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针对10Gbps线卡应用的灵活性接口方案

世界电子元器件 2003年第11期 31-32页

作者： adam healey 杰尔系统系统与架构部

引言许多网络应用都采用10Gbps接口来减小通信瓶径.例如,用户对低成本千兆以太网(GbE)接入和VPLS需求的不断高涨,推动着运营商投入巨大力量建设10GbE城域网.这些网络是对已经向10Gbps SDH(STM-64)和DWDM(密集波分复用)发展的现有传输网... 详细信息

引言许多网络应用都采用10Gbps接口来减小通信瓶径.例如,用户对低成本千兆以太网(GbE)接入和VPLS需求的不断高涨,推动着运营商投入巨大力量建设10GbE城域网.这些网络是对已经向10Gbps SDH(STM-64)和DWDM(密集波分复用)发展的现有传输网络的补充.另外,这些网络所传输的内容一般缘于一个大的数据中心,而这些数据中心都是考虑用通过10Gbps光纤通道接口连接到光通道交换机,进而和服务器联系在一起,并依次连接交换机和存储子系统.

关键词： 10Gbps线卡接口 XFI 热拔插能力 FlexPHY器件光转发器 DWDM 密集波分复用

Why ecosystem characteristics predicted from remotely sensed data are unbiased and biased at the same time-and how this affects applications

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Forest Ecosystems 2024年第1期11卷 24-31页

作者： Goran Ståhl Terje Gobakken Svetlana Saarela Henrik J.Persson Magnus Ekstrom Sean P.healey Zhiqiang Yang Johan Holmgren Eva Lindberg Kenneth Nystrom Emanuele Papucci Patrik Ulvdal Hans OleØrka Erik Næsset Zhengyang Hou Håkan Olsson Ronald E.McRoberts Department of Forest Resource Management Swedish University of Agricultural Sciences90183UmeåSweden Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesÅsNorway USDA Forest Service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing100083China Department of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sensed data are frequently used for predicting and mapping ecosystem characteristics,and spatially explicit wall-to-wall information is sometimes proposed as the best possible source of information for ***,wall-to-wall information typically relies on model-based prediction,and several features of model-based prediction should be understood before extensively relying on this type of *** such feature is that model-based predictors can be considered both unbiased and biased at the same time,which has important implications in several areas of *** this discussion paper,we first describe the conventional model-unbiasedness paradigm that underpins most prediction techniques using remotely sensed(or other)auxiliary *** this point of view,model-based predictors are typically ***,we show that for specific domains,identified based on their true values,the same model-based predictors can be considered biased,and sometimes severely *** suggest distinguishing between conventional model-bias,defined in the statistical literature as the difference between the expected value of a predictor and the expected value of the quantity being predicted,and design-bias of model-based estimators,defined as the difference between the expected value of a model-based estimator and the true value of the quantity being *** show that model-based estimators(or predictors)are typically design-biased,and that there is a trend in the design-bias from overestimating small true values to underestimating large true ***,we give examples of applications where this is important to acknowledge and to potentially make adjustments to correct for the design-bias *** argue that relying entirely on conventional model-unbiasedness may lead to mistakes in several areas of application that use predictions from remotely sensed data.

关键词： Bias Model-based inference Design-based inference

阿哌沙班预防亚临床心房颤动患者卒中或全身栓塞的临床研究

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中国临床药理学杂志 2024年第3期40卷 424-424页

作者： healey J S 戴荣源

亚临床心房颤动因持续时间短,无症状,通常只能通过起搏器或除颤器进行长期持续监测才能发现。加拿大麦克马斯特大学healey团队对亚临床心房颤动患者进行了一项持续6 min至24 h的试验,按双盲、双模拟设计,患者被随机分配接受阿哌沙班,剂... 详细信息

亚临床心房颤动因持续时间短,无症状,通常只能通过起搏器或除颤器进行长期持续监测才能发现。加拿大麦克马斯特大学healey团队对亚临床心房颤动患者进行了一项持续6 min至24 h的试验,按双盲、双模拟设计,患者被随机分配接受阿哌沙班,剂量为5 mg,每日2次(2.5 mg,必要时每日2次)或阿司匹林,剂量为81 mg,每日1次。如果亚临床心房颤动持续超过24 h或出现临床心房颤动,则停止试验药物并开始抗凝治疗。主要疗效结局为卒中或全身性栓塞,在意向治疗人群(所有接受随机化的患者)中进行评估;主要安全性结局为大出血,在接受治疗的人群中进行评估(所有接受随机分组并接受至少一剂指定试验药物的患者,在全因永久停止试验药物后5 d进行随访)。

关键词：持续监测无症状心房颤动麦克马斯特大学阿司匹林随机分配阿哌沙班随机化

Longitudinal bending stiffness does not affect running economy in Nike Vaporfly Shoes

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Journal of Sport and Health Science 2022年第3期11卷 285-292页

