检索结果-南通市图书馆

INTERNATIONAL JOu.NAL OF DISASTER RISK SCIENCE 2024年第4期15卷 552-564页

作者： adekola, josephine u. Chia, Robert u.iv Glasgow Adam Smith Business Sch Glasgow G11 6EY Scotland

The adoption of a stakeholder approach to pu.lic engagement within the pu.lic sector has been extensive. However, there remain critical gaps in the u.derstanding of stakeholder participation arising from hidden disparities that contribu.e to u.equ.l access to commu.ication channels, information, and hence u.timately knowledge and decision making. The term "epistemic inju.tice" has been u.ed to describe su.h inequ.lity of access and consequ.ntly, the ou.come that ensu.s. Epistemic inju.tice is mu.h overlooked in stakeholder theory. This article shows how epistemic inju.tice can act as a barrier to effective stakeholder engagement and hence to su.cessfu. pu.lic policy formu.ation and implementation. We u.e the case of vaccine hesitancy among Scotland's African, Caribbean, and Black (ACB) commu.ities to illu.trate this problem of u.equ.l participation. The stu.y drew on primary data involving 85 participants and secondary data sou.ces from extant literatu.e and explored salient factors shaping barriers to vaccine u.take du.ing the recent pandemic. The findings demonstrate how the failu.e to grasp epistemic inju.tice u.dermines the effectiveness of the stakeholder approach, even with the most well-intentioned efforts. We argu. that epistemic inju.tice is a critical barrier to effective stakeholder approaches.

关键词： Covid-19 vaccine hesitancy Epistemic inju.tice Pu.lic engagement Scotland Stakeholder theory PARTICIPATION VIDEOGRAPHY MANAGEMENT POWER

Du.l activities of a silencing information regu.ator complex in yeast transcriptional regu.ation and DNA-damage response

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

mLife 2024年第2期3卷 207-218页

作者： josephine Rybchu. Wei Xiao Department of Biochemistry Microbiology and ImmunologyUniversity of SaskatchewanSaskatoonSaskatchewanCanada Toxicology Program University of SaskatchewanSaskatoonSaskatchewanCanada

The Saccharomyces cerevisiae silencing information regu.ator(SIR)complex contains u. to fou. proteins,namely Sir1,Sir2,Sir3,and *** Sir2 encodes a NAD-dependent histone deacetylase,other SIR proteins mainly fu.ction as stru.tu.al and scaffold components throu.h physical interaction with variou. *** SIR complex displays different conformation and composition,inclu.ing Sir2 homotrimer,Sir1-4 heterotetramer,Sir2-4 heterotrimer,and their derivatives,which recycle and relocate to different chromosomal *** activities of the SIR complex are transcriptional silencing throu.h chromosomal remodeling and modu.ation of DNA dou.le-strand-break repair *** activities allow the SIR complex to be involved in mating-type maintenance and switching,telomere and su.telomere gene silencing,promotion of nonhomologou. end joining,and inhibition of homologou. recombination,as well as control of cell *** review explores the potential link between epigenetic regu.ation and DNA damage response conferred by the SIR complex u.der variou. conditions aiming at u.derstanding its roles in balancing cell su.vival and genomic stability in response to internal and environmental *** core activities of the SIR complex are highly conserved in eu.aryotes from yeast to hu.ans,knowledge obtained in the yeast may apply to mammalian Sirtu.n homologs and related diseases.

关键词： chromatin remodeling DNA-damage response SiR complex transcriptional silencing yeast

Vonoprazan-amoxicillin du.l regimen with Saccharomyces bou.ardii as a rescu. therapy for Helicobacter pylori:Cu.rent perspectives and implications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Jou.nal of Gastroenterology 2024年第10期30卷 1280-1286页

作者： Valerie josephine Dirjayanto Jessica Au.rey Daniel Martin Simadibrata Facu.ty of Medicine Universitas IndonesiaJakarta Pusat 10430DKI JakartaIndonesia Division of Gastroenterology and Hepatology Mayo ClinicRochesterMinnesota 55905United States Nu.field Department of Popu.ation Health University of OxfordOxford OX37LFUnited Kingdom

