检索结果-南通市图书馆

The Application of Analytical Techniques to Alpha-Synuclein in Parkinson’s Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Analytical Chemistry 2024年第9期15卷 269-285页

作者： olatayo adedayo olahanmi Department of Chemistry Middle Tennessee State University Murfreesboro USA

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor symptoms such as tremors, rigidity, and bradykinesia, as well as non-motor symptoms including cognitive impairment and mood disorders. A hallmark of PD is the accumulation of alpha-synuclein, a presynaptic neuronal protein that aggregates to form Lewy bodies, leading to neuronal dysfunction and cell death. The study of alpha-synuclein and its pathological forms is crucial for understanding the etiology of PD and developing effective diagnostic and therapeutic strategies. Analytical techniques play a pivotal role in elucidating the structure, function, and aggregation mechanisms of alpha-synuclein. Biochemical methods such as Western blotting and enzyme-linked immunosorbent assay (ELISA) are employed to detect and quantify alpha-synuclein in biological samples, offering insights into its expression levels and post-translational modifications. Imaging techniques like immunohistochemistry and positron emission tomography (PET) allow for the visualization of alpha-synuclein aggregates in tissue samples and in vivo, respectively, facilitating the study of its spatial distribution and progression in PD Spectroscopic methods, including nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry, provide detailed structural information on alpha-synuclein and its isoforms, aiding in the identification of conformational changes associated with aggregation. Emerging techniques such as cryo-electron microscopy (Cryo-EM) and single-molecule fluorescence enable high-resolution structural analysis and real-time monitoring of alpha-synuclein aggregation dynamics, respectively. The application of these analytical techniques has significantly advanced our understanding of the pathophysiological role of alpha-synuclein in PD. They have contributed to the identification of potential biomarkers for early diagnosis and the evaluation of therapeutic interventions targeting alpha-synuclein a

关键词： Parkinson’s Disease Alpha-Synuclein Techniques

Attenuation of oxidative stress and hepatic damage by some fermented tropical legume condiment diets in streptozotocin-induced diabetes in rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2012年第9期5卷 692-697页

作者： adedayo.o.ademiluyi Ganiyu oboh Functional Foods and Nutraceuticals Unit Department of BiochemistryFederal University of TechnologyAkure P.M.B.704 Akure340001Nigeria

objective:To investigate the modulatory effect of fermented legume condiments diet on oxidative stress in streptozotocin(STZ) induced diabetic ***:Adult male Wistar rats were randomly divided into six groups with six animals in each *** was induced by intraperitoneal injection of STZ(35 mg/kg b.w.).After being confirmed diabetic,the rats were fed with fermented Bambara *** bean and Soybean diets for 14 *** plasma was obtained after 14-day treatment and analyzed for hepatic damage marker enzymes(AST,ALT and ALP) and in vivo antioxidant ***:The diabetic untreated rats showed elevated (Pof AST,*** and malondialdehyde with reduced activities of glutathiones -transferase,catalase as well as plasma reduced glutathione,vitamin C and total protein ***,treatment of diabetic rats with lermenled legume condiments diets for 14 days significantly(Pove parameters towards normalcy,suggesting their modulation of oxidative stress,which mav be due to their high phenolic content and antioxidant ***:The attenuation of oxidative stress and protection of hepatic tissue damage by the legume condiment diets in STZ induced diabetic rats compare favourably with that of metformin,a well known oral hypoglycemic drug.

关键词： Diabetes oxidative stress Hepatotoxicity Antioxidants Phenolics Soybean African locust bean Bambara groundnut

Modulatory effects of dietary inclusion of garlic(Allium sativum) on gentamycin-induced hepatotoxicity and oxidative stress in rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2013年第6期3卷 470-475页

作者： adedayo.o.ademiluyi Ganiyu oboh Tosin R owoloye oluwaseun J Agbebi Functional Foods Nutraceuticals and Phytomedicine UnitDepartment of BiochemistryFederal University of Technology

objective:To investigate die ameliorative effect of dietary inclusion of garlic(Allium sativum)on gentamycin-induced hepatotoxicity in ***:Adult male rats were randomly divided into four groups with sis animals in each *** 1 and 2 were fed basal diet while Groups 3 and 4 were fed diets containing 2%and 4%garlic respeetively for 27 d prior to gentamycin *** was induced by the intraperitoneal administration at gentamycin(100 mg/kg body weight)for 3 *** liver and plasma were studied for hepatotoxicity and antioxidant ***:Gentamycin induces hepatic damage as revealed by significant(Pon of liver damage marker enzymes(aspartate transaminase and alanine aminotransferase)and reduction in plasma albumin *** also eaused a significant(Pon in plasma and liver enzymatic(catalase,glutathione and super oxygen dehydrogenises)and non-enzymatic(glutathione and vitamin C)antioxidant indices with concomitant increase in the malondialdehyde content;however,there was a significant(Poration of the antioxidant status coupled with significant(Pondialdehyde content,following consumption of diets containing ***:These results suggest that dietary inclusion of garlic powder could protect against gentamycin-induced hepatotoxicity,improve antioxidant status and modulate oxidative stress;a function attributed to their phenolic constituents.

