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Exercise and exerkine upregulation:Brain-derived neurotrophic factor as a potential non-pharmacological therapeutic strategy for Parkinson’s disease

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BIOCELL 2024年第5期48卷 693-706页

作者： VIRAAJ VIsHNU prasad JENNIFER sALLY sAMsON VENKATACHALAM DEEPA PARVATHI Department of Biomedical sciences Sri Ramachandra Institute of Higher Education and ResearchChennai600116India

Physical activity and exercise have several beneficial roles in enhancing both physiological and psychological well-being of an *** addition to aiding the regulation of aerobic and anaerobic metabolism,exercise can stimulate the synthesis of exerkine hormones in the circulatory *** several exerkines that have been investigated for their therapeutic potential,Brain-derived neurotrophic factor(BDNF)is considered the most promising candidate,especially in the management of neurodegenerative *** to the ability of physical activity to enhance BDNF synthesis,several experimental studies conducted so far have validated this hypothesis and produced satisfactory results at the pre-clinical *** review highlights some of the recent animal model studies that have evaluated the efficiency of exercise in enhancing BDNF synthesis and promoting neuroprotective ***,this review focuses on understanding the therapeutic benefits of exercise-induced exerkine synthesis as a non-pharmacological strategy in Parkinson’s disease(PD).Regarding physical activity and exerkine induction,the neuromuscular electrical stimulation(NMEs)strategy could be considered as an alternate treatment modality for patients affected with PD.

关键词： Exercise therapy Dopaminergic neurons Parkinson’s disease Brain-derived neurotrophic factor Electrical stimulation

Comprehensive Overview and Analytical study on Automatic Bird Repellent Laser system for Crop Protection

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Journal of Harbin Institute of Technology(New series) 2024年第1期31卷 38-53页

作者： sireesha Abotula srinivas Gorla prasad Reddy PVGD Mohankrishna s Department of Computer science and Engineering GITAM Deemed to be UniversityVisakhapatnam 530045India Department of Information Technology Andhra UniversityVisakhapatnam 530003India Department of Computer science and systems Engineering Andhra UniversityVisakhapatnam 530003India

Birds are a huge hazard to agriculture all around the world,causing harm to profitable field *** use a variety of techniques to keep them away,including visual,auditory,tactile,and olfactory deterrents. This study presents a comprehensive overview of current bird repellant approaches used in agricultural contexts,as well as potential new ways. The bird repellent techniques include Internet of Things technology,Deep Learning,Convolutional Neural Network,Unmanned Aerial Vehicles,Wireless sensor Networks and Laser biotechnology. This study’s goal is to find and review about previous approach towards repellent of birds in the crop fields using various technologies.

关键词： Bird repellent crop protection IoT UAV Deep Learning

Liver transplantation as an alternative for the treatment of non-resectable liver colorectal cancer: Advancing the therapeutic algorithm

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 154-159页

作者： Badi Rawashdeh Richard Bell Abdul Hakeem Raj prasad Division of Transplant surgery Department of General SurgeryMedical College of WisconsinMilwaukeeWI53226USA Leeds Teaching Hospital LeedsUK

Colorectal cancer is a leading cause of cancerrelated mortality,with nearly half of the affected patients developing liver *** three decades,liver resection(LR)has been the primary curative strategy,yet its applicability is limited to about 20%of *** transplantation(LT)for unresectable metastases was attempted unsuccessfully in the 1990s,with high rates of perioperative death and *** is now more interest in this strategy due to improvements in systemic therapies and surgical techniques.A significant study conducted by the Oslo group showed that patients receiving liver transplants had a 60%chance of survival after five *** better results have been achieved by using advanced imaging for risk stratification and further refining selection criteria,especially in the Norvegian sECA *** review carefully charts the development and history of LT as a treatment option for colorectal cancer liver *** revolutionary path from the early days of exploratory surgery to the current situation of cautious optimism is traced,highlighting the critical clinical developments and improved patient selection standards that have made LT a potentially curative treatment for such challenging very well selected cases.

关键词： Liver transplantation Colorectal cancer liver metastases Non-resectable liver metastases

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单光子态时间波函数的完全刻画

单光子态时间波函数的完全刻画

Robust Facial Biometric Authentication system Using Pupillary Light Reflex for Liveness Detection of Facial Images

第十六届全国量子光学学术报告会

作者：秦忠忠 adarsh s.prasad Travis Brannan rew MacRae A.Lezama A.I.Lvovsky Institute for Quantum science and Technology University of Calgary Quantum Institute for Light and Atoms State Key Laboratory of Precision SpectroscopyEast China Normal University(华东师范大学) Department of Physics University of CaliforniaBerkeleyCalifornia 94720USA

＜正＞单光子与单光子量子比特构成了量子密码学[1],量子通信[2],纠缠交换[3]以及量子计算[4]等量子信息技术的基础。实验中精确测量单光子态的时间-空间模式对提高这些量子信息技术的应用具有重要意义。尽管探测单光子态的空间模式已...

