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“重生”的画家(下)

时代英语（高三版） 2022年第2期 4-7页

作者： V.m.希利尔仲秋(译) 不详

画家们之所以这么钻研马萨乔的画,那是因为在他之前的所有画家都无法掌握的一种绘画方法,他却成功地运用了。马萨乔的画看上去不是平面的效果,他画的画能让你感觉跃然纸上。这就是“透视”,你记得吗,我们曾经提到过它。过去几千年里,画... 详细信息

画家们之所以这么钻研马萨乔的画,那是因为在他之前的所有画家都无法掌握的一种绘画方法,他却成功地运用了。马萨乔的画看上去不是平面的效果,他画的画能让你感觉跃然纸上。这就是“透视”,你记得吗,我们曾经提到过它。过去几千年里,画家们一直希望自己的画作能够具有透视效果,但是,却没有人能够做到这一点。所以文艺复兴时期的画家非常想弄清楚马萨乔到底是如何做到的。马萨乔特别出名的壁画是一幅湿壁画,场景是亚当和夏娃被天使逐出伊甸园。

关键词：马萨乔透视效果绘画方法伊甸园如何做到文艺复兴时期画家

Apixaban, an orally available anticoagulant, inhibits SArS-CoV-2 replication and its major protease in a non-competitive way

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Journal of molecular Cell Biology 2022年第6期14卷 68-71页

作者： Otávio Augusto Chaves Carolina Q.Sacramento Natalia Fintelman-rodrigues Jairo ramos Temerozo Filipe Pereira-Dutra Daniella m.mizurini robson Q.monteiro Leonardo Vazquez Patricia T.Bozza Hugo Caire Castro-Faria-Neto Thiago moreno L.Souza Laboratory of Immunopharmacology Oswaldo Cruz Institute(IOC)Oswaldo Cruz Foundation(Fiocruz)Rio de JaneiroRJ21040-900Brazil National Institute for Science and Technology on Innovation on Neglected Diseases(INCT/IDN) Center for Technological Development in Health(CDTS)Oswaldo Cruz Foundation(Fiocruz)Rio de JaneiroRJ21040-900Brazil National Institute for Science and Technology on Neuroimmunomodulation(INCT/NIm) Oswaldo Cruz Institute(IOC)Oswaldo Cruz Foundation(Fiocruz)Rio de JaneiroRJ21040-900Brazil Laboratory on Thymus research Oswaldo Cruz Institute(IOC)Oswaldo Cruz Foundation(Fiocruz)Rio de JaneiroRJ21040-900Brazil Institute of medical Biochemistry Leopoldo de meis Federal University of Rio de Janeiro(UFRJ)Rio de JaneiroRJ21941-590Brazil

Dear Editor,The severe coronavirus disease 2019(COVID-19)is associated with ***,such as low-molecular-weight heparin,warfarin,thrombin inhibitors,and factor Xa(FXa)inhibitors,are thus recommended by the American Society of Hematology and National Institutes of Health for COVID-19 patients(Wenzler et al.,2020;adam et al.,2021).Clinical trials with anticoagulants have shown the increased survival of critically ill COVID-19 patients under non-invasive and invasive ventilatory assistance(Wenzler et al.,2020;adam et al.,2021),along with decreased consumption of platelets and clotting factors and a reduced risk of hemorrhage(adam et al.,2021).Among the anti-clotting agents,early use of orally available FXa and thrombin inhibitors(Chowdhury et al.,2020;rentsch et al.,2021)prevented high levels of D-dimer,which is the final product from the clotting/fibrinolysis cascade and is directly implicated with severe COVID-19(rentsch et al.,2021).

关键词： al. Clinical heparin

扩张型心肌病患者中解聚素金属蛋白酶及其抑制因子的表达改变

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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 19-20页

作者： Fedak P.W.m. moravec C.S. mcCarthy P.m. 杜媛 Toronto General Hospital 200 Elizabeth St Toronto Ont. M5G 2C4 Canada Dr.

