检索结果-南通市图书馆

Probabilistic analysis of ultimate seismic bearing capacity of strip foundations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock mechanics and Geotechnical Engineering 2018年第4期10卷 717-724页

作者： adam Hamrouni Badreddine Sbartai Daniel Dias Laboratory InfraRes Mohammed Cherif Messaadia UniversitySouk-AhrasAlgeria Department of Civil Engineering Badji Mokhtar-Annaba UniversityAnnabaAlgeria Laboratory LmGHU Skikda UniversitySkikdaAlgeria School of Automotive and Transportation Engineering Hefei University of TechnologyHefei230009China Grenoble Alpes University Laboratory 3SRGrenobleFrance

This paper presents a reliability analysis of the pseudo-static seismic bearing capacity of a strip foundation using the limit equilibrium theory. The first-order reliability method(FORm) is employed to calculate the reliability index. The response surface methodology(RSm) is used to assess the Hasofer e Lind reliability index and then it is optimized using a genetic algorithm(GA). The random variables used are the soil shear strength parameters and the seismic coefficients(khand kv). Two assumptions(normal and non-normal distribution) are used for the random variables. The assumption of uncorrelated variables was found to be conservative in comparison to that of negatively correlated soil shear strength parameters. The assumption of non-normal distribution for the random variables can induce a negative effect on the reliability index of the practical range of the seismic bearing capacity.

关键词： Strip foundations Seismic bearing capacity First-order reliability method (FORm) Response surface methodology (RSm) Reliability Genetic algorithm (GA)

Perspectives on the role of mTORC2 in B lymphocyte development,immunity and tumorigenesis

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2011年第7期2卷 523-530页

作者： adam S.Lazorchak Bing Su Department of Immunobiology and the Vascular Biology and Therapeutic Program Yale School of MedicineNew HavenCT 06519USA

mammalian target of rapamycin complex 2(mTORC2)is a key downstream mediator of phosphoinositol-3-kinase(PI3K)dependent growth factor *** lymphocytes,mTORC2 has emerged as an important regulator of cell development,homeostasis and immune ***,our current understanding of mTORC2 functions and the molecular mechanisms regulating mTORC2 signaling in B and T cells are still largely *** studies have begun to shed light on this important *** have previously reported that mTORC2 mediates growth factor dependent phosphorylation of Akt and facilitates Akt dependent phosphorylation and inactivation of transcription factors FoxO1 and *** have recently explored the functions of mTORC2 in B cells and show that mTORC2 plays a key role in regulating survival and immunoglobulin(Ig)gene recombination of bone marrow B cells through an Akt2-FoxO1 dependent *** recombination is suppressed in proliferating B cells to ensure that DNA double strand breaks are not generated in actively dividing *** results raise the possibility that genetic or pharmacologic inhibition of mTORC2 may promote B cell tumor development as a result of inefficient suppression of Ig recombination in dividing B *** also propose a novel strategy to treat cancers based on our recent discovery that mTORC2 regulates Akt protein stability.

关键词： mTOR lymphocyte B cell cancer mTORC2 FoxO Akt Sin1

The development of the Rook's(Corvus frugilegus)colony in the face of shifting spring phenology

在线全文

学校读者我要写书评

暂无评论

Avian Research 2022年第2期13卷 170-174页

作者： adam Zbyryt Karol Zub Cezary mitrus Doctoral School of Exact and Natural Sciences University of Bialystok mammal Research Institute Polish Academy of Sciences Department of Vertebrate Ecology and Paleontology Institute of BiologyWroclaw University of Environmental and Life Sciences

many birds species breed in *** of the species in the Corvidae family nesting in groups is the Rook(Corvus frugilegus).The construction of the nest is costly for birds and needs high energy ***,birds should optimize the time of nest building in relation to environmental,especially weather,***,birds should adapt their breeding phenology,including the date of starting the construction of nests for climate *** observed the dynamics of increasing numbers of nests in a colony of Rooks in relation to air temperature,wind,rainfall,snowfall and day-length(indirect indicator of photoperiodism).Observations were carried out during three breeding seasons(2015-2017)in a large rookery in a big city in north-eastern *** increase in the number of nests was correlated only with day length and no effect of climatic factors on the number of nests in the colony was *** of nests varied significantly between successive years of *** the case of the Rook(predictable breeders),the photoperiod seems to be the most important factor influencing breeding behavior,especially nest *** the last three decades,increasing temperature and time of spring phases have advanced and have influenced changes in the phenology of the availability of food ***,a rapid decline in the numbers of breeding pairs of the Rook in Poland has been observed,especially in the last three *** attachment to the length of the day,which is the main factor responsible for the development of the breeding colony,makes the Rook appear to be a species with low plasticity in the face of rapid climate ***,we suggest that may indirectly influence the decrease in the breeding population of the Rook.