作者： Laura A.healey Wouter Hoogkamer Integrative Locomotion Laboratory Department of KinesiologyUniversity of MassachusettsAmherstMA 01003-9258USA

Purpose This study aimed to determine the independent effect of the curved carbon-fiber plate in the Nike Vaporfly 4%shoe on running economy and running *** Fifteen healthy male runners completed a metabolic protocol and a biomechanics *** both protocols participants wore 2 different shoes,an intact Nike Vaporfly 4%(VF_(intact))and a cut Nike Vaporfly 4%(VF_(cut)).The VF_(cut) had 6 medio-lateral cuts through the carbon-fiber plate in the forefoot to reduce the effectiveness of the *** the metabolic protocol,participants ran at 14 km/h for 5 min,twice with each shoe,on a force-measuring treadmill while we measured metabolic *** the biomechanics protocol,participants ran across a runway with embedded force plates at 14 km/*** calculated running economy,kinetics,and lower limb joint *** Running economy did not significantly differ between shoe conditions(on average,0.55%±1.77%(mean±SD))worse in the VF_(cut) compared to the VF_(intact);95%confidence interval(-1.44%to 0.40%).Biomechanical differences were only found in the metatarsophalangeal(MTP)joint with increased MTP dorsiflexion angle,angular velocity,and negative power in the VF_(cut).Contact time was 1%longer in the VF_(intact).Conclusion Cutting the carbon-fiber plate and reducing the longitudinal bending stiffness did not have a significant effect on the energy savings in the Nike Vaporfly 4%.This suggests that the plate's stiffening effect on the MTP joint plays a limited role in the reported energy savings,and instead savings are likely from a combination and interaction of the foam,geometry,and plate.

关键词： Biomechanics Footwear Mechanical doping Metabolic rate Performance

Effects of hydrogen peroxide on in vitro infection of Cryptosporidium parvum

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Progress in Natural Science:Materials International 2001年第12期11卷 68-73页

作者：黄克和,杨世广,MarkC.healey College of Veterinary Medicine Nanjing Agricultural University Nanjing 210095 China Department of Animal Dairy and Veterinary Sciences Utah State University Utah 84322-5600 USA Department of Animal Dairy and Veterinary Sciences Utah State University Utah 84322-5600 USA

The effect of hydrogen peroxide (H2O2) on Cryptosporidium parvum infection and the protective function of free radical scavengers were studied in cultured bovine fallopian tubes epithelial cells. H2O2 treatment at 500 μmol/L and 1 mmol/L significantly inhibited excystation of bleach-treated oocysts (p < 0.01) . At 48 h postinoculation, H2O2 at 500 and 750 μmol/L resulted in a significant (p < 0.01) decrease of C. parvum infection by 35 .77% and 58.16% respectively in the cultured cells, when compared with the untreated control. Surprisingly, the infection was significantly increased from 22.21% to 39.33% (p<0.05) with lower concentration of H202( 50 - 200 μmol/L) . The inhibitory and stimulatory effects of H2O2 treatment on C. parvum infection were, to a certain extent, abolished in the presence of reduced glutathione or mannitol. These observations indicate that reactive oxygen species, such as H2O2, may play an important role in C. parvum infection.

关键词： Cryptosporidium parvum hydrogen peroxide free radical scavengers excystation cell culture.

PCR-based methodologies for detection and characterization of Listeria monocytogenes and Listeria ivanovii in foods and environmental sources

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Food Science and Human Wellness 2017年第2期6卷 39-59页

作者： Jin-Qiang Chen Stephanie healey Patrick Regan Pongpan Laksanalamai Zonglin Hu Winchester Engineering&Analytical Center(WEAC) HFR-NE460Office of Regulatory AffairsUS Food and Drug Administration109 Holton StreetWinchesterMA 01890USA MD DHMH Laboratories Administration Division of MicrobiologyRoom 5281770 Ashland Ave.BaltimoreMD 21205USA

Listeria monocytogenes is an important foodborne pathogen responsible for listeriosis,a fatal *** is widely distributed in various foods and environmental *** this review,we focused on addressing PCR-based technologies,including conventional PCR,qPCR and droplet digital PCR(ddPCR).Specifically,we described(a)conventional PCR and mono-,duplex-and multiplex-qPCR methodologies;(b)development and applications of gene HlyA-,Iap-,PrfA–and SsrA-based conventional and qPCR assays as well as PCR assays targeting newly identified gene targets for specific detection of ***;differentiation of viable from dead *** by qPCR in conjugation with propidium monoazide pretreatment;PCR-based serotype identification of *** isolates;PCR-based detection of ***,infecting ruminants,differentiation of *** from other Listeria species;and sigB-gene based PCR identification of Listeria spp;(c)applications of ddPCR in detection of ***;and(d)application of qPCR assays in detection and subtyping of *** in milk and dairy products;meats,meat products and meat-processing environment;and seafood,seafood products and processing *** goal was to provide a relatively comprehensive overview of PCR-based methodologies available in detection,characterization and subtyping of various strains of *** in foods and environmental sources.

