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Pancreas preserving distal duodenectomy: A versatile operation for a range of infra-papillary pathologies

World Journal of Gastroenterology 2017年第23期23卷 4252-4261页

作者： W Kyle mitchell Pradeep F Thomas Abed m Zaitoun adam J Brooks Dileep N Lobo Gastrointestinal Surgery Nottingham Digestive Diseases CentreNational Institute for Health Research Nottingham Biomedical Research CentreNottingham University Hospitals and University of NottinghamQueen's Medical Centre Cellular Pathology Nottingham Digestive Diseases CentreNational Institute for Health Research Nottingham Biomedical Research CentreNottingham University Hospitals and University of NottinghamQueen's Medical Centre

To investigate the range of pathologies treated by pancreas preserving distal duodenectomy (PPDD) and present the outcome of *** lesions of the duodenum are treated conventionally by pancreaticoduodenectomy. Lesions distal to the major papilla may be suitable for a pancreas-preserving distal duodenectomy, potentially reducing morbidity and mortality. We present our experience with this procedure. Selective intraoperative duodenoscopy assessed the relationship of the papilla to the lesion. After duodenal mobilisation and confirmation of the site of the lesion, the duodenum was transected distal to the papilla and beyond the duodenojejunal flexure and a side-to-side duodeno-jejunal anastomosis was formed. Patients were identified from a prospectively maintained database and outcomes determined from digital health records with a dataset including demographics, co-morbidities, mode of presentation, preoperative imaging and assessment, nutritional support needs, technical operative details, blood transfusion requirements, length of stay, pathology including lymph node yield and lymph node involvement, length of follow-up, complications and outcomes. related published literature was also ***-four patients had surgery with the intent of performing PPDD from 2003 to 2016. Nineteen underwent PPDD successfully. Two patients planned for PPDD proceeded to formal pancreaticoduodenectomy (PD) while three had unresectable disease. median post-operative follow-up was 32 mo. Pathologies resected included duodenal adenocarcinoma (n = 6), adenomas (n = 5), gastrointestinal stromal tumours (n = 4) and lipoma, bleeding duodenal diverticulum, locally advanced colonic adenocarcinoma and extrinsic compression (n = 1 each). median postoperative length of stay (LOS) was 8 d and morbidity was low [pain and nausea/vomiting (n = 2), anastomotic stricture (n = 1), pneumonia (n = 1), and overwhelming post-splenectomy sepsis (n = 1, asplenic patient)]. PP

关键词： Pancreas preserving distal duodenectomy Duodenojejunostomy Duodenal disease Surgical technique Adults Indications Treatment Outcome

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Large-area photonic lift-off process for flexible thin-film transistors

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npj Flexible Electronics 2022年第1期6卷 115-124页

作者： adam m.Weidling Vikram STurkani Vahid Akhavan Kurt A.Schroder Sarah L.Swisher Department of Electrical and Computer Engineering University of Minnesota Twin Cities4-174 Keller Hall200 Union Street S.E.MinneapolisMN 55455USA NovaCentrix 400 Parker DriveSuite 1110AustinTX 78728USA

Fabricating flexible electronics on plastic is often limited by the poor dimensional stability of polymer *** mitigate,glass carriers are used during fabrication,but removing the plastic substrate from a carrier without damaging the electronics remains *** we utilize a large-area,high-throughput photonic lift-off(PLO)process to rapidly separate polymer films from rigid *** uses a 150µs pulse of broadband light from flashlamps to lift-off functional thin films from glass carrier substrates coated with a light absorber layer(LAL).modeling indicates that the polymer/LAL interface reaches above 800℃ during PLO,but the top surface of the PI remains below 120℃.An array of indium zinc oxide(IZO)thin-film transistors(TFTs)was fabricated on a polyimide substrate and photonically lifted off from the glass *** TFT mobility was unchanged by *** flexible TFTs were mechanically robust,with no reduction in mobility while flexed.

关键词： film process absorber

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CONVErGENCE AND OPTImALITY OF ADAPTIVE mIXED mETHODS FOr POISSON’S EQUATION IN THE FEEC FrAmEWOrK

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Journal of Computational mathematics 2020年第5期38卷 748-767页

作者： michael Holst Yuwen Li adam mihalik ryan Szypowski Department of mathematics University of CaliforniaSan DiegoCA 92123USA Department of mathematics and Statistics Cal Poly PomonaUSA