关键词： Gentamycin Hepatotoxicity oxidative stress Garlic(Allium sativum) Phytochemicals

Stability analysis of a time-delayed Van der Pol–Helmholtz–Duffing oscillator in fractal space with a non-perturbative approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第4期76卷 22-31页

作者： Yusry o El-Dib Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt

The time-delayed fractal Van der Pol–Helmholtz–Duffing(VPHD)oscillator is the subject of this paper,which explores its mechanisms and highlights its stability *** time-delayed technologies are currently garnering significant attention,the focus of this research remains crucially relevant.A non-perturbative approach is employed to refine and set the stage for the system under *** innovative methodologies introduced yield an equivalent linear differential equation,mirroring the inherent nonlinearities of the ***,the incorporation of quadratic nonlinearity into the frequency formula represents a cutting-edge *** analytical solution's validity is corroborated using a numerical *** conditions are ascertained through the residual Galerkin ***,it is observed that the delay parameter,in the context of the fractal system,reverses its stabilizing influence,impacting both the amplitude of delayed velocity and the *** analytical solution's precision is underscored by its close alignment with numerical ***,the study reveals that fractal characteristics emulate damping *** its applicability across diverse nonlinear dynamical systems,this non-perturbative approach emerges as a promising avenue for future research.

关键词： Van der Pol-Helmholtz-Duffing oscillator fractal space time-delay non-perturbative approach stability analysis El-Dib's frequency formula

A Pragmatic Template for Quadcopter Development

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in Aerospace Science and Technology 2024年第2期9卷 61-74页

作者： Iyenagbe Benjamin Ugheoke Abdulhakeem Hassan Nurudeen olusola Ayodeji Abiire Aniedi okon Edem Emmanuel adedayo Towoju Emmanuel ogo onche Department of Mechanical Engineering Faculty of Engineering University of Abuja Abuja Nigeria

This article presents a pragmatic quadcopter development template for parcel delivery in Nigeria. The quadcopter is equipped with a camera, parcel pouch and wireless telecommunication to capture live events and send them back to the control station for real-time delivery feedback. The study also discusses the design methodology adopted as a conceptual design approach vital to product development, it encompasses information gathering and identifying the problem, creating the solutions systematically and eventually evaluating and developing a concept for the drone and its attributes and presenting clear results for design calculations.

关键词： Drone Unmanned Aeriel Vehicles Quadcopter Drone Development Flight

Making topological protein links using enzymatic reactions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第03期11卷 50-51页

作者： Roger Castells-Graells Todd o.Yeates Department of Chemistry and Biochemistry University of California UCLA-DoE Institute for Genomics and Proteomics

Proteins are exceedingly complex molecules though, at their heart, they are essentially linear polymers. Pull at their ends and one obtains an extended backbone. While that is true in most cases, some natural proteins... 详细信息

关键词： DESIGN

A synthetic microbial community used as a bioinoculant can overcome rice production constraints in acid soils

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第5期67卷 1085-1086页

作者： Maureen o’Callaghan Shengjing Shi Resilient Agriculture Group AgResearchLincolnChristcurch 8140New Zealand

A customised synthetic microbial community(SynCom)composed of carefully selected rhizosphere-competent bacterial strains improved rice growth,yield and resistance to soil acidity and Al toxicity.

关键词： soil soils rhizosphere

Valorization of Tree Bark-Derived Suberin in Applications for the Bio-Based Composites Industry–A Recent Review

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2024年第6期12卷 1029-1042页

作者： Aleksandra Jeżo Institute of Wood Sciences and Furniture SGGWNowoursynowska St.159Warsaw02-776Poland

Bark extracts are sustainable sources of biopolymers and hold great promise for replacing fossil fuel-based polymers,for example,in wood-based *** addition to primary and secondary metabolites,tree bark also contains suberin,which plays a major role in protecting the tree from environmental *** is a natural aliphatic-aromatic cross-linked polyester present in the cell walls of both normal and damaged external tissues,the main component of which are long-chain aliphatic *** main role as a plant ingredient is to protect against microbiological factors and water *** of the most important suberin monomers are suberin fatty acids,known for their hydrophobic and barrier ***,due to the diverse chemical composition of suberin,it is an attractive alternative to hydrocarbon-based *** its potential is recognized,it is not widely used in biocomposites technology,including wood-based composites and the polymer *** article will discuss the current knowledge about the potential of suberin and its components in biocomposites technology,which will include surface finishes,composite adhesives and polymer blends.

关键词： Suberin suberinic acids wood composites biocomposites biopolyester

Investigation of the effects of radial clearance on the screw conveyor performances for different inclinations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第9期92卷 72-80页

作者： Berna Bolat Birgül Aşçıoğlu Temiztaş Enes Sezer Department of Mechanical Engineering Yıldız Technical University34349BeşiktaşİstanbulTurkey

Screw conveyors are widely used for bulk material *** study investigates the critical role of radial clearance,the gap between the screw and the conveyor body,on performance across various inclination *** Discrete Element Method(DEM)is employed to analyze the effects of different radial clearances on conveyor performance for concrete aggregate and sand as bulk *** efficiencies and capacity losses serve as key performance indicators,quantitatively assessed for each radial clearance and inclination *** validation is conducted to corroborate the *** the study,the optimal radial clearance was identified as 1.5 to 3 times of the particle *** optimal clearance minimizes the material jamming and increases the performance for screw conveyors with different inclinations and bulk material types as a result.

关键词： Screw conveyors Radial clearance Discrete element method(DEM) Volumetric efficiency Conveyor performance