＜正＞单光子与单光子量子比特构成了量子密码学[1],量子通信[2],纠缠交换[3]以及量子计算[4]等量子信息技术的基础。实验中精确测量单光子态的时间-空间模式对提高这些量子信息技术的应用具有重要意义。尽管探测单光子态的空间模式已经被广泛研究[5],对其时间模式的研究仍然非常具有挑战性。我们理论提出了可以探测单光子态时间波函数的一种方法——多色光学差拍层析技术。这种方法利用测量平衡零拍探测器在多个局域振荡频率下光电流的自关联函数来获得信号光子的时间密度矩阵,从而获得其时间波函数。我们利用基于热铷原子蒸汽中四波混频过程产生的双光子对来实现预告式单光子源[6]。实验中我们测量了基于此单光子源的纯态以及混态的时间波函数,实验结果与理论符合得非常好[7]。

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Computer Modeling in Engineering & sciences 2024年第4期139卷 725-739页

作者： Puja s.prasad Adepu sree Lakshmi sandeep Kautish simar Preet singh Rajesh Kumar shrivastava Abdulaziz s.Almazyad Hossam M.Zawbaa Ali Wagdy Mohamed CsE Department Geethanjali College of EngineeringHyderabadTelangana501301India Department of Computer science LBEF CampusKathmandu44600Nepal school of Computer science Engineering and Technology(sCsET) Bennett UniversityGreater Noida201310India Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia CeADAR Ireland’s Centre for AI Technological University DublinDublinD07 EWV4Ireland Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Applied science Research Center Applied Science Private UniversityAmman11937Jordan

Pupil dynamics are the important characteristics of face spoofing *** face recognition system is one of the most used biometrics for authenticating individual *** main threats to the facial recognition system are different types of presentation attacks like print attacks,3D mask attacks,replay attacks,*** proposed model uses pupil characteristics for liveness detection during the authentication *** pupillary light reflex is an involuntary reaction controlling the pupil’s diameter at different light *** proposed framework consists of two-phase *** the first phase,the pupil’s diameter is calculated by applying stimulus(light)in one eye of the subject and calculating the constriction of the pupil size on both eyes in different video *** above measurement is converted into feature space using Kohn and Clynes model-defined *** support Vector Machine is used to classify legitimate subjects when the diameter change is normal(or when the eye is alive)or illegitimate subjects when there is no change or abnormal oscillations of pupil behavior due to the presence of printed photograph,video,or 3D mask of the subject in front of the *** the second phase,we perform the facial recognition ***-invariant feature transform(sIFT)is used to find the features from the facial images,with each feature having a size of a 128-dimensional *** features are scale,rotation,and orientation invariant and are used for recognizing facial *** brute force matching algorithm is used for matching features of two different *** threshold value we considered is 0.08 for good *** analyze the performance of the framework,we tested our model in two Face antispoofing datasets named Replay attack datasets and CAsIA-sURF datasets,which were used because they contain the videos of the subjects in each sample having three modalities(RGB,IR,Depth).The CAsIA-sURF datasets showed an 89.9%Equal Err

关键词： sIFT pupil CAsIA-sURF pupillary light reflex replay attack dataset brute force

Patterns,Causes and Perceptions of Human-Large Carnivore Conflict in the Chitwan National Park,Nepal

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Journal of Resources and Ecology 2024年第4期15卷 838-849页

作者： Parwati TIWARI Bishnu prasad BHATTARAI Jagan Nath ADHIKARI Binod BHATTARAI Central Department of Zoology Institute of Science and TechnologyTribhuvan UniversityKathmandu 44600Nepal Department of Zoology Birendra Multiple CampusTribhuvan UniversityChitwan 44200Nepal Nepal Zoological society Kathmandu 44600Nepal

One of the major management problems in and around protected areas is the intensifying conflict between local people and wildlife,especially large *** depredation and human fatalities caused by attacks of carnivores are found to be serious obstacles in conflict *** study aims to explore the patterns,costs,causes and perceptions of human large carnivore conflict in the Nawalpur area of Chitwan National *** patterns of livestock loss and human casualties due to large carnivores(Panthera tigris and Panthera pardus)were analysed using the secondary data reported to Chitwan National Park from 2001 to *** understand the people’s perception towards carnivores and wildlife conservation,150 victim respondents were asked,with one household selected from each *** 19-year study period,a total of 521 incidents caused by large carnivores were reported,which included 33 human casualties and 488 livestock *** was responsible for the maximum conflict incidents in *** total relief provided for human deaths and injuries was Us$17524.41,whereas Us$13702.18 was used to compensate for livestock depredation in the Nawalpur area by authorities of the Chitwan National *** than 64%of the respondents liked the presence of carnivores in their area and had a positive attitude toward the conservation of large carnivores,even though the carnivores were responsible for livestock depredation and human injury and ***’s satisfaction with the relief scheme provided by the government depended on ethnicity,gender,age class,occupation,education,insurance,and livestock ownership,but they believed the scheme was not ***,an effective relief scheme and awareness about the process of relief funding should be conducted in conflict *** awareness programs for local communities about large carnivores,their behavior,and preparing predator-proof corrals would be helpful in minimizing conflict in the study a