Finite Element Exterior Calculus (FEEC) was developed by Arnold, Falk, Winther andothers over the last decade to exploit the observation that mixed variational problems canbe posed on a Hilbert complex, and Galerkin-type mixed methods can then be obtained bysolving finite-dimensional subcomplex problems. Chen, Holst, and Xu (math. Comp. 78(2009) 35–53) established convergence and optimality of an adaptive mixed finite elementmethod using raviart–Thomas or Brezzi–Douglas–marini elements for Poisson’s equationon contractible domains in r^2, which can be viewed as a boundary problem on the derham complex. recently Demlow and Hirani (Found. math. Comput. 14 (2014) 1337–1371) developed fundamental tools for a posteriori analysis on the de rham *** this paper, we use tools in FEEC to construct convergence and complexity resultson domains with general topology and spatial dimension. In particular, we construct areliable and efficient error estimator and a sharper quasi-orthogonality result using a noveltechnique. Without marking for data oscillation, our adaptive method is a contractionwith respect to a total error incorporating the error estimator and data oscillation.

关键词： Finite Element Exterior Calculus Adaptive finite element methods A posteriori error estimates,Convergence Quasi-optimality

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Long-term temporal patterns in flight activities of a migrant diurnal butterfly

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Insect Science 2021年第3期28卷 839-849页

作者： Edit Juhasz adam Gor Daniella Bali Fanni Kerekgyarto Gergely Katona Zsolt Vegvari Department of Evolutionary Zoology and Human Biology University of DebrecenDebrecenHungary Department of Ecology University of Veterinary MedicineBudapestHungary Centre for Ecological research Danube Research InstituteBudapestHungary SDEI Entomology Information Centre Senckenberg Deutsches Entomologisches InstitutMOnchebergGermany

recent studies demonstrated that the Painted Lady(Vanessa cardui),a cosmopolitan diurnal butterfly performs long-range migration between subtropical Africa and north-western Europe,covered by individuals belonging to up to six *** we analyze temporal patterns of complete annual migratory activity of the Painted Lady in Hungary,located in its Central European migratory route,almost completely unstudied *** do so,we used field occurrence data collected between 2000 and 2019 and estimated temporal patterns in migratory activity by fitting kernel density functions on the daily mean number of individuals and observation *** temporal distributions of kernel density estimates were analyzed as a function of time and key climatic predictors of the study *** found that(i)the timing of spring arrivals has been advancing;(ii)the relative intensity of the first and last migratory peaks of the Painted Lady significantly increased during the past decades;and(iii)intensity of the last migratory peak is related to the mean temperature of the previous month,inferring that the migration is shifting to earlier dates and their volume of the migration has substantially intensified,evoking mutually nonexclusive,competing *** study indicates the strengthening migration activities of a southerly distributed,long-distance migrant diurnal butterfly,most probably linked to the northward shift of wintering areas induced by warming trends of the southern parts of ***,the complexity of the likely processes leading to changing migratory strategies calls up for further research in both breeding and wintering areas.

关键词： climatic responsiveness insect migration kernel density estimation Painted Lady

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Schizophrenia-associated microrNA–Gene Interactions in the Dorsolateral Prefrontal Cortex

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Genomics, Proteomics & Bioinformatics 2019年第6期17卷 623-634页

作者： Danielle m.Santarelli adam P.Carroll Heath m.Cairns Paul A.Tooney murray J.Cairns School of Biomedical Sciences and Pharmacy The University of NewcastleCallaghanNSW 2308Australia Centre for Brain and mental Health research Hunter Medical Research InstituteNewcastleNSW 2305Australia

Schizophrenia-associated anomalies in gene expression in postmortem brain can be attributed to a combination of genetic and environmental influences. Given the small effect size of common variants, it is likely that we may only see the combined impact of some of these at the pathway level in small postmortem studies. At the gene level, however, there may be more impact from common environmental exposures mediated by influential epigenomic modifiers, such as microrNA(mirNA). We hypothesise that dysregulation of mirNAs and their alteration of gene expression have significant implications in the pathophysiology of schizophrenia. In this study, we integrate changes in cortical gene and mirNA expression to identify regulatory interactions and networks associated with the disorder. Gene expression analysis in post-mortem prefrontal dorsolateral cortex(BA 46)(n = 74 matched pairs of schizophrenia, schizoaffective, and control samples)was integrated with mirNA expression in the same cohort to identify gene–mirNA regulatory networks. A significant gene–mirNA interaction network was identified, including mir-92 a, mir-495,and mir-134, which converged with differentially expressed genes in pathways involved in neurodevelopment and oligodendrocyte function. The capacity for mirNA to directly regulate gene expression through respective binding sites in BCL11 A, PLP1, and SYT11 was also confirmed to support the biological relevance of this integrated network model. The observations in this study support the hypothesis that mi rNA dysregulation is an important factor in the complex pathophysiology of schizophrenia.

