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Antiretroviral-Drug Resistant Mutations and Genetic Diversity in HIV-1 Infected Individuals in Nigeria

World Journal of AIDS 2014年第2期4卷 187-197页

作者： Olubunmi Ruth Negedu-Momoh Olayeni Stephen Olonitola Lillian Emiola Odama Helen Ineigo Inabo Henry Akwen Mbah Alex Nganga Kasembeli Seth Chekata Inzaule Edward Adekola oladele Titilope Badru Simon Magaji Agwale Centre for Disease Control and Prevention HIV Research Laboratory Kisumu Kenya Department of Microbiology Ahmadu Bello University Zaria Nigeria Department of Microbiology Kogi State University Ayangba Nigeria Family Health International (FHI 360) Abuja Nigeria Innovative Biotech USA Inc Frederick Innovative Technology Center Frederick USA

Introduction: Despite the success derived from antiretroviral therapy, drug resistance (DR) mutations are known to develop and are major impediments to treatment of HIV patients. Therefore, periodic assessment of HIVDR is needed to ensure continuous HAART efficacy. This study assessed the magnitude of drug resistance as well as HIV genetic variability in drug-naive and treated patients in Nigeria. Methodology: Genotypic analysis was performed by sequencing plasma specimens from 40 individuals in a cross sectional study involving 202 HIV infected patients from all the six geopolitical zones of Nigeria. Sequences were analyzed for presence of HIVDR mutation using the algorithm in Stanford HIVDR database and confirmed by IAS-USA 2009 mutation list. Phylogenetic and recombination analyses were done using PAUP V4.0 and REGA V2.0 respectively. Results: Major DR mutations were detected in the reverse transcriptase (RT) gene of 5 (33%) drug experienced and 2 (8%) na?ve patients. Most common mutations were M184V and K103N with no protease (PR) mutations detected. Thymidine analogue mutations (TAMs) and a complex multi resistance mutation Q151M were detected in 3 samples. Polymorphic substitutions were observed in both PR and RT gene. Phylogenetic analysis revealed Group M isolates of G (20), J (1), circulating recombinant forms: CRF02_AG (14), CRF-18-cpx (1), CRF06_cpx (3) and a unique AD recombinant (1). Conclusion: Our findings corroborate previous studies on circulating DR viruses in Nigeria while genetic diversity is on the increase. In view of ART scale-up, monitoring the resistance pattern and genetic diversity will aid in appropriate prevention strategies.

关键词： HIV Drug Resistance Mutation Nigeria

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Evaluation and Effectiveness of Reallocating Traffic Signal Timing at Corridors with High Freight Volume

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Journal of Architectural Environment & Structural Engineering Research 2022年第2期5卷 25-33页

作者： Ijeoma Ihuoma-Walter Celeste Chavis Adewole oladele Civil Engineering Department Morgan State UniversityBaltimoreMD 21251United States Transportation and Urban Infrastructure Studies Morgan State UniversityBaltimoreMD 21251United States

The COVID-19 pandemic drastically altered traffic patterns across the *** more people staying at home and relying on delivery services,there was a reduction in passenger car traffic but an increase in freight *** study investigates the changes in traffic volume and mode splits during the COVID-19 pandemic at the intersection of Broening Highway and Holabird Avenues and investigates traffic signal reallocation strategies that account for the changes in *** study considers morning peak traffic volumes before and during COVID.A methodology was developed to evaluate and measure freight volumes and *** the literature,the cost per kilogram of CO,VOC,and NOx was$5.85,$3,37,and$12.53,*** intersection operated at a level of service(LOS)of C both pre-COVID and during *** volume decreased by 24.3%during COVID at the study location;car volumes declined by 50%,and truck volumes increased by 130%.The total rate of emissions decreased by 22.6%.

关键词： Multi-modal transportation Signalized intersection Freight Vehicle and persons delay COVID Value of time

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Epidemiology of Mpox Outbreaks and Implications for Surveillance in Imo State, Nigeria

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Advances in Infectious Diseases（传染病进展） 2024年第1期 206页

作者： Adeniyi A.Adeniran Ebubechi C.Eronini Olugbenga Asaolu Simisola Adedeji Adaeze Joy Ugwu Marcus Oludare Faith Ehiaghe Ugba Aibinuomo Ayomide Oluwaseyi Tella Adedamola Dania Oluyinka Olayiwola Olanike Suliat oladele Tinuola Daniel Musa Haruna Adebayo O.Amao John O.Ibitoye Oluwagbemiga Obembe Christopher Obanubi Abdulmalik Abubakar

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Comparative Effects of Selected Underutilized Wild Beans on Plasma Lipid Profile and Liver Function of Rats Fed with High Fats Diet

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Food and Nutrition Sciences 2019年第4期10卷 459-468页