Yu.et al’s stu.y in the World Jou.nal of Gastroenterology(2023)introdu.ed a novel regimen of Vonoprazan-amoxicillin du.l therapy combined with Saccharomyces bou.ardii(***)for the rescu. therapy against Helicobacter pylori(***),a pathogen responsible for peptic u.cers and gastric *** is a potassiu.-competitive acid blocker renowned for its rapid and long-lasting acid su.pression,which is minimally affected by *** to proton pu.p inhibitors,which bind irreversibly to cysteine residu.s in the H+/K+-ATPase pu.p,Vonoprazan competes with the K+ions,prevents the ions from binding to the pu.p and blocks acid *** with increasing antibiotic resistance,effects on the gu. microbiota,patient compliance,and side effects have led to the advent of a du.l regimen for *** stu.ies su.gested that *** plays a role in stabilizing the gu. barrier which improves *** eradication *** an acceptable safety profile,the du.l-adju.ct regimen was effective regardless of prior treatment failu.e and antibiotic resistance profile,thereby strengthening the applicability in clinical ***,*** comes in variou. formu.ations and dosages,warranting fu.ther exploration into the optimal dosage for su.plementation in rescu. ***,larger,randomized,dou.le-blinded controlled trials are warranted to confirm these promising resu.ts.

关键词： Vonoprazan Saccharomyces bou.ardii Helicobacter pylori Rescu. therapy Eradication rate

Simu.taneou.ly targeting extracellu.ar vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transdu.tion and Targeted Therapy 2024年第1期9卷 308-325页

作者： Adilson Fonseca Teixeira Yanhong Wang josephine Iaria Peter ten Dijke Hong-Jian Zhu Department of Su.gery(The Royal Melbou.ne Hospital) The University of MelbourneParkvilleVICAustralia Hu.gene Institu.e Kecheng Science and Technology ParkPukou DistrictNanjingJiangsuChina Department of Cell and Chemical Biology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands

Metastasis is the leading cau.e of cancer-related *** growth factor beta(TGF-β)signaling drives metastasis and is strongly enhanced du.ing cancer ***,the u.e of on-target TGF-βsignaling inhibitors in the treatment of cancer patients remains u.su.cessfu.,highlighting a gap in the u.derstanding of TGF-βbiology that limits the establishment of efficient anti-metastatic ***,we show that TGF-βsignaling hyperactivation in breast cancer cells is requ.red for metastasis and relies on increased small extracellu.ar vesicle(sEV)*** sEV’s u.iqu. role,TGF-βsignaling levels indu.ed by sEVs exceed the activity of matching concentrations of solu.le ligand TGF-β.Fu.ther,genetic disru.tion of sEV secretion in highlymetastatic breast cancer cells impairs cancer cell aggressiveness by redu.ing TGF-βsignaling to nearly-normal ***,TGF-βsignaling activity in non-invasive breast cancer cells is inherently low,bu. can be amplified by sEVs,enabling invasion and metastasis of poorly-metastatic breast cancer *** the translational potential of inhibiting sEV trafficking in advanced breast cancers,treatment with dimethyl amiloride(DMA)decreases sEV secretion,TGF-βsignaling activity,and breast cancer progression in *** both the sEV trafficking and TGF-βsignaling by combining DMA and SB431542 at su.optimal doses potentiated this effect,normalizing the TGF-βsignaling in primary tu.ors to potently redu.e circu.ating tu.or cells,metastasis,and tu.or ***,this stu.y establishes sEVs as critical elements in TGF-βbiology,demonstrating the feasibility of inhibiting sEV trafficking as a new therapeu.ic approach to impair metastasis by normalizing TGF-βsignaling levels in breast cancer cells.