关键词： Schizophrenia microrNA Dorsolateral prefrontal cortex Network Neuropathology

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Long-term changes and periodicity of ice phenomena in the high mountain Lake morskie Oko(Tatra mountains,Western Carpathians)

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Journal of mountain Science 2022年第11期19卷 3063-3075页

作者： POCIASK-KArTECZKA Joanna NIECKArZ Zenon CHOIŃSKI adam Institute of Geography and Spatial management Jagiellonian UniversityKraków 30387Poland marian Smoluchowski Institute of Physics Jagiellonian UniversityKraków 30348Poland Institute of Physical Geography and Environmental Planning Adam Mickiewicz University in PoznańPoznań61680Poland

High montain lakes are regarded as sensitive indicators of environmental changes in local and global *** recent years,climate change has considerablely influenced the timing of ice phenomena in these *** objective of the paper is an investigation of long-term changes and periodicity of ice phenomena in high mountain Lake morskie Oko(1392.8 m a.s.l.)located in the Tatra *** the period *** study employed the Lomb-Scargle periodogram,linear regression modelling for temporal trends,correlation analysis,parameters of variability,and flashiness *** of the duration of ice phenomena(~5.4 y)and ice cover on the lake(~13.5 y)was observed,although both are statistically *** cover duration has been interrupted several times by winter thaws after 1996 whereas no such events had been reported *** trend towards a delayed appearance of ice phenomena reaches 4.0 d·decade^(-1)(prved trend towards an earlier ice phenomena disappearance reaches 5.1 d·decade^(-1)(presults in a decline of the number of days with ice phenomena on Lake morskie Oko at a rate of 9.0 d·decade^(-1)(pration of ice cover on Lake morskie Oko has been decreasing at a rate of 10.4 d·decade^(-1).It is attributed to later freezeup(3.9 d·decade^(-1),prlier ice break-up(5.6 d·decade^(-1),preasing trend of average annual air temperature(0.4°C·decade^(-1),priod 1971-2020 is observed.A statistically significant correlation is recorded between ice phenomena and ice cover(beginning,end,duration),average annual air temperature,average air temperature of three summer months(June,July,August),and average air temperature of the six months period from June to *** air temperature induces growing heat resources accumulated in the lake water in the summer and autumn seasons,potentially causing later initiation of ice phenomena in the *** is no statistically significant r

关键词： Ice phenomena Lakes High mountains Climate warming East-Central Europe

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Equivariant analytical mapping of first principles Hamiltonians to accurate and transferable materials models

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npj Computational materials 2022年第1期8卷 1468-1481页

作者： Liwei Zhang Berk Onat Geneviève Dusson adam mcSloy G.Anand reinhard J.maurer Christoph Ortner James r.Kermode Department of mathematics University of British Columbia1984 Mathematics RoadVancouverBCV6T 1Z2Canada Warwick Centre for Predictive modelling School of EngineeringUniversity of WarwickCoventryCV47ALUK Laboratoire de mathématiques UMR CNRS 6623UniversitéBourgogne Franche-Comté16 route de Gray25030BesançonFrance Department of metallurgy and materials Engineering Indian Institute of Engineering Science and Technology-ShibpurHowrahWBIndia Department of Chemistry University of WarwickCoventryCV47ALUK

We propose a scheme to construct predictive models for Hamiltonian matrices in atomic orbital representation from ab initio data as a function of atomic and bond *** scheme goes beyond conventional tight binding descriptions as it represents the ab initio model to full order,rather than in two-centre or three-centre *** achieve this by introducing an extension to the atomic cluster expansion(ACE)descriptor that represents Hamiltonian matrix blocks that transform equivariantly with respect to the full rotation *** approach produces analytical linear models for the Hamiltonian and overlap *** an application to aluminium,we demonstrate that it is possible to train models from a handful of structures computed with density functional theory,and apply them to produce accurate predictions for the electronic *** model generalises well and is able to predict defects accurately from only bulk training data.

关键词： structure Hamiltonian analytical

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Interventions and targets aimed at improving quality in inflammatory bowel disease ambulatory care

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World Journal of Gastroenterology 2013年第38期19卷 6375-6382页

作者： adam V Weizman Geoffrey C Nguyen Division of Gastroenterology Women’s College HospitalUniversity of TorontoTorontoON M5S 1B2Canada mount Sinai Hospital Centre for Inflammatory Bowel Disease University of TorontoTorontoON M5G 1X5Canada Division of Gastroenterology and Hepatology Johns Hopkins School of MedicineBaltimoreMD 21205United States

Over the past decade,there has been increasing focus on improving the quality of healthcare delivered to patients with chronic diseases,including inflammatory bowel *** bowel disease is a complex,chronic condition with associated morbidity,health care costs,and reductions in quality of *** condition is managed primarily in the outpatient *** delivery of high quality of care is suboptimal in several ambulatory inflammatory bowel disease domains including objective assessments of disease activity,the use of steroid-sparing agents,screening prior to anti-tumor necrosis factor therapy,and monitoring thiopurine *** review outlines these gaps in performance and provides potential initiatives aimed at improvement including reimbursement programs,quality improvement frameworks,collaborative efforts in quality improvement,and the use of healthcare information technology.

