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Exposure of children to heavy metals from artisanal gold mining in Nigeria:evidences from bio-monitoring of hairs and nails

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Acta Geochimica 2020年第4期39卷 451-470页

作者： adeniyi johnpaul adewumi Temitope Ayodeji Laniyan Tangfu Xiao Yizhang Liu Zengping Ning Department of Geological Sciences Achievers UniversityOwo.Ondo StateNigeria Department of Environmental Health Sciences College of MedicineUniversity of IbadanIbadanOyo StateNigeria Key Laboratory for Water Quality and Conservation of the Pearl River Delta Ministry of EducationGuangzhou UniversityGuangzhou 510006China School of Environmental Science and Engineering.Guangzhou University Guangzhou 510006China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

In recent times,there had been reported cases of Pb poisoning in Anka gold mining area,Northwest ***,this study was carried out to determine the extent of bioaccumulation of heavy metals in the hairs and nails of children in the *** samples(twenty nails and twenty hairs)samples were collected from ten boys and ten girls of ages 5–9 residing in the *** ascertain the sources of heavy metals in children,15 soils samples,15 groundwater samples,5 samples of mine tailings,and 5 plants samples were *** and nails of the subjects were collected using internationally acceptable *** samples were kept in uncontaminated ziplock bags prior to laboratory preparation and *** samples were cleaned using nonionic detergent(triton X-100)and deionized *** hairs and nails were digested with 10 mL of 6:1 mixture of nitric acid and perchloric *** soils,mine tailings,and plants were air-dried at room temperature,sieved,and chemically digested using the aqua regia *** concentrations of metals in all the samples were determined using highperformance liquid chromatography–inductively coupled plasma–mass *** analysis was employed to unravel potential sources of metals in the *** showed that heavy metals in children of the area are above results from similar studies and pathological ranges for heavy metals in hairs and ***,heavy metals in environmental media are above the recommended *** analysis showed that the metals are mainly from mining and other anthropogenic *** of correlation between heavy metals in hairs and nails with those in geological samples revealed that heavy metal that bioaccumulates in the children of this area are mostly from contaminated environmental *** is recommended that complete remediation and effective health education be carried out in the area.

关键词： Anka Bioaccumulation Children Heavy-metals Hairs Nails

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Prevalence, Awareness and Factors Associated with Glaucoma in a Rural Community of Ekiti State, South West Nigeria

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Open Journal of Ophthalmology 2019年第1期9卷 18-27页

作者： Rasaq Kayode Adewoye Tayo Ibrahim Shuaib Kayode Aremu Taiye Adeyanju Alao Makinde Adebayo adeniyi adewumi Bakare Community Medicine Department Federal Teaching Hospital Ido-Ekiti Nigeria Afe Babalola University Ado-Ekiti Nigeria Ophthalmology Department Federal Teaching Hospital Ido-Ekiti Nigeria ENT Department Federal Teaching Hospital Ido-Ekiti Nigeria Community Medicine Department Federal Teaching Hospital Ido-Ekiti Nigeria Obstetrics and Gynecology Department Federal Teaching Hospital Ido-Ekiti Nigeria

Background: Glaucoma, a group of diseases that have optic neuropathy as a common end point, is the leading cause of irreversible blindness worldwide, accounting for 4.5 million blindness, which is about 12% of global blindness. This study aimed to assess the prevalence, awareness and risk factors associated with glaucoma in a rural community of Ekiti State. Methodology: This was a cross-sectional study conducted during a health outreach. All adults present during the outreach were enrolled into the study and screened for glaucoma and a semi-structured self-administered questionnaire was used for data collection. The validity of the questionnaire was tested at Ijero-Ekiti community before being used for this research. Data obtained was analysed using SPSS version 20 and p-value was predetermined at ≤ 0.05. Results: Majority of respondents were aged 60 years and above with a mean age of 55 ± 11.7. Majority (73%) were females and 41% had secondary education. Prevalence of glaucoma was 10.7%;36% of respondents had heard about glaucoma;and 43.2% of those that had heard were not aware that it can lead to blindness. Increasing age, level of education, procurement of glasses from friends/relatives/roadside, using eyes drop not prescribed, history of previous eyes injury and family history of glaucoma were factors identified as having significant relationship with glaucoma. Conclusion: Glaucoma is prevalent in the community (10.7%). However, level of awareness about the disease (36%) was low. Factors, such as age, level of education, procurement of glasses from quacks, use of eye drops not prescribed, previous injury to the eyes and family history of glaucoma, were shown to have significant relationship with glaucoma. There is need to increase community awareness on glaucoma as a major cause of blindness and the risk factors associated with it. Community screening for people above 40 years for glaucoma is also recommended.