作者： O. A. Awoyinka T. R. Omodara F. C. oladele D. D. Ajayi H. A. Babalola B. A. Olofinbiyi G. S. Adeleye E. O. Odesanmi Department of Medical Biochemistry College of Medicine Ekiti State University Ado Ekiti Nigeria Department of Microbiology Faculty of Sciences Ekiti State University Ado Ekiti Nigeria Department of Chemical Pathology Ekiti State University Teaching Hospital Ado Ekiti Nigeria Department of Science Laboratory (Biochemistry Option) Ekiti State University Ado Ekiti Nigeria Department of Medicine College of Medicine Ekiti State University Ado Ekiti Nigeria Department of Physiology Ekiti State University Ado Ekiti Nigeria Department of Biochemistry Ekiti State University Ado Ekiti Nigeria

Dietary fiber content of beans is known to be responsible in the management of metabolic syndrome by delaying the degree of glucose as fuels, changing fat utilization, and controlling appetite through increased satiety, thus lowering the risk of cardiovascular diseases. Hence some selected varieties of underutilized wild beans were evaluated to study their anti-lipidemic effects. Prior to this, attempts were made to ferment the non-digestible fractions of the beans with fermentable micro-organism and the respective gut metabolites were determined. Lipid profile result carried out in the blood showed high density lipoprotein to be significantly (p ≤ 0.05) high in Pakala group with a value of 2.2 ± 0.02 compared to other groups. While for low density lipoprotein (LDL);rats with Otili in their diet had the highest LDL with a value of 0.45 ± 0.01. However, the group of rats fed with Feregede had the least cholesterol level compared to other groups of rats fed with respective wild beans and the negative control group. Otili had the highest ALP with value of 89 ± 1.0. Otili group also had a significant lower value of both aspartate amino transferase and alanine amino transferase. The biochemical indices reported in this study vary from one type of wild bean to another.

关键词： Metabolic Syndrome Dietary Fibres Anti-Lipidemic Alanine Aminotransferase Aspartate Aminotransferase

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Effect of Deposition Temperature on Some Properties of MOCVD Molybdenum Sulphide Thin Films

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材料科学与工程（中英文B版） 2014年第4期4卷 78-85页

作者： Bolutife Olofinjana Gabriel Osaze Egharevba Bidini Alade Taleatu Olumide Oluwole Akinwunmi Ezekiel oladele Bolarinwa Ajayi Department of Physics Obafemi Awolowo University Ile-lfe Nigeria Department of Chemistry Obafemi Awolowo University lle-Ife Nigeria

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Some of the Mechanisms for Coexistence of Tree Species Diversity in Tropical Forests:A Review of Effects of Tree Density Dependence

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Open Journal of Forestry（林学期刊） 2023年第1期

作者： oladele Fisayo Falade

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Epigenetics in the etiology and management of infertility

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World Journal of Medical Genetics 2022年第2期10卷 7-21页

作者： Tajudeen Olanrewaju Yahaya Danlami M Bashar Esther O oladele Ja'afar Umar Daniel Anyebe Abdulrazaq Izuafa Department of Biological Sciences Federal University Birnin KebbiKebbi State 23401Nigeria Department of Microbiology Federal University Birnin KebbiKebbi State 23401Nigeria Biology Unit Distance Learning InstituteUniversity of LagosLagos State 23401Nigeria Department of Biochemistry and Molecular Biology Federal University Birnin KebbiKebbi State 23401Nigeria

BACKGROUND Epigenetic disruptions have been implicated in some cases of infertility and can serve as therapeutic ***,the involvement of epigenetics in infertility has not received adequate *** This study aimed to determine the epigenetic basis of infertility in order to enhance public *** Relevant articles on the subject were collected from PubMed,RCA,Google Scholar,SpringerLink,and *** articles were pooled together and duplicates were removed using Endnote *** Available information shows that epigenetic mechanisms,mainly DNA methylation,histone modification,and microRNA interference are necessary for normal gametogenesis and *** a result,epigenetic disruptions in genes that control gametogenesis and embryogenesis,such as DDX3X,ADH4,AZF,PLAG1,D1RAS3,CYGB,MEST,JMJD1A,KCNQ1,IGF2,H19,and MTHFR may result in *** DNA methylation during genomic imprinting and parental epigenetic mark erasures,in particular,may affect the DNA epigenomes of sperm and oocytes,resulting in reproductive *** the sperm may also cause reproductive ***,overexpression or repression of certain microRNAs embedded in the ovary,testis,embryo,as well as granulosa cells and oocytes may impair *** infertility is characterized by spermatogenesis failure,which includes oligozoospermia,asthenozoospermia,and teratozoospermia,while female infertility is characterized by polycystic ovary *** epigenetic modifications can be reversed by deactivating the regulatory enzymes,implying that epigenetic reprogramming could help treat infertility in some *** some disorders,epigenetic drugs are available,but none have been formulated for *** Some cases of infertility have an epigenetic etiology and can be treated by reversing the same epigenetic mechanism that caused *** a result,medical practitioners are urged to come up with epigenetic treatments for

关键词： DNA methylation Gametogenesis Infertility Polycystic ovary syndrome Oligozoospermia Teratozoospermia