Background -Disintegrin metalloproteinases(adams) may contribute to structural cardiac remodeling by altering cell-surface matrix receptors(integrins) and activating potent biomolecules. We compared expression of adams, their endogenous inhibitor tissue inhibitor of metalloproteinases(TImP)-3, and integrins in human heart tissue with varied patterns of structural remodeling. methods and results -myocardium was obtained from patients with dilated cardiomyopathy(n=20), hypertrophic obstructive cardiomyopathy(n=5), and nonfailing donor hearts(n=7). Paired samples(n=10) were obtained before left ventricular assist device insertion and at transplantation. The expressions of adam10, adam12, adam15, and adam17, TImP-3, and integrin receptors β1D and β3 were determined by quantitative immunoblotting. Integrin shedding was assessed by the ratio of integrin cleavage products to intact protein abundance. Confocal microscopy was performed. Dilated cardiomyopathy was characterized by increased adam10 and adam15 expression and reduced TImP-3 expression. The integrin β1D cleavage ratio was elevated, indicating receptor shedding. adam10 and adam15 expressions correlated with the cleavage ratio. adam10 colocalized with integrin β1D by confocal microscopy. adam10 expression correlated with clinical indices of chamber dilatation and systolic dysfunction. Hemodynamic unloading reduced adam10 and adam12 expressions and increased integrin β1D expression. adam12 and integrin β1D expressions were increased in HOCm. adam17 was increased in both dilated cardiomyopathy and hypertrophic obstructive cardiomyopathy. Conclusions -Disintegrin metalloproteinases are differentially expressed in human myocardium, reflecting the underlying pattern of structural remodeling. adam10 and adam15 may contribute to cardiac dilatation by reducing cell-matrix interactions via integrin shedding. Targeting disintegrin metalloproteinases, perhaps by restoring deficient TImP-3 levels with gene or cell-based therap

关键词：扩张型心肌病金属蛋白酶解聚肥厚型梗阻性 adam 心肌病患者心腔扩张心脏扩张免疫印记法

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辛辛那提大学理查德·E·林德纳体育中心

城市环境设计 2016年第1期 172-177页

作者： Bernard Tschumi Kim Starr Phu Hoang robert Holton Jane Kim Jonathan Chace Nicholas martin Eva Sopeoglou Joel Aviles Chong-zi Cheng Irene Cheng adam Dayem William Feuerman Thomas Goodwill Daniel Holguin matthew Hufft michaela metcalf Valentin Bontjes van Beek Allis Chee Justin moore

辛辛那提大学在2001年委托伯纳德·屈米为该校运动员设计一座约22000m2的活动中心,为体育训练、管理、运动医疗和一些教学活动提供集中式的设施。学校统筹部门提出在保留所征用地块原有功能的前提下,项目可以选址在学校体育园区内任何... 详细信息

辛辛那提大学在2001年委托伯纳德·屈米为该校运动员设计一座约22000m2的活动中心,为体育训练、管理、运动医疗和一些教学活动提供集中式的设施。学校统筹部门提出在保留所征用地块原有功能的前提下,项目可以选址在学校体育园区内任何地方。

关键词：理查德辛辛那提大学中庭德纳体育

血小板淀粉样前体蛋白加工过程:1种阿尔茨海默病的生物标记物

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世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 53-54页

作者： Hynan L.S Baskin F rosenberg r.N 张平 Department of Neurology University of Texas Southwestern Medical Center Dallas TX United States

The amyloid precursor protein (APP) in brain is processed either by an amyloidogenic pathway by β -secretase and γ -secretase to yield Aβ (β -amyloid 4 kDa) peptide or by α -secretase within the β -amyloid domain to yield non-amyloidogenic products. We have studied blood platelet levels of a 22- kDa fragment containing the Aβ .(β -amyloid 4 kDa) peptide, β -secretase (BACE1), α -secretase (adam10), and APP isoform ratios of the 120- 130 kDa to 110 kDa peptides from 31 Alzheimer’s disease (AD) patients and 10 age-matched healthy control subjects. We found increased levels of Aβ 4, increased activation of β -secretase (BACE1), decreased activation of α -secretase (adam10) and decreased APP ratios in AD patients compared to normal control subjects. These observations indicate that the blood platelet APP is processed by the same amyloidogenic and non-amyloidogenic pathways as utilized in brain and that APP processing in AD patients is altered compared to control subjects and may be a useful bio-marker for the diagnosis of AD, the progression of disease and for monitoring drug responses in clinical trials.

