasha Mountain,Ibadan,Nigeria

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Journal of Mountain Science 2022年第9期19卷 2693-2702页

作者： Taiwo Oladapo BABALOLA Abubakar Alhaji AHMED Ayobami Abayomi POPOOLA Tolulope Mary ADEDEJI Olajumoke Ololade TUNJI-adepoju Institute of Humanities Governance and Social SciencesPan African University(PAUGHSS)Yaounde 900286Cameroon Department of Urban and Regional Planning University of IbadanIbadan 110115Nigeria SARChI Chair for Inclusive Cities University of KwaZulu-NatalDurban 2954South Africa Department of Sociology University of IbadanIbadan 110115Nigeria

The increasing influx of people to mountain base environments has opened up the area to a myriad of problems that threaten the liveability of the residents and the sustainability of the ***,sufficient empirical investigations have not looked at the particular issues that threaten their liveability *** the case of Idi-OriShasha mountain,this study examined the condition of informal urbanization at the mountain-base and equally investigated residents’living *** conducted questionnaire survey with closed and open-ended questions to collect data from 65 out of 533 houses within a buffer of 250 m from the mountain and retrieved 50 completed householdhead *** results revealed that majority of the residents were not satisfied living at the mountainbase because of the inadequate facilities that have contributed to their current living ***,mountain-base residents are liable to many liveability threats such as noise pollution,sleeplessness,building/wall cracks,destructive erosion,and water *** study recommends adequate infrastructural provision intervention in the area in order to upscale liveability dimensions and general residents’living ***,similar studies could be conducted elsewhere for validation and comparison of findings.

关键词： Liveability Mountain Urbanization Living experience