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World Journal of Gastroenterology 2023年第47期29卷 6165-6167页

作者： Matthew Peverelle Jonathan Ng James Peverelle Ryan D.Hirsch adam Testro Liver transplant unit Austin HealthMelbourne 3084Australia Liver transplant unit Austin HealthHeidelberg 3084VictoriaAustralia

There is rapidly increasing uptake of GLP-1 (glucagon-like peptide-1) agonistssuch as semaglutide worldwide for weight loss and management of non-alcoholicsteatohepatitis (NASH). remains a paucity of safety data in the vulnerable NASHcirrhotic population. We report herein the first documented case of liver decompensationand need for liver transplant waitlisting in a patient with NASHcirrhosistreated with semaglutide. Rapid weight loss led to the development ofascites and hepatic encephalopathy and an increase in the patients Model forEndstage Liver Disease-Na (MELD-Na) score from 11 to 22. Aggressive nutritionalsupplementation was commenced and the semaglutide was stopped. Overthe following months she regained her weight and her liver recompensated andher MELD-Na decreased to 13, allowing her to be delisted from the transplantwaitlist. This case serves as a cautionary tale to clinicians using semaglutide in thecirrhotic population and highlights the need for more safety data in this patientgroup.

关键词： Semaglutide Non-alcoholic steatohepatitis Cirrhosis Non-alcoholic steatohepatitis cirrhosis Glucagon-like peptide 1 agonists Weight loss

Protection of armoured vehicles against chemical, biological and radiological contamination

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Defence Technology（防务技术） 2021年第2期17卷 384-392页

作者： adam Wisniewski Jacek Pirszel Military Institute of Armament Technology Wyszynskiego 705-220ZielonkaPoland Military Institute of Chemistry and Radiometry al.gen.Antoniego Chrusciela“Montera”10500-910WarszawaPoland

The article presents problems related to mechanical protection of vehicles with different add-on armours against chemical,biological and radiological *** applies to vehicles with additional passive,reactive and hybrid protection in the form of cassettes against piercing with anti-tank projectiles,piercing with their kinetic energy of impact,and as a result of chemical energy of shaped charges as well as explosively formed *** has been shown how increased ballistic protection of these vehicles at the same time reduces their decontaminability in various places of the vehicle due to the increased additional surface of the vehicle with *** of contamination of these cassettes has been presented as a way of reducing hard to reach surface for decontamination and a method of insulating construction elements(stands),fixing these cassettes to the vehicle,from the environment to prevent contact with contaminated liquids and *** selection of appropriate materials is shown,which may affect the improvement of the decontamination efficiency of the vehicle with such *** applies to the use of materials with low absorption of chemical warfare agents,which prevent the accumulation of large amounts of these agents on contaminated surfaces and improve the effectiveness of *** also shows how to ensure better access of the disinfectant to as much of the vehicle surface as possible,covered with cassettes that have been *** shows how a vehicle,in particular with such cassettes,can provide protection against radar detection when Radar Absorbent Material is used on vehicle cassettes.

关键词： Protection of ERA CBR defence Chemical warfare agents Vehicle decontamination Radar absorbent material Additive manufacturing

Distributional Considerations for Transboundary Risk Governance of Environmental Threats

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International Journal of Disaster Risk Science 2018年第4期9卷 445-453页

作者： adam Rose Price School of Public Policy University of Southern California

Most policy analyses of both short-term and long-term disasters focus on aggregate impacts of their costs and the benefits of policy remedies. Distributional considerations relating to the costs of these disasters and the benefits of their risk management, however, are very important in many cases. This article examines two broad categories of cases in terms of distributional considerations. The first category is where transboundary considerations strongly affect risk governance, as in the case of climate change. The second relates to ordinary, short-term disasters, which include fewer, but still important, transboundary issues. Climate change policy requires information regarding the distribution of impacts and policy responses across countries because it is a global *** disasters involve transboundary considerations much less frequently, so the attention typically shifts to the distribution of benefits and costs within a jurisdiction. In both cases distributional information is needed to evaluate the equity of policies and to provide information for public participation in the policy process. This article offers modeling and policy approaches to address these issues.