关键词：淀粉样前体蛋白阿尔茨海默病加工过程生物标记物血小板 β-淀粉样蛋白 β-分泌酶 β-淀粉状蛋白 AD患者正常对照

快速评价髂动脉栓塞的多普勒频谱分析与股动脉直接测量

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实用医学影像杂志 1998年第1期 8-8页

作者： J. adam van der Vliet Willem N. J. C. Van Asten Jose' H. Haenen Albert P. m. Boll Frans G. m. Buskens 郝彦威

为了减轻临床工作负担并提高髂动脉系统无创性血液动力学评价效果,需要选择合适的病人。利用传统的股动脉压直接穿刺测量技术和计算机多普勒频谱分析,研究了股动脉中的血流速率。为了证实50％或以上的狭窄,上述两种快速评价髂动脉栓塞... 详细信息

为了减轻临床工作负担并提高髂动脉系统无创性血液动力学评价效果,需要选择合适的病人。利用传统的股动脉压直接穿刺测量技术和计算机多普勒频谱分析,研究了股动脉中的血流速率。为了证实50％或以上的狭窄,上述两种快速评价髂动脉栓塞的试验均与利用2.5的高峰收缩速率比值的双重超声成像做了比较。在一系列怀疑有髂动脉栓塞性疾病的17例患者(34根髂动脉)中,发现两种方法与双重扫描比较时。

关键词：髂动脉快速评价多普勒频谱股动脉压直接测量动脉栓塞性疾病血流速率峰收缩双重扫描无创性

Factors Associated with Children’s Death Due to Congenital Heart Disease in Two National Hospitals of Niamey

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International Journal of Clinical medicine 2024年第11期15卷 502-511页

作者： m’baye Salissou Seck m’baye Samaila Aboubacar Kamaye moumouni Abdou Siddo Hadjara Garba moumouni Adehossi Irene Abdoul Djafar mamoudou Tsague Kengni Hermann Nestor Amadou Douada Issoufou Alzouma maliki Abdoulaye moctar mianroh Hybi Langtar Laouan Hamidou Ngo Yon Laurence Carole Guindo Aissata Ndobo Valerine Siddikatou Djibrilla Touré Ali Faculty of Health Sciences Andr Salifou University of Zinder Zinder Niger Faculty of Science of Health Abdou Moumouni University Niamey Niger Faculty of medicine and Science Pharmaceuticals University of Douala Douala Cameroon General reference Hospital in Niamey Niamey Niger Pedagogical and research Unit Mohamed V University Rabat Morocco Faculty of Health Sciences Adam Barka University of Abeche Abeche Chad Faculty of Health Sciences Dan Dicko Dankoulodo University of Maradi Maradi Niger Point G Hospital Center Bamako Mali Faculty of medicine and Biomedical Sciences of Yaound 1 Yaound Cameroon Faculty of Health Sciences University of Buea Buea Cameroon

Introduction: Congenital heart disease is a major cause of children’s death. In Niger, despite the frequency of these pathologies, very few studies have been carried out on associated mortality in a paediatric environment. The objective of this work was to look for the risk factors of children with congenital heart disease’s death in Niamey. Patients and method: It is about a cross-sectional study for descriptive and analytical purposes in children aged from 0 to 15 years. Carriers of congenital heart disease followed from January 2016 to July 2021 in two national hospitals in Niamey. The variable depends and the main ante was the occurrence of deaths (yes or no). The explanatory variables were related to the characteristics of the patients, the type of heart disease and management among others. Chi’s tests2 Pearson’s or Fischer’s exact test were used (P results: During the period of the research, 514 cases of congenital heart disease were studied, including 132 deaths (25.68%). The average age of patients was 14.64 months [10 days - 15 years]. The sex ratio was 1.08. The most common reason for consultation was respiratory distress that was found in 74.90% of patients. Interventricular communication (IVC) and intear communication (CIA) were the most found type of heart disease with 36.53% and 20.44% of cases respectively. Only 9.54% of patients (n = 48) had received surgical management. The risk factors associated with mortality were pulmonary arterial hypertension (54.17%), pulmonary disease (44.55%) and the presence of anemia (63.16%) [Or > 1;p Conclusion: Congenital heart diseases remain an important cause of death among children in Niger. The pulmonary arterial hypertension and the associated comorbidities such as broncho-pulmonary diseases were the main associated factors. In the meantime, an optimal technical management of these factors will help to reduce this mortality.