关键词： Foodborne pathogens Listeria monocytogenes Listeria ivanovii qPCR

The national forest inventory in China:history-results-international context

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Forest Ecosystems 2015年第4期2卷 288-303页

作者： Wei Sheng Zeng Erkki Tomppo Sean P.healey Klaus V.Gadow Academy of Forest Inventory and Planning State Forestry Administration Natural Resources Institute Finland Forest Service United States Department of Agriculture University of G?ttingen Beijing Forestry University Department of Forestry and Wood Technology University of Stellenbosch

Background： National forest resource assessments Inventories （NFI＇s）, constitute an important nationa and monitoring, commonly known as National Forest information infrastructure in many countries. Methods： This study presents details about developments of the NFI in China, including sampling and plot design and the uses of alternative data sources, and specifically · reviews the evolution of the national forest inventory in China through the 20th and 21st centuries, with some reference to Europe and the US; · highlights the emergence of some common international themes： consistency of measurement; sampling designs; implementation of improved technology; expansion of the variables monitored more efficient scientific transparency;· presents an example of how China＇s expanding NFI exemplifies these global trends. Results： Main results and important changes in China＇s NFI are documented, both to support continued trend analysis and to provide data users with historical perspective. Conclusions： New technologies and data needs ensure that the Chinese NFI, like the national inventories in other countries, will continue to evolve. Within the context of historical change and current conditions, likely directions for this evolution are suggested.

关键词： China Europe USA National forest inventories Forest inventory and analysis

Prevalence and methodologies for detection,characterization and subtyping of Listeria monocytogenes and *** in foods and environmental sources

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Food Science and Human Wellness 2017年第3期6卷 97-120页

作者： Jin-Qiang Chena Patrick Regan Pongpan Laksanalamai Stephanie healey Zonglin Hua Winchester Engineering Analytical Center(WEAC)HFR-NE460Office of Regulatory AffairsUS Food and Drug Administration109 Holton StreetWinchesterMA 01890USA MD DHMH Laboratories Administration Division of MicrobiologyRoom 5281770 Ashland Ave.BaltimoreMD 21205USA

Listeria monocytogenes,one of the most important foodborne pathogens,can cause listeriosis,a lethal disease for ***,which is closely related to ***,is also widely distributed in nature and infects mainly warm-blooded ruminants,causing economic ***,there are high priority needs for methodologies for rapid,specific,cost-effective and accurate detection,characterization and subtyping of *** and *** in foods and environmental *** this review,we(A)described *** and ***,world-wide incidence of listeriosis,and prevalence of various *** strains in food and environmental sources;(B)comprehensively reviewed different types of traditional and newly developed methodologies,including culture-based,antigen/antibody-based,LOOP-mediated isothermal amplification,matrix-assisted laser desorption ionization-time of flight-mass spectrometry,DNA microarray,and genomic sequencing for detection and characterization of *** in foods and environmental sources;(C)comprehensively summarized different subtyping methodologies,including pulsed-field gel electrophoresis,multi-locus sequence typing,ribotyping,and phage-typing,and whole genomic sequencing *** subtyping of *** strains from food and environmental sources;and(D)described the applications of these methodologies in detection and subtyping of *** in foods and food processing facilities.

关键词： Foodborne pathogens Listeria monocytogenes Listeria ivanovii Molecular characterization Subtyping

How to Heat a Planet? Impact of Anthropogenic Landscapes on Earth’s Albedo and Temperature

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International Journal of Geosciences 2020年第6期11卷 420-457页

作者： Mark healey Lindfield Australia

Today anthropogenic climate change is underway and predicted future global temperatures vary significantly. However, the drivers of current climate change and their links to Earth’s natural glacial cycle have yet to be fully resolved. Currently, many on a local level understand, and are exposed to, the heat energy generated by what’s referred to as the urban heat island effect (UHI), whereby natural flora with higher albedos is replaced by manmade urban areas with lower albedos. This heat effect is not constrained to these regions and all anthropogenic surfaces with lower albedos need to be studied and quantified as the accumulated additional heat energy (infrared energy) is trapped within Earth’s atmosphere and could affect the Earth on a planetary level. Deployed satellites have detected critical changes to Earth’s albedo to lower levels, however the cause and impact of these changes have yet to be fully understood and incorporated into Global Circulation models (GCMs). Here it’s shown that industrialization of anthropogenic landscape practices of the past century has displaced millions of square kilometres of naturally high albedo grasslands with lower albedo agricultural landscapes. Utilising a fundamental Energy Balance Model, (EBM) it’s demonstrated these specific changes have generated vast amounts of additional heat energy which is trapped by the atmosphere, transferred and stored within the oceans of the Earth as shown in Figure 1

关键词： Earth Albedo Anthropogenic Landscape Changes Heat Fluxes Earth’s Energy Budget Glacial Cycle Gaia Links