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Development of Extraction and Detection Method for a Chemotherapeutic Drug with Phenytoin in Biological Samples

Advances in Biological Chemistry 2024年第4期14卷 103-110页

作者： Michael Arnot Nicolas Brice adan garcia Victor Lomeli My Phuong Vu Karno Ng Department of Chemistry & Biochemistry California State University San Marcos San Marcos CA U.S.A.

Dexamethasone is classified as a corticosteroid and is commonly used among cancer patients to decrease the amount of swelling around the tumor. Among patients with cancer, in particular brain tumors, seizures can become a daily routine in their everyday lives. To counteract the seizures, an antiepileptic drug such as phenytoin is administered to act as an anticonvulsant. Phenytoin and dexamethasone are frequently administrated concurrently to brain cancer patients. A previous study has shown that phenytoin serum concentration decreases when administrated concurrently with dexamethasone. Thus, it is important to monitor the concentration of these two drugs in biological samples to ensure that the proper dosages are administrated to the patients. This study aims to develop an effective extraction and detection method for dexamethasone and phenytoin. A reverse-phase high-performance liquid chromatography (HPLC) method with UV/Vis detection has been developed to separate phenytoin and dexamethasone at 219 nm and 241 nm respectively from urine samples. The mobile phase consists of a mixture of 0.01 M KH2PO4, acetonitrile, and methanol adjusted to pH 5.6 (48:32:20) and is pumped at a flow rate of 1.0 mL/min. Calibration curves were prepared for phenytoin and dexamethasone (r2 > 0.99). An efficient solid-phase extraction (SPE) method for the extraction of dexamethasone and phenytoin from urine samples was developed with the use of C-18 cartridges. The percent recovery for phenytoin and dexamethasone is 95.4% (RSD = 1.15%) and 81.1% (RSD = 3.56%) respectively.

关键词： Dexamethasone Phenytoin Cancer Drug Interaction Solid Phase Extraction

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Analysis of Health Risk Due to the Presence of Radioactivity and Chemical Elements in Groundwater,Aldama Municipality,Chihuahua,Mexico

引用

Journal of Environmental Protection 2013年第11期4卷 1265-1271页

作者： Lourdes Villalba Luis Colmenero-Sujo adan Pinales-Munguia Guadalupe Estrada-Gutierrez Hector Rubio-Arias Fernando Mireles-garcia Ignacio Davila-Rangel College of Engineering Autonomous University of ChihuahuaCircuito No.1Campus UniversitarioChihuahuaChih.Mexico Technology of Chihuahua Institute ChihuahuaChih.Mexico College of Animal Husbandry and Ecology Autonomous University of Chihuahua.Periferico Francisco R.AlmadaChihuahuaChih.Mexico Regional Center of Nuclear Studies Autonomous University of ZacatecasCipres 10Frac.La PenuelaZacatecasZac.Mexico

There exist potential health risks due to the presence of some elements in groundwater. This study presents measurements of gross alpha and beta activity and chemical concentrations (fluorides and nitrates) in 25 water wells in Aldama municipality, Chihuahua, Mexico. Total alpha and beta emitter analyses were performed at the Academic Unit of Nuclear Studies at the Autonomous University of Zacatecas. Radioactive elements were concentrated by total evaporation. All samples were measured with a Wallac-Oy 1411 liquid scintillate with a pulse separation option (Pulse Shape Analysis) for 6 h. Fluorine and nitrate analyses were performed at the Faculty of Engineering of the Autonomous University of Chihuahua by flow injection-hydride generation collection-atomic absorption spectrometry. Exposure levels were calculated for each well and found to exceed maximum limits allowed under Mexican law in terms of 1) gross alpha and beta activity;and 2) fluoride and nitrate concentrations. Gross alpha activity in two wells exceeded the reference value of 0.56 Bq·L-1. Fluorides and nitrates were found in 40% and 48% of water wells, respectively. Fluoride values were higher than 1.5 mg·L-1, and the exposure doses for adults and children exceeded the reference value of 0.06 mg·kg-1·d-1. Children are the most vulnerable, since their intake doses are near or above of 0.12 mg·kg-1·d-1 of the minimum level of risk for the development of skeletal fluorosis or bone fractures. On the other hand, while nitrate concentrations in water wells exceeded the drinking water limit of 10 mg·L-1, this does not represent a serious health risk, since the calculated exposure doses for adults and children are below the chronic reference level of 1.6 mg·kg-1·d-1established by the USEPA.

关键词： Dose Fluorides Nitrates Public Health Radioactivity Well Water

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