关键词： Climate change Disasters Distributional effects Policy analysis Risk governance Transboundary impacts

Sharp Inequalities for BMO Functions

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Chinese Annals of Mathematics,Series B 2015年第2期36卷 225-236页

作者： adam OSEKOWSKI Faculty of Mathematics Informatics and Mechanics University of Warsaw

纸的目的是为围住的吝啬的摆动的功能学习突然地弱类型的界限。让 0 p 我间隔被包含在里面。作者为任何东西显示出那：我和任何子集 E 我积极措施， $$\begin { 数组 }{*{ 20 } c }{\frac {{\left |我 \right|^{-\tfrac { 1 }{ p }}}}{{... 详细信息

纸的目的是为围住的吝啬的摆动的功能学习突然地弱类型的界限。让 0 p 我间隔被包含在里面。作者为任何东西显示出那：我和任何子集 E 我积极措施， $$\begin { 数组 }{*{ 20 } c }{\frac {{\left |我 \right|^{-\tfrac { 1 }{ p }}}}{{\left |E \right|^{ 1 -\tfrac { 1 }{ p }}}}\int_E {\left |{\phi -\frac { 1 }{{\left |我 \right|}}\int_I {\phi dy }}\right|dx \leqslant \left\|\phi \right\|_{ BMO (I)} ， 0For 各个 p，右边上的常数是可能的最好。证明在联系贝尔曼功能的明确的评估上休息。结果是 Slavin， Vasyunin 和 Volberg 有关的更早的工作的补充弱类型， L 为 BMO 班的 p 和指数的界限。

关键词： BMO函数不等式夏普电子商务弱型平均子集镝

Laser technology in Poland： 2013-2016

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Frontiers of Optoelectronics 2017年第3期10卷 267-272页

作者： adam CENIAN Institute of Fluid-Flow Machinery Polish Academy of Sciences Gdaflsk Poland

This paper presents the state of art of laser technologies in Poland. A list of primary laser technology development centers is included. The involvement of Polish scientists in the development of lasers and fourth generation synchrotron light sources as well as their applications is discussed. The development of laser applications in medical therapy and diagnostics, material micro- and macro-processing as well as environmental monitoring and protection, safety, and security is presented.

关键词： laser technologies synchrotron light sources,laser micro-processing laser diagnostics laser medical applications

Predictability and Risk of Extreme Winter PM_(2.5)Concentration in Beijing

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Journal of Meteorological Research 2023年第5期37卷 632-642页

作者： Jingpeng LIU adam A.SCAIFE Nick DUNSTONE Hong-Li REN Doug SMITH Steven CHARDIMAN Bo WU China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreChina Meteorological AdministrationBeijing 100081China Met Office Hadley Centre Exeter EX13PBUnited Kingdom College of Engineering Mathematicsand Physical SciencesUniversity of ExeterExeter EX44QGUnited Kingdom State Key Laboratory of Severe Weather and Institute of Tibetan Plateau Meteorology Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

Air pollution remains a serious environmental and social problem in many big cities in the *** to predict and estimate the risk of extreme air pollution is unsettled *** study tries to provide a solution to this challenge by examining the winter PM_(2.5)concentration in Beijing based on the UNprecedented Simulation of Extremes with ENsembles(UNSEEN)*** PM_(2.5)concentration observations in Beijing,Japanese 55-yr reanalysis data,and the Met Office near term climate prediction system(DePreSys3a)large ensemble simulations are used,and 10,000proxy series are generated with the model fidelity *** is found that in Beijing,the main meteorological driver of PM_(2.5)concentration is monthly 850-hPa meridional wind(V850).Although the skill in prediction of V850 is low on seasonal and longer timescales,based on the UNSEEN,we use large ensemble of initialized climate simulations of V850 to estimate the current chance and risk of unprecedented PM_(2.5)concentration in *** unravel that there is a 3%(2.1%–3.9%)chance of unprecedented low monthly V850 corresponding to high PM_(2.5)in each winter,within the 95%range,calculated by bootstrap resampling of the ***,we use the relationship between air quality and winds to remove the meridional wind influence from the observed record,and find that anthropogenic intervention appears to have reduced the risk of extreme PM_(2.5)in Beijing in recent years.