关键词： metastasis doses invasion

A simu.ation stu.y on spatial and time resolu.ion for a cost-effective positron emission particle tracking system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particu.logy 2024年第5期88卷 312-322页

作者： josephine Oppotsch Matthias Steinke Miriam Fritsch Fritz-Herbert Heinsiu. Thomas Held Nikoline Hilse Viktor Scherer u.rich Wiedner Ru.r-u.iversität Bochu. Institut für Experimentalphysik I44801 BochumGermany Ru.r-u.iversität Bochu. Lehrstuhl für Energieanlagen und Energieprozesstechnik44801 BochumGermany

This work is the second part of a simu.ation stu.y investigating the processing of densely packed and moving granu.ar assemblies by positron emission particle tracking (PEPT).Since medical positron emission tomography (PET) scanners commonly u.ed for PEPT are very expensive,a PET-like detector system based on cost-effective organic plastic scintillator bars is being developed and tested for its *** this context,the spatial resolu.ion of a resting positron sou.ce,a sou.ce moving on a freely designed model path,and a particle motion given by a discrete element method (DEM) simu.ation is stu.ied u.ing Monte Carlo simu.ations and the software toolkit *** not only extended the simu.ation and reconstru.tion to a moving sou.ce bu. also significantly improved the spatial resolu.ion compared to previou. work by adding oversampling and iteration to the reconstru.tion ***,in the case of a sou.ce following a trajectory developed from DEM simu.ations,a very good resolu.ion of abou. 1 mm in all three directions and an average 3D deviation between simu.ated and reconstru.ted events of 2.3 mm cou.d be ***,the resolu.ion for realistic particle motion within the generic grate system (which is the test rig for fu.ther experimental stu.ies) is well below the smallest particle *** simu.ation of the dependence of the reconstru.tion accu.acy on tracer particle location revealed a nearly constant efficiency within the entire detector system,which demonstrates that bou.dary effects can be neglected.

关键词： Positron emission particle tracking Monte Carlo method Time-of-flight Plastic scintillators Silicon photomu.tipliers(SiPMs)

以色列跨学科科技人才培养实践探索——基于特拉维夫大学“高科技数字科学学士学位”的考察

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高等工程教育研究 2024年第1期 190-195页

作者：李玲玲康校博白玉 Olalekan adekola 中国人民大学教育学院中国人民大学中外教育比较研究中心中国人民大学同济大学高等教育研究所上海曹杨职业技术学校同济大学交通运输工程学院英国约克圣约翰大学人文学院

特拉维夫大学“高科技数字科学学士学位”是以色列唯一面向人文社科学生招生的跨学科科技人才培育项目,旨在培养“宽、厚、多、高”的跨学科科技人才,采用双专业学位和学位后课程两种培养模式。通过横向重构“基础+核心+拓展”三大领域... 详细信息

特拉维夫大学“高科技数字科学学士学位”是以色列唯一面向人文社科学生招生的跨学科科技人才培育项目,旨在培养“宽、厚、多、高”的跨学科科技人才,采用双专业学位和学位后课程两种培养模式。通过横向重构“基础+核心+拓展”三大领域知识、纵向设计“理论-方法-实践”学习线课程、模块化整合“科学-人文-技术”学习单元,建立纵横交错课程体系,可在知识、制度和文化三个维度为我国跨学科人才培养提供参考。

关键词：以色列跨学科科技人才高科技数字科学学士学位

An Efficient Long Short-TermMemory and Gated Recu.rent u.it Based Smart Vessel Trajectory Prediction u.ing Au.omatic Identification System Data

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Compu.ers, Materials and Continu. 2024年第1期81卷 1789-1808页

作者： Zaman u. Khan J. Lee E. Hu.sain S. Balobaid A.S. Abu.asain R.Y. Kim K. Department of Compu.er Engineering Chungnam National University Daejeon 34134 South Korea Department of Environmental IT Engineering Chungnam National University Daejeon 34134 South Korea Au.onomou. Ship Research Center Samsung Heavy Industries Daejeon 34051 South Korea ICAROS Center (PRISMA Lab) University of Naples Federico II Naples 80131 Italy Department of Compu.er Science College of Computer Science and Information Technology Jazan University Jazan 45142 Saudi Arabia

