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Natural compounds and extracts from Mexican medicinal plants with anti-leishmaniasis activity: An update

Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1105-1110页

作者： Gabriel Alfonso Gutiérrez-Rebolledo Susan Drier-Jonas María adelina jim.nez-arellanes Unidad de Investigación Médica en Farmacología Hospital de EspecialidadesCentro Médico Nacional Siglo XXIInstituto Mexicano del Seguro SocialAv. Cuauhtémoc 330Col. DoctoresDelg. Cuauhtémoc06720 Ciudad de MéxicoMexico

Leishmaniasis is considered as an emerging, uncontrolled disease and is endemic in 98 countries. Annually, about 2 million cases of cutaneous and 500000 cases of visceraltype leishmaniasis are recorded and 60000 persons died from the disease. In Mexico,cutaneous leishmaniasis is known as chiclero's ulcer and is reported in 22 states, it is considered as a health problem. For its treatment, pentavalent antimonial drugs are administered. These drugs cause severe side effects, are costly. Drug-resistant cases have been reported and have been developing for over 70 years. One alternative to the drugs that are currently available is to find active molecules in medicinal plants. Dihydrocorynantheine, corynantheine and corynantheidine are active against Leishmania major,while harmane, pleiocarpin, buchtienin, luteolin and quercetin are active against Leishmania donovani. In Mexico, about 20 medicinal plants have been evaluated against Leishmania mexicana, among which the most active are Tridax procumbens, Lonchocarpus xuul and Pentalinon andrieuxii. From these plants, active compounds with IC_(50)≤30 mg/mL or m M have been isolated, such as 3(S)-16,17-didehydrofalcarinol or Oxylipin, cholestra-4,20,24-trien-3-one or pentalinosterol, 24-methylcholest-4-24(28)-dien-3-one, cholest-4-en-3-one, 6,7-dihydroneridie-none, neridienone, cholest-5,20,24-trien-3β-ol, and isocordoin. Today, only pentalinonsterol has been synthesized and assayed in the visceral leishmaniasis experimental model using BALB/c mice infected with Leishmania donovani. Liposome formulation of this compound administered by intravenous route at 2.5 mg/kg showed a significant reduction of parasite load in mouse liver and spleen.

关键词： Active extracts Leishmaniasis Antileishmanicidal activity Natural compounds Mexican medicinal plants

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Hepatoprotective properties of oleanolic and ursolic acids in anti-tubercular drug-induced liver damage

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 625-632页

作者： Gabriel A.Gutiérrez-Rebolledo Georgina A.Siordia-Reyes Mariana Meckes-Fischer adelina jim.nez-arellanes Unidad de Investigación Médica en Farmacología (UIMF) UMAE Hospital de EspecialidadesCentro Médico Nacional-Siglo XXI (CMN-SXXI)Instituto Mexicano del Seguro Social (IMSS) Servicio de Patología UMAE Hospital de PediatríaCMN-SXXIIMSS Centro de Diagnóstico en Metabolismo Energético y Medicina Mitocondrial A.C.

Objective:To estimate to what extent the mixture of ursolic acid and oleanolic acid,in addition to the antitubercular standard regime,affects the hepatotoxicity ***:Liver injury was induced in male BALB/c mice by administering,per os and daily for 11 weeks,a combination of anti-Tubercular(anti-TB) agents Rifampicin(10 mg/kg),Isoniazid(10 mg/kg),and Pyrazinamide(30 mg/kg).The ursolic acid and oleanolic acid mixture at doses of 100 or 200 μg/mouse/day was subcutaneously injected throughout the entire study period(11 weeks).Biochemical and hematological analysis was supplemented by liver histological ***:Animals treated with the mixture of triterpenic acids exhibited significantly decreased aspartate transaminase and alanine aminotransferase levels and amelioration of the histopathological alterations produced by the anti-TB ***:The triterpene mixture is able to prevent the steatosis induced by the anti-TB drugs.

关键词： Ursolic acid Oleanolic acid Hepatoprotector effect Antitubercular drugs Triterpenes

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Anti-inflammatory evaluation and acute toxicity of three food supplements that contain Moussonia deppeana

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 134-140页

作者： Gabriel Alfonso Gutiérrez-Rebolledo Mariana Zuleima Pérez-González Alejandro Zamilpa María adelina jim.nez-arellanes Unidad de Investigación Médica en Farmacología Hospital de EspecialidadesCentro Médico Nacional Siglo XXI(CMN-SXXI)Instituto Mexicano del Seguro Social(IMSS)Av.Cuauhtémoc 330Col.DoctoresDeleg.Cuauhtémoc06720 Ciudad de México(CDMX)Mexico Centro de Investigación Biomédica del Sur(CIBIS) IMSSArgentina No.1Col.Centro62790 XochitepecMorelosMexico

Objective:To identify the anti-inflammatory activity through two murine models and in the median Lethal Dose(LD_(50)) of three dietary supplements that contain Moussonia ***:The anti-inflammatory activity of three dietary supplements(Cicatrisan/Gastricus^(R),Gastinol^(R),and Gastrovita^(R)) EtOH extracts was evaluated by TPA and by carrageenan murine models;also,median Lethal Dose(LD_(50)) was *** was quantified by High-Performance Liquid Chromatography.β-sitosterol,stigmasterol and the mixture of ursolic and oleanolic acids were identified in all supplements by TLC;however,none of these dietary supplements contain ***:For the TPA model,Cicatrisan/Gastricus^(R)generated a notable effect with 38.24%*** in the carrageenan model,it also exhibited noteworthy anti-inflammatory activity of ear edema with 66.39%of paw edema inhibition at 150 mg/kg,followed by Gastinol^(R) and Gastrovita^(R) with 50%at 300 mg/***,LD_(50) was >2 g/kg for all supplements,when was administered intragastrically and Body Weight(BW) gain in mice was not altered after 14 ***:Of the three food supplements containing ***,only the EtOH extract from the Cicatrisan/Gastricus^(R)formulation(tablets) showed significant anti-inflammatory activity in both experimental models and the LD_(50) was > 2 g/kg.

关键词： Moussonia deppeana Food supplements Acute inflammation Mexican medicinal plants Herbal remedies Traditional medicine

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Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1116-1125页

作者： María adelina jim.nez-arellanes Gabriel Alfonso Gutiérrez-Rebolledo Mariana Meckes-Fischer Rosalba León-Díaz Unidad de Investigación Médica en Farmacología.UMAE Hospital de Especialidades Centro Médico Nacional-Siglo XXI.Instituto Mexicano del Seguro Social

Drug-induced liver injury encompasses a spectrum of diseases ranging from mild biochemical abnormalities to acute liver failure; example of this scenery is hepatotoxicity caused by the first-line antituberculous drugs isoniazid, rifampin and pyrazinamide, which are basic for treatment of drug-sensible and drug-resistant tuberculosis. In the search for pharmacological alternatives to prevent liver damage, antitubercular drugs have been the subject of numerous studies and published reviews, a great majority of them carried out by Asian countries. At the same time, hepatoprotectors from plant source are now emerging as a possible alternative to counteract the toxic effects of these therapeutic agents. The present review aims to highlight the most recent studies on the subject, based information published in scientific databases such as Scopus and Pub Med.

关键词： Medicinal plants Hepatoprotective effect Antitubercular drugs-induced hepatotoxicity Natural compounds

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