关键词： UNprecedented Simulation of Extremes with ENsembles(UNSEEN) climate risk PM_(2.5) Beijing

Comparative genome analysis of three euplotid protists provides insights into the evolution of nanochromosomes in unicellular eukaryotic organisms

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Marine Life Science & Technology 2023年第3期5卷 300-315页

作者： Didi Jin Chao Li Xiao Chen adam Byerly Naomi AStover Tengteng Zhang Chen Shao Yurui Wang Laboratory of Protozoological Biodiversity and Evolution in Wetland College of Life SciencesShaanxi Normal UniversityXi’an 710119China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Laboratory of Marine Protozoan Biodiversity and Evolution Marine CollegeShandong UniversityWeihai 264209China Department of Computer Science and Information Systems Bradley UniversityPeoria 61625USA Department of Biology Bradley UniversityPeoria 61625USA

One of the most diverse clades of ciliated protozoa,the class Spirotrichea,displays a series of unique characters in terms of eukaryotic macronuclear(MAC)genome,including high fragmentation that produces ***,the genomic diversity and evolution of nanochromosomes and gene families for spirotrich MAC genomes are poorly *** this study,we assemble the MAC genome of a representative euplotid(a new model organism in Spirotrichea)species,Euplotes *** results indicate that:(a)the MAC genome includes 35,465 contigs with a total length of 97.3 Mb and a contig N50 of 3.4 kb,and contains 13,145 complete nanochromosomes and 43,194 predicted genes,with the majority of these nanochromosomes containing tiny introns and harboring only one gene;(b)genomic comparisons between *** and other reported spirotrichs indicate that average GC content and genome fragmentation levels exhibit interspecifc variation,and chromosome breaking sites(CBSs)might be lost during evolution,resulting in the increase of multi-gene nanochromosome;(c)gene families associated with chitin metabolism and FoxO signaling pathway are expanded in ***,suggesting their potential roles in environment adaptation and survival strategies of ***;and(d)a programmed ribosomal frameshift(PRF)with a conservative motif 5′-AAATAR-3′tends to occur in longer genes with more exons,and PRF genes play an important role in many cellular regulation processes.

关键词： Ciliate Euplotes Genome fragmentation Gene family expansion

MiR-140 downregulates fatty acid synthesis by targeting transforming growth factor alpha(TGFA)in bovine mammary epithelial cells

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Journal of Integrative Agriculture 2022年第10期21卷 3004-3016页

作者： CHU Shuang-feng ZHAO Tian-qi Abdelaziz adam Idriss ARBAB YANG Yi CHEN Zhi YANG Zhang-ping College of Animal Science and Technology Yangzhou UniversityYangzhou 225009P.R.China Joint International Research Laboratory of Agriculture&Agri-Product Safety Yangzhou UniversityYangzhou 225009P.R.China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses College of Veterinary MedicineYangzhou UniversityYangzhou 225009P.R.China

Fat is an indispensable nutrient and basic metabolite for sustaining life,and milk is particularly rich in fatty acids,including a variety of saturated and unsaturated fatty ***(miRNA)and mRNA play an important role in the regulation of milk fat metabolism in mammary gland *** has been shown that lipid metabolism has a complex transcriptional regulation,but the mechanism by which milk fat synthesis is regulated through miRNA–mRNA interactions is poorly *** this study,we performed transcriptome sequencing with bovine mammary gland tissue in the late lactation(270 and 315 days after parturition)to identify the key gene that regulating milk fat metabolism.A total of 1207 differentially coexpressed genes were selected,828 upregulated genes and 379 downregulated genes were *** transforming growth factor alpha(TGFA)gene was selected as the target gene,and luciferase reporter assay,Western blotting and q RT-PCR were used for further *** results demonstrated that miR-140 was an upstream regulator of TGFA,and miR-140 could inhibit(P<0.01)unsaturated fatty acid and triglyceride(TAGs)production in bovine mammary epithelial cells(BMECs).In contrast,TGFA promoted(P<0.01)unsaturated fatty acid and TAG *** experiments further indicated the mi R-140/TGFA regulatory *** together,these results suggest that the mi R-140/TGFA pathway can inhibit(P<0.01)milk fat metabolism and improve milk quality by genetic means.