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Evaluation of Entrance Skin Dose from Paediatric Diagnostic X-Ray Examination

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Open Journal of Radiology（放射学期刊） 2023年第1期

作者： Moromoke Oluwayemisi Adelayi oladele Samuel Ajayi

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Outcome of Symptom-Based RT-PCR Testing for SARS-CoV-2: Experience from a Large Public Testing Centre in Nigeria

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Advances in Infectious Diseases 2022年第4期12卷 799-812页

作者： Aigbe Gregory Ohihoin Kazeem Adewale Osuolale Patrick Azuka Okwuraiwe Adesola Zaidat Musa Ayorinde Babatunde James Chika Kingsley Onwuamah Olufemi Samuel Amoo Joseph Ojonugwa Shaibu Fehintola Ige Esther Ngozi Ohihoin Emelda Chukwu Ngozi Mirabel Otuonye Tajudeen Bamidele Adeola Olukosi Olusola Ajibaye Yekeen Raheem David oladele Agatha Nkiru David Babatunde Adewale Rosemary Audu Oliver Ezechi Nkiruka Nnonyelum Odunukwe Richard Adegbola Babatunde Lawal Salako Clinical Sciences Department Nigerian Institute of Medical Research Yaba Lagos Grants and M/E Unit (Biostatistics) Nigerian Institute of Medical Research Yaba Lagos Centre for Human Virology and Genomics Microbiology Department Nigerian Institute of Medical Research Yaba Lagos Department of Biochemistry and Nutrition Nigerian Institute of Medical Research Yaba Lagos Centre of Infectious Disease Research Microbiology Department Nigerian Institute of Medical Research Yaba Lagos Central Research Laboratory Nigerian Institute of Medical Research Yaba Lagos Department of Molecular Biology and Biotechnology Nigerian Institute of Medical Research Yaba Lagos Clinical Diagnostic Laboratory Nigerian Institute of Medical Research Yaba Lagos Department of Public Health Nigerian Institute of Medical Research Yaba Lagos

Background: Access to testing for SARS-CoV-2 in Nigeria is still highly restricted. Only patients who are symptomatic for SARS-CoV-2 are selected for testing. This pattern of testing will miss a large proportion of individuals with the infection who are asymptomatic and presymptomatic. This study reports the experience of a symptom-based study from a large testing centre in Nigeria. Methods: A cross-sectional study, reviewing data collected from respondents presenting at the Nigerian Institute of Medical Research (NIMR) modified drive-through center for COVID-19 test between the period March 31st and August 31st, 2020 were included in the analysis. Results: A total of 9891 participants were recruited into the study and 2465 participants (24.9%) had a positive PCR result for SARS-CoV-2. The majority of the respondents were above 18 years old, n = 9163 (93.4%). The average age of the respondents was 36.7 years (sd 13.8 years). The age of the participants has a significant effect on SARS-CoV-2 status (AOR = 1.009, CI, 1.005 to 1.012, p = 0.0001). There was a male preponderance, n = 5652 (57.6%). The odds of having a positive status for SARS-CoV-2 were 0.9 times lower for female participants. The majority of the respondents had a history of travel, n = 6788 (68.6%). Cough was the commonest symptom, n = 1062 (10.7%) followed by fever, n = 979 (9.9%). The mortality rate was 0.1%. Among the participants with comorbidity, 31 (51.7%) had positive results for SARS-CoV-2 while 29 (48.3%) had negative results. Conclusion: Symptom-based approach to testing for SARS-CoV-2 in Nigeria revealed a high positivity rate, while mortality from those tested in the study is low. Age and gender appear to play a significant role in the dynamics of the disease.

关键词： SARS-CoV-2 COVID-19 Symptoms RT-PCR Nigeria

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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coinfection with Malaria in Selected States in Nigeria

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Advances in Infectious Diseases（传染病进展） 2024年第2期 442页

作者： Oluwagbemiga Olanrewaju Aina Olufemi Samuel Amoo Kazeem Adewale Osuolale Adewale Kayode Ojogbede Azuka Patrick Okwuraiwe David Ayoola oladele Adesola Zaidat Musa Tajudeen Akanji Bamidele Celestina Onyinye Okoyenta Abideen Olurotimi Salako Toyosi Yekeen Raheem Ifeoma Eugenia Idigbe Fehintola Anthonia Ige Joseph Ojonugwa Shaibu Gregory Aigbe Ohihoin Kikelomo Wright Bisola Adebayo Hussein Abdu-Razzaq Abdulrahman Ahmad Mustapha Imam Bashir Bello Tambuwal Muhammad Shuaibu Gobir Richard Ikwuogu Christian Tetsola Gloria Patrick-Ferife Nathaniel Enamuotor Mildred Okowa William Nwachukwu Cornelius Ohonsi Magdalene Egede Chinwe Ochu Ehimario Igumbor Oliver Chukwujekwu Ezechi Babatunde Lawal Salako Rosemary Ajuma Audu

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