关键词： Breeding colony Climate change Corvus frugilegus Nest building Photoperiodism Predictable breeding

Reliability analysis of shallow tunnels using the response surface methodology

在线全文

学校读者我要写书评

暂无评论

Underground Space 2017年第4期2卷 246-258页

作者： adam Hamrouni Daniel Dias Badreddine Sbartai Grenoble Alpes Uniersity Laboratory 3SRGrenobleFrance mohamnmed Cherif messaadia University Laboratory InfraResSouk-AhrasAlgeria Department of Civil Engineering University Bdji Mokhtar Annaba&LMGHU LaboratoryUniversity 204out1955 SkikdaAlgeria

A probabilistic study of a circular tunnel excavated in a soil mass using the response surface methodology(RSm)is presented.A deterministic model based on two-dimensional numerical simulations in a transversal section is used,and the serviceability limit state(SLS)is considered in the *** model permits the surface settlement curve and the bending moment on the tunnel lining to be *** the soil parameters are considered as random ***ﬁrst-order reliability method(FORm)and the response surface methodology(RSm)are utilized for the assessment of the Hasofer-Lind reliability index(bHL)optimized by the use of a genetic algorithm(GA).Two assumptions(normal and non-normal distribution)were used for the random *** comparison analysis considering a correlation between the friction angle and the cohesion indicates that the results are conservative if a negative correlation among strength parameters is not taken into *** assumption of a non-normal distribution for the random variables has an important effect on the reliability index for the practical range of values of surface settlements.

关键词： Tunnel Convergence-conﬁnement method FORm Response surface reliability Limit states Approximate performance function Genetic algorithm

Bounded type Siegel disks of finite type maps with few singular values Dedicated to the memory of Professor Lei Tan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China mathematics 2018年第12期61卷 2139-2156页

作者： Arnaud Chéritat adam Lawrence Epstein CNRS Institut de Mathematiques de ToulouseUniversite Paul SabatierToulouse F-31062France mathematics Institute University of WarwickCoventry CV47ALUK

Let U be an open subset of the Riemann sphere C. We give sufficient conditions for which a finite type map f : U →C with at most three singular values has a Siegel disk compactly contained in U and whose boundary is a quasicircle containing a unique critical point. The main tool is quasiconformal surgery à la Douady-Ghys-Herman-(S′)wia tek. We also give sufficient conditions for which, instead, ? has not compact closure in U. The main tool is the Schwarzian derivative and area inequalities à la Graczyk-(S′)wia tek.

关键词： Siegel disks quasicircles quasiconformal surgery Schwarzian derivative

FIB Secondary Etching method for Fabrication of Fine CNT Forest metamaterials

在线全文

学校读者我要写书评

暂无评论

Nano-micro Letters 2017年第4期9卷 73-80页

作者： adam Pander Akimitsu Hatta Hiroshi Furuta Department of Electronic and Photonic Systems Engineering Kochi University of TechnologyTosayamadaKamiKochi 782-8502Japan Center for Nanotechnology Research InstituteKochi University of TechnologyTosayamadaKamiKochi 782-8502Japan

Anisotropic materials, like carbon nanotubes(CNTs), are the perfect substitutes to overcome the limitations of conventional metamaterials; however, the successful fabrication of CNT forest metamaterial structures is still very challenging. In this study, a new method utilizing a focused ion beam(FIB) with additional secondary etching is presented, which can obtain uniform and fine patterning of CNT forest nanostructures for metamaterials and ranging in sizes from hundreds of nanometers to several micrometers. The influence of the FIB processing parameters on the morphology of the catalyst surface and the growth of the CNT forest was investigated, including the removal of redeposited material,decreasing the average surface roughness(from 0.45 to 0.15 nm), and a decrease in the thickness of the Fe *** results showed that the combination of FIB patterning and secondary etching enabled the growth of highly aligned, highdensity CNT forest metamaterials. The improvement in the quality of single-walled CNTs(SWNTs), defined by the very high G/D peak ratio intensity of 10.47, demonstrated successful fine patterning of CNT forest for the first time. With a FIB patterning depth of 10 nm and a secondary etching of 0.5 nm, a minimum size of 150 nm of CNT forest metamaterials was achieved. The development of the FIB secondary etching method enabled for the first time, the fabrication of SWNT forest metamaterials for the optical and infrared regime, for future applications, e.g., in superlenses, antennas,or thermal metamaterials.

关键词： Carbon nanotubes metamaterial FIB patterning Secondary etching method Chemical vapor deposition

Crystal Structure of Arabidopsis thaliana Dawdle Forkhead-Associated Domain Reveals a Conserved Phospho-Threonine Recognition Cleft for Dicer-Like 1 Binding

在线全文

学校读者我要写书评

暂无评论

molecular Plant 2013年第4期6卷 1290-1300页

作者： Satoru machida Y.adam Yuan Department of Biological Sciences and Centre for Bioimaging Sciences National University of Singapore 14 Science Drive 4 Singapore 117543 Singapore Temasek Lifesciences Laboratory National University of Singapore 1 Research Link Singapore 117604 Singapore mechanobiology Institute National University of Singapore T-lab Building 5A Engineering Drive 1 Singapore 117411 Singapore

