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Cardiovascular Risk Factors in the Civil Service of Oyo State, South-Western Nigeria: An Epidemic with an Unmatched Response

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World Journal of Cardiovascular Diseases 2020年第8期10卷 587-607页

作者： Olaniyan Akintunde Babatunde Sunday Olakunle Olarewaju Adeleye Abiodun Adeomi Joel Olufunminiyi Akande Sunday Thomas Sola adenike iyanuoluwa olugbenga-bello James O. Bamidele Department of Community Medicine Ladoke Akintola University of Technology Ogbomoso Oyo State Nigeria Oriire Local Government Health Authority Ikoyi-Ile Oyo State Nigeria Department of Community Medicine Osun State University Osogbo Osun State Nigeria Department of Community Medicine Obafemi Awolowo University Ile-Ife Osun State Nigeria Department of Chemical Pathology BOWEN University Teaching Hospital Ogbomoso Oyo State Nigeria Nigeria Field Epidemiology and Laboratory Training Programme Asokoro Abuja Nigeria Department of Community Medicine Ekiti State University Ado-Ekiti Ekiti State Nigeria

Background: Worldwide, the burden of cardiovascular (CV) risk factors is rising with devastating impacts on the productive workforce. In developing nations, it has further led to an unstable population pyramid as a result of premature deaths of her workforce leading to the continued tapering of the pyramidal apex. Inspite of this, many studies were conducted among the general population neglecting the local government civil servants who are seen as policy implementers. Therefore, the study assessed the pattern of CV risk factors in South-western Nigeria. Methods: A cross-sectional study was conducted among 260 local government workers selected by multistage sampling technique from July to September 2017. A pretested, interviewer-administered questionnaire was administered to obtain socio-demographic and behavioural information. Lipid analysis, anthropometric, blood pressure, fasting blood glucose measurements were done according to protocols. Data were analyzed using IBM SPSS version 25;bivariate analysis was done using Chi-square. Level of significance was at 5%. Results: The mean age of respondents was 46.0 ± 6.7 years. The proportion of participants with good knowledge of risk factors was 57.7%. The proportion of respondent with hypertension, visceral obesity, general obesity, diabetes, smoking and physical inactivity was 40.4%, 35.0%, 52.2%, 38.2%, 5.8% and 75.8% respectively. The prevalence of elevated total cholesterol (↑TC), raised low-density lipoprotein (

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Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations

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Chronic Diseases and Translational Medicine 2021年第2期7卷 88-99页

作者： Lateef Olabisi Okeleji Ayodeji Folorunsho Ajayi Grace Adebayo-Gege Victoria Oyetayo Aremu Oluwadunsin iyanuoluwa Adebayo Emmanuel Tayo Adebayo Cardio-thoracic Unit Obafemi Awolowo University Teaching Hospitallle-IfeOsun stateNigeria Department of Physiology Ladoke Akintola University of TechnologyOgbomosoOyo StateNigeria Department of Physiology Baze UniversityKuchigoroJabiAbujaNigeria

Respiratory health in the general population declines regardless of the presence of pulmonary *** stress has been implicated as one of the mechanisms involved in respiratory *** review was to evaluate studies that relate oxidative stress factors with pulmonary function among the general population without prior respiratory *** search yielded 54 ***-one studies qualified for incorporation in this *** to the heterogeneity of the review,studies were discussed based on identified oxidative stress factors responsible for pulmonary *** stress biomarkers,including gene polymorphisms of nuclear factor erythroid 2-related factor 2,heme oxygenase 1,glutathione S transferase,superoxide dismutase,and lipid peroxidation products were involved in lung function *** addition,the antioxidant status of individuals in reference to dietary antioxidant intake and exposure to environmental pollutants affected oxidative stress and pulmonary function,as indicated by forced expired volume in one second,forced vital capacity,and forced expiratory flow at 25%-75%.This review indicated that oxidative stress is implicated in the gradual decline of lung function among the general population,and gene polymorphism along the antioxidant defense line and/or their interaction with air pollutants reduce lung *** polymorphic forms among individuals explain why the rate of lung function decline differs among *** antioxidants have respiratory health benefits in antioxidant gene polymorphic ***,the genetic composition of an individual may be considered for monitoring and identifying people at risk of respiratory illnesses.

关键词： Pulmonary diseases Oxidative stress Respiratory function test Epidemiology

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Syntheses of Coordination Compounds of 2-Amino-3-Methylbutanoic Acid Their Mixed Ligand Complexes and Antibacterial Activities

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Advances in Biological Chemistry 2020年第3期10卷 67-85页

作者： Temitayo O. Aiyelabola iyanuoluwa E. Okunade Johan H. L. Jordaan Daniel P. Otto Department of Chemistry Obafemi Awolowo University Ile-Ife Osun State Nigeria Research Focus Area for Chemical Resource Beneficiation Laboratory for Analytical Services North-West University Potchefstroom South Africa

Coordination compounds of 2-amino-3-methylbutanoic acid were synthesized with chromium(III) and oxovanadium(IV) ions. M:L;1:2. Adducts of these complexes using 1,10-phenantroline and ethylenediamine were further synthesized, M:L, (1:2). These compounds were characterized using electronic, infra-red spectrophotometry, magnetic susceptibility measurement and percentage metal analyses. The zones of inhibition and minimum inhibitory concentrations of the compounds against eight microbes were studied. The results obtained indicated an octahedral geometry for the Cr(III) complexes, indicative of additional coordination of two water molecules. On the other hand a square pyramid geometry was obtained for the binary oxovanadium complex and its 1,10-phenantroline adduct. However, for the oxovanadium ethylenediamine adduct a distorted octahedral geometry was proposed. The result for the antibacterial studies indicated that both mixed ligand complexes of 1,10-phenantroline exhibited good antibacterial activity, and in some cases better activity than the standard, streptomycin.

关键词： Coordination Compounds 2-Amino-3-Methylbutanoic Acid Mixed Ligand Complexes Minimum Inhibitory Concentration 1 10-Phenantroline Ethylenediamine

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