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Antioxidant activity of dichloromethane fraction of Dichrocephala integrifolia in Salmonella typhi-infected rats

Journal of Integrative Medicine 2019年第6期17卷 438-445页

作者： Gaetan Olivier Fankem Michel Archange Fokam Tagne Paul Aime Noubissi Angèle Foyet Fondjo Idrice Kamtchouing adela ngwewondo Henri Wambe Joseph Ngakou Mukam Rene Kamgang Animal Physiology Laboratory Faculty of ScienceUniversity of YaoundéI237Cameroon Department of Biological Science Faculty of ScienceUniversity of Ngaoundéré237Cameroon Department of Zoology and Animal Physiology Faculty of ScienceUniversity of Buea237Cameroon Department of Applied Sciences for Health Higher Institute of Applied SciencesUniversity Institute of Gulf of Guinea237Cameroon Laboratory of Endocrinology and Radioisotopes Institute of Medical Research and Medicinal Plants Studies(IMPM)Yaoundé237Cameroon Department of Biological Science Faculty of ScienceUniversity of Dschang237Cameroon

Objective: Infectious diseases such as typhoid fever lead to the formation of free radicals which can damage the body. Many medicinal plants have antioxidant molecules that neutralize free radicals. The present work evaluated the antioxidant activity and histopathological effects of the dichloromethane fraction of Dichrocephala integrifolia in Salmonella typhi-infected ***: The S. typhi-infected rats concurrently received daily doses of D. integrifolia extract at doses of 25, 50 and 100 mg/kg body weight or ciprofloxacin(5 mg/kg body weight) for 15 days. Body temperature was measured daily during infection and treatment periods. At the end of treatment period, the animals were sacrificed and biological responses including hematological parameters, superoxide dismutase and catalase activities, and glutathione, malondialdehyde and nitric oxide concentrations were ***: The elevated body temperature induced by infection was significantly decreased in animals treated with 25, 50 or 100 mg/kg of the extract. Platelet levels decreased slightly in infected rats, while treatment with the dichloromethane fraction of D. integrifolia significantly increased platelet levels;this response was greater than that elicited by ciprofloxacin. The doses of 50 and 100 mg/kg of the dichloromethane fraction of D. integrifolia notably decreased monocyte and neutrophil values. Activity of superoxide dismutase and catalase and levels of glutathione in the tissues of treated animals were increased significantly(P < 0.01), while malondialdehyde and nitric oxide levels were significantly decreased(P < 0.01), following treatment with the dichloromethane fraction of D. ***: The results of this study show that the dichloromethane fraction of D. integrifolia has protective effects against a series of pathological conditions initiated by oxidation and tissue damage in the course of a S. typhi infection.

关键词： Typhoid fever Salmonella typhi Dichrocephala integrifolia Antioxidant stress Hematology

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