Dawdle （DDL） is a microRNA processing protein essential for the development of Arabidopsis. DDL contains a putative nuclear localization signal at its amino-terminus and forkhead-associated （FHA） domain at the carboxyl-termi- nus. Here, we report the crystal structure of the FHA domain of Arabidopsis Dawdle, determined by multiple-wavelength anomalous dispersion method at 1.7-A resolution. DDL FHA structure displays a seven-stranded 13-sandwich architec- ture that contains a unique structural motif comprising two long anti-parallel strands. Strikingly, crystal packing of the DDL FHA domain reveals that a glutamate residue from the symmetry-related DDL FHA domain, a structural mimic of the phospho-threonine, is specifically recognized by the structurally conserved phospho-threonine binding cleft. Consistently with the structural observations, co-immuno-precipitation experiments performed in Nicotiana benthami- ana show that the DDL FHA domain co-immuno-precipitates with DCL1 fragments containing the predicted pThr＋3（lle/ Val/Leu/Asp） motif. Taken together, we count the recognition of the target residue by the canonical binding cleft of the DDL FHA domain as the key molecular event to instate FHA domain-mediated protein-protein interaction in plant miRNA processing.

关键词： Arabidopsis DCL1 Arabidopsis DDL forkhead-associated domain phospho-threonine microRNA processing.

Apoptosis and DNA damage in human spermatozoa

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2011年第1期13卷 36-42页

作者： R John Aitken adam J Koppers ARC Centre of Excellence in Biotechnology and Development Priority Research Centre in Reproductive Science Discipline of Biological Sciences School of Environmental and Life Sciences University of Newcastle Callaghan NSW 2308 Australia Department of Anatomy and Developmental Biology School of Biomedical Sciences Monash University Clayton VIC 3800 Australia

DNA damage is frequently encountered in spermatozoa of subfertile males and is correlated with a range of adverse clinical outcomes including impaired fertilization, disrupted preimplantation embryonic development, increased rates of miscarriage and an enhanced risk of disease in the progeny. The etiology of DNA fragmentation in human spermatozoa is closely correlated with the appearance of oxidative base adducts and evidence of impaired spermiogenesis. We hypothesize that oxidative stress impedes spermiogenesis, resulting in the generation of spermatozoa with poorly remodelled chromatin. These defective cells have a tendency to default to an apeptotic pathway associated with motility loss, caspase activation, phosphatidylserine exteriorization and the activation of free radical generation by the mitochondria. The latter induces lipid peroxidation and oxidative DNA damage, which then leads to DNA fragmentation and cell death. The physical architecture of spermatozoa prevents any nucleases activated as a result of this apoptotic process from gaining access to the nuclear DNA and inducing its fragmentation. It is for this reason that a majority of the DNA damage encountered in human spermatozoa seems to be oxidative. Given the important role that oxidative stress seems to have in the etiology of DNA damage, there should be an important role for antioxidants in the treatment of this condition. If oxidative DNA damage in spermatozoa is providing a sensitive readout of systemic oxidative stress, the implications of these findings could stretch beyond our immediate goal of trying to minimize DNA damage in spermatozoa as a prelude to assisted conception therapy.

关键词： apoptosis DNA damage oxidative stress spermatozoa

modulation of individual components of gastric motor response to duodenal glucose

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第35期19卷 5863-5869页

作者： adam m Deane Laura K Besanko Carly m Burgstad marianne J Chapman michael Horowitz Robert JL Fraser Discipline of Acute Care medicine University of Adelaide Intensive Care Unit Royal Adelaide Hospital National Health and medical Research Council of Australia Centre for Clinical Research Excellence in Nutritional Physiology and Outcomes Investigation and Procedures Unit Repatriation General Hospital Department of Gastroenterology and Hepatology Royal Adelaide Hospital Discipline of medicine University of Adelaide Royal Adelaide Hospital

AIm:To evaluate individual components of the antro-pyloro-duodenal(APD)motor response to graded small intestinal glucose infusions in healthy ***:APD manometry was performed in 15healthy subjects(12 male;40±5 years,body mass index 26.5±1.6 kg/m2)during four 20-min intraduodenal infusions of glucose at 0,0.5,1.0 and 1.5 kcal/min,in a randomised double-blinded *** solutions were infused at a rate of 1 mL/min and separated by 40-min"wash-out"*** are mean±*** analyses are repeated measure analysis of variance with Bonferroni post-hoc ***:At 0 kcal/min frequency of pressure waves were:antrum(7.5±1.8 waves/20 min)and isolated pyloric pressure waves(IPPWs)(8.0±2.3 waves/20min)with pyloric tone(0.0±0.9 mmHg).Intraduodenal glucose infusion acutely increased IPPW frequency(Pmulation was observed at 1.0 kcal/min for pyloric phasic pressure waves(P=0.002)and 1.5 kcal/min for pyloric tone and antral ***:There is hierarchy for the activation of gastrointestinal motor responses to duodenal glucose *** increase in IPPWs is the first response observed.

关键词： Glucose Gastrointestinal motility Pyloric Antral Duodenum manometry motor activity Blood glucose