关键词： bovine mammary epithelial cells TGFA transcriptome sequencing miR-140 fatty acid metabolism

Think global,cube local:an Earth Observation Data Cube’s contribution to the Digital Earth vision

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Big Earth Data 2023年第3期7卷 831-859页

作者： Martin Sudmanns Hannah Augustin Brian Killough Gregory Giuliani Dirk Tiede Alex Leith Fang Yuan adam Lewis Department of Geoinformatics Paris Lodron University SalzburgSalzburgAustria NASA Langley ResearchCenter HamptonVAUSA Institute for Environmental Sciences University of GenevaenviroSPACEGenevaSwitzerland Institute for Environmental Sciences University of GenevaGRID-GenevaGenevaSwitzerland Geoscience Australia CanberraACTAustralia Group on Earth Observations(GEO)DigitalEarth Africa GenevaSwitzerland

The technological landscape for managing big Earth observation(EO)data ranges from global solutions on large cloud infrastructures with web-based access to self-hosted *** data cubes are a leading technology for facilitating big EO data analysis and can be deployed on different spatial scales:local,national,regional,or *** EO data cubes with a geographic focus(“local EO data cubes”)have been ***,their alignment with the Digital Earth(DE)vision and the benefits and trade-offs in creating and maintaining them ought to be further *** investigate local EO data cubes from five perspectives(science,business and industry,government and policy,education,communities and citizens)and illustrate four examples covering three continents at different geographic scales(Swiss Data Cube,semantic EO data cube for Austria,DE Africa,Virginia Data Cube).A local EO data cube can benefit many stakeholders and players but requires several technical *** developments include enabling local EO data cubes based on public,global,and cloud-native EO data streaming and interoperability between local EO data *** argue that blurring the dichotomy between global and local aligns with the DE vision to access the world’s knowledge and explore information about the planet.

关键词： Earth Observation data cube Digital Earth interoperability workflows open data cube

Organizational Data Breach:Building Conscious Care Behavior in Incident Response

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Computer Systems Science & Engineering 2022年第2期40卷 505-515页

作者： Adlyn adam Teoh Norjihan Binti Abdul Ghani Muneer Ahmad Nz Jhanjhi Mohammed A.Alzain Mehedi Masud Department of Information Systems Faculty of Computer Science&Information TechnologyUniversiti Malaya50603Kuala LumpurMalaysia School of Computer Science and Engineering SCE Taylor’s UniversitySubang Jaya47500Malaysia Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia

Organizational and end user data breaches are highly implicated by the role of information security conscious care behavior in respective incident *** research study draws upon the literature in the areas of information security,incident response,theory of planned behaviour,and protection motivation theory to expand and empirically validate a modified framework of information security conscious care behaviour *** applicability of the theoretical framework is shown through a case study labelled as a cyber-attack of unprecedented scale and sophistication in Singapore’s history to-date,the 2018 SingHealth data *** single in-depth case study observed information security awareness,policy,experience,attitude,subjective norms,perceived behavioral control,threat appraisal and self-efficacy as emerging prominently in the framework’s applicability in incident *** data analysis did not support threat severity relationship with conscious care *** findings from the above-mentioned observations are presented as possible key drivers in the shaping information security conscious care behaviour in real-world cyber incident management.

关键词： End user computing organizational behavior incident response data breach computer emergency response team cyber-attack