关键词： depredation human wildlife conflict leopard tiger relief fund

New Approach to synchronize General Relativity and Quantum Mechanics with Constant “K”-Resulting Dark Matter as a New Fundamental Force Particle

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第1期10卷 292-302页

作者： siva prasad Kodukula Visakhapatnam India

Planck scale plays a vital role in describing fundamental forces. space time describes strength of fundamental force. In this paper, Einstein’s general relativity equation has been described in terms of contraction and expansion forces of space time. According to this, the space time with Planck diameter is a flat space time. This is the only diameter of space time that can be used as signal transformation in special relativity. This space time diameter defines the fundamental force which belongs to that space time. In quantum mechanics, this space time diameter is only the quantum of space which belongs to that particular fundamental force. Einstein’s general relativity equation and Planck parameters of quantum mechanics have been written in terms of equations containing a constant “K”, thus found a new equation for transformation of general relativity space time in to quantum space time. In this process of synchronization, there is a possibility of a new fundamental force between electromagnetic and gravitational forces with Planck length as its space time diameter. It is proposed that dark matter is that fundamental force carrying particle. By grand unification equation with space-time diameter, we found a coupling constant as per standard model “αsub>ssub>” for that fundamental force is 1.08 × 10sup>-23sup>. Its energy calculated as 113 MeV. A group of experimental scientists reported the energy of dark matter particle as 17 MeV. Thorough review may advance science further.

关键词： General Relativity Quantum Mechanics space Time Dark Matter A New Fundamental Constant “K”

Detection and clearance in Alzheimer’s disease: leading with illusive chemical, structural and morphological features of the targets

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Neural Regeneration Research 2024年第3期19卷 497-498页

作者： Luís Gales i3s−Instituto de Investigação e Inovação em saúde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs−Instituto de Ciências Biomédicas Abel salazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly specific interactions between biomolecules,such as antigen-antibody,protein-ligand,or nucleic acid base pair complementary are on the basis of the organization of complex *** same principles may be tentatively used in molecular medicine for diagnosis and therapeutics.A molecule can be designed to selectively bind a protease and thereby inhibit the production of a peptide that forms toxic aggregates in the brain or an antibody may be produced to bind specifically to that peptide for detection or clearance ***,interference in biological systems is not that *** a start there is the inhibition of the physiological role of the protease;moreover,several cleavage fragments may be produced,which may continue to diverge due to putative post-translational modification and self-assembly processes,hiding the toxic target in a“soup”of peptide species varying in size,structure and chemical composition.A perspective of the current status and challenges in targeting peptide species for diagnosis and treatment in the context of Alzheimer’s disease is given.

关键词： Alzheimer diagnosis thereby

Comprehensive analysis of uncertainty quantification for the^(58)Ni(n,p)^(58)Co reaction cross section

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Chinese Physics C 2024年第9期48卷 170-175页

作者： Mahesh Choudhary Aman sharma Namrata singh Mahima Upadhyay Punit Dubey A.Gandhi Akash Hingu G Mishra sukanya De L.s.Danu Ajay Kumar R.G.Thomas saurav sood sajin prasad s.Mukherjee I.N.Ruskov Yu.N.Kopatch A.Kumar Department of Physics Banaras Hindu UniversityVaranasi 221005India Horia Hulubei National Institute of Physics and Nuclear Engineering-IFIN-HH Bucharest 077125Romania Department of Physics The Maharaja Sayajirao University of BarodaVadodara 390002India Nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India Health Physics Division Bhabha Atomic Research CentreMumbai 400085India Department of Electrical Power Engineering Brno University of TechnologyBrno 61600Czech Republic Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of SciencesSofia 1784Bulgaria Joint Institute for Nuclear Research(JINR) Dubna 141980Russia

In this study,we measured the^(58)Ni(n,p)^(58)Co reaction cross section with neutron energies of 1.06,1.86,and 2.85 *** cross section was measured using neutron activation techniques andγ-ray spectroscopy,and it was compared with cross section data available in the ***,we calculated the covariance matrix of the measured cross section for the aforementioned nuclear *** uncertainties of the theoretical calculation for^(58)Ni(n,p)^(58)Co reaction cross section were calculated via Monte Carlo *** this study,we used uncertainties in the optical model and level density parameters to calculate uncertainties in the theoretical cross *** theoretical calculations were performed by using *** this study,we aim to analyze the effect of uncertainties of the nuclear model input as well as different experimental variables used to obtain the values of reaction cross section.

关键词： ^(58)Ni(n p)^(58)Co reaction γ-ray spectroscopy uncertainty quantification of cross section covariance analysis