关键词： Glaucoma Blindness Neuropathy

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Maternal Serum Lipids in Pre-Eclamptic and Normotensive Pregnant Women: A Case-Control Study

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Open Journal of Obstetrics and Gynecology 2021年第11期11卷 1619-1628页

作者： Olumide Emmanuel Adewara Adeleye Niyi Ogundolire Adebayo Augustine adeniyi Segun Murtala Ghazali Sunday Babatunde Awoyinka Idowu Adebara Olumide Mojisola Ayankunle Ayokunle Moses Olumodeji Olabisi Timothy Adeyemo adewumi Bakare Department of Obstetrics and Gynaecology Afe Babalola University Ado-Ekiti Ekiti State Nigeria Department of Obstetrics and Gynaecology Federal Teaching Hospital Ido-Ekiti Ekiti State Nigeria Department of Chemical Pathology Afe Babalola University Ado-Ekiti Ekiti State Nigeria Department of Obstetrics and Gynaecology Lagos State University Teaching Hospital Ikeja Lagos State Nigeria

Background: Preeclampsia-eclampsia is a major contributor to maternal and fetal, morbidity and mortality especially in low to middle income countries. This hypertensive disorder of pregnancy remains a disease of theories due to its unclear etiology. We evaluated for possible associations between maternal serum lipids and preeclampsia. Methods: This was a prospective case-control study that recruited 60 consenting women diagnosed with preeclampsia (cases) and 60 normotensive healthy pregnant women (controls), matched for maternal age and gestational age over an 8-month period (18th June, 2014 to 18th February, 2015) at the Federal Teaching Hospital Ido-Ekiti, Nigeria. Cases and controls were recruited using the non-probability convenience sampling. Fasting venous blood samples were collected in both cases and controls and analyzed for serum total cholesterol (TC), triglycerides (TG), high density lipoproteins (HDL) and low density lipoproteins (LDL) using Randox standard enzymatic methods. Data obtained were analyzed using SPSS version 18 to compare and test for significance using Student t-test, Chi-square, and Pearson’s correlation as the appropriate. Tests of association were determined using logistic regression models. The difference was considered significant at P Findings: The mean serum levels of TC, HDL and LDL were significantly (p < 0.001) higher in the pre-eclamptics (6.6 ± 2.9 mmol/L, 2.1 ± 1.0 mmol/L and 3.6 ± 2.6 mmol/L) th

关键词： Pregnancy and Serum Lipids Serum Lipids and Preeclampsia Preeclampsia

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Labetalol versus Hydralazine in the Management of Severe Pre-Eclampsia at Tertiary Hospitals in a Low-Resource Setting: A Randomised Controlled Trial

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Open Journal of Obstetrics and Gynecology 2023年第6期13卷 1058-1067页

作者： Uzoma Otutoaja Adeyemo Olabisi Timothy Emmanuel Olumide Adewara Olufunmilayo Victoria Adebara Augustine Adebayo adeniyi Babatunde Sunday Awoyinka Raymond Akujuobi Okere Idowu Oluseyi Adebara adewumi Bakare Mojisola Olumide Ayankunle Department of Obstetrics and Gynaecology Ado-Ekiti/Federal Teaching Hospital Afe Babalola University Ido-Ekiti Nigeria Department of Paediatrics Ado-Ekiti/Federal Teaching Hospital Afe Babalola University Ido-Ekiti Nigeria

Objective: Intravenous labetalol and hydralazine are both considered first-line medications for the management of acute-onset, severe hypertension in pregnant and postpartum women. The study compared the efficacy and safety profile of intravenous labetalol and hydralazine in the control hypertension in severe pre-eclampsia. Materials and Methods: One hundred patients who presented with severe pre-eclampsia were randomized into two study groups. The fifty patients in each arm of the study received either intravenous labetalol or intravenous hydralazine for the control of blood pressure. Results: The mean age of the labetalol subjects was 28.6 ± 5.47 years while that of their hydralazine counterparts was 29.12 ± 5.77 years. The majority of respondents in both groups were primigravidae (76% vs. 78%) (P = 0.813). The number of doses of drug needed to significantly lower the mean systolic blood pressure was slightly lower in the labetalol group (2 doses) compared to the hydralazine group (5 doses) (t = 0.803Y, P = 0.977). The incidence of headaches which were the commonest complaints was comparable in both groups 8% and 10% of respondents respectively (P > 0.05). Conclusion: Although both intravenous labetalol and hydralazine are useful in patients with severe pre-eclampsia, the response to labetalol was better with comparable side effects.

关键词： Blood Pressure Hydralazine Labetalol Low-Resource Setting Severe Pre-Eclampsia Side Effects

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