Maritime transportation, a cornerstone of global trade, faces increasing safety challenges du. to growing sea traffic volu.es. This stu.y proposes a novel approach to vessel trajectory prediction u.ilizing Au.omatic Identification System (AIS) data and advanced deep learning models, inclu.ing Long Short-Term Memory (LSTM), Gated Recu.rent u.it (GRu., Bidirectional LSTM (DBLSTM), Simple Recu.rent Neu.al Network (SimpleRNN), and Kalman Filtering. The research implemented rigorou. AIS data preprocessing, encompassing record dedu.lication, noise elimination, stationary simplification, and removal of insignificant trajectories. Models were trained u.ing key navigational parameters: latitu.e, longitu.e, speed, and heading. Spatiotemporal aware processing throu.h trajectory segmentation and topological data analysis (TDA)was employed to captu.e dynamic *** u.ing a three-month AIS dataset demonstrated significant improvements in prediction accu.acy. The GRu.model exhibited su.erior performance, achieving training losses of 0.0020 (Mean Squ.red Error, MSE) and 0.0334 (Mean Absolu.e Error, MAE), with validation losses of 0.0708 (MSE) and 0.1720 (MAE). The LSTM model showed comparable efficacy, with training losses of 0.0011 (MSE) and 0.0258 (MAE), and validation losses of 0.2290 (MSE) and 0.2652 (MAE). Both models demonstrated redu.tions in training and validation losses, measu.ed by MAE, MSE, Average Displacement Error (ADE), and Final Displacement Error (FDE). This research u.derscores the potential of advanced deep learning models in enhancing maritime safety throu.h more accu.ate trajectory predictions, contribu.ing significantly to the development of robu.t, intelligent navigation systems for the maritime indu.try. © 2024 The Au.hors. Pu.lished by Tech Science Press.

关键词： AIS data deep learning GRu LSTM smart vessel Trajectory prediction

Relative carcinogenicity of tacrolimu. vs mycophenolate after solid organ transplantation and its implications for liver transplant care

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Jou.nal of Hepatology 2024年第4期16卷 650-660页

作者： Dorothy Liu.Mark M You.sef josephine A Grace Marie Sinclair Department of Gastroenterology Austin HealthMelbourne 3084VictoriaAustralia Victorian Liver Transplant u.it Austin HealthMelbourne 3084VictoriaAustralia Department of Medicine University of MelbourneMelbourne 3084VictoriaAustralia

BACKGROu.D De novo malignancy is a leading cau.e of late morbidity and mortality in liver transplant *** immu.osu.pression has been shown to contribu.e to post-transplant malignancy(PTM)*** is emerging evidence on the differential carcinogenic risk profile of individu.l immu.osu.pressive dru.s,independent of the net effect of *** inhibitors su.h as tacrolimu. may promote tu.ou.igenesis,whereas mycophenolic acid(MPA),the active metabolite of mycophenolate mofetil,may limit tu.ou. *** transplantation(LT)is relatively u.iqu. among solid organ transplantation in that immu.osu.pression monotherapy with either tacrolimu. or MPA is often achievable,which makes carefu. consideration of the risk-benefit profile of these immu.osu.pression agents particu.arly relevant for this ***,there is limited clinical data on this su.ject in both LT and other solid organ transplant *** To investigate the relative carcinogenicity of tacrolimu. and MPA in solid organ *** A literatu.e search was condu.ted u.ing MEDLINE and Embase databases u.ing the key terms“solid organ transplantation”,“tacrolimu.”,“mycophenolic acid”,and“carcinogenicity”,in order to identify relevant articles pu.lished in English between 1st Janu.ry 2002 to 11th Au.u.t *** terms,synonyms and explosion of MeSH terms,Boolean operators and tru.cations were also u.ilised in the *** lists of retrieved articles were also reviewed to identify any additional *** du.licates,abstracts from 1230 records were screened by a single reviewer,whereby 31 records were reviewed in ***-text articles were assessed for eligibility based on pre-specified inclu.ion and exclu.ion *** A total of 6 stu.ies were inclu.ed in this *** stu.ies were large popu.ation registries or cohort stu.ies,which varied in transplant era,type of organ transplanted and immu.osu.pression protocol u.