关键词： Congenital Heart Disease Associated Factors to Lethality Niger

Fungal diversity notes 1–110:taxonomic and phylogenetic contributions to fungal species

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Fungal Diversity 2015年第3期72卷 1-197页

作者： Jian Kui Liu Kevin D.Hyde E.B.Gareth Jones Hiran A.Ariyawansa Darbhe J.Bhat Saranyaphat Boonmee Sajeewa S.N.maharachchikumbura Eric H.C.mcKenzie rungtiwa Phookamsak Chayanard Phukhamsakda Belle Damodara Shenoy mohamed A,Abdel-Wahab Bart Buyck Jie Chen K.W.Thilini Chethana Chonticha Singtripop Dong Qin Dai Yu Cheng Dai Dinushani ADaranagama Asha J.Dissanayake mingkwan Doilom melvina J.D’souza Xin Lei Fan Ishani DGoonasekara Kazuyuki Hirayama Sinang Hongsanan Subashini C.Jayasiri ruvishika S.Jayawardena Samantha C.Karunarathna Wen Jing Li Ausana mapook Chada Norphanphoun Ka Lai Pang rekhani H.Perera Derek Peršoh Umpava Pinruan Indunil CSenanayake Sayanh Somrithipol Satinee Suetrong Kazuaki Tanaka Kasun m.Thambugala Qing Tian Saowaluck Tibpromma Danushka Udayanga Nalin N.Wijayawardene Dhanuska Wanasinghe Komsit Wisitrassameewong Xiang Yu Zeng Faten AAbdel-Aziz Slavomir adamčík Ali H.Bahkali Nattawut Boonyuen Timur Bulgakov Philippe Callac Putarak Chomnunti Katrin Greiner Akira Hashimoto Valerie Hofstetter Ji Chuan Kang David Lewis Xing Hong Li Xing Zhong Liu Zuo Yi Liu misato matsumura Peter E.mortimer Gerhard rambold Emile randrianjohany Genki Sato Veera Sri-Indrasutdhi Cheng ming Tian Annemieke Verbeken Wolfgang von Brackel Yong Wang Ting Chi Wen Jian Chu Xu Ji Ye Yan rui Lin Zhao Erio Camporesi Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanChina Institute of Excellence in Fungal research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Botany and microbiology King Saudi UniversityRiyadhSaudi Arabia manaaki Whenua Landcare research Private Bag 92170AucklandNew Zealand Formerly Department of Botany Goa UniversityGoaIndia No.128/1–J Azad Housing SocietyCurcaGoa VelhaIndia muséum national d’histoire naturelle Dépt.Systématique etévolutionUMR 720575005 ParisFrance Institute of microbiology&Beijing Key Laboratory for Forest Pest Control Beijing Forestry UniversityPO Box 61Beijing 100083China Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesNo.9 of Shu Guang Hua Yuan Zhong LuHaidian DistrictBeijing 10097China The Key Laboratory for Silviculture and Conservation of ministry of Education Beijing Forestry UniversityBeijing 100083China mycology University of BayreuthUniversitätsstraße 3095440 BayreuthGermany The United Graduate School of Agricultural Sciences Iwate University18-8 Ueda 3 chomeMorioka 020-8550Japan Apple Experiment Station Aomori Prefectural Agriculture and Forestry Research Center24 FukutamiBotandairaKuroishiAomori 036-0332Japan Department of Plant Protection Agroscope Changins-Wadenswil Research Station ACWRte de Duiller1260 NyonSwitzerland Department of Botany and microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany Faculty of ScienceSohag UniversitySohagEgypt Institute of Botany Slovak Academy of SciencesDúbravskácesta 984523 BratislavaSlovakia Hirosaki University Bleakwood262 CR 3062NewtonTexas 75966USA Faculty of Agriculture and Life Sciences Hirosaki University3 Bunkyo-choHirosakiAomori