关键词： Ambulatory care Crohn’s disease Inflammatory bowel disease Quality improvement Ulcerative colitis

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Uprooting phylogenetic uncertainty in coalescent species delimitation： A meta-analysis of empirical studies

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Current Zoology 2015年第5期61卷 866-873页

作者： Itzue W. C AVIEDES-SOLIS Nassima m. BOUZID Barbara L. BANBUrY adam D. LEACHE Department of Biology University of Washington Seattle WA 98195 USA Burke museum of Natural History and Culture University of Washington Seattle WA 98195 USA

Phylogenetic and phylogeographic studies rely on the accurate quantification of biodiversity. In recent studies of taxonomically ambiguous groups, species boundaries are often determined based on multi-locus sequence data. Bayesian Phylogenetics and Phylogeography （BPP） is a coalescent-based method frequently used to delimit species; however, empirical studies suggest that the requirement of a user-specified guide tree biases the range of possible outcomes. We evaluate fifteen multi-locus datasets using the most recent iteration of BPP, which eliminates the need for a user-specified guide tree and reconstructs the species tree in synchrony with species delimitation （= unguided species delimitation）. We found that the number of species recovered with guided versus unguided species delimitation was the same except for two cases, and that posterior probabilities were generally lower for the unguided analyses as a result of searching across species trees in addition to species delimitation models. The guide trees used in previous studies were often discordant with the species tree topologies estimated by BPP. We also compared species trees estimated using BPP and ＊BEAST and found that when the topologies are the same, BPP tends to give higher posterior probabilities [Current Zoology 61 （5）： 866-873, 2015].

关键词： BPP Species delimitation Phylogeography Species tree

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metal-organic frameworks of lanthanide iminodiacetates and tartrates:Synthesis,structural characterization and luminescence properties——Commemorating the 100th anniversary of the birth of Academician Guangxian Xu

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Journal of rare Earths 2021年第5期39卷 487-494页

作者： melissa Fairley m.m.Varuni S.Livera Wanmin Chen Jorge H.S.K.monteiro adam Schmitt Ana de Bettencourt-Dias Sue roberts Zhiping Zheng Department of Chemistry and Biochemistry University of ArizonaTucsonAZ 85721USA Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China Department of Chemistry University of NevadaRenoNV 89557USA

Two series of lanthanide-containing metal-organic frameworks(Ln-mOFs)of the general formula{[Ln(HIDA)_(2)H_(2)O]ClO_(4)·H_(2)O}_n(Ln=La(1),Nd(2),Eu(3),Gd(4),Tb(5),Eu:Tb(6);H_(2)IDA=iminodiacetic acid)and[Ln(TT)(HTT)(H_(2)O)_3]_n(Ln=Eu(7),Gd(8),Tb(9),Dy(10),and Eu:Tb(11);H_(2)TT=tartaric acid)were synthesized by reacting Ln(ClO_(4))_3 with iminodiacetic acid and L-tartaric acid,*** compounds were structurally characterized by single-crystal X-ray *** analyses are co nsistent with the corre sponding crystallographically generated *** reover,the luminescence properties of both the single and mixed-lanthanide complexes were *** infrared,red,and green emissions that are characteristic of Nd(Ⅲ),Eu(Ⅲ),and Tb(Ⅲ)are observed for 2,3/7,and 5/9,*** the two mixed-lanthanide complex systems 6 and 11,depending on the relative amount of Eu(Ⅲ)and Tb(Ⅲ),the color of emission can be *** is found that a small amount of Eu(Ⅲ)is adequate for the observation of the most intense transition of Eu(Ⅲ).This is believed to be a result of energy transfer from Tb(Ⅲ)to Eu(Ⅲ)within the same complex-a conclusion supported by the significantly shortened lifetime of Tb(Ⅲ)and the accompanying enhanced lifetime of Eu(Ⅲ)in the mixedlanthanide complex with respect to the corresponding values for the pure Tb(Ⅲ)and Eu(Ⅲ)complexes with the same ligand.

关键词： Lanthanides metal-organic frameworks Luminescence rare earths

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