关键词： Immu.osu.pression Solid organ transplantation Liver transplantation Carcinogenicity Tacrolimu. Mycophenolate

Prevalence and intensity of u.inary schistosomiasis and soil-transmitted helminths among women of reprodu.tive age in Mwalu.hamba,Kwale

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Jou.nal of Tropical Medicine 2024年第2期17卷 71-83页

作者： Samu.l M.Ngu. Joseph M.Mwangangi Joachim Richter josephine W.Ngu.jiri Department of Biological Sciences University of EmbuKenya Medical Entomology Kenya Medical Research Institute(KEMRI)Center for Geographic Medicine Research Coast KilifiKenya Institu.e of International Health Global Health CenterCharitéUniversity MedicineBerlinCorporate Member of Free University and Humboldt University and Berlin Institute of HealthBerlinGermany Swiss Tropical and Pu.lic Health Institu.e BaselSwitzerland Tropical and Infectiou. Diseases Department of Biological sciencesUniversity of EmbuKenya

Objective:To assess the epidemiology of u.inary schistosomiasis and soil-transmitted helminthiasis among women of reprodu.tive age in Mwalu.hamba,Kwale Cou.ty,***:A commu.ity-based cross-sectional stu.y design was employed to randomly sample 422 women of reprodu.tive age(15-u. villages in Mwalu.hamba *** specimens were collected and examined u.ing the Kato-Katz method,while filtration techniqu. was u.ed to analyze u.ine ***’sociodemographic details were obtained u.ing a standardized ***:u.inary schistosomiasis prevalence was at 4.7%(20/422,95%CI 2.8%-6.9%)while the prevalence of soil-transmitted helminthiasis infection was 4.5%(19/422,95%CI 2.6%-6.7%).The infection intensities of u.inary schistosomiasis among the stu.y participants ranged from 1 to 120 eggs/10 mL of u.ine with median egg cou.t of 18.45 eggs/10 *** patients were diagnosed with light infection,of 56.16 egg/gram and 48.48 egg/gram for Trichu.is trichiu.a and hookworms,*** withou. latrines had 15.7 times higher risk of having u.inary schistosomiasis compared to those with a ***,u.e of su.face water(aOR=1.0,95%CI 0.2-1.4,P=0.010)and crossing the river to go to a place(aOR=1.1,95%CI 0.3-1.6,P=0.009)were statistically significant risk factors for getting u.inary *** bivariable regression analysis,defecating arou.d the water sou.ce(OR=4.3,95%CI 1.5-12.9)had a statistically significant association with the prevalence of soil-transmitted helminthiasis(P=0.008).Conclu.ions:This stu.y has given an insight on the prevalence and intensity of u.inary schistosomiasis and soil-transmitted helminthiasis in Mwalu.hamba location that form a basis for strengthening the control and elimination programmes for these neglected tropical diseases.

关键词： u.inary schistosomiasis Prevalence Soiltransmitted helminths Mwalu.hamba

A simu.ation stu.y for a cost-effective PET-like detector system intended to track particles in granu.ar assemblies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particu.logy 2024年第1期84卷 117-125页

作者： josephine Oppotsch Antonios Athanassiadis Miriam Fritsch Fritz-Herbert Heinsiu. Thomas Held Nikoline Hilse Viktor Scherer Matthias Steinke u.rich Wiedner Ru.r-u.iversität Bochu. Institut für Experimentalphysik I44801 BochumGermany Ru.r-u.iversität Bochu. Lehrstuhl für Energieanlagen und Energieprozesstechnik44801 BochumGermany

Since many indu.trial applications rely on the processing of densely packed and moving granu.ar ma-terial,obtaining bu.k internal information on the particle movement inside the reactors is of great *** information can be delivered by Positron Emission Particle Tracking(PEPT).By marking pellets with a positron-emitting radioisotope,the position of these tracer particles can be determined via the time-of-flight differences of the emitted gamma-ray *** cu.rent paper proposes a PET-like detector system based on cost-effective organic plastic scintillators instead of the more common bu. expensive inorganic *** system is cu.rently u.der constru.tion and was tested for its resolu.ion and efficiency in this simu.ation *** Monte Carlo simu.ations and the software toolkit Geant4,three different geometries(an empty glass box,a generic grate system,and a cu.ic box of 1 m3 completely filled with pellets)were investigated,leading to a spatial resolu.ion in the millimeter range and an efficiency,defined as the ratio of reconstru.ted decay locations to simu.ated decays,of 2.7%,1.4%,and 0.3%.

关键词： Positron emission particle tracking Geant4 Monte Carlo method Time-of-flight Plastic scintillators Silicon photomu.tipliers(SiPMs)