This paper is a compilation of notes on 110 fungal taxa,including one new family,10 new genera,and 76 new species,representing a wide taxonomic and geographic *** new family,Paradictyoarthriniaceae is introduced based on its distinct lineage in Dothideomycetes and its unique *** family is sister to Biatriosporaceae and *** new genera are Allophaeosphaeria(Phaeosphaeriaceae),Amphibambusa(Amphisphaeriaceae),Brunneomycosphaerella(Capnodiales genera incertae cedis),Chaetocapnodium(Capnodiaceae),Flammeascoma(Anteagloniaceae),multiseptospora(Pleosporales genera incertae cedis),Neogaeumannomyces(magnaporthaceae),Palmiascoma(Bambusicolaceae),Paralecia(Squamarinaceae)and Sarimanas(melanommataceae).The newly described species are the Ascomycota Aliquandostipite manochii,Allophaeosphaeria dactylidis,***,Alternaria cesenica,Amphibambusa bambusicola,Amphisphaeria sorbi,Annulohypoxylon thailandicum,Atrotorquata spartii,Brunneomycosphaerella laburni,Byssosphaeria musae,Camarosporium aborescentis,***,***,Chaetocapnodium siamensis,Chaetothyrium agathis,Colletotrichum sedi,Conicomyces pseudotransvaalensis,Cytospora berberidis,***,Diaporthe thunbergiicola,Diatrype palmicola,Dictyosporium aquaticum,***,***,Didymella cirsii,Dinemasporium nelloi,Flammeascoma bambusae,Kalmusia italica,***,Keissleriella sparticola,Lauriomyces synnematicus,Leptosphaeria ebuli,Lophiostoma pseudodictyosporium,***,Lophiotrema eburnoides,montagnula graminicola,multiseptospora thailandica,myrothecium macrosporum,Natantispora unipolaris,Neogaeumannomyces bambusicola,Neosetophoma clematidis,***,Oxydothis atypica,Palmiascoma gregariascomum,Paraconiothyrium nelloi,***,Paradictyoarthrinium tectonicola,Paralecia pratorum,Paraphaeosphaeria spartii,Pestalotiopsis digitalis,***,***,Phaeoisaria pseudoclematidis,Phragmocapnias philippinensis,Pseudocamarosporium cotinae,Pseudocercospora tam

关键词： Ascomycota Basidiomycota Global Taxonomy Initiative Phylogeny Taxonomy

Braamcamp Freire中学,葡萄牙里斯本

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建筑技艺 2014年第9期20卷 106-111页

作者： CVD Barquitectos Cristina Verissimo Diogo Burnay Joo Falco rodolfo reis Joana Barrelas Tiago Santos adam Pelissero Andre Barbosa ngelo Branquinho Ari Nieto Guilherme Bivar Hugo Nascimento Inês Carrapio Irune Ardanza Josè maria Lavena Leonor Vaz Pinto Luigi martinelli miguel Travesso Silvia Amaral Silvia maggi *** 严佳钰

Braamcamp Freire中学位于里斯本庞蒂尼亚历史城区的边缘，占地约17380m^2，毗邻起伏的地势。除了学校北面的山谷，整个校园都是庞蒂尼亚城区的一部分。该校始建于1986年，由五栋标准化预制建筑组成——中间一栋为平层，另外四栋为二层... 详细信息

Braamcamp Freire中学位于里斯本庞蒂尼亚历史城区的边缘，占地约17380m^2，毗邻起伏的地势。除了学校北面的山谷，整个校园都是庞蒂尼亚城区的一部分。该校始建于1986年，由五栋标准化预制建筑组成——中间一栋为平层，另外四栋为二层建筑。这些建筑按照东西向排列，通过走廊相互连接。学校设施包括一个体育馆和一个地势较低的户外操场，两者与教学楼都没有连接。

关键词：里斯本葡萄牙中学建筑标准化东西向体育馆教学楼